TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.511 | Formula: C23H23N3O4S
H donors: 2 H acceptors: 4 LogP: 3.76 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1OC)C1CC(=O)Nc2c1c(O)nc(n2)SCc1ccccc1
InChi: 1S/C23H23N3O4S/c1-3-30-17-10-9-15(11-18(17)29-2)16-12-19(27)24-21-20(16)22(28)26-23(25-21)31-13-14-7-5-4-6-8-14/h4-11,16H,3,12-13H2,1-2H3,(H2,24,25,26,27,28)
InChiKey: NFVJKFMNFCIXAJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0154	0.0544	0.041
Echinococcus granulosus	cathepsin b	0.1981	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0154	0.0544	0.0544
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Plasmodium vivax	vivapain-1	0.0154	0.0544	0.2343
Echinococcus multilocularis	cysteine protease	0.0409	0.1865	0.186
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.0544	0.041
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1981	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0409	0.1865	0.186
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0719	0.3469	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.0467	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0154	0.0544	0.041
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0409	0.1865	0.186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0409	0.1865	0.186
Schistosoma mansoni	cathepsin F (C01 family)	0.0409	0.1865	0.1749
Treponema pallidum	fructose-bisphosphate aldolase	0.0284	0.1219	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.0544	0.041
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.0544	0.1471
Entamoeba histolytica	cysteine proteinase, putative	0.0409	0.1865	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0154	0.0544	0.0544
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0154	0.0544	0.041
Plasmodium falciparum	serine repeat antigen 5	0.0154	0.0544	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0544	0.0544
Brugia malayi	Papain family cysteine protease containing protein	0.0409	0.1865	0.1865
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.0467	0.5127
Onchocerca volvulus		0.0409	0.1865	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Trypanosoma cruzi	cysteine peptidase, putative	0.0409	0.1865	0.1832
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Echinococcus multilocularis	cathepsin b	0.1981	1	1
Echinococcus granulosus	cysteine protease	0.0154	0.0544	0.0539
Mycobacterium tuberculosis	Probable peptidase	0.0056	0.004	0.0384
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Toxoplasma gondii	cathepsin CPL	0.0409	0.1865	0.5181
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Onchocerca volvulus	Cathepsin L homolog	0.0409	0.1865	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0154	0.0544	0.041
Giardia lamblia	Cathepsin B precursor	0.0719	0.3469	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0154	0.0544	0.2343
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0719	0.3469	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0409	0.1865	0.4515
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Entamoeba histolytica	cysteine proteinase, putative	0.0409	0.1865	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0154	0.0544	0.0506
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0141	0.0481	0.0345
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0154	0.0544	0.2343
Echinococcus granulosus	cathepsin L	0.0154	0.0544	0.0539
Plasmodium vivax	unspecified product	0.0154	0.0544	0.2343
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0154	0.0544	0.2343
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.0544	0.041
Toxoplasma gondii	cathepsin B	0.0719	0.3469	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.0544	0.041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0154	0.0544	0.2343
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Loa Loa (eye worm)	hypothetical protein	0.0076	0.014	0.014
Plasmodium falciparum	serine repeat antigen 7	0.0154	0.0544	0.2343
Echinococcus multilocularis	prolyl endopeptidase	0.0141	0.0481	0.0475
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0154	0.0544	0.041
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0154	0.0544	0.1214
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Onchocerca volvulus		0.0409	0.1865	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0154	0.0544	0.2343
Schistosoma mansoni	cathepsin S (C01 family)	0.0154	0.0544	0.041
Plasmodium vivax	vivapain-2	0.0409	0.1865	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0154	0.0544	0.2343
Plasmodium falciparum	serine repeat antigen 1	0.0154	0.0544	0.2343
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0719	0.3469	0.3442
Trypanosoma cruzi	cysteine peptidase, putative	0.0409	0.1865	0.1832
Loa Loa (eye worm)	ctsf protein	0.0409	0.1865	0.1865
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0719	0.3469	0.3376
Echinococcus multilocularis	cathepsin L cysteine protease	0.0409	0.1865	0.186
Trypanosoma cruzi	cysteine protease, putative	0.0154	0.0544	0.0506
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Trypanosoma cruzi	cysteine proteinase, putative	0.0154	0.0544	0.0506
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Echinococcus granulosus	cathepsin L cysteine protease	0.0154	0.0544	0.0539
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Brugia malayi	cathepsin L-like precursor	0.0409	0.1865	0.1865
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0154	0.0544	0.2343
Echinococcus granulosus	cathepsin b	0.1981	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0056	0.004	0.0384
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1981	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0409	0.1865	1
Onchocerca volvulus		0.0154	0.0544	0.0461
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0141	0.0481	0.0345
Schistosoma mansoni	cathepsin C	0.0154	0.0544	0.041
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Onchocerca volvulus	Cathepsin F homolog	0.0409	0.1865	1
Toxoplasma gondii	cathepsin CPC1	0.0154	0.0544	0.1214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0056	0.004	0.0748
Trypanosoma brucei	prolyl endopeptidase	0.0141	0.0481	0.1285
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0154	0.0544	0.2343
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0154	0.0544	0.2343
Echinococcus multilocularis	cathepsin L	0.0154	0.0544	0.0539
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0409	0.1865	0.1865
Schistosoma mansoni	cathepsin F (C01 family)	0.0409	0.1865	0.1749
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0409	0.1865	0.1865
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0409	0.1865	0.4515
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0154	0.0544	0.2343
Brugia malayi	cathepsin L-like cysteine proteinase	0.0154	0.0544	0.0544
Entamoeba histolytica	cysteine proteinase, putative	0.0409	0.1865	1
Onchocerca volvulus	Cathepsin L homolog	0.0409	0.1865	1
Loa Loa (eye worm)	hypothetical protein	0.1981	1	1
Brugia malayi	cathepsin L precursor	0.0154	0.0544	0.0544
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.0544	0.1471
Brugia malayi	fibroinase precursor	0.0154	0.0544	0.0544
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0154	0.0544	0.2343
Loa Loa (eye worm)	hypothetical protein	0.0409	0.1865	0.1865
Echinococcus granulosus	cathepsin L	0.0154	0.0544	0.0539
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Schistosoma mansoni	cathepsin B (C01 family)	0.0154	0.0544	0.041
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0409	0.1865	0.186
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0154	0.0544	0.2343
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.014	0.2347
Echinococcus multilocularis	cysteine protease	0.0409	0.1865	0.186
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0409	0.1865	0.1865
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.014	0.0135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Loa Loa (eye worm)	fibroinase	0.0409	0.1865	0.1865
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.014	0.0135
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0409	0.1865	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0544	0.0544
Echinococcus granulosus	cathepsin l1	0.0409	0.1865	0.186
Onchocerca volvulus		0.0409	0.1865	1
Giardia lamblia	Cathepsin B precursor	0.0719	0.3469	1
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0409	0.1865	1
Onchocerca volvulus		0.0409	0.1865	1
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0154	0.0544	0.041
Plasmodium falciparum	serine repeat antigen 4	0.0154	0.0544	0.2343
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0154	0.0544	0.2343
Leishmania major	cysteine peptidase A (CPA)	0.0409	0.1865	0.5322
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.014	0.5
Plasmodium falciparum	serine repeat antigen 9	0.0154	0.0544	0.2343
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0481	0.0481
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.1219	0.5106
Giardia lamblia	Fructose-bisphosphate aldolase	0.0284	0.1219	0.2305
Loa Loa (eye worm)	cysteine protease	0.0409	0.1865	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0544	0.0544
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Onchocerca volvulus		0.0409	0.1865	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0409	0.1865	0.4515
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.014	0.2919
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0409	0.1865	0.1832
Loa Loa (eye worm)	hypothetical protein	0.0409	0.1865	0.1865
Echinococcus granulosus	prolyl endopeptidase	0.0141	0.0481	0.0475
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0154	0.0544	0.0506
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Onchocerca volvulus	Cathepsin L homolog	0.0154	0.0544	0.0461
Onchocerca volvulus		0.0409	0.1865	1
Echinococcus granulosus	cathepsin l1	0.0409	0.1865	0.186
Trypanosoma cruzi	cysteine proteinase, putative	0.0154	0.0544	0.0506
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0154	0.0544	0.0544
Plasmodium falciparum	serine repeat antigen 3	0.0154	0.0544	0.2343
Plasmodium vivax	serine-repeat antigen (SERA)	0.0154	0.0544	0.2343
Loa Loa (eye worm)	cathepsin B	0.0719	0.3469	0.3469
Trypanosoma cruzi	prolyl endopeptidase	0.0141	0.0481	0.0442
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Trypanosoma cruzi	cysteine peptidase, putative	0.0409	0.1865	0.1832
Entamoeba histolytica	cysteine protease, putative	0.0409	0.1865	1
Plasmodium falciparum	serine repeat antigen 8	0.0154	0.0544	0.2343
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0544	0.0544
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0141	0.0481	0.1285
Plasmodium vivax	serine-repeat antigen (SERA)	0.0154	0.0544	0.2343
Trypanosoma cruzi	major cysteine proteinase, putative	0.0154	0.0544	0.0506
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0409	0.1865	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Echinococcus multilocularis	cathepsin b	0.1981	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1981	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Trypanosoma cruzi	cysteine peptidase, putative	0.0409	0.1865	0.1832
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Echinococcus multilocularis	cathepsin L	0.0154	0.0544	0.0539
Plasmodium falciparum	serine repeat antigen 2	0.0154	0.0544	0.2343
Toxoplasma gondii	prolyl endopeptidase	0.0141	0.0481	0.1022
Plasmodium vivax	vivapain-2	0.0409	0.1865	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0284	0.1219	0.2305
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0409	0.1865	0.186
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0544	0.0544
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0409	0.1865	0.4515
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Onchocerca volvulus		0.0409	0.1865	1
Giardia lamblia	Cathepsin B precursor	0.0719	0.3469	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.0544	0.0544
Brugia malayi	cathepsin F-like cysteine proteinase	0.0154	0.0544	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0544	0.0544
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Trypanosoma cruzi	cruzipain precursor, putative	0.0409	0.1865	0.1832
Brugia malayi	Cathepsin L-like precursor	0.0409	0.1865	0.1865
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Plasmodium vivax	vivapain-3	0.0154	0.0544	0.2343
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.014	0.2347
Onchocerca volvulus		0.0409	0.1865	1
Brugia malayi	prolyl oligopeptidase family protein	0.0141	0.0481	0.0481
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.014	0.5
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0223	0.0906	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1981	1	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.0467	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0284	0.1219	0.5106
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0719	0.3469	1
Leishmania major	cathepsin L-like protease	0.0409	0.1865	0.5322
Plasmodium vivax	unspecified product	0.0154	0.0544	0.2343
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0154	0.0544	0.2343
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1981	1	1
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0126	0.0404	0.4425
Loa Loa (eye worm)	hypothetical protein	0.0409	0.1865	0.1865
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0154	0.0544	0.041
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0154	0.0544	0.041
Schistosoma mansoni	cathepsin F (C01 family)	0.0409	0.1865	0.1749
Plasmodium falciparum	serine repeat antigen 6	0.0154	0.0544	0.2343
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0409	0.1865	0.5322
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0154	0.0544	0.0544
Brugia malayi	Probable ClpP-like protease	0.0076	0.014	0.014
Toxoplasma gondii	cathepsin CPC2	0.0154	0.0544	0.1214
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.0544	0.0506
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.014	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 830958