TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 410.489 | Formula: C21H22N4O3S
H donors: 1 H acceptors: 2 LogP: 3.61 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCOc1ccc(cc1)CNC(=O)Cn1ncn2c(c1=O)cc1c2cc(s1)C
InChi: 1S/C21H22N4O3S/c1-3-8-28-16-6-4-15(5-7-16)11-22-20(26)12-25-21(27)18-10-19-17(9-14(2)29-19)24(18)13-23-25/h4-7,9-10,13H,3,8,11-12H2,1-2H3,(H,22,26)
InChiKey: LASHKRQKKBKBIZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin S (C01 family)	0.0131	0.0719	0.0682
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Echinococcus granulosus	cathepsin L cysteine protease	0.0146	0.0821	0.077
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0131	0.0719	0.2439
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0383	0.2455	0.2477
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0131	0.0719	0.0719
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0383	0.2455	0.2448
Echinococcus multilocularis	cathepsin L	0.0131	0.0719	0.0702
Echinococcus granulosus	integrin beta 2	0.1083	0.7272	0.7395
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0131	0.0719	0.1876
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1451	0.9809	1
Schistosoma mansoni	hypothetical protein	0.0174	0.1012	0.0982
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0131	0.0719	0.2439
Plasmodium vivax	unspecified product	0.0131	0.0719	0.2722
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0155	0.0886	0.0838
Schistosoma mansoni	cathepsin F (C01 family)	0.0368	0.2353	0.2357
Loa Loa (eye worm)	hypothetical protein	0.0043	0.011	0.011
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0131	0.0719	0.2722
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0539	0.3531	0.3564
Onchocerca volvulus		0.0383	0.2455	1
Echinococcus granulosus	cathepsin L	0.0146	0.0821	0.077
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0236	0.1439	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.0449	0.0413
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0383	0.2455	0.2455
Brugia malayi	cathepsin L-like cysteine proteinase	0.0131	0.0719	0.0684
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.016	0.0258
Onchocerca volvulus		0.0383	0.2455	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1451	0.9809	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0131	0.0719	0.2722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0368	0.2353	0.6598
Brugia malayi	Matrixin family protein	0.0103	0.0528	0.0492
Plasmodium falciparum	serine repeat antigen 9	0.0131	0.0719	0.2439
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0131	0.0719	0.1876
Loa Loa (eye worm)	hypothetical protein	0.1451	0.9809	0.9809
Brugia malayi	Papain family cysteine protease containing protein	0.0383	0.2455	0.2426
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Schistosoma mansoni	hypothetical protein	0.0174	0.1012	0.0982
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0383	0.2455	0.2477
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0146	0.0821	0.2168
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0131	0.0719	0.2722
Trypanosoma cruzi	cysteine proteinase, putative	0.0146	0.0821	0.077
Onchocerca volvulus		0.0383	0.2455	1
Mycobacterium leprae	PROBABLE HYDROLASE	0.0052	0.0175	1
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2455	0.2426
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0449	0.0425
Brugia malayi	Kelch motif family protein	0.0232	0.1415	0.1382
Entamoeba histolytica	cysteine proteinase, putative	0.0146	0.0821	0.0583
Echinococcus multilocularis	cysteine protease	0.0383	0.2455	0.2477
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0131	0.0719	0.2722
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0045	0.0125	0.0073
Plasmodium falciparum	serine repeat antigen 7	0.0131	0.0719	0.2439
Schistosoma mansoni	cathepsin B (C01 family)	0.0131	0.0719	0.0682
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Loa Loa (eye worm)	hypothetical protein	0.0368	0.2353	0.2353
Echinococcus granulosus	calpain A	0.0045	0.0125	0.0056
Onchocerca volvulus		0.005	0.0161	0.0655
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0146	0.0821	0.288
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2455	0.2426
Loa Loa (eye worm)	hypothetical protein	0.0037	0.007	0.007
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0045	0.0125	0.0093
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2455	0.2448
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0131	0.0719	0.0682
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0131	0.0719	0.0682
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0146	0.0821	0.2168
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.0719	0.1876
Brugia malayi	beta-lactamase family protein	0.0037	0.007	0.0032
Loa Loa (eye worm)	calpain family protein 1	0.0043	0.0111	0.0111
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0383	0.2455	0.6891
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0131	0.0719	0.1876
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.0719	0.1876
Onchocerca volvulus	Matrilysin homolog	0.0095	0.0469	0.191
Brugia malayi	cathepsin B-like cysteine proteinase	0.1451	0.9809	0.9809
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0368	0.2353	0.6598
Entamoeba histolytica	cysteine proteinase 2	0.0146	0.0821	0.0583
Brugia malayi	beta-lactamase family protein	0.0037	0.007	0.0032
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.0719	0.1876
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0131	0.0719	0.0682
Loa Loa (eye worm)	matrixin family protein	0.0103	0.0528	0.0528
Brugia malayi	Papain family cysteine protease containing protein	0.0146	0.0821	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0719	0.0719
Plasmodium vivax	vivapain-1	0.0146	0.0821	0.3147
Plasmodium falciparum	serine repeat antigen 5	0.0131	0.0719	0.2439
Loa Loa (eye worm)	hypothetical protein	0.0368	0.2353	0.2353
Plasmodium vivax	serine-repeat antigen (SERA)	0.0131	0.0719	0.2722
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.016	0.0092
Brugia malayi	Matrixin family protein	0.0043	0.011	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0037	0.007	0.007
Schistosoma mansoni	cathepsin C	0.0131	0.0719	0.0682
Onchocerca volvulus	Cathepsin L homolog	0.0383	0.2455	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0146	0.0821	0.077
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0131	0.0719	0.0682
Brugia malayi	Papain family cysteine protease containing protein	0.0131	0.0719	0.0684
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0131	0.0719	0.0682
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0368	0.2353	0.2324
Onchocerca volvulus		0.0383	0.2455	1
Loa Loa (eye worm)	integrin beta-2	0.1479	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0131	0.0719	0.1876
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0449	0.0389
Entamoeba histolytica	cysteine proteinase, putative	0.0146	0.0821	0.0583
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0043	0.011	0.0058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0146	0.0821	0.2168
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0232	0.1415	0.1415
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0033	0.0033
Echinococcus multilocularis	cathepsin L cysteine protease	0.0383	0.2455	0.2477
Schistosoma mansoni	integrin beta subunit	0.0851	0.5674	0.5761
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0146	0.0821	0.077
Onchocerca volvulus		0.0043	0.011	0.045
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0131	0.0719	0.0682
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0131	0.0719	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0719	0.0719
Leishmania major	cysteine peptidase A (CPA)	0.0383	0.2455	0.6891
Onchocerca volvulus	Cathepsin L homolog	0.0383	0.2455	1
Brugia malayi	beta-lactamase	0.0037	0.007	0.0032
Brugia malayi	Papain family cysteine protease containing protein	0.0131	0.0719	0.0684
Plasmodium vivax	vivapain-2	0.0383	0.2455	1
Brugia malayi	Matrixin family protein	0.0043	0.011	0.0073
Trypanosoma cruzi	major cysteine proteinase, putative	0.0131	0.0719	0.0666
Plasmodium vivax	serine-repeat antigen (SERA)	0.0131	0.0719	0.2722
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0131	0.0719	0.0684
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.0719	0.1876
Loa Loa (eye worm)	hypothetical protein	0.005	0.0164	0.0164
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0539	0.3531	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0131	0.0719	0.0684
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Echinococcus granulosus	geminin	0.0174	0.1012	0.0967
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.016	0.0092
Leishmania major	hypothetical protein, conserved	0.005	0.016	0.0258
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0383	0.2455	0.6891
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.007	0.0017
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0045	0.0125	0.0073
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1451	0.9809	1
Onchocerca volvulus	Cathepsin F homolog	0.0383	0.2455	1
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2455	0.2426
Trypanosoma cruzi	major cysteine proteinase, putative	0.0131	0.0719	0.0666
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Brugia malayi	Papain family cysteine protease containing protein	0.0131	0.0719	0.0684
Toxoplasma gondii	cathepsin B	0.0539	0.3531	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0175	0.0175
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Schistosoma mansoni	cathepsin F (C01 family)	0.0383	0.2455	0.2461
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0052	0.0175	0.0762
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0449	0.0405
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.0659	0.0659
Schistosoma mansoni	hypothetical protein	0.0061	0.0233	0.0184
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0449	0.0389
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.007	0.007
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Echinococcus multilocularis	cathepsin b	0.1451	0.9809	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.007	0.0032
Toxoplasma gondii	cathepsin CPC1	0.0131	0.0719	0.1876
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0131	0.0719	0.2722
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1451	0.9809	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.007	0.007
Onchocerca volvulus	Cathepsin L homolog	0.0131	0.0719	0.293
Brugia malayi	MH2 domain containing protein	0.0122	0.0659	0.0623
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0131	0.0719	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0037	0.007	0.007
Entamoeba histolytica	cysteine protease, putative	0.0383	0.2455	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0164	0.0126
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0054	0.0016
Plasmodium falciparum	serine repeat antigen 2	0.0131	0.0719	0.2439
Echinococcus multilocularis	cathepsin b	0.1451	0.9809	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0131	0.0719	0.1876
Toxoplasma gondii	cathepsin CPC2	0.0131	0.0719	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0043	0.011	0.011
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0131	0.0719	0.0682
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1451	0.9809	1
Brugia malayi	fibroinase precursor	0.0131	0.0719	0.0684
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0146	0.0821	0.2168
Trypanosoma cruzi	cruzipain precursor, putative	0.0383	0.2455	0.2448
Loa Loa (eye worm)	beta-lactamase	0.0037	0.007	0.007
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0131	0.0719	0.2722
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0368	0.2353	0.2344
Brugia malayi	cathepsin L-like precursor	0.0368	0.2353	0.2324
Brugia malayi	cathepsin F-like cysteine proteinase	0.0131	0.0719	0.0684
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.016	0.0375
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0161	0.011
Brugia malayi	cathepsin L precursor	0.0131	0.0719	0.0684
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0131	0.0719	0.1876
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0164	0.0164
Mycobacterium ulcerans	hydrolase	0.0052	0.0175	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0383	0.2455	0.2477
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0449	0.0405
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0095	0.0469	0.191
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0054	0.0054
Onchocerca volvulus		0.0037	0.007	0.0286
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2455	0.2426
Onchocerca volvulus		0.0037	0.007	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0539	0.3531	1
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2455	0.2426
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0146	0.0821	0.0786
Giardia lamblia	Cathepsin B precursor	0.0539	0.3531	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0383	0.2455	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0383	0.2455	0.2448
Plasmodium falciparum	serine repeat antigen 1	0.0131	0.0719	0.2439
Echinococcus granulosus	cathepsin L	0.0131	0.0719	0.0666
Echinococcus granulosus	cathepsin b	0.1451	0.9809	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0131	0.0719	0.2722
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0131	0.0719	0.2722
Plasmodium vivax	unspecified product	0.0146	0.0821	0.3147
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0131	0.0719	0.1876
Loa Loa (eye worm)	hypothetical protein	0.005	0.0161	0.0161
Brugia malayi	hypothetical protein	0.005	0.016	0.0122
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0131	0.0719	0.0682
Echinococcus multilocularis	cathepsin L	0.0146	0.0821	0.0805
Plasmodium vivax	vivapain-2	0.0383	0.2455	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.0659	0.0659
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0146	0.0821	0.0786
Entamoeba histolytica	cysteine proteinase, putative	0.0368	0.2353	0.9417
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2455	0.2448
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Plasmodium falciparum	serine repeat antigen 8	0.0131	0.0719	0.2439
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0131	0.0719	0.2722
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Loa Loa (eye worm)	hypothetical protein	0.0037	0.007	0.007
Brugia malayi	Cathepsin L-like precursor	0.0368	0.2353	0.2324
Onchocerca volvulus	Matrilysin homolog	0.0043	0.011	0.045
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0131	0.0719	0.0684
Loa Loa (eye worm)	hypothetical protein	0.005	0.016	0.016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.0719	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0037	0.007	0.007
Brugia malayi	hypothetical protein	0.0232	0.1415	0.1382
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0539	0.3531	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0131	0.0719	0.1876
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Trypanosoma cruzi	cysteine proteinase, putative	0.0146	0.0821	0.077
Echinococcus granulosus	cathepsin l1	0.0383	0.2455	0.2448
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0164	0.0126
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.016	0.0258
Loa Loa (eye worm)	cysteine protease	0.0383	0.2455	0.2455
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Plasmodium falciparum	serine repeat antigen 3	0.0131	0.0719	0.2439
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0383	0.2455	1
Trypanosoma cruzi	cysteine protease, putative	0.0146	0.0821	0.077
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2455	0.2426
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0449	0.0405
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2455	0.2448
Toxoplasma gondii	cathepsin CPL	0.0383	0.2455	0.6891
Entamoeba histolytica	cysteine proteinase, putative	0.0146	0.0821	0.0583
Entamoeba histolytica	cysteine proteinase, putative	0.0383	0.2455	1
Brugia malayi	Matrixin family protein	0.0043	0.011	0.0073
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0045	0.0125	0.0056
Echinococcus multilocularis	cysteine protease	0.0383	0.2455	0.2477
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2455	0.6891
Loa Loa (eye worm)	fibroinase	0.0383	0.2455	0.2455
Loa Loa (eye worm)	matrix metalloproteinase	0.0043	0.011	0.011
Brugia malayi	Hemopexin family protein	0.0061	0.0233	0.0196
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0131	0.0719	0.0682
Entamoeba histolytica	cysteine proteinase, putative	0.0383	0.2455	1
Echinococcus granulosus	cathepsin l1	0.0368	0.2353	0.2344
Onchocerca volvulus		0.0383	0.2455	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0719	0.0719
Loa Loa (eye worm)	ctsf protein	0.0383	0.2455	0.2455
Echinococcus granulosus	cathepsin b	0.1451	0.9809	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0146	0.0821	0.0583
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.007	0.0038
Plasmodium falciparum	serine repeat antigen 4	0.0131	0.0719	0.2439
Echinococcus multilocularis	calpain A	0.0045	0.0125	0.0093
Giardia lamblia	Cathepsin B precursor	0.0539	0.3531	1
Trichomonas vaginalis	conserved hypothetical protein	0.0131	0.0719	0.1876
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Loa Loa (eye worm)	hypothetical protein	0.0368	0.2353	0.2353
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0383	0.2455	1
Echinococcus multilocularis	integrin beta 2	0.1083	0.7272	0.7405
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Onchocerca volvulus		0.0037	0.007	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0131	0.0719	0.1876
Onchocerca volvulus		0.0383	0.2455	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.011	0.011
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0131	0.0719	0.0719
Plasmodium vivax	vivapain-3	0.0146	0.0821	0.3147
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0719	0.0719
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2455	0.2448
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0131	0.0719	0.1876
Onchocerca volvulus		0.0131	0.0719	0.293
Loa Loa (eye worm)	cathepsin B	0.0539	0.3531	0.3531
Echinococcus multilocularis	tumor protein p63	0.0342	0.2171	0.2187
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0131	0.0719	0.1876
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1415	0.1415
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0052	0.0175	0.0137
Giardia lamblia	Cathepsin B precursor	0.0539	0.3531	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0131	0.0719	0.2722
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0539	0.3531	0.3553
Brugia malayi	Papain family cysteine protease containing protein	0.0146	0.0821	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0719	0.0719
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0383	0.2455	0.2455
Echinococcus granulosus	cysteine protease	0.0146	0.0821	0.077
Plasmodium falciparum	serine repeat antigen 6	0.0131	0.0719	0.2439
Loa Loa (eye worm)	calpain family protein 1	0.0032	0.0033	0.0033
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0155	0.0886	0.0872
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.007	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0383	0.2455	0.2455
Echinococcus multilocularis	geminin	0.0174	0.1012	0.1001
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0146	0.0821	0.0786
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Loa Loa (eye worm)	matrixin family protein	0.0095	0.0469	0.0469
Entamoeba histolytica	cysteine proteinase, putative	0.0146	0.0821	0.0583
Brugia malayi	Matrixin family protein	0.0043	0.011	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0719	0.0719
Echinococcus granulosus	tumor protein p63	0.0342	0.2171	0.2157
Onchocerca volvulus		0.0368	0.2353	0.9588
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0131	0.0719	0.0719
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Onchocerca volvulus		0.0383	0.2455	1
Brugia malayi	Cathepsin L-like precursor	0.0368	0.2353	0.2324
Trichomonas vaginalis	conserved hypothetical protein	0.0131	0.0719	0.1876
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2455	0.6891
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2455	0.6891
Schistosoma mansoni	cathepsin F (C01 family)	0.0383	0.2455	0.2461
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0131	0.0719	0.2439
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0111	0.0111
Brugia malayi	calpain family protein 1	0.0043	0.0111	0.0074
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0449	0.0425
Leishmania major	cathepsin L-like protease	0.0383	0.2455	0.6891
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.0449	0.0449
Entamoeba histolytica	cysteine protease, putative	0.0146	0.0821	0.0583
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0043	0.0111	0.0059
Onchocerca volvulus		0.0061	0.0233	0.0951
Brugia malayi	calpain family protein 1	0.0043	0.0111	0.0074

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 832468