TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 339.411 | Formula: C18H17N3O2S
H donors: 2 H acceptors: 4 LogP: 2.8 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: C#CCSc1nc(O)c2c(n1)NC(=O)CC2c1ccc(cc1C)C
InChi: 1S/C18H17N3O2S/c1-4-7-24-18-20-16-15(17(23)21-18)13(9-14(22)19-16)12-6-5-10(2)8-11(12)3/h1,5-6,8,13H,7,9H2,2-3H3,(H2,19,20,21,22,23)
InChiKey: QXEHWGNQNIESLL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0042	0.0034
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0042	0.0142	0.2001
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0037	0.0115	0.1549
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0022	0.0014
Toxoplasma gondii	aldo-keto reductase	0.0037	0.0115	0.1549
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0037	0.0115	0.0107
Schistosoma mansoni	tyrosine kinase	0.0265	0.1375	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0022	0.0014
Onchocerca volvulus		0.0213	0.1084	0.1064
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0621	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0129	0.0621	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0037	0.0115	0.0949
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0042	0.0142	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.005	0.0282
Schistosoma mansoni	tyrosine kinase	0.0121	0.0576	0.0554
Echinococcus multilocularis	aldo keto reductase	0.0129	0.0621	0.06
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0042	0.0142	0.012
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0142	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0142	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0026	0.005	0.0042
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0121	0.0576	0.0554
Echinococcus multilocularis	conserved hypothetical protein	0.003	0.0075	0.0053
Brugia malayi	SWIRM domain containing protein	0.0042	0.0142	0.0142
Schistosoma mansoni	eukaryotic translation initiation factor 4e	0.0037	0.0113	0.009
Brugia malayi	hypothetical protein	0.0026	0.005	0.005
Onchocerca volvulus		0.0093	0.0424	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0022	0.0014
Schistosoma mansoni	high-affinity choline transporter	0.0374	0.1973	0.1955
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0093	0.0424	0.0424
Onchocerca volvulus		0.0129	0.0621	0.06
Entamoeba histolytica	protein kinase, putative	0.0197	0.0999	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0142	0.0134
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0621	0.06
Brugia malayi	amine oxidase, flavin-containing family protein	0.0042	0.0142	0.0142
Echinococcus granulosus	dnaJ subfamily C 6	0.0062	0.0252	0.023
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.1826	1	1
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0042	0.0101
Brugia malayi	RE40412p	0.003	0.0075	0.0075
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0621	0.06
Schistosoma mansoni	tyrosine kinase	0.0265	0.1375	0.1355
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0621	1
Leishmania major	eukaryotic translation initiation factor eIF-4E, putative	0.0037	0.0113	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0374	0.1973	0.1966
Loa Loa (eye worm)	hypothetical protein	0.003	0.0075	0.0067
Echinococcus multilocularis		0.0042	0.0142	0.012
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0621	0.06
Leishmania major	hypothetical protein, conserved	0.0026	0.005	0.0088
Toxoplasma gondii	zinc finger CDGSH-type domain-containing protein	0.003	0.0075	0.0886
Leishmania major	UDP-galactopyranose mutase	0.0042	0.0142	0.105
Toxoplasma gondii	aldose reductase, putative	0.0129	0.0621	1
Onchocerca volvulus		0.003	0.0075	0.0053
Plasmodium vivax	replication factor C subunit 1, putative	0.0021	0.0022	0.1071
Schistosoma mansoni	amine oxidase	0.0042	0.0142	0.012
Plasmodium falciparum	aldo-keto reductase, putative	0.0037	0.0115	0.7981
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0129	0.0621	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0042	0.0197
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0621	1
Loa Loa (eye worm)	oxidoreductase	0.0129	0.0621	0.0614
Echinococcus multilocularis	aldo keto reductase	0.0129	0.0621	0.06
Brugia malayi	Protein kinase domain containing protein	0.0147	0.072	0.072
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0042	0.0142	1
Echinococcus multilocularis	dual specificity	0.0197	0.0999	0.0979
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0621	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0042	0.0118
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0042	0.0118
Schistosoma mansoni	CDGSH-type Zn finger-containing protein-like protein	0.053	0.284	0.2824
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0129	0.0621	1
Brugia malayi	DKFZp564C0469 protein	0.0021	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0022	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0042	0.0034
Schistosoma mansoni	amine oxidase	0.0042	0.0142	0.012
Loa Loa (eye worm)	oxidoreductase	0.0129	0.0621	0.0614
Echinococcus granulosus	aldo keto reductase	0.0129	0.0621	0.06
Trypanosoma cruzi	aldo-keto reductase	0.0129	0.0621	0.6129
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.06	0.3223	0.9707
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0093	0.0424	0.0424
Onchocerca volvulus		0.0129	0.0621	0.06
Mycobacterium ulcerans	arylamine N-acetyltransferase Nat	0.0617	0.332	1
Brugia malayi	translation initiation factor 4E	0.0037	0.0113	0.0113
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0042	0.0142	0.012
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0021	0.0022	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0621	1
Echinococcus multilocularis	aldo keto reductase	0.0129	0.0621	0.06
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.005	0.3128
Loa Loa (eye worm)	oxidoreductase	0.0129	0.0621	0.0614
Trichomonas vaginalis	aldo/keto reductase, putative	0.0129	0.0621	1
Echinococcus multilocularis	insulin receptor	0.0265	0.1375	0.1355
Echinococcus granulosus	solute carrier family 5	0.0041	0.0136	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0042	0.0034
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0037	0.0115	0.0093
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0075	0.5023
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0933	0.0926
Mycobacterium tuberculosis	Arylamine N-acetyltransferase Nat (arylamine acetylase)	0.0617	0.332	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0042	0.0101
Mycobacterium ulcerans	oxidoreductase	0.0129	0.0621	0.1851
Mycobacterium ulcerans	oxidoreductase	0.0042	0.0142	0.0405
Echinococcus multilocularis	aldehyde reductase	0.0092	0.0415	0.0393
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0621	0.06
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0621	0.06
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0621	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0621	0.06
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0121	0.0576	0.0568
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0037	0.0113	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0142	0.0134
Echinococcus granulosus	aldehyde reductase	0.0092	0.0415	0.0393
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.003	0.0075	0.5023
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0037	0.0113	0.1505
Trichomonas vaginalis	aldo-keto reductase, putative	0.0037	0.0115	0.1549
Trichomonas vaginalis	aldo-keto reductase, putative	0.0037	0.0115	0.1549
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0129	0.0621	0.6051
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.1826	1	1
Echinococcus granulosus	hypothetical protein	0.0129	0.0621	0.06
Brugia malayi	RE40412p	0.003	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0621	0.0614
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0129	0.0621	0.0621
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0041	0.0136	0.0114
Mycobacterium tuberculosis	Probable oxidoreductase	0.0129	0.0621	0.1864
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0037	0.0113	0.0923
Onchocerca volvulus		0.0129	0.0621	0.06
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0621	0.06
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0021	0.0022	0.0043
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0042	0.0101
Schistosoma mansoni	tyrosine kinase	0.0119	0.0564	0.0543
Schistosoma mansoni	sodium/solute symporter	0.0041	0.0136	0.0114
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0129	0.0621	0.6051
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.005	0.3128
Mycobacterium leprae	Possible oxidoreductase	0.0037	0.0115	0.1549
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.005	0.3128
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0115	0.0323
Entamoeba histolytica	aldose reductase, putative	0.0129	0.0621	0.6129
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0075	0.5023
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0042	0.0101
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0621	1
Brugia malayi	GH02984p	0.0374	0.1973	0.1973
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0037	0.0113	0.1505
Echinococcus granulosus	cdgsh iron sulfur domain containing protein	0.05	0.2673	0.2657
Schistosoma mansoni	tyrosine kinase	0.0121	0.0576	0.0554
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0197	0.0999	1
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0042	0.0142	0.1226
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0621	0.06
Trypanosoma brucei	aldo-keto reductase, putative	0.0129	0.0621	0.6129
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0075	0.5023
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0265	0.1375	0.1355
Echinococcus granulosus	insulin receptor	0.0265	0.1375	0.1355
Brugia malayi	Protein kinase domain containing protein	0.0197	0.0999	0.0999
Onchocerca volvulus		0.0093	0.0424	0.0403
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.1826	1	1
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0042	0.0142	0.012
Treponema pallidum	DNA ligase (lig)	0.0021	0.0022	0.5
Schistosoma mansoni	potassium channel beta	0.0037	0.0115	0.0093
Echinococcus multilocularis	solute carrier family 5	0.0041	0.0136	0.0114
Schistosoma mansoni	tyrosine kinase	0.0121	0.0576	0.0554
Echinococcus granulosus	conserved hypothetical protein	0.003	0.0075	0.0053
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0041	0.0136	0.1905
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0197	0.0999	0.0992
Brugia malayi	Common central domain of tyrosinase family protein	0.0093	0.0424	0.0424
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0008	0.0016
Plasmodium falciparum	protoporphyrinogen oxidase	0.0042	0.0142	1
Brugia malayi	Protein kinase domain containing protein	0.0265	0.1375	0.1375
Echinococcus multilocularis	high affinity choline transporter 1	0.0374	0.1973	0.1955
Schistosoma mansoni	aldo-keto reductase	0.0129	0.0621	0.06
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0621	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0129	0.0621	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0621	0.06
Leishmania major	aldo-keto reductase-like protein	0.0129	0.0621	0.6051
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0621	0.06
Loa Loa (eye worm)	ShTK domain-containing protein	0.0093	0.0424	0.0417
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0037	0.0115	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0213	0.1084	0.1077
Toxoplasma gondii	histone lysine-specific demethylase	0.0042	0.0142	0.2001
Loa Loa (eye worm)	tyrosinase 1	0.0093	0.0424	0.0417
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0042	0.0142	0.2001
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.06	0.3223	0.9707
Brugia malayi	DnaJ domain containing protein	0.0062	0.0252	0.0252
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.1826	1	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0621	1
Onchocerca volvulus		0.0093	0.0424	0.0403
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0042	0.0101
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0621	0.06
Brugia malayi	topoisomerase	0.0021	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0185	0.0933	0.0926
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0037	0.0115	0.0115
Mycobacterium leprae	Conserved hypothetical protein	0.0092	0.0415	0.6554
Mycobacterium ulcerans	monoamine oxidase	0.0042	0.0142	0.0405
Brugia malayi	Uncharacterized hematopoietic stem/progenitor cells protein MDS029	0.0213	0.1084	0.1084
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0621	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0424	0.0417
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0041	0.0136	0.0114
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0129	0.0621	0.0621
Echinococcus granulosus	epidermal growth factor receptor	0.0121	0.0576	0.0554
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0062	0.0252	0.3834
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0042	0.0101
Giardia lamblia	Aldose reductase	0.0129	0.0621	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0129	0.0621	0.0621
Plasmodium falciparum	replication factor C subunit 1, putative	0.0021	0.0022	0.1071
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0115	0.0339
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0621	0.06
Onchocerca volvulus		0.0093	0.0424	0.0403
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0062	0.0252	0.0244
Echinococcus granulosus	eukaryotic translation initiation factor 4E	0.0037	0.0113	0.009
Echinococcus multilocularis	dnaJ subfamily C 6	0.0062	0.0252	0.023
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0621	0.06
Echinococcus granulosus	aldo keto reductase	0.0129	0.0621	0.06
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0037	0.0115	0.0768
Echinococcus granulosus	voltage gated potassium channel subunit	0.0037	0.0115	0.0093
Brugia malayi	NADH-dependent xylose reductase	0.0037	0.0115	0.0115
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.003	0.0075	0.5023
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0197	0.0999	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0621	0.06
Mycobacterium tuberculosis	Possible oxidoreductase	0.0042	0.0142	0.0421
Schistosoma mansoni	hypothetical protein	0.053	0.284	0.2824
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0041	0.0136	0.0114
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0621	0.06
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0142	0.0134
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0129	0.0621	1
Leishmania major	eukaryotic translation initiation factor-like	0.0037	0.0113	0.0741
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0041	0.0136	0.0114
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0037	0.0115	0.1549
Entamoeba histolytica	aldose reductase, putative	0.0129	0.0621	0.6129
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0621	0.06
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0037	0.0113	0.1505
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0042	0.0101
Echinococcus multilocularis	cdgsh iron sulfur domain containing protein	0.05	0.2673	0.2657
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0265	0.1375	0.1355
Giardia lamblia	Aldose reductase	0.0129	0.0621	1
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0037	0.0113	0.1505
Leishmania major	prostaglandin f synthase, putative	0.0129	0.0621	0.6051
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0037	0.0115	0.1549
Brugia malayi	Pax transcription activation domain interacting protein	0.0021	0.0022	0.0022
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0042	0.0042
Schistosoma mansoni	serine/threonine protein kinase	0.0197	0.0999	0.0979
Echinococcus granulosus	dual specificity	0.0197	0.0999	0.0979
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0042	0.0142	0.0421
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0042	0.0142	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0093	0.0424	0.0424
Schistosoma mansoni	tyrosine kinase	0.0119	0.0564	0.0543
Schistosoma mansoni	hypothetical protein	0.0062	0.0252	0.023
Loa Loa (eye worm)	hypothetical protein	0.003	0.0075	0.0067
Echinococcus granulosus	aldo keto reductase	0.0129	0.0621	0.06
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.1826	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0042	0.0042
Schistosoma mansoni	tyrosine kinase	0.0119	0.0564	0.0543
Onchocerca volvulus		0.003	0.0075	0.0053
Echinococcus multilocularis		0.0035	0.01	0.0078
Onchocerca volvulus		0.0041	0.0136	0.0114
Onchocerca volvulus		0.0024	0.0042	0.0019
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-1	0.0037	0.0113	0.0923
Schistosoma mansoni	inositol transporter	0.0041	0.0136	0.0114
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0621	1
Schistosoma mansoni	tyrosinase precursor	0.0093	0.0424	0.0403
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.005	0.0282
Entamoeba histolytica	protein kinase domain containing protein	0.0197	0.0999	1
Mycobacterium ulcerans	dehydrogenase	0.0042	0.0142	0.0405
Onchocerca volvulus		0.0042	0.0142	0.012
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0042	0.0321
Brugia malayi	hypothetical protein	0.0042	0.0142	0.0142
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0037	0.0115	0.7981
Mycobacterium ulcerans	hypothetical protein	0.0346	0.1818	0.5465
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0621	0.06
Echinococcus multilocularis	eukaryotic translation initiation factor 4E	0.0037	0.0113	0.009
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0042	0.0142	0.1226
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0197	0.0999	1
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0037	0.0115	0.0949
Plasmodium falciparum	CDGSH iron-sulfur domain-containing protein, putative	0.003	0.0075	0.5023
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0042	0.0142	0.0405
Brugia malayi	hypothetical protein	0.0021	0.0022	0.0022
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0042	0.0197
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0558	0.299	0.9004
Brugia malayi	hypothetical protein	0.0021	0.0022	0.0022
Plasmodium falciparum	aldehyde reductase, putative	0.0037	0.0115	0.7981
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0142	1
Schistosoma mansoni	tyrosinase precursor	0.0093	0.0424	0.0403
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0042	0.0142	0.012
Echinococcus granulosus	high affinity choline transporter 1	0.0374	0.1973	0.1955
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0042	0.0101
Loa Loa (eye worm)	translation initiation factor 4E	0.0037	0.0113	0.0105
Trypanosoma brucei	prostaglandin f synthase	0.0129	0.0621	0.6129
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0115	0.1549
Toxoplasma gondii	PfMNL-2 CISD1 family iron-sulfur protein, putative	0.003	0.0075	0.0886
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0037	0.0113	0.1505
Onchocerca volvulus		0.0129	0.0621	0.06
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0129	0.0621	0.06
Loa Loa (eye worm)	ShTK domain-containing protein	0.0093	0.0424	0.0417
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0021	0.0022	0.0022
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0621	0.06
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0022	0.0014
Leishmania major	eukaryotic translation initiation factor-like protein	0.0037	0.0113	0.0741
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0042	0.0142	1
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0037	0.0113	0.0923
Schistosoma mansoni	hypothetical protein	0.003	0.0075	0.0053
Leishmania major	hypothetical protein, unknown function	0.003	0.0075	0.0353
Trichomonas vaginalis	aldo-keto reductase, putative	0.0129	0.0621	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0093	0.0424	0.0424
Loa Loa (eye worm)	TK/INSR protein kinase	0.0265	0.1375	0.1368
Schistosoma mansoni	serine/threonine protein kinase	0.1826	1	1
Entamoeba histolytica	aldose reductase, putative	0.0129	0.0621	0.6129
Echinococcus multilocularis	epidermal growth factor receptor	0.0121	0.0576	0.0554
Toxoplasma gondii	zinc finger cdgsh type protein	0.003	0.0075	0.0886
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0037	0.0115	0.0949
Echinococcus granulosus	sodium:glucose cotransporter	0.0041	0.0136	0.0114
Entamoeba histolytica	hypothetical protein	0.0197	0.0999	1
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.1826	1	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0129	0.0621	0.0621
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0042	0.0142	0.012
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0708	0.07
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0142	0.0134
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.005	0.0282
Schistosoma mansoni	pol-related	0.0129	0.0621	0.06
Trichomonas vaginalis	aldo-keto reductase, putative	0.0037	0.0115	0.1549
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.005	0.0461
Chlamydia trachomatis	DNA ligase	0.0021	0.0022	0.1071
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0041	0.0136	0.0114
Onchocerca volvulus		0.0129	0.0621	0.06
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0424	0.0417
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0042	0.0197
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0129	0.0621	0.06
Brugia malayi	Furin-like cysteine rich region family protein	0.0121	0.0576	0.0576
Brugia malayi	ShTK domain containing protein	0.0093	0.0424	0.0424
Echinococcus granulosus	epidermal growth factor receptor	0.0121	0.0576	0.0554
Trypanosoma brucei	aldo/keto reductase, putative	0.0037	0.0115	0.0949
Onchocerca volvulus		0.0129	0.0621	0.06
Echinococcus multilocularis	epidermal growth factor receptor	0.0121	0.0576	0.0554
Onchocerca volvulus		0.0037	0.0115	0.0093
Schistosoma mansoni	aldo-keto reductase	0.0129	0.0621	0.06
Trypanosoma cruzi	aldo/keto reductase, putative	0.0129	0.0621	0.6129
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0041	0.0136	0.0114
Loa Loa (eye worm)	oxidoreductase	0.0129	0.0621	0.0614
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0042	0.0142	0.012
Schistosoma mansoni	inositol transporter	0.0041	0.0136	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0136	0.0129
Loa Loa (eye worm)	oxidoreductase	0.0129	0.0621	0.0614
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0197	0.0999	1
Plasmodium vivax	aldehyde reductase, putative	0.0037	0.0115	0.7981
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0142	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0022	0.0014
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0042	0.0142	1
Brugia malayi	Sodium:solute symporter family protein	0.0041	0.0136	0.0136
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0037	0.0113	0.0923
Trichomonas vaginalis	aldo/keto reductase, putative	0.0129	0.0621	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0042	0.0042
Echinococcus multilocularis	aldo keto reductase	0.0129	0.0621	0.06
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0042	0.0321
Entamoeba histolytica	protein kinase, putative	0.0197	0.0999	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 831105