Detailed information for compound 832466

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.437 | Formula: C19H18N4O2S
  • H donors: 1 H acceptors: 2 LogP: 3.11 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CNC(=O)Cn1ncn2c(c1=O)cc1c2cc(s1)C
  • InChi: 1S/C19H18N4O2S/c1-12-3-5-14(6-4-12)9-20-18(24)10-23-19(25)16-8-17-15(7-13(2)26-17)22(16)11-21-23/h3-8,11H,9-10H2,1-2H3,(H,20,24)
  • InChiKey: WBUCFSBTDFTCDZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0227 0.0702 0.0667
Leishmania major cathepsin L-like protease 0.0737 0.2553 0.7106
Loa Loa (eye worm) hypothetical protein 0.0043 0.0037 0.0037
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Echinococcus multilocularis histone deacetylase 0.0043 0.0037 0.0016
Leishmania major cathepsin L-like protease 0.0737 0.2553 0.7106
Echinococcus granulosus cathepsin l1 0.064 0.2203 0.2173
Onchocerca volvulus Cathepsin L homolog 0.064 0.2203 1
Onchocerca volvulus 0.064 0.2203 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2788 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0037 0.0037
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.064 0.2203 0.2203
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0037 0.0016
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0115 0.0299 0.0262
Schistosoma mansoni cathepsin S (C01 family) 0.0227 0.0702 0.0667
Onchocerca volvulus 0.064 0.2203 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Trypanosoma cruzi cysteine peptidase, putative 0.0737 0.2553 0.2525
Loa Loa (eye worm) hypothetical protein 0.0053 0.0073 0.0073
Loa Loa (eye worm) calpain family protein 1 0.0053 0.0073 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Trypanosoma cruzi cysteine proteinase, putative 0.0253 0.0798 0.0763
Brugia malayi calpain family protein 1 0.0053 0.0073 0.0036
Brugia malayi hypothetical protein 0.009 0.0208 0.0171
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Giardia lamblia Cathepsin B precursor 0.1019 0.3577 1
Plasmodium falciparum serine repeat antigen 4 0.0227 0.0702 0.3068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0056 0.0082 0.0044
Loa Loa (eye worm) cysteine protease 0.064 0.2203 0.2203
Loa Loa (eye worm) hypothetical protein 0.009 0.0208 0.0208
Plasmodium vivax unspecified product 0.0227 0.0702 0.3068
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0227 0.0702 0.0667
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2788 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0227 0.0702 0.0667
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2788 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0115 0.0299 0.0738
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0115 0.0299 0.0277
Loa Loa (eye worm) hypothetical protein 0.0227 0.0702 0.0702
Brugia malayi cathepsin Z-like cysteine proteinase 0.0227 0.0702 0.0667
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0115 0.0299 0.0738
Brugia malayi Cell death protein 3 precursor 0.009 0.0208 0.0171
Echinococcus granulosus cathepsin L 0.0227 0.0702 0.0667
Echinococcus granulosus inhibitor of apoptosis protein 0.0172 0.0503 0.0467
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0343 0.1126 0.1107
Plasmodium vivax unspecified product 0.0253 0.0798 0.3513
Echinococcus granulosus cathepsin l1 0.0613 0.2106 0.2077
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0227 0.0702 0.3068
Echinococcus multilocularis cathepsin b 0.2788 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0115 0.0299 0.0738
Brugia malayi prolyl oligopeptidase family protein 0.0115 0.0299 0.0262
Echinococcus granulosus Dipeptidyl peptidase 9 0.0115 0.0299 0.0262
Echinococcus granulosus cysteine protease 0.0253 0.0798 0.0763
Leishmania major cathepsin L-like protease 0.064 0.2203 0.6116
Brugia malayi fibroinase precursor 0.0227 0.0702 0.0667
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1019 0.3577 0.3553
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Plasmodium falciparum serine repeat antigen 8 0.0227 0.0702 0.3068
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0082 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0613 0.2106 0.4884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Loa Loa (eye worm) hypothetical protein 0.0227 0.0702 0.0702
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0115 0.0299 0.0262
Brugia malayi cathepsin L precursor 0.0227 0.0702 0.0667
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0227 0.0702 0.3068
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0227 0.0702 0.0667
Schistosoma mansoni cathepsin C 0.0227 0.0702 0.0667
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0227 0.0702 0.0667
Toxoplasma gondii cathepsin CPC1 0.0227 0.0702 0.1877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Echinococcus multilocularis inhibitor of apoptosis protein 0.0172 0.0503 0.0482
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0227 0.0702 0.3068
Loa Loa (eye worm) ctsf protein 0.064 0.2203 0.2203
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0227 0.0702 0.3068
Loa Loa (eye worm) hypothetical protein 0.0227 0.0702 0.0702
Echinococcus granulosus cathepsin L 0.0253 0.0798 0.0763
Loa Loa (eye worm) hypothetical protein 0.0047 0.0051 0.0051
Brugia malayi Cathepsin L-like precursor 0.064 0.2203 0.2173
Loa Loa (eye worm) hypothetical protein 0.0613 0.2106 0.2106
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0172 0.0503 0.0467
Echinococcus granulosus geminin 0.0165 0.048 0.0444
Entamoeba histolytica cysteine proteinase 1, putative 0.0253 0.0798 0.0641
Loa Loa (eye worm) hypothetical protein 0.0088 0.02 0.02
Onchocerca volvulus 0.064 0.2203 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.0798 0.0763
Loa Loa (eye worm) hypothetical protein 0.0039 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0613 0.2106 0.2106
Plasmodium falciparum cysteine proteinase falcipain 2b 0.064 0.2203 1
Echinococcus multilocularis caspase 2 0.009 0.0208 0.0187
Entamoeba histolytica cysteine proteinase, putative 0.0613 0.2106 0.9359
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.0798 0.0641
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Loa Loa (eye worm) hypothetical protein 0.0227 0.0702 0.0702
Leishmania major cysteine peptidase A (CPA) 0.064 0.2203 0.6116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Schistosoma mansoni hypothetical protein 0.0172 0.0503 0.0467
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0172 0.0503 0.0482
Plasmodium vivax vivapain-2 0.064 0.2203 1
Brugia malayi Papain family cysteine protease containing protein 0.0253 0.0798 0.0763
Echinococcus multilocularis geminin 0.0165 0.048 0.0459
Plasmodium falciparum serine repeat antigen 1 0.0227 0.0702 0.3068
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0227 0.0702 0.0667
Trypanosoma cruzi cysteine peptidase, putative 0.0737 0.2553 0.2525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Brugia malayi Cathepsin L-like precursor 0.0613 0.2106 0.2077
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0227 0.0702 0.3068
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.0798 0.0641
Loa Loa (eye worm) hypothetical protein 0.2788 1 1
Schistosoma mansoni caspase-7 (C14 family) 0.009 0.0208 0.0171
Brugia malayi Papain family cysteine protease containing protein 0.064 0.2203 0.2173
Echinococcus granulosus cathepsin L cysteine proteinase 0.064 0.2203 0.2173
Loa Loa (eye worm) hypothetical protein 0.0227 0.0702 0.0702
Toxoplasma gondii cathepsin CPC2 0.0227 0.0702 0.1877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Echinococcus multilocularis apoptotic protease activating factor 1 0.009 0.0208 0.0187
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.0798 0.0641
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.0798 0.0641
Plasmodium falciparum serine repeat antigen 6 0.0227 0.0702 0.3068
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2788 1 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1019 0.3577 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0227 0.0702 0.3068
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Onchocerca volvulus Cathepsin F homolog 0.064 0.2203 1
Schistosoma mansoni cathepsin F (C01 family) 0.0613 0.2106 0.2077
Brugia malayi cathepsin F-like cysteine proteinase 0.0227 0.0702 0.0667
Schistosoma mansoni hypothetical protein 0.0165 0.048 0.0444
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0172 0.0503 0.0467
Giardia lamblia Cathepsin B precursor 0.1019 0.3577 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.064 0.2203 0.2185
Entamoeba histolytica cysteine proteinase, putative 0.064 0.2203 1
Trypanosoma cruzi cysteine proteinase, putative 0.0253 0.0798 0.0763
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0227 0.0702 0.0667
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.0798 0.0334
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0082 0.0044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Echinococcus granulosus cathepsin l cysteine peptidase 0.064 0.2203 0.2173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.0798 0.0334
Toxoplasma gondii preprocathepsin c precursor, putative 0.0227 0.0702 0.1877
Leishmania major cathepsin L-like protease 0.064 0.2203 0.6116
Echinococcus granulosus cathepsin b 0.2788 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0227 0.0702 0.0667
Loa Loa (eye worm) cathepsin B 0.1019 0.3577 0.3577
Onchocerca volvulus Cell death protein 3 homolog 0.009 0.0208 0.0944
Brugia malayi Cathepsin L-like precursor 0.064 0.2203 0.2173
Loa Loa (eye worm) hypothetical protein 0.064 0.2203 0.2203
Loa Loa (eye worm) hypothetical protein 0.0613 0.2106 0.2106
Schistosoma mansoni hypothetical protein 0.009 0.0208 0.0171
Echinococcus multilocularis cysteine protease 0.064 0.2203 0.2185
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0227 0.0702 0.3068
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1019 0.3577 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0227 0.0702 0.0702
Trypanosoma brucei cysteine peptidase C (CPC) 0.1019 0.3577 1
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0037 0.0016
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0227 0.0702 0.0702
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Loa Loa (eye worm) hypothetical protein 0.0227 0.0702 0.0702
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0172 0.0503 0.0467
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.064 0.2203 0.5219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.0798 0.2148
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Echinococcus granulosus caspase 2 0.009 0.0208 0.0171
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Loa Loa (eye worm) prolyl oligopeptidase 0.0343 0.1126 0.1126
Brugia malayi prolyl oligopeptidase family protein 0.0343 0.1126 0.1093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Onchocerca volvulus Cathepsin L homolog 0.0227 0.0702 0.3186
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.0798 0.0763
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0227 0.0702 0.0667
Leishmania major cathepsin L-like protease 0.064 0.2203 0.6116
Brugia malayi Cathepsin L-like precursor 0.0613 0.2106 0.2077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Plasmodium falciparum serine repeat antigen 9 0.0227 0.0702 0.3068
Onchocerca volvulus 0.064 0.2203 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0115 0.0299 0.0262
Echinococcus multilocularis cathepsin L cysteine protease 0.064 0.2203 0.2185
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0053 0.0073 0.0036
Echinococcus granulosus calpain A 0.0056 0.0082 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0253 0.0798 0.0763
Brugia malayi hypothetical protein 0.0088 0.02 0.0163
Brugia malayi calpain family protein 1 0.0053 0.0073 0.0036
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Onchocerca volvulus 0.0613 0.2106 0.9563
Entamoeba histolytica cysteine protease, putative 0.064 0.2203 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Onchocerca volvulus 0.064 0.2203 1
Brugia malayi Papain family cysteine protease containing protein 0.0227 0.0702 0.0667
Loa Loa (eye worm) papain family cysteine protease containing protein 0.064 0.2203 0.2203
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0343 0.1126 0.5113
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0227 0.0702 0.3068
Echinococcus multilocularis cathepsin L 0.0253 0.0798 0.0778
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0172 0.0503 0.0467
Echinococcus multilocularis cathepsin b 0.2788 1 1
Leishmania major cathepsin L-like protease 0.0737 0.2553 0.7106
Trypanosoma cruzi cysteine protease, putative 0.0253 0.0798 0.0763
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.071 0.2457 0.2428
Plasmodium falciparum cysteine proteinase falcipain 3 0.064 0.2203 1
Giardia lamblia Cathepsin B precursor 0.1019 0.3577 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0613 0.2106 0.2077
Trypanosoma cruzi cysteine peptidase, putative 0.0737 0.2553 0.2525
Plasmodium vivax serine-repeat antigen (SERA) 0.0227 0.0702 0.3068
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0227 0.0702 0.3068
Echinococcus multilocularis cysteine protease 0.064 0.2203 0.2185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Echinococcus granulosus cathepsin L cysteine protease 0.0253 0.0798 0.0763
Plasmodium falciparum serine repeat antigen 2 0.0227 0.0702 0.3068
Brugia malayi cathepsin Z-like cysteine proteinase 0.0227 0.0702 0.0667
Trypanosoma cruzi major cysteine proteinase, putative 0.0227 0.0702 0.0667
Trypanosoma cruzi major cysteine proteinase, putative 0.0323 0.1052 0.1019
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1019 0.3577 0.3553
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0227 0.0702 0.3068
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0227 0.0702 0.3068
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.064 0.2203 0.5219
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0613 0.2106 0.4884
Onchocerca volvulus 0.0227 0.0702 0.3186
Onchocerca volvulus 0.064 0.2203 1
Toxoplasma gondii cathepsin CPL 0.064 0.2203 0.6116
Loa Loa (eye worm) hypothetical protein 0.009 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0172 0.0503 0.0503
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Onchocerca volvulus Cathepsin L homolog 0.064 0.2203 1
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0115 0.0299 0.0738
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.0798 0.0763
Schistosoma mansoni cathepsin F (C01 family) 0.064 0.2203 0.2173
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0227 0.0702 0.0667
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0343 0.1126 0.1093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Toxoplasma gondii cathepsin B 0.1019 0.3577 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Plasmodium vivax vivapain-3 0.0253 0.0798 0.3513
Plasmodium vivax vivapain-2 0.064 0.2203 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0227 0.0702 0.3068
Plasmodium falciparum serine repeat antigen 3 0.0227 0.0702 0.3068
Plasmodium falciparum cysteine proteinase falcipain 1 0.0253 0.0798 0.3513
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Loa Loa (eye worm) histone deacetylase 0.0043 0.0037 0.0037
Brugia malayi Cathepsin L-like precursor 0.064 0.2203 0.2173
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Onchocerca volvulus Deterin homolog 0.0172 0.0503 0.2283
Schistosoma mansoni cathepsin F (C01 family) 0.064 0.2203 0.2173
Plasmodium falciparum cysteine proteinase falcipain 2a 0.064 0.2203 1
Brugia malayi Cathepsin L-like precursor 0.064 0.2203 0.2173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.0798 0.2148
Leishmania major cathepsin L-like protease 0.064 0.2203 0.6116
Onchocerca volvulus 0.064 0.2203 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0253 0.0798 0.0763
Loa Loa (eye worm) fibroinase 0.064 0.2203 0.2203
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0056 0.0082 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.064 0.2203 0.5219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Brugia malayi Cathepsin L-like precursor 0.064 0.2203 0.2173
Entamoeba histolytica cysteine proteinase 2 0.0253 0.0798 0.0641
Schistosoma mansoni cathepsin B (C01 family) 0.0227 0.0702 0.0667
Echinococcus granulosus cathepsin b 0.2788 1 1
Plasmodium vivax vivapain-1 0.0253 0.0798 0.3513
Onchocerca volvulus 0.0172 0.0503 0.2283
Schistosoma mansoni inhibitor of apoptosis protein 0.0172 0.0503 0.0467
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0037 0.0016
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0343 0.1126 0.1093
Plasmodium falciparum serine repeat antigen 5 0.0227 0.0702 0.3068
Leishmania major cathepsin L-like protease 0.064 0.2203 0.6116
Brugia malayi cathepsin L-like precursor 0.0613 0.2106 0.2077
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0227 0.0702 0.0667
Echinococcus granulosus apoptotic protease activating factor 1 0.009 0.0208 0.0171
Echinococcus multilocularis calpain A 0.0056 0.0082 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Loa Loa (eye worm) hypothetical protein 0.0172 0.0503 0.0503
Trypanosoma cruzi cysteine peptidase, putative 0.064 0.2203 0.2173
Brugia malayi cathepsin L-like cysteine proteinase 0.0227 0.0702 0.0667
Echinococcus multilocularis histone deacetylase 7 0.0043 0.0037 0.0016
Loa Loa (eye worm) histone deacetylase 7A 0.0043 0.0037 0.0037
Echinococcus multilocularis cathepsin l cysteine peptidase 0.064 0.2203 0.2185
Entamoeba histolytica cysteine protease, putative 0.0253 0.0798 0.0641
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.064 0.2203 0.5219
Trypanosoma cruzi cruzipain precursor, putative 0.0737 0.2553 0.2525
Echinococcus multilocularis cathepsin L cysteine protease 0.064 0.2203 0.2185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0737 0.2553 0.7106
Echinococcus multilocularis cathepsin L 0.0227 0.0702 0.0681
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0227 0.0702 0.3068
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0227 0.0702 0.0702
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0227 0.0702 0.0667
Entamoeba histolytica cysteine proteinase, putative 0.064 0.2203 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2788 1 1
Onchocerca volvulus 0.009 0.0208 0.0944
Schistosoma mansoni hypothetical protein 0.0165 0.048 0.0444
Brugia malayi Papain family cysteine protease containing protein 0.0253 0.0798 0.0763
Plasmodium falciparum serine repeat antigen 7 0.0227 0.0702 0.3068
Brugia malayi Cathepsin L-like precursor 0.064 0.2203 0.2173
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0227 0.0702 0.3068
Loa Loa (eye worm) calpain family protein 1 0.0039 0.0022 0.0022

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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