TDR Targets

Basic information

Technical information

TDR Targets ID: 830962
Name: N-(4-chlorophenyl)-1-methylsulfonyl-3,4-dihyd ro-2H-quinoline-6-carboxamide
MW: 364.846 | Formula: C17H17ClN2O3S
H donors: 1 H acceptors: 3 LogP: 2.92 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)NC(=O)c1ccc2c(c1)CCCN2S(=O)(=O)C
InChi: 1S/C17H17ClN2O3S/c1-24(22,23)20-10-2-3-12-11-13(4-9-16(12)20)17(21)19-15-7-5-14(18)6-8-15/h4-9,11H,2-3,10H2,1H3,(H,19,21)
InChiKey: HLLGWQMVWVEVND-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-chlorophenyl)-1-mesyl-3,4-dihydro-2H-quinoline-6-carboxamide
ZINC05278441
T6003370

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Onchocerca volvulus		0.0258	0.1608	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0258	0.1608	1
Giardia lamblia	Cathepsin B precursor	0.0425	0.3161	1
Onchocerca volvulus		0.0258	0.1608	1
Onchocerca volvulus	Cathepsin L homolog	0.0258	0.1608	1
Brugia malayi	Cathepsin L-like precursor	0.0258	0.1608	0.1524
Onchocerca volvulus	Cathepsin L homolog	0.0258	0.1608	1
Schistosoma mansoni	adhesion regulating molecule 1 (110 kD cell membrane glycoprotein)	0.0162	0.0719	0.0627
Brugia malayi	Adhesion regulating molecule conserved region family protein	0.0162	0.0719	0.0627
Echinococcus multilocularis	cathepsin L cysteine protease	0.0258	0.1608	0.1524
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0258	0.1608	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1163	1	1
Onchocerca volvulus		0.0258	0.1608	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.1608	0.4929
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1163	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0425	0.3161	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0425	0.3161	0.3093
Plasmodium falciparum	serine repeat antigen 7	0.0095	0.0099	0.0613
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Plasmodium falciparum	serine repeat antigen 9	0.0095	0.0099	0.0613
Leishmania major	cathepsin L-like protease	0.0258	0.1608	0.5087
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0258	0.1608	0.4929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.1608	0.4929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0258	0.1608	0.4929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Plasmodium falciparum	serine repeat antigen 3	0.0095	0.0099	0.0613
Onchocerca volvulus	Cathepsin F homolog	0.0258	0.1608	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0258	0.1608	0.4929
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0258	0.1608	0.1524
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.1608	0.4929
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0095	0.0099	0.0613
Trypanosoma cruzi	cysteine peptidase, putative	0.0258	0.1608	0.1524
Echinococcus multilocularis	cathepsin b	0.1163	1	1
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1608	0.1524
Leishmania major	cysteine peptidase A (CPA)	0.0258	0.1608	0.5087
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0258	0.1608	0.1524
Trypanosoma cruzi	cysteine peptidase, putative	0.0258	0.1608	0.1524
Plasmodium falciparum	serine repeat antigen 5	0.0095	0.0099	0.0613
Plasmodium falciparum	serine repeat antigen 2	0.0095	0.0099	0.0613
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0258	0.1608	0.4929
Brugia malayi	Cathepsin L-like precursor	0.0258	0.1608	0.1524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0425	0.3161	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.1608	0.4929
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0425	0.3161	0.3093
Brugia malayi	Cathepsin L-like precursor	0.0258	0.1608	0.1524
Entamoeba histolytica	cysteine proteinase, putative	0.0258	0.1608	1
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1608	0.1524
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0425	0.3161	1
Onchocerca volvulus	Proteasomal ubiquitin receptor ADRM1 homolog	0.0103	0.0171	0.0481
Echinococcus multilocularis	cathepsin L cysteine protease	0.0258	0.1608	0.1524
Toxoplasma gondii	adhesion regulating molecule region protein, putative	0.0162	0.0719	0.2027
Entamoeba histolytica	cysteine protease, putative	0.0258	0.1608	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0258	0.1608	0.1524
Echinococcus multilocularis	adhesion regulating molecule 1	0.0162	0.0719	0.0627
Brugia malayi	Cathepsin L-like precursor	0.0258	0.1608	0.1524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0258	0.1608	0.4929
Loa Loa (eye worm)	hypothetical protein	0.1163	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0258	0.1608	0.1524
Brugia malayi	Cathepsin L-like precursor	0.0258	0.1608	0.1524
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1163	1	1
Onchocerca volvulus		0.0258	0.1608	1
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1608	0.1524
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0258	0.1608	0.1524
Leishmania major	cathepsin L-like protease	0.0258	0.1608	0.5087
Leishmania major	cathepsin L-like protease	0.0258	0.1608	0.5087
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.1608	0.4929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.1608	0.4929
Echinococcus multilocularis	cysteine protease	0.0258	0.1608	0.1524
Echinococcus granulosus	cathepsin l1	0.0258	0.1608	0.1524
Plasmodium falciparum	serine repeat antigen 8	0.0095	0.0099	0.0613
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.1608	0.4929
Echinococcus granulosus	cathepsin b	0.1163	1	1
Brugia malayi	Cathepsin L-like precursor	0.0258	0.1608	0.1524
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0258	0.1608	0.4929
Schistosoma mansoni	cathepsin F (C01 family)	0.0258	0.1608	0.1524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Onchocerca volvulus		0.0258	0.1608	1
Onchocerca volvulus		0.0258	0.1608	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0258	0.1608	0.1524
Toxoplasma gondii	cathepsin CPL	0.0258	0.1608	0.4929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.1608	0.4929
Loa Loa (eye worm)	ctsf protein	0.0258	0.1608	0.1524
Plasmodium falciparum	serine repeat antigen 1	0.0095	0.0099	0.0613
Schistosoma mansoni	cathepsin F (C01 family)	0.0258	0.1608	0.1524
Brugia malayi	cathepsin L-like precursor	0.0258	0.1608	0.1524
Leishmania major	cathepsin L-like protease	0.0258	0.1608	0.5087
Onchocerca volvulus		0.0258	0.1608	1
Echinococcus granulosus	cathepsin l1	0.0258	0.1608	0.1524
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0095	0.0099	0.0613
Giardia lamblia	Cathepsin B precursor	0.0425	0.3161	1
Brugia malayi	Cathepsin L-like precursor	0.0258	0.1608	0.1524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Leishmania major	cathepsin L-like protease	0.0258	0.1608	0.5087
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0258	0.1608	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0719	0.0627
Plasmodium falciparum	serine repeat antigen 6	0.0095	0.0099	0.0613
Plasmodium vivax	vivapain-2	0.0258	0.1608	1
Loa Loa (eye worm)	hypothetical protein	0.0258	0.1608	0.1524
Loa Loa (eye worm)	fibroinase	0.0258	0.1608	0.1524
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0258	0.1608	0.4929
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0258	0.1608	0.4929
Plasmodium vivax	vivapain-2	0.0258	0.1608	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0095	0.0099	0.0613
Onchocerca volvulus		0.0258	0.1608	1
Entamoeba histolytica	cysteine proteinase, putative	0.0258	0.1608	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0258	0.1608	0.4929
Echinococcus multilocularis	cysteine protease	0.0258	0.1608	0.1524
Brugia malayi	Papain family cysteine protease containing protein	0.0258	0.1608	0.1524
Loa Loa (eye worm)	cathepsin B	0.0425	0.3161	0.3093
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0258	0.1608	0.1524
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0258	0.1608	0.1524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0258	0.1608	0.4929
Trypanosoma cruzi	cysteine peptidase, putative	0.0258	0.1608	0.1524
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0258	0.1608	0.4929
Echinococcus granulosus	cathepsin b	0.1163	1	1
Echinococcus multilocularis	cathepsin b	0.1163	1	1
Leishmania major	cathepsin L-like protease	0.0258	0.1608	0.5087
Toxoplasma gondii	cathepsin B	0.0425	0.3161	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0258	0.1608	0.1524
Plasmodium falciparum	serine repeat antigen 4	0.0095	0.0099	0.0613
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1163	1	1
Echinococcus granulosus	adhesion regulating molecule 1	0.0162	0.0719	0.0627
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0258	0.1608	0.1524
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1163	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.1608	0.4929
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0258	0.1608	0.4929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.1608	0.4929
Giardia lamblia	Cathepsin B precursor	0.0425	0.3161	1
Leishmania major	cathepsin L-like protease	0.0258	0.1608	0.5087
Leishmania major	cathepsin L-like protease	0.0258	0.1608	0.5087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0258	0.1608	0.4929
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0095	0.0099	0.0613
Loa Loa (eye worm)	cysteine protease	0.0258	0.1608	0.1524
Entamoeba histolytica	cysteine proteinase, putative	0.0258	0.1608	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0258	0.1608	0.1524
Brugia malayi	Cathepsin L-like precursor	0.0258	0.1608	0.1524

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 830962