Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | importin beta-1, putative | 0.0027 | 0.0079 | 0.003 |
Entamoeba histolytica | hypothetical protein | 0.0027 | 0.0079 | 0.137 |
Mycobacterium ulcerans | beta-lactamase | 0.0209 | 0.1458 | 0.1949 |
Brugia malayi | RNA, U transporter 1 | 0.0095 | 0.0595 | 0.408 |
Mycobacterium leprae | Probable lipase LipE | 0.0209 | 0.1458 | 0.2106 |
Trypanosoma brucei | beta lactamase | 0.0074 | 0.0434 | 0.2675 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0209 | 0.1458 | 0.2237 |
Echinococcus granulosus | snurportin 1 | 0.0357 | 0.2583 | 1 |
Onchocerca volvulus | 0.0209 | 0.1458 | 1 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.011 | 0.0756 |
Schistosoma mansoni | importin beta-1 | 0.0033 | 0.0127 | 0.0489 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0074 | 0.0434 | 0.0274 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0027 | 0.0079 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.1458 | 0.5644 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.011 | 0.0425 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.0198 | 0.0221 |
Brugia malayi | Inositol-1 | 0.0043 | 0.0198 | 0.1358 |
Plasmodium vivax | hypothetical protein, conserved | 0.0209 | 0.1458 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0.0198 | 0.099 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0518 | 0.3807 | 0.5929 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0357 | 0.2583 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0209 | 0.1458 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0.0079 | 0.003 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0848 | 0.6309 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0209 | 0.1458 | 0.2237 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.0198 | 0.0765 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0209 | 0.1458 | 0.5643 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.011 | 0.0425 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0085 | 0.0521 | 0.2016 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0209 | 0.1458 | 0.5643 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0027 | 0.0079 | 0.003 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0848 | 0.6309 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.1458 | 0.5644 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0025 | 0.006 | 0.0229 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0043 | 0.0198 | 0.0766 |
Schistosoma mansoni | lamin | 0.0031 | 0.011 | 0.0425 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0198 | 0.0765 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.0198 | 0.0992 |
Toxoplasma gondii | ABC1 family protein | 0.0209 | 0.1458 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0198 | 0.0222 |
Trichomonas vaginalis | esterase, putative | 0.0209 | 0.1458 | 0.2237 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.1365 | 0.5283 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0033 | 0.0127 | 0.0479 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0209 | 0.1458 | 0.1949 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0154 | 0.1041 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.1458 | 0.5644 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0209 | 0.1458 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0209 | 0.1458 | 0.1316 |
Echinococcus multilocularis | geminin | 0.0197 | 0.1365 | 0.5283 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0207 | 0.1444 | 0.2083 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0043 | 0.0198 | 0.0766 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0474 | 0.347 | 0.5379 |
Plasmodium vivax | importin-beta 2, putative | 0.0033 | 0.0127 | 0.0479 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0209 | 0.1458 | 1 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0848 | 0.6309 | 0.9454 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0106 | 0.041 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0209 | 0.1458 | 0.1316 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0025 | 0.006 | 0.0409 |
Mycobacterium ulcerans | lipase LipD | 0.0209 | 0.1458 | 0.1949 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0474 | 0.347 | 0.5061 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.011 | 0.0427 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0209 | 0.1458 | 0.2237 |
Mycobacterium tuberculosis | Conserved protein | 0.0209 | 0.1458 | 0.1316 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0198 | 0.0765 |
Leishmania major | importin beta-1 subunit, putative | 0.0027 | 0.0079 | 0.0136 |
Echinococcus granulosus | geminin | 0.0197 | 0.1365 | 0.5283 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.033 | 0.2375 | 0.2248 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0043 | 0.0198 | 1 |
Echinococcus multilocularis | musashi | 0.0031 | 0.011 | 0.0425 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0209 | 0.1458 | 0.2237 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0794 | 0.59 | 1 |
Brugia malayi | beta-lactamase | 0.0209 | 0.1458 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0198 | 0.099 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0207 | 0.1444 | 0.1928 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0198 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.1458 | 0.5644 |
Onchocerca volvulus | 0.0209 | 0.1458 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0127 | 0.049 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0474 | 0.347 | 0.3361 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0043 | 0.0198 | 0.0766 |
Mycobacterium tuberculosis | Conserved protein | 0.0209 | 0.1458 | 0.1316 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0033 | 0.0127 | 0.0489 |
Brugia malayi | beta-lactamase family protein | 0.0209 | 0.1458 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0033 | 0.0127 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0209 | 0.1458 | 0.1316 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.1458 | 0.5644 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 0.2583 | 1 |
Echinococcus multilocularis | lamin | 0.0031 | 0.011 | 0.0425 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0043 | 0.0198 | 0.0766 |
Brugia malayi | Importin beta-1 subunit | 0.0033 | 0.0127 | 0.0869 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0791 | 0.588 | 0.879 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0127 | 0.0479 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0043 | 0.0198 | 0.0766 |
Loa Loa (eye worm) | inositol-1 | 0.0043 | 0.0198 | 0.0767 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0043 | 0.0198 | 0.0766 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0207 | 0.1444 | 0.1302 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0074 | 0.0434 | 0.0439 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.0198 | 0.0992 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0518 | 0.3807 | 0.5583 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0209 | 0.1458 | 0.1316 |
Schistosoma mansoni | ran | 0.0025 | 0.006 | 0.0229 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0209 | 0.1458 | 0.1316 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0209 | 0.1458 | 0.1949 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0198 | 0.099 |
Mycobacterium ulcerans | hypothetical protein | 0.0209 | 0.1458 | 0.1949 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0518 | 0.3807 | 0.3704 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.0264 | 0.1878 | 0.1743 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0794 | 0.59 | 0.0472 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.0198 | 0.0992 |
Schistosoma mansoni | ran | 0.0025 | 0.006 | 0.0229 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.0198 | 0.9972 |
Mycobacterium leprae | conserved hypothetical protein | 0.0209 | 0.1458 | 0.2106 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0043 | 0.0198 | 0.0221 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.011 | 0.0425 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0209 | 0.1458 | 0.5643 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0043 | 0.0198 | 0.0992 |
Echinococcus granulosus | importin subunit beta 1 | 0.0033 | 0.0127 | 0.0489 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.011 | 0.0425 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0209 | 0.1458 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.1458 | 0.5644 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0154 | 0.1041 | 0.1305 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.1365 | 0.5283 |
Echinococcus multilocularis | snurportin 1 | 0.0357 | 0.2583 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.011 | 0.0425 |
Loa Loa (eye worm) | beta-lactamase | 0.0209 | 0.1458 | 0.5644 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0209 | 0.1458 | 0.2237 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0198 | 0.099 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0209 | 0.1458 | 0.5644 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0043 | 0.0198 | 0.1361 |
Onchocerca volvulus | 0.0209 | 0.1458 | 1 | |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0043 | 0.0198 | 0.0766 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0209 | 0.1458 | 1 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0085 | 0.0521 | 0.2016 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.0264 | 0.1878 | 0.2789 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.0794 | 0.59 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0209 | 0.1458 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0043 | 0.0198 | 0.0221 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0209 | 0.1458 | 0.5643 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0848 | 0.6309 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.0198 | 0.0765 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.0074 | 0.0434 | 0.0365 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0043 | 0.0198 | 0.0222 |
Mycobacterium ulcerans | multidrugs-transport integral membrane protein Mmr-like | 0.0895 | 0.6662 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0209 | 0.1458 | 0.1316 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.011 | 0.0427 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0043 | 0.0198 | 0.0766 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0025 | 0.006 | 0.0229 |
Mycobacterium ulcerans | multidrug-transport integral membrane protein Mmr | 0.0225 | 0.1583 | 0.2142 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0043 | 0.0198 | 0.0222 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0209 | 0.1458 | 0.1316 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0033 | 0.0127 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.011 | 0.0427 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.011 | 0.0756 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0209 | 0.1458 | 0.1316 |
Echinococcus granulosus | lamin | 0.0031 | 0.011 | 0.0425 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0198 | 0.099 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0043 | 0.0198 | 1 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0025 | 0.006 | 0.0231 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 53 uM | Inhibitory activity against HIV integrase in the strand transfer step | ChEMBL. | 9873453 |
IC50 (binding) | = 53 uM | Inhibitory activity against HIV integrase in the strand transfer step | ChEMBL. | 9873453 |
IC50 (binding) | = 75 uM | Inhibitory activity against HIV integrase in the 3' processing step | ChEMBL. | 9873453 |
IC50 (binding) | = 75 uM | Inhibitory activity against HIV integrase in the 3' processing step | ChEMBL. | 9873453 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.