Detailed information for compound 831315

Basic information

Technical information
  • TDR Targets ID: 831315
  • Name: 1-[(2,5-dimethylphenyl)methyl]-6-fluoro-3-(4- fluorophenyl)sulfonylquinolin-4-one
  • MW: 439.474 | Formula: C24H19F2NO3S
  • H donors: 0 H acceptors: 3 LogP: 5.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)c(=O)c(cn2Cc1cc(C)ccc1C)S(=O)(=O)c1ccc(cc1)F
  • InChi: 1S/C24H19F2NO3S/c1-15-3-4-16(2)17(11-15)13-27-14-23(24(28)21-12-19(26)7-10-22(21)27)31(29,30)20-8-5-18(25)6-9-20/h3-12,14H,13H2,1-2H3
  • InChiKey: ZKKZMFCAIVAGHD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(2,5-dimethylphenyl)methyl]-6-fluoro-3-(4-fluorophenyl)sulfonyl-quinolin-4-one
  • 1-[(2,5-dimethylphenyl)methyl]-6-fluoro-3-(4-fluorophenyl)sulfonyl-4-quinolinone
  • 1-(2,5-dimethylbenzyl)-6-fluoro-3-(4-fluorophenyl)sulfonyl-4-quinolone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax unspecified product 0.0229 0.0815 0.306
Echinococcus granulosus cathepsin b 0.2559 1 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0155 0.0155
Schistosoma mansoni hypothetical protein 0.0061 0.0156 0.0156
Trypanosoma brucei prolyl oligopeptidase, putative 0.0078 0.0223 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.0815 0.2212
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.001 0.0002
Entamoeba histolytica cysteine proteinase 2 0.0281 0.102 0.3839
Loa Loa (eye worm) hypothetical protein 0.0641 0.2438 0.2431
Toxoplasma gondii cathepsin CPL 0.0693 0.2643 0.7223
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0066
Loa Loa (eye worm) hypothetical protein 0.0061 0.0156 0.0146
Echinococcus granulosus Dipeptidyl peptidase 9 0.0131 0.0431 0.0431
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0133 0.0439 0.0431
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.0815 0.2212
Leishmania major cathepsin L-like protease 0.0882 0.3389 0.9268
Entamoeba histolytica cysteine protease, putative 0.0229 0.0815 0.3062
Plasmodium vivax serine-repeat antigen (SERA) 0.0229 0.0815 0.306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Loa Loa (eye worm) histone deacetylase 7A 0.0043 0.0084 0.0075
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0229 0.0815 0.2066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Giardia lamblia Cysteine protease 0.0229 0.0815 0.2066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.009 0.009
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0076 0.0067
Loa Loa (eye worm) hypothetical protein 0.0052 0.0118 0.0109
Plasmodium vivax vivapain-1 0.0281 0.102 0.3837
Onchocerca volvulus Cathepsin L homolog 0.0693 0.2643 1
Schistosoma mansoni inhibitor of apoptosis protein 0.0133 0.0439 0.0439
Brugia malayi Bromodomain containing protein 0.0037 0.006 0.0052
Brugia malayi calpain family protein 1 0.0056 0.0134 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0882 0.3389 0.9268
Entamoeba histolytica cysteine proteinase, putative 0.0281 0.102 0.3839
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0078 0.0223 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0076 0.0184
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.001 0.0001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.009 0.008
Loa Loa (eye worm) hypothetical protein 0.0043 0.0084 0.0075
Entamoeba histolytica cysteine proteinase, putative 0.0641 0.2438 0.9223
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0229 0.0815 0.0815
Brugia malayi calpain family protein 1 0.0056 0.0134 0.0125
Schistosoma mansoni cathepsin s 0.0052 0.0118 0.0118
Onchocerca volvulus 0.0693 0.2643 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0076 0.0255
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0118 0.0109
Loa Loa (eye worm) hypothetical protein 0.004 0.007 0.006
Echinococcus multilocularis histone deacetylase 0.0043 0.0084 0.0084
Trypanosoma cruzi prolyl endopeptidase 0.0155 0.0525 0.0517
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0133 0.0439 0.0439
Schistosoma mansoni histone deacetylase hda2 0.0043 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0641 0.2438 0.2431
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0693 0.2643 0.2643
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0364 0.1349 0.5009
Plasmodium falciparum serine repeat antigen 3 0.0229 0.0815 0.306
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0229 0.0815 0.306
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0155 0.0525 0.1413
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0066
Giardia lamblia Cathepsin L-like protease 0.0229 0.0815 0.2066
Schistosoma mansoni cathepsin F (C01 family) 0.0641 0.2438 0.2438
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.009 0.0081
Entamoeba histolytica cysteine proteinase, putative 0.0693 0.2643 1
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0084 0.0076
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0155 0.0146
Toxoplasma gondii cathepsin CPC1 0.0229 0.0815 0.2212
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0058 0.0144 0.0144
Entamoeba histolytica cysteine proteinase, putative 0.0281 0.102 0.3839
Schistosoma mansoni gamma-secretase subunit aph-1 0.0239 0.0857 0.0857
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0693 0.2643 0.2636
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.102 0.2773
Giardia lamblia Encystation-specific protease 0.0229 0.0815 0.2066
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0041 0.0076 0.0255
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0229 0.0815 0.306
Brugia malayi cathepsin L-like precursor 0.0641 0.2438 0.2432
Schistosoma mansoni cathepsin F (C01 family) 0.0693 0.2643 0.2643
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0693 0.2643 0.7223
Entamoeba histolytica cysteine protease, putative 0.0229 0.0815 0.3062
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0949 0.3656 0.365
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0229 0.0815 0.0815
Loa Loa (eye worm) hypothetical protein 0.0041 0.0076 0.0066
Loa Loa (eye worm) hypothetical protein 0.2559 1 1
Trypanosoma brucei histone deacetylase 3 0.0043 0.0084 0.0207
Plasmodium falciparum histone deacetylase, putative 0.0043 0.0084 0.0284
Plasmodium falciparum cysteine proteinase falcipain 3 0.0693 0.2643 1
Trypanosoma brucei prolyl endopeptidase 0.0155 0.0525 0.1415
Plasmodium falciparum peptidase, putative 0.0041 0.0076 0.0252
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0229 0.0815 0.2066
Echinococcus granulosus histone deacetylase 6 0.0043 0.0084 0.0084
Trypanosoma cruzi cysteine proteinase, putative 0.0281 0.102 0.1012
Brugia malayi Cathepsin L-like precursor 0.0693 0.2643 0.2637
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.009 0.009
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0693 0.2643 0.7223
Plasmodium falciparum serine repeat antigen 4 0.0229 0.0815 0.306
Plasmodium vivax unspecified product 0.0281 0.102 0.3837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0882 0.3389 0.9268
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0144 0.0144
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0364 0.1349 0.1349
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0084 0.0084
Plasmodium vivax vivapain-2 0.0693 0.2643 1
Echinococcus multilocularis cathepsin L 0.0229 0.0815 0.0815
Echinococcus multilocularis cathepsin L 0.0281 0.102 0.102
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0949 0.3656 0.3656
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0693 0.2643 0.2636
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0693 0.2643 0.2643
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0041 0.0076 0.0076
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0051 0.0051
Trypanosoma brucei histone deacetylase 4 0.0043 0.0084 0.0207
Onchocerca volvulus 0.0061 0.0156 0.0405
Loa Loa (eye worm) hypothetical protein 0.0061 0.0156 0.0146
Giardia lamblia Cathepsin B precursor 0.0229 0.0815 0.2066
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0229 0.0815 0.306
Leishmania major cathepsin L-like protease 0.0693 0.2643 0.7223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0882 0.3389 0.9268
Loa Loa (eye worm) hypothetical protein 0.0641 0.2438 0.2431
Brugia malayi prolyl oligopeptidase family protein 0.0131 0.0431 0.0423
Giardia lamblia Cathepsin L precursor 0.0229 0.0815 0.2066
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Entamoeba histolytica cysteine protease, putative 0.0229 0.0815 0.3062
Trypanosoma brucei cysteine peptidase C (CPC) 0.0949 0.3656 1
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2559 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0281 0.102 0.1012
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0229 0.0815 0.2066
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0281 0.102 0.102
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0229 0.0815 0.0815
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0693 0.2643 0.7223
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0693 0.2643 0.7223
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0229 0.0815 0.2212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.0815 0.2212
Loa Loa (eye worm) cysteine protease 0.0693 0.2643 0.2636
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0229 0.0815 0.306
Brugia malayi Bromodomain containing protein 0.0073 0.0201 0.0192
Onchocerca volvulus Prolyl endopeptidase homolog 0.0155 0.0525 0.1828
Trypanosoma cruzi Aph-1 protein, putative 0.0093 0.0281 0.0273
Trypanosoma cruzi cruzipain precursor, putative 0.0882 0.3389 0.3383
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0229 0.0815 0.0815
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0041 0.0076 0.0255
Loa Loa (eye worm) hypothetical protein 0.0052 0.0118 0.0109
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2559 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0229 0.0815 0.2212
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0229 0.0815 0.2212
Trypanosoma cruzi oligopeptidase b 0.0078 0.0223 0.0214
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2559 1 1
Giardia lamblia Cathepsin B precursor 0.0229 0.0815 0.2066
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0229 0.0815 0.306
Brugia malayi Cathepsin L-like precursor 0.0693 0.2643 0.2637
Plasmodium falciparum serine repeat antigen 6 0.0229 0.0815 0.306
Leishmania major oligopeptidase b 0.0078 0.0223 0.0585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0882 0.3389 0.9268
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0229 0.0815 0.2212
Toxoplasma gondii cathepsin B 0.0949 0.3656 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Trypanosoma brucei oligopeptidase b 0.0078 0.0223 0.0587
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0229 0.0815 0.0807
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0229 0.0815 0.306
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0229 0.0815 0.306
Toxoplasma gondii preprocathepsin c precursor, putative 0.0229 0.0815 0.2212
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Trypanosoma cruzi cysteine peptidase, putative 0.0693 0.2643 0.2637
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0118 0.011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0118 0.0109
Trypanosoma cruzi cysteine peptidase, putative 0.0882 0.3389 0.3383
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.001 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0155 0.0155
Brugia malayi TAR-binding protein 0.0061 0.0155 0.0146
Entamoeba histolytica cysteine protease, putative 0.0229 0.0815 0.3062
Loa Loa (eye worm) ctsf protein 0.0693 0.2643 0.2636
Loa Loa (eye worm) hypothetical protein 0.0037 0.0061 0.0051
Onchocerca volvulus Cathepsin L homolog 0.0229 0.0815 0.2949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0882 0.3389 0.9268
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0043 0.0084 0.0075
Brugia malayi Papain family cysteine protease containing protein 0.0229 0.0815 0.0807
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Loa Loa (eye worm) hypothetical protein 0.009 0.0269 0.026
Brugia malayi Papain family cysteine protease containing protein 0.0229 0.0815 0.0807
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0041 0.0076 0.0184
Leishmania major cathepsin L-like protease 0.0693 0.2643 0.7223
Echinococcus multilocularis cathepsin b 0.2559 1 1
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0133 0.0439 0.0439
Schistosoma mansoni cathepsin F (C01 family) 0.0693 0.2643 0.2643
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0076 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Leishmania major cathepsin L-like protease 0.0882 0.3389 0.9268
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0229 0.0815 0.306
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0882 0.3389 0.9268
Brugia malayi fibroinase precursor 0.0229 0.0815 0.0807
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0229 0.0815 0.2212
Giardia lamblia Hypothetical protein 0.0229 0.0815 0.2066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0882 0.3389 0.9268
Onchocerca volvulus Deterin homolog 0.0133 0.0439 0.1498
Brugia malayi Histone deacetylase family protein 0.0043 0.0084 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.0815 0.2212
Giardia lamblia Cathepsin L precursor 0.0229 0.0815 0.2066
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0076 0.0255
Giardia lamblia Cathepsin B precursor 0.0229 0.0815 0.2066
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0155 0.0155
Loa Loa (eye worm) RNA binding protein 0.0061 0.0155 0.0145
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0078 0.0223 0.5
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0229 0.0815 0.2066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.0815 0.2212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0229 0.0815 0.2212
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0229 0.0815 0.3062
Onchocerca volvulus 0.0133 0.0439 0.1498
Schistosoma mansoni cathepsin S (C01 family) 0.0229 0.0815 0.0815
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Echinococcus multilocularis cathepsin L cysteine protease 0.0693 0.2643 0.2643
Brugia malayi Cathepsin L-like precursor 0.0641 0.2438 0.2432
Schistosoma mansoni bromodomain containing protein 0.0062 0.0156 0.0156
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0281 0.102 0.1012
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Echinococcus granulosus inhibitor of apoptosis protein 0.0133 0.0439 0.0439
Brugia malayi Papain family cysteine protease containing protein 0.0281 0.102 0.1012
Brugia malayi cathepsin F-like cysteine proteinase 0.0229 0.0815 0.0807
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0949 0.3656 1
Echinococcus multilocularis histone deacetylase 7 0.0043 0.0084 0.0084
Brugia malayi Papain family cysteine protease containing protein 0.0229 0.0815 0.0807
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0229 0.0815 0.0815
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.0815 0.2212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.102 0.2773
Onchocerca volvulus Cathepsin L homolog 0.0693 0.2643 1
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0084 0.0076
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0229 0.0815 0.306
Echinococcus multilocularis cathepsin b 0.2559 1 1
Entamoeba histolytica hypothetical protein 0.0229 0.0815 0.3062
Onchocerca volvulus 0.0693 0.2643 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0641 0.2438 0.6662
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0155 0.0525 0.0525
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0131 0.0431 0.0423
Plasmodium vivax unspecified product 0.0052 0.0118 0.0413
Toxoplasma gondii hypothetical protein 0.0041 0.0076 0.0184
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0084 0.0084
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0078 0.0223 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0281 0.102 0.1012
Giardia lamblia Cysteine protease 0.0229 0.0815 0.2066
Schistosoma mansoni caspase-7 (C14 family) 0.0061 0.0156 0.0156
Schistosoma mansoni cathepsin B (C01 family) 0.0229 0.0815 0.0815
Schistosoma mansoni hypothetical protein 0.0494 0.186 0.186
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0076 0.0067
Toxoplasma gondii cathepsin CPC2 0.0229 0.0815 0.2212
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0155 0.0155
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0229 0.0815 0.0815
Loa Loa (eye worm) hypothetical protein 0.0229 0.0815 0.0807
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0239 0.0857 0.0849
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.009 0.009
Toxoplasma gondii histone deacetylase HDAC1 0.0043 0.0084 0.0207
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0142 0.0142
Plasmodium falciparum cysteine proteinase falcipain 1 0.0281 0.102 0.3837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0882 0.3389 0.9268
Entamoeba histolytica cysteine proteinase, putative 0.0693 0.2643 1
Brugia malayi Cathepsin L-like precursor 0.0693 0.2643 0.2637
Brugia malayi Histone deacetylase family protein 0.0043 0.0084 0.0076
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0229 0.0815 0.0815
Leishmania major cysteine peptidase A (CPA) 0.0693 0.2643 0.7223
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0142 0.0142
Entamoeba histolytica cysteine proteinase, putative 0.0281 0.102 0.3839
Leishmania major cathepsin L-like protease 0.0693 0.2643 0.7223
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0155 0.0145
Onchocerca volvulus 0.0693 0.2643 1
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.102 0.1012
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0084 0.0076
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0076 0.0255
Entamoeba histolytica cysteine protease, putative 0.0693 0.2643 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Plasmodium vivax vivapain-2 0.0693 0.2643 1
Echinococcus granulosus prolyl endopeptidase 0.0155 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0693 0.2643 0.2636
Giardia lamblia Cathepsin L-like protease 0.0229 0.0815 0.2066
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0281 0.102 0.102
Brugia malayi Papain family cysteine protease containing protein 0.0693 0.2643 0.2637
Plasmodium falciparum serine repeat antigen 9 0.0229 0.0815 0.306
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0364 0.1349 0.1349
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0078 0.0223 0.0585
Giardia lamblia Cathepsin L precursor 0.0229 0.0815 0.2066
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0155 0.0155
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Echinococcus multilocularis cysteine protease 0.0693 0.2643 0.2643
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0229 0.0815 0.2212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.102 0.2773
Giardia lamblia Cathepsin B precursor 0.0949 0.3656 1
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0693 0.2643 0.7223
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0133 0.0439 0.0431
Echinococcus granulosus geminin 0.0494 0.186 0.186
Loa Loa (eye worm) histone deacetylase 0.0043 0.0084 0.0075
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0155 0.0525 0.0525
Giardia lamblia Cathepsin L precursor 0.0229 0.0815 0.2066
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0084 0.0084
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Onchocerca volvulus 0.0693 0.2643 1
Plasmodium vivax histone deacetylase, putative 0.0043 0.0084 0.0284
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0229 0.0815 0.306
Leishmania major cathepsin L-like protease 0.0693 0.2643 0.7223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0229 0.0815 0.306
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0114 0.0363 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0229 0.0815 0.306
Echinococcus granulosus cathepsin L cysteine proteinase 0.0693 0.2643 0.2643
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0641 0.2438 0.6662
Echinococcus multilocularis gamma secretase subunit aph 1 0.0239 0.0857 0.0857
Brugia malayi prolyl oligopeptidase family protein 0.0155 0.0525 0.0517
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.0815 0.2212
Echinococcus multilocularis prolyl endopeptidase 0.0155 0.0525 0.0525
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0693 0.2643 0.7223
Echinococcus granulosus cathepsin L 0.0281 0.102 0.102
Giardia lamblia Cysteine protease 0.0229 0.0815 0.2066
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2559 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0051 0.0051
Echinococcus granulosus histone deacetylase 7 0.0043 0.0084 0.0084
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0229 0.0815 0.0815
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0229 0.0815 0.306
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.009 0.009
Brugia malayi Cathepsin L-like precursor 0.0693 0.2643 0.2637
Loa Loa (eye worm) hypothetical protein 0.0229 0.0815 0.0807
Brugia malayi gamma-secretase subunit aph-1 0.0239 0.0857 0.0849
Loa Loa (eye worm) hypothetical protein 0.0229 0.0815 0.0807
Plasmodium vivax histone deacetylase 2, putative 0.0043 0.0084 0.0284
Trypanosoma cruzi cysteine peptidase, putative 0.0882 0.3389 0.3383
Echinococcus granulosus gamma secretase subunit aph 1 0.0239 0.0857 0.0857
Leishmania major histone deacetylase, putative 0.0043 0.0084 0.0205
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0052 0.0118 0.011
Echinococcus multilocularis cathepsin L cysteine protease 0.0693 0.2643 0.2643
Echinococcus granulosus histone deacetylase 6 0.0043 0.0084 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Trypanosoma cruzi cysteine peptidase, putative 0.0882 0.3389 0.3383
Trypanosoma brucei Aph-1 protein, putative 0.0093 0.0281 0.0747
Trypanosoma cruzi oligopeptidase b 0.0078 0.0223 0.0214
Loa Loa (eye worm) hypothetical protein 0.0069 0.0185 0.0175
Echinococcus granulosus cathepsin L cysteine protease 0.0281 0.102 0.102
Echinococcus granulosus histone deacetylase 0.0043 0.0084 0.0084
Echinococcus granulosus cathepsin l1 0.0693 0.2643 0.2643
Brugia malayi cathepsin Z-like cysteine proteinase 0.0229 0.0815 0.0807
Brugia malayi cathepsin Z-like cysteine proteinase 0.0229 0.0815 0.0807
Giardia lamblia Hypothetical protein 0.0229 0.0815 0.2066
Onchocerca volvulus 0.0693 0.2643 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.0815 0.0807
Brugia malayi cathepsin L-like cysteine proteinase 0.0229 0.0815 0.0807
Plasmodium falciparum serine repeat antigen 7 0.0229 0.0815 0.306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0693 0.2643 0.7223
Loa Loa (eye worm) hypothetical protein 0.0229 0.0815 0.0807
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0078 0.0223 0.0214
Brugia malayi Cathepsin L-like precursor 0.0641 0.2438 0.2432
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.009 0.009
Echinococcus multilocularis caspase 2 0.0061 0.0156 0.0156
Brugia malayi Cell death protein 3 precursor 0.0061 0.0156 0.0147
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0041
Echinococcus multilocularis cysteine protease 0.0693 0.2643 0.2643
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0041 0.0076 0.0076
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0155 0.0155
Toxoplasma gondii prolyl endopeptidase 0.0155 0.0525 0.1415
Loa Loa (eye worm) hypothetical protein 0.0155 0.0525 0.0516
Plasmodium falciparum serine repeat antigen 8 0.0229 0.0815 0.306
Trypanosoma cruzi major cysteine proteinase, putative 0.0418 0.1561 0.1554
Giardia lamblia Cathepsin L precursor 0.0229 0.0815 0.2066
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0131 0.0431 0.1158
Giardia lamblia Cysteine protease 0.0229 0.0815 0.2066
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0281 0.102 0.102
Echinococcus granulosus tar DNA binding protein 0.0061 0.0155 0.0155
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0076 0.0255
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2559 1 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0041 0.0076 0.0184
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0229 0.0815 0.0807
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0144 0.0144
Echinococcus multilocularis calpain family protein 1, d 0.0041 0.0076 0.0076
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Echinococcus granulosus cathepsin L 0.0229 0.0815 0.0815
Loa Loa (eye worm) hypothetical protein 0.0133 0.0439 0.043
Plasmodium falciparum serine repeat antigen 5 0.0229 0.0815 0.306
Onchocerca volvulus 0.0693 0.2643 1
Schistosoma mansoni hypothetical protein 0.0133 0.0439 0.0439
Loa Loa (eye worm) calpain family protein 1 0.0041 0.0076 0.0066
Trypanosoma cruzi major cysteine proteinase, putative 0.0229 0.0815 0.0807
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0058 0.0144 0.0144
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0009 0.0009
Plasmodium falciparum histone deacetylase 2 0.0043 0.0084 0.0284
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0131 0.0431 0.0431
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0229 0.0815 0.0815
Leishmania major cathepsin L-like protease 0.0693 0.2643 0.7223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0693 0.2643 0.7223
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0131 0.0431 0.1156
Echinococcus granulosus cathepsin l1 0.0641 0.2438 0.2438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0229 0.0815 0.2212
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0041 0.0076 0.0184
Brugia malayi Cathepsin L-like precursor 0.0693 0.2643 0.2637
Onchocerca volvulus 0.0693 0.2643 1
Giardia lamblia Cathepsin B precursor 0.0229 0.0815 0.2066
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0131 0.0431 0.0423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0229 0.0815 0.0807
Echinococcus granulosus cysteine protease 0.0281 0.102 0.102
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0494 0.186 0.186
Loa Loa (eye worm) prolyl oligopeptidase 0.0041 0.0076 0.0066
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0364 0.1349 0.1349
Loa Loa (eye worm) hypothetical protein 0.005 0.0109 0.01
Trypanosoma brucei histone deacetylase, putative 0.0043 0.0084 0.0207
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0078 0.0223 0.0214
Plasmodium falciparum serine repeat antigen 2 0.0229 0.0815 0.306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Echinococcus granulosus calpain A 0.0058 0.0144 0.0144
Trypanosoma cruzi cysteine protease, putative 0.0281 0.102 0.1012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0693 0.2643 0.7223
Entamoeba histolytica cysteine proteinase 1, putative 0.0281 0.102 0.3839
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0229 0.0815 0.0807
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0229 0.0815 0.306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0693 0.2643 0.7223
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0076 0.0252
Entamoeba histolytica cysteine proteinase, putative 0.0281 0.102 0.3839
Onchocerca volvulus Cell death protein 3 homolog 0.0061 0.0156 0.0405
Plasmodium vivax vivapain-3 0.0281 0.102 0.3837
Giardia lamblia Cathepsin L precursor 0.0229 0.0815 0.2066
Giardia lamblia Cathepsin B precursor 0.0949 0.3656 1
Loa Loa (eye worm) cathepsin B 0.0949 0.3656 0.365
Brugia malayi prolyl oligopeptidase family protein 0.0364 0.1349 0.1342
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0041 0.0076 0.0184
Brugia malayi cathepsin L precursor 0.0229 0.0815 0.0807
Onchocerca volvulus Cathepsin F homolog 0.0693 0.2643 1
Entamoeba histolytica cysteine protease, putative 0.0229 0.0815 0.3062
Echinococcus granulosus histone deacetylase 6 0.0043 0.0084 0.0084
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0134 0.0134
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0155 0.0145
Echinococcus multilocularis apoptotic protease activating factor 1 0.0061 0.0156 0.0156
Echinococcus granulosus apoptotic protease activating factor 1 0.0061 0.0156 0.0156
Echinococcus multilocularis acylamino acid releasing enzyme 0.0041 0.0076 0.0076
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0229 0.0815 0.0807
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0693 0.2643 1
Echinococcus granulosus caspase 2 0.0061 0.0156 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0229 0.0815 0.2212
Loa Loa (eye worm) prolyl oligopeptidase 0.0364 0.1349 0.1341
Giardia lamblia Cathepsin B precursor 0.0949 0.3656 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0229 0.0815 0.3062
Loa Loa (eye worm) hypothetical protein 0.0041 0.0077 0.0067
Entamoeba histolytica cysteine protease, putative 0.0229 0.0815 0.3062
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0229 0.0815 0.2212
Loa Loa (eye worm) hypothetical protein 0.0133 0.0439 0.043
Loa Loa (eye worm) hypothetical protein 0.0056 0.0134 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.102 0.2773
Brugia malayi Cathepsin L-like precursor 0.0693 0.2643 0.2637
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0076 0.0067
Trypanosoma cruzi Aph-1 protein, putative 0.0093 0.0281 0.0273
Brugia malayi hypothetical protein 0.0024 0.001 0.0001
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0693 0.2643 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0229 0.0815 0.2212
Onchocerca volvulus 0.0229 0.0815 0.2949
Echinococcus multilocularis calpain A 0.0058 0.0144 0.0144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0882 0.3389 0.9268
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0133 0.0439 0.0439
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.083 0.3184 0.3178
Loa Loa (eye worm) calpain family protein 1 0.0056 0.0134 0.0125
Loa Loa (eye worm) fibroinase 0.0693 0.2643 0.2636
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0949 0.3656 1
Onchocerca volvulus 0.0641 0.2438 0.921
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0009 0.0009
Brugia malayi RNA binding protein 0.0061 0.0155 0.0146
Echinococcus granulosus cathepsin b 0.2559 1 1
Leishmania major cathepsin L-like protease 0.0882 0.3389 0.9268
Schistosoma mansoni cathepsin C 0.0229 0.0815 0.0815
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Brugia malayi hypothetical protein 0.009 0.0269 0.026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0229 0.0815 0.2212
Leishmania major histone deacetylase, putative 0.0043 0.0084 0.0205
Echinococcus granulosus acylamino acid releasing enzyme 0.0041 0.0076 0.0076
Echinococcus multilocularis geminin 0.0494 0.186 0.186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0693 0.2643 0.7223
Giardia lamblia Cathepsin B precursor 0.0229 0.0815 0.2066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.009 0.009
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0131 0.0431 0.0431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0882 0.3389 0.9268
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.0118 0.011
Echinococcus granulosus cathepsin l cysteine peptidase 0.0693 0.2643 0.2643
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0882 0.3389 0.9268
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0693 0.2643 0.7223
Echinococcus multilocularis inhibitor of apoptosis protein 0.0133 0.0439 0.0439
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0118 0.011
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0131 0.0431 0.1158
Brugia malayi hypothetical protein 0.0061 0.0156 0.0147
Brugia malayi Cathepsin L-like cysteine proteinase 0.0641 0.2438 0.2432
Brugia malayi Cathepsin L-like precursor 0.0052 0.0118 0.011
Plasmodium falciparum serine repeat antigen 1 0.0229 0.0815 0.306
Entamoeba histolytica cysteine protease, putative 0.0281 0.102 0.3839
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0131 0.0431 0.1158

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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