Detailed information for compound 831313

Basic information

Technical information
  • TDR Targets ID: 831313
  • Name: 6-fluoro-1-[(4-methoxyphenyl)methyl]-3-phenyl sulfonylquinolin-4-one
  • MW: 423.457 | Formula: C23H18FNO4S
  • H donors: 0 H acceptors: 3 LogP: 4.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Cn1cc(c(=O)c2c1ccc(c2)F)S(=O)(=O)c1ccccc1
  • InChi: 1S/C23H18FNO4S/c1-29-18-10-7-16(8-11-18)14-25-15-22(30(27,28)19-5-3-2-4-6-19)23(26)20-13-17(24)9-12-21(20)25/h2-13,15H,14H2,1H3
  • InChiKey: PBURWTORAQYFKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-fluoro-1-[(4-methoxyphenyl)methyl]-3-phenylsulfonyl-quinolin-4-one
  • 6-fluoro-1-[(4-methoxyphenyl)methyl]-3-phenylsulfonyl-4-quinolinone
  • 6-fluoro-1-(4-methoxybenzyl)-3-phenylsulfonyl-4-quinolone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0347 0.1304 0.1303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0262 0.0943 0.2606
Leishmania major cathepsin L-like protease 0.0639 0.2548 0.7083
Echinococcus multilocularis histone deacetylase 0.0043 0.0009 0.0009
Plasmodium vivax serine-repeat antigen (SERA) 0.0211 0.0724 0.2817
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0211 0.0724 0.0723
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0262 0.0943 0.0935
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0884 0.3593 0.3587
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Loa Loa (eye worm) hypothetical protein 0.0211 0.0724 0.0724
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0262 0.0943 0.0763
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0062 0.0061
Entamoeba histolytica cysteine proteinase, putative 0.0587 0.2329 0.8799
Brugia malayi Papain family cysteine protease containing protein 0.0211 0.0724 0.0723
Onchocerca volvulus Cathepsin L homolog 0.0639 0.2548 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0639 0.2548 0.2548
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0117 0.0323 0.0877
Onchocerca volvulus 0.0211 0.0724 0.2838
Echinococcus granulosus cathepsin l cysteine peptidase 0.0639 0.2548 0.2546
Loa Loa (eye worm) ctsf protein 0.0639 0.2548 0.2548
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0262 0.0943 0.0763
Trypanosoma cruzi cysteine peptidase, putative 0.0826 0.3345 0.3339
Onchocerca volvulus 0.0639 0.2548 1
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0009 0.0008
Echinococcus multilocularis cysteine protease 0.0639 0.2548 0.2548
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0117 0.0323 0.0877
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Loa Loa (eye worm) fibroinase 0.0639 0.2548 0.2548
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0262 0.0943 0.0942
Brugia malayi Cathepsin L-like precursor 0.0639 0.2548 0.2546
Schistosoma mansoni hypothetical protein 0.0164 0.0524 0.0523
Onchocerca volvulus 0.0639 0.2548 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0211 0.0724 0.2817
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0015 0.0015
Loa Loa (eye worm) histone deacetylase 0.0043 0.0009 0.0009
Plasmodium vivax unspecified product 0.0051 0.0046 0.0144
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0035
Entamoeba histolytica cysteine protease, putative 0.0639 0.2548 1
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0639 0.2548 0.2548
Toxoplasma gondii preprocathepsin c precursor, putative 0.0211 0.0724 0.1995
Echinococcus multilocularis geminin 0.0164 0.0524 0.0524
Plasmodium falciparum serine repeat antigen 9 0.0211 0.0724 0.2817
Echinococcus granulosus cathepsin b 0.2388 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0262 0.0943 0.368
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0639 0.2548 1
Schistosoma mansoni cathepsin F (C01 family) 0.0587 0.2329 0.2327
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0211 0.0724 0.0723
Brugia malayi Histone deacetylase family protein 0.0043 0.0009 0.0008
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0211 0.0724 0.0723
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0347 0.1304 0.1303
Loa Loa (eye worm) histone deacetylase 7A 0.0043 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2388 1 1
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0117 0.0323 0.0877
Loa Loa (eye worm) hypothetical protein 0.0055 0.0062 0.0062
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0211 0.0724 0.0723
Brugia malayi fibroinase precursor 0.0211 0.0724 0.0723
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0211 0.0724 0.2817
Echinococcus granulosus histone deacetylase 6 0.0043 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0211 0.0724 0.0724
Brugia malayi Histone deacetylase family protein 0.0043 0.0009 0.0008
Brugia malayi Papain family cysteine protease containing protein 0.0262 0.0943 0.0942
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0211 0.0724 0.2817
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Brugia malayi Cathepsin L-like precursor 0.0639 0.2548 0.2546
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Trypanosoma cruzi cysteine peptidase, putative 0.0826 0.3345 0.3339
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0211 0.0724 0.2817
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0639 0.2548 0.2548
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0211 0.0724 0.0724
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0117 0.0323 0.0315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Trypanosoma cruzi cysteine peptidase, putative 0.0262 0.0943 0.0935
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Plasmodium vivax vivapain-1 0.0262 0.0943 0.368
Toxoplasma gondii cathepsin CPL 0.0639 0.2548 0.7083
Loa Loa (eye worm) hypothetical protein 0.0051 0.0046 0.0046
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0211 0.0724 0.0723
Loa Loa (eye worm) cathepsin B 0.0884 0.3593 0.3593
Trypanosoma brucei cysteine peptidase C (CPC) 0.0884 0.3593 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0015 0.0013
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0237 0.0835 0.0835
Onchocerca volvulus Cathepsin L homolog 0.0639 0.2548 1
Loa Loa (eye worm) hypothetical protein 0.0211 0.0724 0.0724
Brugia malayi Cathepsin L-like precursor 0.0639 0.2548 0.2546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Echinococcus granulosus calpain A 0.0058 0.0073 0.0071
Leishmania major cathepsin L-like protease 0.0639 0.2548 0.7083
Trypanosoma cruzi cruzipain precursor, putative 0.0051 0.0046 0.0037
Brugia malayi Cathepsin L-like precursor 0.0051 0.0046 0.0044
Entamoeba histolytica cysteine proteinase, putative 0.0262 0.0943 0.1201
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0015 0.0013
Echinococcus multilocularis inhibitor of apoptosis protein 0.0041 0.0002 0.0002
Entamoeba histolytica cysteine proteinase, putative 0.0262 0.0943 0.1201
Brugia malayi cathepsin Z-like cysteine proteinase 0.0211 0.0724 0.0723
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0347 0.1304 0.1304
Loa Loa (eye worm) prolyl oligopeptidase 0.0347 0.1304 0.1304
Entamoeba histolytica cysteine proteinase, putative 0.0639 0.2548 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0211 0.0724 0.2817
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Onchocerca volvulus 0.0639 0.2548 1
Brugia malayi Cathepsin L-like precursor 0.0587 0.2329 0.2327
Plasmodium falciparum serine repeat antigen 5 0.0211 0.0724 0.2817
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Brugia malayi cathepsin L-like cysteine proteinase 0.0211 0.0724 0.0723
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2388 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0826 0.3345 0.3339
Trypanosoma cruzi cysteine protease, putative 0.0262 0.0943 0.0935
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0117 0.0323 0.0315
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Onchocerca volvulus 0.0587 0.2329 0.914
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Plasmodium vivax vivapain-2 0.0639 0.2548 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0015 0.0013
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0211 0.0724 0.0723
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0639 0.2548 0.6356
Brugia malayi prolyl oligopeptidase family protein 0.0347 0.1304 0.1303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Onchocerca volvulus 0.0639 0.2548 1
Loa Loa (eye worm) hypothetical protein 0.0211 0.0724 0.0724
Plasmodium vivax unspecified product 0.0262 0.0943 0.368
Toxoplasma gondii cathepsin CPC2 0.0211 0.0724 0.1995
Leishmania major cathepsin L-like protease 0.0639 0.2548 0.7083
Loa Loa (eye worm) hypothetical protein 0.0211 0.0724 0.0724
Brugia malayi Papain family cysteine protease containing protein 0.0211 0.0724 0.0723
Plasmodium falciparum serine repeat antigen 3 0.0211 0.0724 0.2817
Toxoplasma gondii cathepsin B 0.0884 0.3593 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0347 0.1304 0.5117
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0009 0.0009
Leishmania major cathepsin L-like protease 0.0826 0.3345 0.9309
Brugia malayi cathepsin F-like cysteine proteinase 0.0211 0.0724 0.0723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0262 0.0943 0.2606
Giardia lamblia Cathepsin B precursor 0.0884 0.3593 1
Brugia malayi Cathepsin L-like precursor 0.0639 0.2548 0.2546
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0774 0.3126 0.312
Brugia malayi Cathepsin L-like cysteine proteinase 0.0587 0.2329 0.2327
Echinococcus granulosus cathepsin L cysteine proteinase 0.0639 0.2548 0.2546
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0211 0.0724 0.2817
Onchocerca volvulus Cathepsin F homolog 0.0639 0.2548 1
Echinococcus granulosus cathepsin L 0.0262 0.0943 0.0942
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0051 0.0046 0.0044
Echinococcus multilocularis cathepsin L cysteine protease 0.0639 0.2548 0.2548
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0262 0.0943 0.0942
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0211 0.0724 0.2817
Brugia malayi prolyl oligopeptidase family protein 0.0117 0.0323 0.0322
Echinococcus multilocularis histone deacetylase 7 0.0043 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0587 0.2329 0.5592
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0058 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0041 0.0002 0.0002
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0009 0.0008
Brugia malayi cathepsin L-like precursor 0.0587 0.2329 0.2327
Onchocerca volvulus 0.0639 0.2548 1
Echinococcus multilocularis cathepsin L 0.0262 0.0943 0.0943
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0211 0.0724 0.2817
Loa Loa (eye worm) hypothetical protein 0.0639 0.2548 0.2548
Schistosoma mansoni gamma-secretase subunit aph-1 0.0237 0.0835 0.0834
Loa Loa (eye worm) hypothetical protein 0.0211 0.0724 0.0724
Loa Loa (eye worm) hypothetical protein 0.0587 0.2329 0.2329
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0015 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0639 0.2548 0.2541
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0211 0.0724 0.0723
Trypanosoma cruzi cruzipain precursor, putative 0.0826 0.3345 0.3339
Schistosoma mansoni cathepsin F (C01 family) 0.0639 0.2548 0.2546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Brugia malayi cathepsin Z-like cysteine proteinase 0.0211 0.0724 0.0723
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0117 0.0323 0.0322
Schistosoma mansoni cathepsin s 0.0051 0.0046 0.0044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2388 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0587 0.2329 0.5592
Plasmodium falciparum serine repeat antigen 2 0.0211 0.0724 0.2817
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Echinococcus granulosus histone deacetylase 6 0.0043 0.0009 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Entamoeba histolytica cysteine proteinase, putative 0.0262 0.0943 0.1201
Schistosoma mansoni hypothetical protein 0.0164 0.0524 0.0523
Plasmodium falciparum cysteine proteinase falcipain 3 0.0639 0.2548 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0211 0.0724 0.2817
Brugia malayi gamma-secretase subunit aph-1 0.0237 0.0835 0.0834
Onchocerca volvulus 0.0639 0.2548 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0117 0.0323 0.0323
Echinococcus granulosus geminin 0.0164 0.0524 0.0523
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Loa Loa (eye worm) cysteine protease 0.0639 0.2548 0.2548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Loa Loa (eye worm) hypothetical protein 0.0587 0.2329 0.2329
Plasmodium falciparum serine repeat antigen 1 0.0211 0.0724 0.2817
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0884 0.3593 0.3592
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0639 0.2548 0.2548
Leishmania major cathepsin L-like protease 0.0639 0.2548 0.7083
Entamoeba histolytica cysteine proteinase 2 0.0262 0.0943 0.1201
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0058 0.0073 0.0071
Brugia malayi Papain family cysteine protease containing protein 0.0639 0.2548 0.2546
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0211 0.0724 0.2817
Entamoeba histolytica cysteine proteinase, putative 0.0262 0.0943 0.1201
Brugia malayi Cathepsin L-like precursor 0.0639 0.2548 0.2546
Brugia malayi Cathepsin L-like precursor 0.0639 0.2548 0.2546
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0211 0.0724 0.0724
Onchocerca volvulus Cathepsin L homolog 0.0211 0.0724 0.2838
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0884 0.3593 1
Plasmodium falciparum serine repeat antigen 4 0.0211 0.0724 0.2817
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2388 1 1
Onchocerca volvulus 0.0639 0.2548 1
Echinococcus granulosus histone deacetylase 0.0043 0.0009 0.0008
Echinococcus granulosus cathepsin b 0.2388 1 1
Schistosoma mansoni cathepsin C 0.0211 0.0724 0.0723
Brugia malayi Cathepsin L-like precursor 0.0587 0.2329 0.2327
Brugia malayi calpain family protein 1 0.0055 0.0062 0.0061
Giardia lamblia Cathepsin B precursor 0.0884 0.3593 1
Schistosoma mansoni cathepsin B (C01 family) 0.0211 0.0724 0.0723
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0073 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Echinococcus granulosus cathepsin L cysteine protease 0.0262 0.0943 0.0942
Loa Loa (eye worm) hypothetical protein 0.0051 0.0046 0.0046
Entamoeba histolytica cysteine proteinase, putative 0.0639 0.2548 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0262 0.0943 0.0942
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0211 0.0724 0.2817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Entamoeba histolytica cysteine protease, putative 0.0262 0.0943 0.1201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0009 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.0639 0.2548 0.2546
Loa Loa (eye worm) hypothetical protein 0.0041 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0639 0.2548 0.6356
Loa Loa (eye worm) hypothetical protein 0.2388 1 1
Echinococcus multilocularis calpain A 0.0058 0.0073 0.0073
Echinococcus multilocularis cysteine protease 0.0639 0.2548 0.2548
Plasmodium vivax unspecified product 0.0211 0.0724 0.2817
Leishmania major cathepsin L-like protease 0.0826 0.3345 0.9309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0015 0.0015
Leishmania major cathepsin L-like protease 0.0826 0.3345 0.9309
Schistosoma mansoni histone deacetylase hda2 0.0043 0.0009 0.0008
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0211 0.0724 0.0724
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Echinococcus granulosus cathepsin l1 0.0639 0.2548 0.2546
Echinococcus granulosus histone deacetylase 6 0.0043 0.0009 0.0008
Trypanosoma cruzi cysteine proteinase, putative 0.0262 0.0943 0.0935
Plasmodium falciparum serine repeat antigen 7 0.0211 0.0724 0.2817
Toxoplasma gondii cathepsin CPC1 0.0211 0.0724 0.1995
Echinococcus multilocularis cathepsin b 0.2388 1 1
Brugia malayi calpain family protein 1 0.0055 0.0062 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Echinococcus granulosus Dipeptidyl peptidase 9 0.0117 0.0323 0.0322
Trypanosoma cruzi Aph-1 protein, putative 0.0092 0.022 0.0211
Loa Loa (eye worm) hypothetical protein 0.0043 0.0009 0.0009
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2388 1 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0211 0.0724 0.2817
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0015 0.0013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0639 0.2548 0.6356
Echinococcus granulosus cysteine protease 0.0262 0.0943 0.0942
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0015 0.0013
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0062 0.0062
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0046 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0639 0.2548 0.6356
Giardia lamblia Cathepsin B precursor 0.0884 0.3593 1
Plasmodium vivax vivapain-2 0.0639 0.2548 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0211 0.0724 0.0716
Echinococcus granulosus histone deacetylase 7 0.0043 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0089 0.0206 0.0206
Trypanosoma cruzi Aph-1 protein, putative 0.0092 0.022 0.0211
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0639 0.2548 1
Trypanosoma brucei Aph-1 protein, putative 0.0092 0.022 0.0587
Echinococcus multilocularis cathepsin L 0.0211 0.0724 0.0724
Brugia malayi Papain family cysteine protease containing protein 0.0262 0.0943 0.0942
Echinococcus granulosus cathepsin l1 0.0587 0.2329 0.2327
Echinococcus multilocularis cathepsin b 0.2388 1 1
Schistosoma mansoni cathepsin S (C01 family) 0.0211 0.0724 0.0723
Leishmania major cysteine peptidase A (CPA) 0.0639 0.2548 0.7083
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0073 0.0071
Trypanosoma cruzi cysteine peptidase, putative 0.0051 0.0046 0.0037
Echinococcus multilocularis gamma secretase subunit aph 1 0.0237 0.0835 0.0835
Echinococcus granulosus cathepsin L 0.0211 0.0724 0.0723
Plasmodium vivax vivapain-3 0.0262 0.0943 0.368
Plasmodium falciparum serine repeat antigen 6 0.0211 0.0724 0.2817
Trypanosoma cruzi major cysteine proteinase, putative 0.0398 0.1522 0.1514
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0117 0.0323 0.0877
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0211 0.0724 0.2817
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0826 0.3345 0.9309
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0211 0.0724 0.2817
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0211 0.0724 0.0723
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0211 0.0724 0.0723
Brugia malayi cathepsin L precursor 0.0211 0.0724 0.0723
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0041 0.0002 0.0002
Entamoeba histolytica cysteine proteinase 1, putative 0.0262 0.0943 0.1201
Echinococcus granulosus gamma secretase subunit aph 1 0.0237 0.0835 0.0834
Trypanosoma cruzi cysteine proteinase, putative 0.0262 0.0943 0.0935
Loa Loa (eye worm) hypothetical protein 0.0051 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0587 0.2329 0.2329
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0884 0.3593 1
Brugia malayi hypothetical protein 0.0089 0.0206 0.0205
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0211 0.0724 0.0723
Plasmodium falciparum serine repeat antigen 8 0.0211 0.0724 0.2817
Brugia malayi Papain family cysteine protease containing protein 0.0211 0.0724 0.0723
Leishmania major cathepsin L-like protease 0.0639 0.2548 0.7083
Echinococcus multilocularis cathepsin L cysteine protease 0.0639 0.2548 0.2548

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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