TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 338.384 | Formula: C17H14N4O2S
H donors: 0 H acceptors: 2 LogP: 4.48 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1n1nnc2c(c1=O)sc1c2c(C)cc(n1)C
InChi: 1S/C17H14N4O2S/c1-9-8-10(2)18-16-13(9)14-15(24-16)17(22)21(20-19-14)11-6-4-5-7-12(11)23-3/h4-8H,1-3H3
InChiKey: NTDROUGEDGYOKP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine protease, putative	0.0143	0.0787	0.0787
Plasmodium vivax	serine-repeat antigen (SERA)	0.0136	0.074	0.3184
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0383	0.2325	0.2325
Brugia malayi	Kelch motif family protein	0.0172	0.0972	0.0972
Onchocerca volvulus		0.007	0.0316	0.1292
Schistosoma mansoni	importin beta-1	0.0028	0.0047	0.0047
Leishmania major	hypothetical protein, conserved	0.007	0.0316	0.0877
Schistosoma mansoni	caspase-7 (C14 family)	0.0058	0.0239	0.0239
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0214	0.1244	0.1244
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0383	0.2325	0.2325
Toxoplasma gondii	cathepsin CPC1	0.0136	0.074	0.2054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Brugia malayi	calpain family protein 1	0.0042	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0183	0.0183
Brugia malayi	Matrixin family protein	0.0059	0.0247	0.0247
Mycobacterium tuberculosis	Conserved protein	0.007	0.0316	0.11
Trichomonas vaginalis	esterase, putative	0.007	0.0316	0.0877
Giardia lamblia	Encystation-specific protease	0.0136	0.074	0.2054
Loa Loa (eye worm)	cathepsin B	0.0582	0.3604	0.3604
Giardia lamblia	Cathepsin B precursor	0.0582	0.3604	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0297	0.1777	0.1777
Echinococcus granulosus	cathepsin L	0.0136	0.074	0.074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0143	0.0787	0.2183
Leishmania major	cathepsin L-like protease	0.0383	0.2325	0.6451
Onchocerca volvulus		0.0136	0.074	0.3131
Brugia malayi	beta-lactamase	0.007	0.0316	0.0316
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0136	0.074	0.074
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0383	0.2325	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2325	0.6451
Brugia malayi	hypothetical protein	0.0025	0.0027	0.0027
Mycobacterium ulcerans	lipase LipD	0.007	0.0316	0.9576
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0136	0.074	0.3184
Onchocerca volvulus	Cathepsin L homolog	0.0383	0.2325	1
Onchocerca volvulus	Cathepsin L homolog	0.0136	0.074	0.3131
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0072	0.0329	0.0329
Entamoeba histolytica	cysteine proteinase 1, putative	0.0143	0.0787	0.3384
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0136	0.074	0.074
Brugia malayi	Cell death protein 3 precursor	0.0058	0.0239	0.0239
Brugia malayi	Hemopexin family protein	0.0084	0.0405	0.0405
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0027	0.0076
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Loa Loa (eye worm)	hypothetical protein	0.007	0.0316	0.0316
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0136	0.074	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0376	0.2279	0.2279
Echinococcus granulosus	calpain A	0.0044	0.0153	0.0153
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0018	0.0018
Echinococcus granulosus	cathepsin l1	0.0376	0.2279	0.2279
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2325	0.6451
Trypanosoma cruzi	cysteine peptidase, putative	0.0143	0.0787	0.0787
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.0787	0.3384
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.004	0.0125	0.0125
Echinococcus multilocularis	cathepsin L cysteine protease	0.0383	0.2325	0.2325
Loa Loa (eye worm)	hypothetical protein	0.0136	0.074	0.074
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0013	0.0037
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2325	0.6451
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0376	0.2279	0.2279
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0027	0.0117
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0018	0.0018
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0143	0.0787	0.3384
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1579	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.0316	0.0877
Mycobacterium tuberculosis	Conserved protein	0.007	0.0316	0.11
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Entamoeba histolytica	cysteine protease, putative	0.0136	0.074	0.3184
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.0316	0.0877
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2325	0.6451
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0183	0.0183
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0612	0.0612
Brugia malayi	beta-lactamase family protein	0.007	0.0316	0.0316
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0153	0.0153
Entamoeba histolytica	cysteine proteinase, putative	0.0383	0.2325	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2325	0.6451
Loa Loa (eye worm)	beta-lactamase	0.007	0.0316	0.0316
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Plasmodium vivax	unspecified product	0.0136	0.074	0.3184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0136	0.074	0.2054
Onchocerca volvulus		0.0376	0.2279	0.9799
Echinococcus granulosus	cathepsin l1	0.0383	0.2325	0.2325
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0153	0.0153
Leishmania major	cysteine peptidase A (CPA)	0.0383	0.2325	0.6451
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0153	0.0153
Loa Loa (eye worm)	hypothetical protein	0.007	0.0316	0.0316
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0136	0.074	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0329	0.0329
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0018	0.0018
Onchocerca volvulus	Cathepsin L homolog	0.0383	0.2325	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0143	0.0787	0.0787
Echinococcus multilocularis	cathepsin L	0.0136	0.074	0.074
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0018	0.0049
Giardia lamblia	Cathepsin L precursor	0.0136	0.074	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0247	0.0247
Echinococcus granulosus	tumor protein p63	0.0332	0.1997	0.1997
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0582	0.3604	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0136	0.074	0.074
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0612	0.0612
Giardia lamblia	Cathepsin B precursor	0.0582	0.3604	1
Loa Loa (eye worm)	hypothetical protein	0.0136	0.074	0.074
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0247	0.0247
Echinococcus granulosus	cysteine protease	0.0143	0.0787	0.0787
Echinococcus granulosus	integrin beta 2	0.0802	0.5014	0.5014
Loa Loa (eye worm)	cysteine protease	0.0383	0.2325	0.2325
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2325	0.6451
Loa Loa (eye worm)	hypothetical protein	0.0049	0.018	0.018
Schistosoma mansoni	cathepsin F (C01 family)	0.0376	0.2279	0.2279
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.0316	0.0316
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0383	0.2325	0.6451
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0013	0.0037
Giardia lamblia	Hypothetical protein	0.0136	0.074	0.2054
Leishmania major	cathepsin L-like protease	0.0383	0.2325	0.6451
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0376	0.2279	0.2279
Brugia malayi	RNA, U transporter 1	0.0079	0.0377	0.0377
Plasmodium vivax	vivapain-2	0.0383	0.2325	1
Plasmodium vivax	unspecified product	0.0143	0.0787	0.3384
Leishmania major	cathepsin L-like protease	0.0383	0.2325	0.6451
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0027	0.0117
Onchocerca volvulus	Matrilysin homolog	0.0131	0.0707	0.2989
Giardia lamblia	Cathepsin L precursor	0.0136	0.074	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0083	0.0083
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0136	0.074	0.2054
Brugia malayi	Matrixin family protein	0.0059	0.0247	0.0247
Mycobacterium tuberculosis	Probable hydrolase	0.007	0.0316	0.11
Schistosoma mansoni	hypothetical protein	0.0297	0.1777	0.1777
Toxoplasma gondii	cathepsin B	0.0582	0.3604	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2325	0.6451
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0136	0.074	0.2054
Echinococcus granulosus	cathepsin L	0.0143	0.0787	0.0787
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2325	0.6451
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0136	0.074	0.074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.2279	0.6322
Brugia malayi	Papain family cysteine protease containing protein	0.0143	0.0787	0.0787
Leishmania major	cathepsin L-like protease	0.0383	0.2325	0.6451
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2325	0.6451
Onchocerca volvulus	Cathepsin F homolog	0.0383	0.2325	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0136	0.074	0.3184
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0047	0.0047
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2325	0.6451
Loa Loa (eye worm)	hypothetical protein	0.007	0.0316	0.0316
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0136	0.074	0.2054
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0383	0.2325	1
Onchocerca volvulus	Matrilysin homolog	0.0059	0.0247	0.0992
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0136	0.074	0.3184
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0383	0.2325	0.2325
Leishmania major	cathepsin L-like protease	0.0383	0.2325	0.6451
Echinococcus multilocularis	caspase 2	0.0058	0.0239	0.0239
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2325	0.2325
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0047	0.0203
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Entamoeba histolytica	cysteine protease, putative	0.0136	0.074	0.3184
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2325	0.2325
Plasmodium falciparum	importin beta, putative	0.0028	0.0047	0.0203
Leishmania major	hypothetical protein, conserved	0.0025	0.0027	0.0076
Onchocerca volvulus		0.0383	0.2325	1
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2325	0.2325
Entamoeba histolytica	cysteine protease, putative	0.0136	0.074	0.3184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2325	0.6451
Giardia lamblia	Cathepsin L-like protease	0.0136	0.074	0.2054
Schistosoma mansoni	hypothetical protein	0.0165	0.0924	0.0924
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2325	0.2325
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.0316	0.0877
Brugia malayi	Matrixin family protein	0.0143	0.0783	0.0783
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2325	0.6451
Giardia lamblia	Cysteine protease	0.0136	0.074	0.2054
Leishmania major	cathepsin L-like protease	0.0383	0.2325	0.6451
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0136	0.074	0.3184
Plasmodium falciparum	serine repeat antigen 9	0.0136	0.074	0.3184
Entamoeba histolytica	cysteine protease, putative	0.0136	0.074	0.3184
Brugia malayi	cathepsin F-like cysteine proteinase	0.0136	0.074	0.074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Plasmodium falciparum	serine repeat antigen 2	0.0136	0.074	0.3184
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.007	0.0316	0.11
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.007	0.0316	0.11
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0143	0.0787	0.0787
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2325	0.6451
Loa Loa (eye worm)	hypothetical protein	0.004	0.0128	0.0128
Giardia lamblia	Cathepsin B precursor	0.0136	0.074	0.2054
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0136	0.074	0.2054
Loa Loa (eye worm)	hypothetical protein	0.007	0.0316	0.0316
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0136	0.074	0.2054
Entamoeba histolytica	hypothetical protein	0.0023	0.0013	0.0058
Loa Loa (eye worm)	hypothetical protein	0.1579	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0027	0.0027
Brugia malayi	Matrixin family protein	0.0059	0.0247	0.0247
Echinococcus granulosus	cathepsin L cysteine protease	0.0143	0.0787	0.0787
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.0316	0.0316
Loa Loa (eye worm)	ctsf protein	0.0383	0.2325	0.2325
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0013	0.0013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0376	0.2279	0.6322
Mycobacterium tuberculosis	Probable lipase LipD	0.007	0.0316	0.11
Trichomonas vaginalis	conserved hypothetical protein	0.0136	0.074	0.2054
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0153	0.0153
Onchocerca volvulus		0.0059	0.0247	0.0992
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.007	0.0316	0.9576
Plasmodium falciparum	serine repeat antigen 5	0.0136	0.074	0.3184
Loa Loa (eye worm)	hypothetical protein	0.0376	0.2279	0.2279
Giardia lamblia	Cathepsin L precursor	0.0136	0.074	0.2054
Mycobacterium ulcerans	beta-lactamase	0.007	0.0316	0.9576
Entamoeba histolytica	cysteine protease, putative	0.0136	0.074	0.3184
Toxoplasma gondii	cathepsin CPL	0.0383	0.2325	0.6451
Brugia malayi	calpain family protein 1	0.0042	0.0141	0.0141
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1579	1	1
Echinococcus granulosus	apoptotic protease activating factor 1	0.004	0.0128	0.0128
Brugia malayi	cathepsin L-like cysteine proteinase	0.0136	0.074	0.074
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0136	0.074	0.3184
Giardia lamblia	Cathepsin L precursor	0.0136	0.074	0.2054
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0136	0.074	0.2054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0143	0.0787	0.2183
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0136	0.074	0.074
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0143	0.0787	0.0787
Plasmodium falciparum	serine repeat antigen 4	0.0136	0.074	0.3184
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0136	0.074	0.2054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.007	0.0316	0.11
Loa Loa (eye worm)	hypothetical protein	0.0383	0.2325	0.2325
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0582	0.3604	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.011	0.011
Echinococcus multilocularis	calpain A	0.0044	0.0153	0.0153
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0047	0.0047
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0582	0.3604	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0143	0.0787	0.2183
Onchocerca volvulus		0.0383	0.2325	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0083	0.0083
Plasmodium falciparum	serine repeat antigen 7	0.0136	0.074	0.3184
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0383	0.2325	0.2325
Echinococcus multilocularis	beta LACTamase domain containing family member	0.007	0.0316	0.0316
Brugia malayi	MH2 domain containing protein	0.0116	0.0612	0.0612
Echinococcus multilocularis	cathepsin L cysteine protease	0.0383	0.2325	0.2325
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0018	0.0018
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0383	0.2325	1
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0013	0.0037
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1579	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0136	0.074	0.2054
Leishmania major	cathepsin L-like protease	0.0383	0.2325	0.6451
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.0316	0.0877
Schistosoma mansoni	cathepsin C	0.0136	0.074	0.074
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2325	0.2325
Giardia lamblia	Cathepsin B precursor	0.0582	0.3604	1
Mycobacterium leprae	conserved hypothetical protein	0.007	0.0316	0.9576
Plasmodium falciparum	serine repeat antigen 3	0.0136	0.074	0.3184
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0047	0.0131
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0044	0.0153	0.0153
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0582	0.3604	0.3604
Plasmodium falciparum	serine repeat antigen 6	0.0136	0.074	0.3184
Giardia lamblia	Cathepsin L precursor	0.0136	0.074	0.2054
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0446	0.2727	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2325	0.6451
Brugia malayi	hypothetical protein	0.0172	0.0972	0.0972
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0136	0.074	0.3184
Loa Loa (eye worm)	hypothetical protein	0.0136	0.074	0.074
Giardia lamblia	Cysteine protease	0.0136	0.074	0.2054
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.007	0.0316	0.0316
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1579	1	1
Brugia malayi	fibroinase precursor	0.0136	0.074	0.074
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2325	0.2325
Mycobacterium tuberculosis	Conserved protein	0.007	0.0316	0.11
Plasmodium vivax	serine-repeat antigen (SERA)	0.0136	0.074	0.3184
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0136	0.074	0.3184
Schistosoma mansoni	cathepsin B (C01 family)	0.0136	0.074	0.074
Onchocerca volvulus		0.007	0.0316	0.1292
Loa Loa (eye worm)	hypothetical protein	0.0136	0.074	0.074
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0018	0.0018
Echinococcus granulosus	cathepsin b	0.1579	1	1
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0044	0.0153	0.0153
Plasmodium falciparum	serine repeat antigen 1	0.0136	0.074	0.3184
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0136	0.074	0.074
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0383	0.2325	0.6451
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.0787	0.3384
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0136	0.074	0.2054
Brugia malayi	cathepsin L precursor	0.0136	0.074	0.074
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0153	0.0153
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0153	0.0153
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0136	0.074	0.074
Mycobacterium tuberculosis	Probable lipase LipE	0.007	0.0316	0.11
Plasmodium vivax	vivapain-2	0.0383	0.2325	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Mycobacterium ulcerans	hypothetical protein	0.007	0.0316	0.9576
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Brugia malayi	Integrin beta pat-3 precursor	0.1095	0.6896	0.6896
Trichomonas vaginalis	conserved hypothetical protein	0.0136	0.074	0.2054
Loa Loa (eye worm)	hypothetical protein	0.007	0.0316	0.0316
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0136	0.074	0.3184
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0044	0.0153	0.0153
Echinococcus multilocularis	apoptotic protease activating factor 1	0.004	0.0128	0.0128
Trypanosoma brucei	hypothetical protein, conserved	0.007	0.0316	0.0877
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0027	0.0117
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0136	0.074	0.074
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0047	0.0131
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0136	0.074	0.074
Plasmodium vivax	vivapain-3	0.0143	0.0787	0.3384
Echinococcus multilocularis	cysteine protease	0.0383	0.2325	0.2325
Trypanosoma cruzi	major cysteine proteinase, putative	0.0136	0.074	0.074
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0136	0.074	0.2054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0383	0.2325	0.2325
Echinococcus multilocularis	cathepsin b	0.1579	1	1
Loa Loa (eye worm)	hypothetical protein	0.0136	0.074	0.074
Onchocerca volvulus		0.0383	0.2325	1
Loa Loa (eye worm)	matrix metalloproteinase	0.0059	0.0247	0.0247
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0136	0.074	0.074
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0018	0.0049
Brugia malayi	Papain family cysteine protease containing protein	0.0136	0.074	0.074
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0047	0.0131
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0143	0.0787	0.2183
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0136	0.074	0.2054
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0153	0.0153
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0136	0.074	0.2054
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0136	0.074	0.074
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.0316	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0376	0.2279	0.2279
Mycobacterium ulcerans	esterase/lipase LipP	0.007	0.0316	0.9576
Echinococcus granulosus	beta LACTamase domain containing family member	0.007	0.0316	0.0316
Brugia malayi	beta-lactamase family protein	0.007	0.0316	0.0316
Giardia lamblia	Cathepsin L-like protease	0.0136	0.074	0.2054
Brugia malayi	Papain family cysteine protease containing protein	0.0383	0.2325	0.2325
Mycobacterium leprae	PROBABLE HYDROLASE	0.0072	0.0329	1
Giardia lamblia	Cathepsin B precursor	0.0136	0.074	0.2054
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0018	0.0049
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0136	0.074	0.2054
Giardia lamblia	Cathepsin B precursor	0.0136	0.074	0.2054
Loa Loa (eye worm)	hypothetical protein	0.0136	0.074	0.074
Loa Loa (eye worm)	calpain family protein 1	0.0031	0.0069	0.0069
Echinococcus multilocularis	geminin	0.0165	0.0924	0.0924
Echinococcus multilocularis	snurportin 1	0.0297	0.1777	0.1777
Onchocerca volvulus		0.0084	0.0405	0.1677
Loa Loa (eye worm)	matrixin family protein	0.0143	0.0783	0.0783
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0136	0.074	0.3184
Onchocerca volvulus		0.007	0.0316	0.1292
Onchocerca volvulus		0.0383	0.2325	1
Brugia malayi	hypothetical protein	0.004	0.0128	0.0128
Schistosoma mansoni	integrin beta subunit	0.063	0.3911	0.3911
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0136	0.074	0.074
Mycobacterium ulcerans	hydrolase	0.0072	0.0329	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0136	0.074	0.074
Brugia malayi	Papain family cysteine protease containing protein	0.0143	0.0787	0.0787
Trypanosoma cruzi	cysteine proteinase, putative	0.0143	0.0787	0.0787
Leishmania major	cathepsin L-like protease	0.0383	0.2325	0.6451
Onchocerca volvulus		0.0383	0.2325	1
Echinococcus granulosus	snurportin 1	0.0297	0.1777	0.1777
Trypanosoma cruzi	major cysteine proteinase, putative	0.0136	0.074	0.074
Echinococcus multilocularis	cysteine protease	0.0383	0.2325	0.2325
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0018	0.0077
Giardia lamblia	Cathepsin B precursor	0.0136	0.074	0.2054
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0136	0.074	0.3184
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0131	0.0707	0.2989
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0239	0.0239
Onchocerca volvulus		0.0049	0.018	0.0703
Loa Loa (eye worm)	fibroinase	0.0383	0.2325	0.2325
Brugia malayi	Papain family cysteine protease containing protein	0.0136	0.074	0.074
Schistosoma mansoni	hypothetical protein	0.0084	0.0405	0.0405
Entamoeba histolytica	hypothetical protein	0.0136	0.074	0.3184
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0083	0.0083
Brugia malayi	cathepsin L-like precursor	0.0376	0.2279	0.2279
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0383	0.2325	0.2325
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.018	0.018
Onchocerca volvulus		0.004	0.0128	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0172	0.0972	0.0972
Plasmodium falciparum	serine repeat antigen 8	0.0136	0.074	0.3184
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0143	0.0787	0.0787
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2325	0.6451
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0018	0.0077
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.0787	0.3384
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2325	0.6451
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0153	0.0153
Brugia malayi	Matrixin family protein	0.0059	0.0247	0.0247
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0136	0.074	0.3184
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0047	0.0047
Entamoeba histolytica	cysteine proteinase, putative	0.0383	0.2325	1
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0059	0.0247	0.0247
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0072	0.0329	0.1149
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.0316	0.0877
Loa Loa (eye worm)	hypothetical protein	0.007	0.0316	0.0316
Giardia lamblia	Cysteine protease	0.0136	0.074	0.2054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Schistosoma mansoni	cathepsin F (C01 family)	0.0383	0.2325	0.2325
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0018	0.0018
Schistosoma mansoni	cathepsin F (C01 family)	0.0383	0.2325	0.2325
Echinococcus multilocularis	calpain family protein 1, d	0.0031	0.0069	0.0069
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Giardia lamblia	Cathepsin B precursor	0.0136	0.074	0.2054
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0136	0.074	0.3184
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0247	0.0247
Mycobacterium leprae	Probable lipase LipE	0.007	0.0316	0.9576
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0136	0.074	0.074
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1579	1	1
Brugia malayi	Cathepsin L-like precursor	0.0376	0.2279	0.2279
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.0316	0.0316
Entamoeba histolytica	cysteine protease, putative	0.0136	0.074	0.3184
Entamoeba histolytica	cysteine proteinase 2	0.0143	0.0787	0.3384
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0027	0.0027
Loa Loa (eye worm)	matrixin family protein	0.0131	0.0707	0.0707
Mycobacterium tuberculosis	Probable esterase LipL	0.007	0.0316	0.11
Schistosoma mansoni	hypothetical protein	0.0165	0.0924	0.0924
Onchocerca volvulus	Cell death protein 3 homolog	0.0058	0.0239	0.096
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0042	0.0141	0.0141
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0153	0.0153
Giardia lamblia	Cathepsin L precursor	0.0136	0.074	0.2054
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2325	0.2325
Loa Loa (eye worm)	calpain family protein 1	0.0042	0.0141	0.0141
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0136	0.074	0.2054
Plasmodium vivax	vivapain-1	0.0143	0.0787	0.3384
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0183	0.0183
Onchocerca volvulus		0.0383	0.2325	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0136	0.074	0.2054
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0136	0.074	0.3184
Plasmodium vivax	hypothetical protein, conserved	0.007	0.0316	0.1359
Toxoplasma gondii	ABC1 family protein	0.007	0.0316	0.0877
Schistosoma mansoni	hypothetical protein	0.004	0.0128	0.0128
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0172	0.0972	0.0972
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2325	0.2325
Trypanosoma cruzi	cysteine peptidase, putative	0.0383	0.2325	0.2325
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.007	0.0316	0.0316
Brugia malayi	Cathepsin L-like precursor	0.0376	0.2279	0.2279
Giardia lamblia	Cysteine protease	0.0136	0.074	0.2054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2325	0.6451
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0582	0.3604	0.3604
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2325	0.6451
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0013	0.0037
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0136	0.074	0.3184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0143	0.0787	0.0787
Echinococcus granulosus	geminin	0.0165	0.0924	0.0924
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0136	0.074	0.2054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0383	0.2325	0.6451
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0383	0.2325	0.6451
Echinococcus multilocularis	cathepsin L	0.0143	0.0787	0.0787
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0136	0.074	0.2054
Echinococcus multilocularis	integrin beta 2	0.0802	0.5014	0.5014
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0136	0.074	0.074
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0214	0.1244	0.1244
Echinococcus granulosus	cathepsin b	0.1579	1	1
Onchocerca volvulus		0.0383	0.2325	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0069	0.0069
Schistosoma mansoni	cathepsin S (C01 family)	0.0136	0.074	0.074
Echinococcus multilocularis	cathepsin b	0.1579	1	1
Brugia malayi	Importin beta-1 subunit	0.0028	0.0047	0.0047
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0136	0.074	0.2054
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0018	0.0077
Entamoeba histolytica	cysteine proteinase, putative	0.0376	0.2279	0.98
Brugia malayi	Papain family cysteine protease containing protein	0.0136	0.074	0.074
Loa Loa (eye worm)	integrin beta-2	0.1095	0.6896	0.6896
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0136	0.074	0.2054
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0027	0.0076
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0136	0.074	0.3184
Trypanosoma cruzi	cruzipain precursor, putative	0.0383	0.2325	0.2325
Entamoeba histolytica	cysteine protease, putative	0.0383	0.2325	1
Echinococcus multilocularis	tumor protein p63	0.0332	0.1997	0.1997
Toxoplasma gondii	cathepsin CPC2	0.0136	0.074	0.2054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.0787	0.3384
Brugia malayi	Cathepsin L-like precursor	0.0383	0.2325	0.2325
Echinococcus granulosus	caspase 2	0.0058	0.0239	0.0239
Giardia lamblia	Hypothetical protein	0.0136	0.074	0.2054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Onchocerca volvulus		0.0026	0.0038	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0141	0.0141
Entamoeba histolytica	cysteine protease, putative	0.0143	0.0787	0.3384
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0383	0.2325	0.6451
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0044	0.0153	0.0153

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 833515