TDR Targets

Basic information

Technical information

TDR Targets ID: 831284
Name: N-(3-methoxyphenyl)-2-[[4-(4-methoxyphenyl)-5 -[(1-methylpyrrol-2-yl)methyl]-1,2,4-triazol- 3-yl]sulfanyl]acetamide
MW: 463.552 | Formula: C24H25N5O3S
H donors: 1 H acceptors: 3 LogP: 3.51 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)n1c(SCC(=O)Nc2cccc(c2)OC)nnc1Cc1cccn1C
InChi: 1S/C24H25N5O3S/c1-28-13-5-7-19(28)15-22-26-27-24(29(22)18-9-11-20(31-2)12-10-18)33-16-23(30)25-17-6-4-8-21(14-17)32-3/h4-14H,15-16H2,1-3H3,(H,25,30)
InChiKey: AIFLLHWMZIKAAP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-methoxyphenyl)-2-[[4-(4-methoxyphenyl)-5-[(1-methyl-2-pyrrolyl)methyl]-1,2,4-triazol-3-yl]thio]acetamide
N-(3-methoxyphenyl)-2-[[4-(4-methoxyphenyl)-5-[(1-methylpyrrol-2-yl)methyl]-1,2,4-triazol-3-yl]thio]acetamide
N-(3-methoxyphenyl)-2-[[4-(4-methoxyphenyl)-5-[(1-methylpyrrol-2-yl)methyl]-1,2,4-triazol-3-yl]sulfanyl]ethanamide
MLS000118700
SMR000095640
MLS000878580

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	Rap/Ran GTPase activating protein, putative	0.0058	0.5	0.5
Echinococcus granulosus	synaptotagmin protein 4	0.0058	0.5	0.5
Plasmodium vivax	double C2-like domain-containing protein, putative	0.0058	0.5	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.5	0.5
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Echinococcus multilocularis	extended synaptotagmin 2	0.0058	0.5	0.5
Echinococcus multilocularis	synaptotagmin	0.0058	0.5	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Schistosoma mansoni	synaptotagmin	0.0058	0.5	0.5
Echinococcus granulosus	synaptotagmin	0.0058	0.5	0.5
Trypanosoma brucei	predicted C2 domain protein	0.0058	0.5	0.5
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0058	0.5	0.5
Trypanosoma brucei	C2 domain containing protein, putative	0.0058	0.5	0.5
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0058	0.5	0.5
Schistosoma mansoni	hypothetical protein	0.0058	0.5	0.5
Echinococcus multilocularis		0.0058	0.5	0.5
Schistosoma mansoni	rabphilin-3a	0.0058	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0058	0.5	0.5
Trypanosoma brucei	synaptotagmin, putative	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Echinococcus granulosus	synaptotagmin	0.0058	0.5	0.5
Trichomonas vaginalis	copine, putative	0.0058	0.5	0.5
Schistosoma mansoni	glut4 vesicle protein-related	0.0058	0.5	0.5
Loa Loa (eye worm)	copine family protein	0.0058	0.5	0.5
Brugia malayi	Synaptotagmin protein 3	0.0058	0.5	0.5
Trichomonas vaginalis	copine, putative	0.0058	0.5	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0058	0.5	0.5
Echinococcus multilocularis	NEDD4 E3 ubiquitin protein ligase WWP1	0.0058	0.5	0.5
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0058	0.5	0.5
Trichomonas vaginalis	copine, putative	0.0058	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Echinococcus multilocularis	copine 9	0.0058	0.5	0.5
Echinococcus multilocularis	synaptotagmin	0.0058	0.5	0.5
Echinococcus granulosus	copine 9	0.0058	0.5	0.5
Onchocerca volvulus	Multiple C2 domain and transmembrane region protein homolog	0.0058	0.5	0.5
Entamoeba histolytica	protein kinase, putative	0.0058	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0058	0.5	0.5
Onchocerca volvulus		0.0058	0.5	0.5
Trichomonas vaginalis	copine, putative	0.0058	0.5	0.5
Entamoeba histolytica	C2 domain containing protein	0.0058	0.5	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0058	0.5	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0058	0.5	0.5
Echinococcus multilocularis	synaptotagmin 2	0.0058	0.5	0.5
Echinococcus granulosus	intersectin 2	0.0058	0.5	0.5
Schistosoma mansoni	hypothetical protein	0.0058	0.5	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0058	0.5	0.5
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Leishmania major	c2 domain protein, putative	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0058	0.5	0.5
Trichomonas vaginalis	Proline-rich protein, putative	0.0058	0.5	0.5
Trypanosoma brucei	C2 domain/Ankyrin repeats (3 copies), putative	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0058	0.5	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0058	0.5	0.5
Schistosoma mansoni	nedd-4-like E3 ubiquitin-protein ligase	0.0058	0.5	0.5
Schistosoma mansoni	protein kinase C	0.0058	0.5	0.5
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0058	0.5	0.5
Echinococcus multilocularis	synaptotagmin 15	0.0058	0.5	0.5
Echinococcus granulosus	synaptotagmin 2	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Trichomonas vaginalis	vab10 spectraplakin, putative	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.5	0.5
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0058	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0058	0.5	0.5
Echinococcus granulosus	myoferlin	0.0058	0.5	0.5
Echinococcus multilocularis	unc 13 (munc13)	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Leishmania major	phospholipase c-like protein	0.0058	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0058	0.5	0.5
Plasmodium falciparum	ferlin, putative	0.0058	0.5	0.5
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0058	0.5	0.5
Echinococcus multilocularis	C2 calcium lipid binding region, CaLB	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0058	0.5	0.5
Schistosoma mansoni	synaptotagmin 12	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Trypanosoma cruzi	synaptotagmin, putative	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Echinococcus multilocularis	intersectin 2	0.0058	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.5	0.5
Echinococcus multilocularis	myoferlin	0.0058	0.5	0.5
Trypanosoma cruzi	cytoskeleton associated protein, putative	0.0058	0.5	0.5
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0058	0.5	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Echinococcus granulosus	protein piccolo	0.0058	0.5	0.5
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0058	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0058	0.5	0.5
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0058	0.5	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0058	0.5	0.5
Plasmodium vivax	ferlin, putative	0.0058	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0058	0.5	0.5
Brugia malayi	Synaptotagmin I	0.0058	0.5	0.5
Trypanosoma cruzi	C2 domain/Ankyrin repeats (3 copies), putative	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Entamoeba histolytica	C2 domain containing protein	0.0058	0.5	0.5
Trypanosoma cruzi	cAMP binding protein, putative	0.0058	0.5	0.5
Trichomonas vaginalis	splicing factor 3A subunit, putative	0.0058	0.5	0.5
Echinococcus granulosus	synaptotagmin 15	0.0058	0.5	0.5
Trypanosoma brucei	C2 domain containing protein, putative	0.0058	0.5	0.5
Echinococcus granulosus	NEDD4 E3 ubiquitin protein ligase WWP1	0.0058	0.5	0.5
Entamoeba histolytica	C2 domain containing protein	0.0058	0.5	0.5
Onchocerca volvulus		0.0058	0.5	0.5
Entamoeba histolytica	C2 domain containing protein	0.0058	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0058	0.5	0.5
Echinococcus granulosus	active breakpoint cluster region	0.0058	0.5	0.5
Trypanosoma cruzi	phosphoinositide-specific phospholipase C, putative	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.5	0.5
Trypanosoma brucei	predicted C2 domain protein	0.0058	0.5	0.5
Brugia malayi	Copine family protein	0.0058	0.5	0.5
Entamoeba histolytica	calcium-binding protein, putative	0.0058	0.5	0.5
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Echinococcus multilocularis	copine 9	0.0058	0.5	0.5
Loa Loa (eye worm)	Nedd4-PD	0.0058	0.5	0.5
Echinococcus granulosus	UNCoordinated family member unc 13	0.0058	0.5	0.5
Echinococcus granulosus	Protein kinase C brain isozyme	0.0058	0.5	0.5
Brugia malayi	calpain 5	0.0058	0.5	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0058	0.5	0.5
Entamoeba histolytica	C2 domain protein, putative	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0058	0.5	0.5
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0058	0.5	0.5
Schistosoma mansoni	phospholipase C-like protein 2 plc-L2	0.0058	0.5	0.5
Echinococcus multilocularis	protein piccolo	0.0058	0.5	0.5
Echinococcus multilocularis	UNCoordinated family member (unc 13)	0.0058	0.5	0.5
Entamoeba histolytica	C2 domain containing protein	0.0058	0.5	0.5
Trichomonas vaginalis	calcium-dependent lipid-binding protein, putative	0.0058	0.5	0.5
Echinococcus granulosus	calpain 5	0.0058	0.5	0.5
Schistosoma mansoni	synaptotagmin	0.0058	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.5	0.5
Trichomonas vaginalis	annexin VII, putative	0.0058	0.5	0.5
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Plasmodium vivax	ferlin, putative	0.0058	0.5	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Schistosoma mansoni	synaptotagmin	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Trypanosoma brucei	Coiled-coil and C2 domain-containing protein	0.0058	0.5	0.5
Toxoplasma gondii	hypothetical protein	0.0058	0.5	0.5
Echinococcus multilocularis	synaptotagmin	0.0058	0.5	0.5
Entamoeba histolytica	C2 domain containing protein	0.0058	0.5	0.5
Schistosoma mansoni	fer-1-related	0.0058	0.5	0.5
Brugia malayi	Synapse defective protein 1	0.0058	0.5	0.5
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0058	0.5	0.5
Schistosoma mansoni	hypothetical protein	0.0058	0.5	0.5
Echinococcus granulosus	protein kinase c epsilon type	0.0058	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0058	0.5	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0058	0.5	0.5
Toxoplasma gondii	C2 domain-containing protein	0.0058	0.5	0.5
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0058	0.5	0.5
Trypanosoma cruzi	synaptotagmin, putative	0.0058	0.5	0.5
Onchocerca volvulus		0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Toxoplasma gondii	hypothetical protein	0.0058	0.5	0.5
Echinococcus granulosus	extended synaptotagmin 2	0.0058	0.5	0.5
Leishmania major	copine i-like protein	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Echinococcus multilocularis	calpain 5	0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Brugia malayi	Protein kinase c protein 2	0.0058	0.5	0.5
Schistosoma mansoni	E3 ubiquitin-protein ligase nedd-4	0.0058	0.5	0.5
Loa Loa (eye worm)	synaptotagmin-1	0.0058	0.5	0.5
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0058	0.5	0.5
Plasmodium falciparum	double C2-like domain-containing protein	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Echinococcus multilocularis	serine threonine protein kinase	0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0058	0.5	0.5
Trichomonas vaginalis	ion channel nompc, putative	0.0058	0.5	0.5
Echinococcus granulosus	synaptotagmin	0.0058	0.5	0.5
Entamoeba histolytica	C2 domain containing protein	0.0058	0.5	0.5
Toxoplasma gondii	ferlin family protein	0.0058	0.5	0.5
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.5	0.5
Toxoplasma gondii	Sma protein	0.0058	0.5	0.5
Echinococcus granulosus	synaptotagmin	0.0058	0.5	0.5
Echinococcus granulosus	unc 13 munc13	0.0058	0.5	0.5
Schistosoma mansoni	synaptotagmin	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Schistosoma mansoni	mctp-related	0.0058	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.5	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0058	0.5	0.5
Toxoplasma gondii	Elicitor-responsive protein, putative	0.0058	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0058	0.5	0.5
Loa Loa (eye worm)	phosphatidylinositol 3-kinase catalytic subunit gamma	0.0058	0.5	0.5
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0058	0.5	0.5
Echinococcus multilocularis	protein kinase c epsilon type	0.0058	0.5	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0058	0.5	0.5
Brugia malayi	NEDD4.2	0.0058	0.5	0.5
Onchocerca volvulus		0.0058	0.5	0.5
Schistosoma mansoni	rab3 interacting molecule (rim)-related	0.0058	0.5	0.5
Echinococcus granulosus	synaptotagmin	0.0058	0.5	0.5
Echinococcus granulosus	neural cell expressed developmentally	0.0058	0.5	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0058	0.5	0.5
Brugia malayi	protein kinase C II.	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0058	0.5	0.5
Brugia malayi	Copine VIII	0.0058	0.5	0.5
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0058	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.5	0.5
Echinococcus multilocularis	active breakpoint cluster region	0.0058	0.5	0.5
Trypanosoma cruzi	C2 domain containing protein, putative	0.0058	0.5	0.5
Schistosoma mansoni	unc-13 (munc13)	0.0058	0.5	0.5
Entamoeba histolytica	DENN domain protein	0.0058	0.5	0.5
Onchocerca volvulus		0.0058	0.5	0.5
Trichomonas vaginalis	synaptotagmin, putative	0.0058	0.5	0.5
Echinococcus multilocularis	synaptotagmin	0.0058	0.5	0.5
Schistosoma mansoni	unc-13 (munc13)	0.0058	0.5	0.5
Toxoplasma gondii	hypothetical protein	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Trypanosoma brucei	predicted C2 domain protein	0.0058	0.5	0.5
Schistosoma mansoni	synaptotagmin	0.0058	0.5	0.5
Schistosoma mansoni	synaptotagmin	0.0058	0.5	0.5
Trypanosoma brucei	cAMP binding protein, putative	0.0058	0.5	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0058	0.5	0.5
Schistosoma mansoni	unc-13 (munc13)	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Trypanosoma brucei	C2 domain containing protein, putative	0.0058	0.5	0.5
Schistosoma mansoni	otoferlin	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Entamoeba histolytica	C2 domain containing protein	0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Echinococcus granulosus	protein kinase C gamma type	0.0058	0.5	0.5
Echinococcus granulosus	multiple C2 and transmembrane domain containing protein	0.0058	0.5	0.5
Trypanosoma cruzi	Coiled-coil and C2 domain-containing protein	0.0058	0.5	0.5
Onchocerca volvulus		0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Echinococcus multilocularis	synaptotagmin	0.0058	0.5	0.5
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0058	0.5	0.5
Brugia malayi	WW domain containing protein	0.0058	0.5	0.5
Plasmodium falciparum	ferlin, putative	0.0058	0.5	0.5
Onchocerca volvulus	Putative cc2d1b protein	0.0058	0.5	0.5
Loa Loa (eye worm)	C2 domain-containing protein	0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Trichomonas vaginalis	copine, putative	0.0058	0.5	0.5
Echinococcus granulosus	Immunoglobulin E set	0.0058	0.5	0.5
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0058	0.5	0.5
Schistosoma mansoni	synaptic ras gtpase activating protein syngap	0.0058	0.5	0.5
Onchocerca volvulus		0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0058	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.5	0.5
Schistosoma mansoni	hypothetical protein	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Entamoeba histolytica	C2 domain containing protein	0.0058	0.5	0.5
Leishmania major	c2 domain protein, putative	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Echinococcus granulosus	copine 9	0.0058	0.5	0.5
Echinococcus multilocularis	multiple C2 and transmembrane domain containing protein	0.0058	0.5	0.5
Trypanosoma brucei	C2 domain containing protein, putative	0.0058	0.5	0.5
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0058	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0058	0.5	0.5
Schistosoma mansoni	hypothetical protein	0.0058	0.5	0.5
Brugia malayi	phospholipase C homolog	0.0058	0.5	0.5
Echinococcus multilocularis	synaptotagmin protein 4	0.0058	0.5	0.5
Trichomonas vaginalis	synaptotagmin 1,2, putative	0.0058	0.5	0.5
Echinococcus granulosus	otoferlin	0.0058	0.5	0.5
Schistosoma mansoni	rho gtpase activating protein	0.0058	0.5	0.5
Onchocerca volvulus		0.0058	0.5	0.5
Brugia malayi	C2 domain containing protein	0.0058	0.5	0.5
Schistosoma mansoni	synaptotagmin 12	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Trichomonas vaginalis	synaptotagmin 1, 3, C.elegans, putative	0.0058	0.5	0.5
Echinococcus granulosus	C2 calcium lipid binding region CaLB	0.0058	0.5	0.5
Echinococcus multilocularis	neural cell expressed, developmentally	0.0058	0.5	0.5
Brugia malayi	Synapse defective protein 1	0.0058	0.5	0.5
Schistosoma mansoni	copine	0.0058	0.5	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0058	0.5	0.5
Schistosoma mansoni	synaptotagmin-like protein	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0058	0.5	0.5
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0058	0.5	0.5
Trichomonas vaginalis	Circumsporozoite protein precursor, putative	0.0058	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.5	0.5
Brugia malayi	LD23056p	0.0058	0.5	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0058	0.5	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.5	0.5
Toxoplasma gondii	phosphoinositide phospholipase PIPLC	0.0058	0.5	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1424889
Search by Saint Jude

Bibliographic References

No literature references available for this target.

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Detailed information for compound 831284