TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 435.398 | Formula: C22H31BrN2O2
H donors: 0 H acceptors: 1 LogP: 4.54 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCC12CN3CC(C2=O)(CN(C1)C3c1cc(Br)ccc1OCC)CCC
InChi: 1S/C22H31BrN2O2/c1-4-9-21-12-24-14-22(10-5-2,20(21)26)15-25(13-21)19(24)17-11-16(23)7-8-18(17)27-6-3/h7-8,11,19H,4-6,9-10,12-15H2,1-3H3
InChiKey: IBAFJQFNYCHVQJ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0215	0.0215
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0143	0.0064
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0113	0.0356	0.0236
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0553	0.2284	0.2172
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.0318	0.0318
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0143	0.0143
Trypanosoma brucei	glucosidase, putative	0.0553	0.2284	1
Trichomonas vaginalis	glycoside hydrolase, putative	0.0255	0.0977	0.1625
Trichomonas vaginalis	beta-glucosidase, putative	0.0128	0.0422	0.0701
Toxoplasma gondii	facilitative glucose transporter GT1	0.0105	0.0318	0.0987
Brugia malayi	Glycosyl hydrolases family 2, sugar binding domain containing protein	0.0056	0.0105	0.003
Trichomonas vaginalis	beta-mannosidase, putative	0.0052	0.0086	0.0143
Onchocerca volvulus	Glucosylceramidase homolog	0.0921	0.3896	0.5408
Echinococcus granulosus	fucosidase alpha L 1 tissue	0.0415	0.1678	0.1678
Brugia malayi	hypothetical protein	0.0069	0.0164	0.0089
Schistosoma mansoni	ceramide glucosyltransferase	0.0737	0.3089	0.3408
Echinococcus multilocularis	General substrate transporter	0.009	0.0254	0.0112
Echinococcus granulosus	neutral alpha glucosidase AB	0.0553	0.2284	0.2284
Loa Loa (eye worm)	hypothetical protein	0.0281	0.1089	0.1089
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0143	0.0068
Echinococcus granulosus	phosphorylase b kinase regulatory	0.0069	0.0164	0.0164
Brugia malayi	Ceramide glucosyltransferase	0.0737	0.3089	0.3037
Trichomonas vaginalis	beta-galactosidase, putative	0.016	0.0559	0.093
Brugia malayi	dihydrofolate reductase family protein	0.0882	0.3726	0.3678
Trichomonas vaginalis	glucosylceramidase, putative	0.0921	0.3896	0.6481
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.027	0.1044	0.4565
Echinococcus granulosus	non lysosomal glucosylceramidase	0.0416	0.1682	0.1682
Trichomonas vaginalis	alpha-glucosidase, putative	0.0553	0.2284	0.3799
Echinococcus multilocularis	phosphorylase b kinase regulatory	0.0069	0.0164	0.0021
Schistosoma mansoni	bile acid beta-glucosidase-related	0.0416	0.1682	0.1811
Schistosoma mansoni	glucose transport protein	0.0105	0.0318	0.0263
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0143	0.0143
Trichomonas vaginalis	glucosylceramidase, putative	0.097	0.4114	0.6842
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0143	0.0143
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0094	0.0272	0.0452
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.0318	0.0318
Echinococcus multilocularis	lysosomal alpha glucosidase	0.2313	1	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0553	0.2284	0.3799
Schistosoma mansoni	mannosidase alpha class 2a	0.0089	0.0249	0.0185
Trichomonas vaginalis	glucosylceramidase, putative	0.0921	0.3896	0.6481
Echinococcus multilocularis	endoplasmic reticulum mannosyl oligosaccharide	0.0094	0.0272	0.013
Echinococcus multilocularis	beta galactosidase	0.0371	0.1484	0.1361
Trichomonas vaginalis	alpha-glucosidase, putative	0.027	0.1044	0.1736
Schistosoma mansoni	alpha-l-fucosidase	0.0415	0.1678	0.1806
Onchocerca volvulus		0.0089	0.0249	0.0124
Mycobacterium ulcerans	alpha-mannosidase	0.014	0.0475	0.0872
Leishmania major	alpha glucosidase II subunit, putative	0.0553	0.2284	1
Schistosoma mansoni	alpha-glucosidase	0.2061	0.8897	1
Echinococcus multilocularis	phosphorylase b kinase regulatory	0.0069	0.0164	0.0021
Echinococcus granulosus	lysosomal alpha glucosidase	0.2313	1	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.027	0.1044	0.1736
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.0737	0.3089	0.4239
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0094	0.0272	0.0452
Loa Loa (eye worm)	beta-glucuronidase	0.0052	0.0086	0.0086
Loa Loa (eye worm)	glycosyl hydrolase family 38 protein	0.014	0.0475	0.0475
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0143	0.0064
Brugia malayi	Sugar transporter family protein	0.0105	0.0318	0.0244
Trichomonas vaginalis	alpha-glucosidase, putative	0.0553	0.2284	0.3799
Brugia malayi	RNA binding protein	0.0065	0.0143	0.0068
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0182	0.0657	0.1093
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0105	0.0318	0.0178
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0094	0.0272	0.0452
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.0318	0.0529
Trypanosoma cruzi	hypothetical protein, conserved	0.0553	0.2284	1
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.014	0.0475	0.0789
Trichomonas vaginalis	glycoside hydrolases, putative	0.0128	0.0422	0.0701
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0002	0.0003
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0143	0.0143
Echinococcus granulosus	phosphorylase b kinase regulatory	0.0069	0.0164	0.0164
Trichomonas vaginalis	glucosylceramidase, putative	0.0921	0.3896	0.6481
Trichomonas vaginalis	glucosylceramidase, putative	0.097	0.4114	0.6842
Loa Loa (eye worm)	mannosidase	0.0094	0.0272	0.0272
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0467	0.1908	0.8273
Schistosoma mansoni	mannosyl-oligosaccharide alpha-12-mannosidase	0.0094	0.0272	0.021
Trypanosoma brucei	lysosomal alpha-mannosidase precursor, putative	0.0125	0.0408	0.1782
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0002	0.0003
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0553	0.2284	0.3799
Schistosoma mansoni	glucose transport protein	0.0105	0.0318	0.0263
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.027	0.1044	0.1736
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0467	0.1908	1
Echinococcus granulosus	beta galactosidase	0.0371	0.1484	0.1484
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0182	0.0657	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0272	0.0272
Echinococcus granulosus	mannosyl oligosaccharide 12 alpha mannosidase	0.0094	0.0272	0.0272
Loa Loa (eye worm)	alpha-L-fucosidase	0.0415	0.1678	0.1678
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0094	0.0272	0.0452
Trypanosoma cruzi	lysosomal alpha-mannosidase precursor, putative	0.0125	0.0408	0.1782
Echinococcus granulosus	lysosomal alpha mannosidase	0.0125	0.0408	0.0408
Trichomonas vaginalis	glucosylceramidase, putative	0.1403	0.6012	1
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0002	0.0003
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.0318	0.0178
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0094	0.0272	0.0452
Brugia malayi	manba-prov protein	0.0052	0.0086	0.0011
Trichomonas vaginalis	alpha-glucosidase, putative	0.027	0.1044	0.1736
Loa Loa (eye worm)	ceramide glucosyltransferase	0.0737	0.3089	0.3089
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0522	0.2147	0.5599
Trichomonas vaginalis	alpha-glucosidase, putative	0.0553	0.2284	0.3799
Onchocerca volvulus		0.0104	0.0314	0.0218
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.1403	0.6012	0.5981
Schistosoma mansoni	phosphorylase B kinase beta kpbb	0.0069	0.0164	0.0088
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0094	0.0272	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0268	0.0268
Trichomonas vaginalis	conserved hypothetical protein	0.016	0.0559	0.093
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0553	0.2284	0.2225
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0002	0.0003
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0094	0.0272	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0109	0.0109
Brugia malayi	Glycosyl hydrolases family 31 protein	0.027	0.1044	0.0975
Trichomonas vaginalis	glucosylceramidase, putative	0.0921	0.3896	0.6481
Trichomonas vaginalis	glucosylceramidase, putative	0.1403	0.6012	1
Trichomonas vaginalis	alpha-mannosidase, putative	0.014	0.0475	0.0789
Echinococcus granulosus	endoplasmic reticulum mannosyl oligosaccharide	0.0094	0.0272	0.0272
Trichomonas vaginalis	glucosylceramidase, putative	0.1403	0.6012	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0249	0.0249
Loa Loa (eye worm)	hypothetical protein	0.027	0.1044	0.1044
Echinococcus multilocularis	dihydrofolate reductase	0.0882	0.3726	0.3635
Brugia malayi	phosphorylase B kinase alpha regulatory chain	0.0069	0.0164	0.0089
Trichomonas vaginalis	glucosylceramidase, putative	0.1403	0.6012	1
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0002	0.0003
Trichomonas vaginalis	maltase-glucoamylase, putative	0.027	0.1044	0.1736
Echinococcus granulosus	dnaJ subfamily B	0.0418	0.1692	0.1692
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0143	0.0064
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0553	0.2284	0.2284
Echinococcus multilocularis	alpha mannosidase 2	0.0089	0.0249	0.0108
Echinococcus multilocularis	non lysosomal glucosylceramidase	0.0416	0.1682	0.1561
Trypanosoma cruzi	hypothetical protein, conserved	0.0553	0.2284	1
Echinococcus multilocularis	bile acid beta glucosidase	0.0416	0.1682	0.1561
Mycobacterium tuberculosis	Possible conserved exported protein	0.0847	0.3573	0.9581
Schistosoma mansoni	dihydrofolate reductase	0.0882	0.3726	0.4131
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0164	0.0164
Trichomonas vaginalis	alpha-glucosidase, putative	0.0553	0.2284	0.3799
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.027	0.1044	0.4565
Trypanosoma brucei	glycosyl hydrolase-like protein	0.027	0.1044	0.4565
Trypanosoma cruzi	lysosomal alpha-mannosidase precursor, putative	0.0125	0.0408	0.1782
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0882	0.3726	1
Schistosoma mansoni	beta-galactosidase	0.0371	0.1484	0.1587
Schistosoma mansoni	hypothetical protein	0.0418	0.1692	0.1822
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.1403	0.6012	0.6012
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.0318	0.0318
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.0272	0.0452
Trypanosoma brucei	lysosomal alpha-mannosidase precursor, putative	0.0099	0.0291	0.1269
Onchocerca volvulus		0.0089	0.0249	0.0124
Mycobacterium tuberculosis	Conserved protein	0.0069	0.0164	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0554	0.2289	0.2289
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0467	0.1908	0.835
Brugia malayi	Glycosyl hydrolases family 38 protein	0.0089	0.0249	0.0175
Loa Loa (eye worm)	myosin heavy chain	0.0069	0.0164	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0164	0.0164
Echinococcus multilocularis	lysosomal alpha mannosidase	0.0125	0.0408	0.0269
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.0318	0.0318
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0467	0.1908	0.835
Schistosoma mansoni	alpha-glucosidase	0.2061	0.8897	1
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.027	0.1044	0.1274
Echinococcus multilocularis	dnaJ subfamily B	0.0418	0.1692	0.1571
Trichomonas vaginalis	alpha-glucosidase, putative	0.027	0.1044	0.1736
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0094	0.0272	0.0452
Loa Loa (eye worm)	sugar transporter	0.0105	0.0318	0.0318
Schistosoma mansoni	hypothetical protein	0.0151	0.0523	0.0496
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0143	0.0064
Brugia malayi	Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1	0.0094	0.0272	0.0197
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0882	0.3726	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0553	0.2284	0.3799
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0094	0.0272	0.0452
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0094	0.0272	0.0452
Onchocerca volvulus		0.1644	0.7066	1
Echinococcus granulosus	bile acid beta glucosidase	0.0416	0.1682	0.1682
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0094	0.0272	0.0452
Trichomonas vaginalis	glucosylceramidase, putative	0.0921	0.3896	0.6481
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0132	0.0052
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0467	0.1908	0.835
Echinococcus granulosus	dihydrofolate reductase	0.0882	0.3726	0.3726
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0094	0.0272	0.0452
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.027	0.1044	0.2195
Brugia malayi	thymidylate synthase	0.0104	0.0314	0.024
Brugia malayi	hypothetical protein	0.0069	0.0164	0.0089
Schistosoma mansoni	lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1)	0.0057	0.0109	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0002	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0249	0.0249
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0467	0.1908	1
Loa Loa (eye worm)	hypothetical protein	0.0371	0.1484	0.1484
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.0078	0.0202	0.0336
Schistosoma mansoni	phosphorylase B kinase alpha kpb1	0.0069	0.0164	0.0088
Trichomonas vaginalis	glucosylceramidase, putative	0.1403	0.6012	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0164	0.0164
Echinococcus multilocularis	ceramide glucosyltransferase	0.0737	0.3089	0.2989
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0553	0.2284	0.6023
Plasmodium vivax	hypothetical protein, conserved	0.0113	0.0356	0.0236
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.0318	0.0178
Echinococcus granulosus	thymidylate synthase	0.0104	0.0314	0.0314
Schistosoma mansoni	lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1)	0.0125	0.0408	0.0366
Brugia malayi	Alpha-L-fucosidase family protein	0.0415	0.1678	0.1614
Echinococcus granulosus	General substrate transporter	0.009	0.0254	0.0254
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	0.0415	0.1678	0.1557
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0522	0.2147	0.3571
Schistosoma mansoni	bile acid beta-glucosidase-related	0.0416	0.1682	0.1811
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0164	0.0273
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0553	0.2284	1
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.0083	0.0225	0.0375
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0882	0.3726	1
Brugia malayi	Glycosyl hydrolases family 38 protein	0.0089	0.0249	0.0175
Trichomonas vaginalis	glucosylceramidase, putative	0.0921	0.3896	0.6481
Brugia malayi	lysosomal alpha-mannosidase	0.0089	0.0249	0.0175
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0104	0.0314	0.0259
Echinococcus multilocularis	thymidylate synthase	0.0104	0.0314	0.0174
Brugia malayi	phosphorylase B kinase beta regulatory chain	0.0069	0.0164	0.0089
Chlamydia trachomatis	dihydrofolate reductase	0.0882	0.3726	0.5
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0049	0.0076	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0164	0.0164
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0104	0.0314	0.0654
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0553	0.2284	0.3799
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.2313	1	1
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0094	0.0272	0.0452
Trichomonas vaginalis	glucosylceramidase, putative	0.1403	0.6012	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0921	0.3896	0.6481
Schistosoma mansoni	lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1)	0.0089	0.0249	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0272	0.0272
Brugia malayi	Beta-glucuronidase precursor	0.0052	0.0086	0.0011
Schistosoma mansoni	alpha glucosidase	0.0553	0.2284	0.2495
Trichomonas vaginalis	alpha-glucosidase, putative	0.027	0.1044	0.1736
Echinococcus multilocularis	transfer RNA-Trp	0.0094	0.0272	0.013
Trichomonas vaginalis	alpha-glucosidase, putative	0.027	0.1044	0.1736
Echinococcus granulosus	ceramide glucosyltransferase	0.0737	0.3089	0.3089
Brugia malayi	Glycosyl hydrolases family 38 protein	0.014	0.0475	0.0402
Schistosoma mansoni	glucose transport protein	0.0105	0.0318	0.0263
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.0076	0.0126
Echinococcus multilocularis	lysosomal alpha glucosidase	0.2313	1	1
Echinococcus multilocularis	mannosyl oligosaccharide 1,2 alpha mannosidase	0.0094	0.0272	0.013
Loa Loa (eye worm)	glycosyl hydrolase family 2	0.0056	0.0105	0.0105
Loa Loa (eye worm)	thymidylate synthase	0.0104	0.0314	0.0314
Entamoeba histolytica	alpha-1,2-mannosidase, putative	0.0847	0.3573	1
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0164	0.0273
Mycobacterium ulcerans	alpha-L-fucosidase	0.0415	0.1678	0.4249
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.0318	0.0178
Giardia lamblia	Ceramide glucosyltransferase	0.0334	0.1324	0.5
Loa Loa (eye worm)	dihydrofolate reductase	0.0882	0.3726	0.3726
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0143	0.0064
Brugia malayi	Dihydrofolate reductase	0.0882	0.3726	0.3678
Schistosoma mansoni	hypothetical protein	0.0105	0.0318	0.0263
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.0164	0.0273
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0002	0.0003
Mycobacterium ulcerans	thymidylate synthase	0.0104	0.0314	0.0422
Leishmania major	glycosyl hydrolase-like protein	0.027	0.1044	0.4565
Schistosoma mansoni	ceramide glucosyltransferase	0.0737	0.3089	0.3408
Brugia malayi	TAR-binding protein	0.0065	0.0143	0.0068

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 830006