Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0146 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0134 | 0.9115 | 0.9115 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0054 | 0.3258 | 0.3258 |
Echinococcus multilocularis | cathepsin b | 0.0134 | 0.9115 | 0.9115 |
Echinococcus granulosus | carbonic anhydrase II | 0.0146 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0134 | 0.9115 | 0.8817 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.3258 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3258 | 0.3258 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0054 | 0.3258 | 0.3258 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0146 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0054 | 0.3258 | 0.3258 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0054 | 0.3258 | 0.3258 |
Echinococcus granulosus | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Leishmania major | carbonic anhydrase-like protein | 0.0146 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0134 | 0.9115 | 0.9115 |
Echinococcus granulosus | cathepsin b | 0.0134 | 0.9115 | 0.9115 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.2523 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0134 | 0.9115 | 0.9115 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0054 | 0.3258 | 0.3258 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0044 | 0.2523 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0146 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0054 | 0.3258 | 0.5 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0134 | 0.9115 | 0.9115 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0146 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.2523 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0134 | 0.9115 | 0.9115 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0134 | 0.9115 | 0.9115 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0146 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3258 | 0.3258 |
Echinococcus granulosus | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0146 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0146 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0044 | 0.2523 | 0.2523 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0146 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.3258 | 0.3258 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.9115 | 0.9115 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0134 | 0.9115 | 0.9115 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.3258 | 0.3258 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.2523 | 0.5 |
Loa Loa (eye worm) | cathepsin B | 0.0044 | 0.2523 | 0.2523 |
Schistosoma mansoni | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.3258 | 0.3258 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0054 | 0.3258 | 0.3258 |
Echinococcus multilocularis | carbonic anhydrase | 0.0054 | 0.3258 | 0.3258 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.3258 | 0.3258 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5012 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.