TDR Targets

Basic information

Technical information

TDR Targets ID: 833516
Name: 5-(2-methoxyethylamino)-2-[(E)-2-(3-methoxyph enyl)ethenyl]-1,3-oxazole-4-carbonitrile
MW: 299.324 | Formula: C16H17N3O3
H donors: 1 H acceptors: 2 LogP: 3.39 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COCCNc1oc(nc1C#N)C=Cc1cccc(c1)OC
InChi: 1S/C16H17N3O3/c1-20-9-8-18-16-14(11-17)19-15(22-16)7-6-12-4-3-5-13(10-12)21-2/h3-7,10,18H,8-9H2,1-2H3/b7-6+
InChiKey: FVZOXPIHZYMKBN-VOTSOKGWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(2-methoxyethylamino)-2-[2-(3-methoxyphenyl)ethenyl]-1,3-oxazole-4-carbonitrile
5-(2-methoxyethylamino)-2-[2-(3-methoxyphenyl)vinyl]oxazole-4-carbonitrile
5-(2-methoxyethylamino)-2-[(E)-2-(3-methoxyphenyl)vinyl]oxazole-4-carbonitrile
5-(2-methoxyethylamino)-2-[2-(3-methoxyphenyl)vinyl]-4-oxazolecarbonitrile
5-(2-methoxyethylamino)-2-[(E)-2-(3-methoxyphenyl)vinyl]-4-oxazolecarbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Mycobacterium ulcerans	esterase/lipase LipP	0.007	0.0346	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0045	0.0183	0.0182
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0056	0.0056
Entamoeba histolytica	cysteine proteinase, putative	0.0378	0.2305	0.9796
Brugia malayi	beta-lactamase	0.007	0.0346	0.0346
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0137	0.0768	0.2055
Onchocerca volvulus		0.0378	0.2305	0.9794
Giardia lamblia	Cathepsin L precursor	0.0137	0.0768	0.2055
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0768	0.0768
Plasmodium vivax	unspecified product	0.0137	0.0768	0.3263
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.0346	0.0345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.0768	0.2055
Onchocerca volvulus		0.007	0.0346	0.1296
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.0768	0.2055
Brugia malayi	calpain family protein 1	0.0043	0.017	0.017
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0029	0.008
Loa Loa (eye worm)	hypothetical protein	0.1587	1	1
Giardia lamblia	Cathepsin B precursor	0.0137	0.0768	0.2055
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0009	0.0009
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0045	0.0183	0.0182
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0144	0.0815	0.225
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Mycobacterium tuberculosis	Conserved protein	0.007	0.0346	0.1242
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.0346	0.0345
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0386	0.2352	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0047	0.0076
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0386	0.2352	0.6492
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0137	0.0768	0.3238
Plasmodium falciparum	serine repeat antigen 8	0.0137	0.0768	0.3238
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0137	0.0768	0.0768
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0137	0.0768	0.2055
Echinococcus multilocularis	cathepsin L	0.0137	0.0768	0.0768
Onchocerca volvulus		0.0386	0.2352	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0137	0.0768	0.3263
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0076	0.0324
Entamoeba histolytica	hypothetical protein	0.0023	0.0043	0.0058
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0585	0.3623	0.3623
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0047	0.0047
Plasmodium vivax	vivapain-1	0.0144	0.0815	0.3465
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0047	0.0129
Leishmania major	cathepsin L-like protease	0.0386	0.2352	0.6492
Toxoplasma gondii	ABC1 family protein	0.007	0.0346	0.0881
Giardia lamblia	Cathepsin B precursor	0.0585	0.3623	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Giardia lamblia	Hypothetical protein	0.0137	0.0768	0.2055
Brugia malayi	RNA, U transporter 1	0.008	0.0407	0.0407
Schistosoma mansoni	cathepsin S (C01 family)	0.0137	0.0768	0.0768
Giardia lamblia	Cathepsin L-like protease	0.0137	0.0768	0.2055
Entamoeba histolytica	cysteine proteinase, putative	0.0144	0.0815	0.3384
Plasmodium vivax	vivapain-2	0.0386	0.2352	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0056	0.0202
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0386	0.2352	0.6464
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0137	0.0768	0.0768
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0137	0.0768	0.3263
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0043	0.0117
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1587	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0144	0.0815	0.0815
Trypanosoma cruzi	major cysteine proteinase, putative	0.0137	0.0768	0.0768
Giardia lamblia	Cathepsin L-like protease	0.0137	0.0768	0.2055
Onchocerca volvulus		0.0386	0.2352	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0768	0.0768
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0047	0.1123
Giardia lamblia	Cathepsin B precursor	0.0137	0.0768	0.2055
Mycobacterium leprae	Probable lipase LipE	0.007	0.0346	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0386	0.2352	0.2352
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0137	0.0768	0.3263
Brugia malayi	Papain family cysteine protease containing protein	0.0144	0.0815	0.0815
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0378	0.2305	0.6332
Plasmodium vivax	vivapain-2	0.0386	0.2352	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0386	0.2352	0.6464
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.0768	0.2055
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0183	0.0183
Schistosoma mansoni	hypothetical protein	0.03	0.1809	0.1809
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.007	0.0346	0.1242
Toxoplasma gondii	cathepsin B	0.0585	0.3623	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0137	0.0768	0.3238
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0386	0.2352	0.6492
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0144	0.0815	0.225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Echinococcus multilocularis	beta LACTamase domain containing family member	0.007	0.0346	0.0345
Brugia malayi	Cathepsin L-like precursor	0.0378	0.2305	0.2305
Onchocerca volvulus		0.0386	0.2352	1
Onchocerca volvulus	Cathepsin L homolog	0.0386	0.2352	1
Entamoeba histolytica	cysteine proteinase, putative	0.0144	0.0815	0.3384
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0137	0.0768	0.2055
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0047	0.0076
Mycobacterium ulcerans	hypothetical protein	0.007	0.0346	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0209	0.0209
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0386	0.2352	0.6492
Trypanosoma cruzi	cysteine peptidase, putative	0.0144	0.0815	0.0815
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0386	0.2352	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.0642	0.0642
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Onchocerca volvulus		0.0386	0.2352	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0029	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0043	0.0042
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0137	0.0768	0.0768
Loa Loa (eye worm)	fibroinase	0.0386	0.2352	0.2352
Schistosoma mansoni	hypothetical protein	0.0166	0.0955	0.0955
Toxoplasma gondii	cathepsin CPC1	0.0137	0.0768	0.2055
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0386	0.2352	0.6492
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0386	0.2352	0.6492
Trypanosoma cruzi	cysteine peptidase, putative	0.0386	0.2352	0.2352
Plasmodium vivax	unspecified product	0.0144	0.0815	0.3465
Schistosoma mansoni	hypothetical protein	0.0034	0.0112	0.0112
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0047	0.0047
Loa Loa (eye worm)	cysteine protease	0.0386	0.2352	0.2352
Brugia malayi	calpain family protein 1	0.0043	0.017	0.017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Echinococcus granulosus	cathepsin L	0.0137	0.0768	0.0768
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Brugia malayi	Cathepsin L-like precursor	0.0386	0.2352	0.2352
Giardia lamblia	Cysteine protease	0.0137	0.0768	0.2055
Brugia malayi	cathepsin L-like precursor	0.0378	0.2305	0.2305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0386	0.2352	0.6464
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0076	0.0132
Trypanosoma cruzi	cruzipain precursor, putative	0.0386	0.2352	0.2352
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0056	0.0056
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.0346	0.0345
Onchocerca volvulus		0.0027	0.0067	0.0088
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0386	0.2352	0.6492
Plasmodium falciparum	importin beta, putative	0.0028	0.0076	0.0287
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0183	0.0183
Mycobacterium tuberculosis	Probable esterase LipL	0.007	0.0346	0.1242
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.007	0.0346	1
Loa Loa (eye worm)	hypothetical protein	0.0386	0.2352	0.2352
Onchocerca volvulus	Cathepsin L homolog	0.0386	0.2352	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.007	0.0346	0.0345
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0144	0.0815	0.0815
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0137	0.0768	0.318
Entamoeba histolytica	cysteine proteinase, putative	0.0386	0.2352	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1587	1	1
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0209	0.0209
Entamoeba histolytica	cysteine proteinase 1, putative	0.0144	0.0815	0.3384
Brugia malayi	beta-lactamase family protein	0.007	0.0346	0.0346
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0137	0.0768	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0009	0.0009
Schistosoma mansoni	ran	0.0021	0.0029	0.0029
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0137	0.0768	0.3238
Leishmania major	hypothetical protein, conserved	0.007	0.0346	0.0953
Echinococcus granulosus	cathepsin l1	0.0386	0.2352	0.2352
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0137	0.0768	0.2055
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0386	0.2352	0.6464
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0585	0.3623	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0346	0.0345
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0043	0.017	0.017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.0768	0.2055
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Echinococcus granulosus	cathepsin l1	0.0378	0.2305	0.2305
Leishmania major	cathepsin L-like protease	0.0386	0.2352	0.6492
Trypanosoma cruzi	cysteine peptidase, putative	0.0386	0.2352	0.2352
Echinococcus multilocularis	integrin beta 2	0.1083	0.679	0.679
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0076	0.021
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0386	0.2352	0.6492
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0137	0.0768	0.2055
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0137	0.0768	0.2055
Plasmodium falciparum	serine repeat antigen 7	0.0137	0.0768	0.3238
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0009	0.0022
Echinococcus multilocularis	tumor protein p63	0.0335	0.2029	0.2029
Plasmodium falciparum	serine repeat antigen 4	0.0137	0.0768	0.3238
Loa Loa (eye worm)	cathepsin B	0.0585	0.3623	0.3623
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0045	0.0183	0.0182
Trichomonas vaginalis	conserved hypothetical protein	0.0137	0.0768	0.2055
Loa Loa (eye worm)	hypothetical protein	0.007	0.0346	0.0345
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Loa Loa (eye worm)	calpain family protein 1	0.0032	0.0098	0.0098
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.03	0.1809	0.1809
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0137	0.0768	0.318
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0585	0.3623	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.0768	0.2055
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0585	0.3623	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0144	0.0815	0.0815
Giardia lamblia	Cathepsin L precursor	0.0137	0.0768	0.2055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0098	0.0098
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0047	0.0129
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0183	0.0183
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0212	0.0212
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0045	0.0183	0.0182
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0047	0.0047
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.0346	0.0881
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0386	0.2352	0.2352
Brugia malayi	hypothetical protein	0.0232	0.1375	0.1375
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Loa Loa (eye worm)	calpain family protein 1	0.0043	0.017	0.017
Echinococcus multilocularis	cathepsin L cysteine protease	0.0386	0.2352	0.2352
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0137	0.0768	0.3263
Brugia malayi	Cathepsin L-like precursor	0.0386	0.2352	0.2352
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0768	0.0768
Trypanosoma cruzi	cysteine proteinase, putative	0.0144	0.0815	0.0815
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.007	0.0346	0.1242
Echinococcus multilocularis	geminin	0.0166	0.0955	0.0955
Onchocerca volvulus		0.0386	0.2352	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Loa Loa (eye worm)	hypothetical protein	0.0378	0.2305	0.2305
Plasmodium falciparum	serine repeat antigen 6	0.0137	0.0768	0.3238
Echinococcus granulosus	cathepsin L	0.0144	0.0815	0.0815
Mycobacterium tuberculosis	Probable lipase LipE	0.007	0.0346	0.1242
Giardia lamblia	Cysteine protease	0.0137	0.0768	0.2055
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0378	0.2305	0.2305
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0056	0.0076
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0047	0.1123
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0378	0.2305	0.2305
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0043	0.0037
Trypanosoma cruzi	cysteine proteinase, putative	0.0144	0.0815	0.0815
Schistosoma mansoni	cathepsin F (C01 family)	0.0386	0.2352	0.2352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0386	0.2352	0.6464
Brugia malayi	cathepsin F-like cysteine proteinase	0.0137	0.0768	0.0768
Echinococcus granulosus	cathepsin L cysteine protease	0.0144	0.0815	0.0815
Mycobacterium tuberculosis	Probable hydrolase	0.007	0.0346	0.1242
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0137	0.0768	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0112	0.0112
Entamoeba histolytica	cysteine protease, putative	0.0137	0.0768	0.318
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0029	0.0029
Loa Loa (eye worm)	beta-lactamase	0.007	0.0346	0.0345
Toxoplasma gondii	cathepsin CPL	0.0386	0.2352	0.6464
Toxoplasma gondii	cathepsin CPC2	0.0137	0.0768	0.2055
Leishmania major	cathepsin L-like protease	0.0386	0.2352	0.6492
Loa Loa (eye worm)	hypothetical protein	0.007	0.0346	0.0345
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0029	0.0123
Mycobacterium ulcerans	lipase LipD	0.007	0.0346	1
Echinococcus granulosus	integrin beta 2	0.1083	0.679	0.679
Entamoeba histolytica	cysteine protease, putative	0.0137	0.0768	0.318
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1587	1	1
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1375	0.1375
Echinococcus multilocularis	cathepsin L	0.0144	0.0815	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0768	0.0768
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0137	0.0768	0.2055
Entamoeba histolytica	cysteine proteinase, putative	0.0144	0.0815	0.3384
Leishmania major	cathepsin L-like protease	0.0386	0.2352	0.6492
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0386	0.2352	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0144	0.0815	0.3441
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.0768	0.2055
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0386	0.2352	0.6464
Giardia lamblia	Cathepsin B precursor	0.0585	0.3623	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Giardia lamblia	Cysteine protease	0.0137	0.0768	0.2055
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0137	0.0768	0.0768
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0212	0.0212
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0043	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0212	0.0212
Echinococcus granulosus	geminin	0.0166	0.0955	0.0955
Onchocerca volvulus		0.007	0.0346	0.1296
Loa Loa (eye worm)	hypothetical protein	0.0378	0.2305	0.2305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0137	0.0768	0.2055
Entamoeba histolytica	cysteine proteinase, putative	0.0386	0.2352	1
Leishmania major	cathepsin L-like protease	0.0386	0.2352	0.6492
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0043	0.0037
Brugia malayi	hypothetical protein	0.0025	0.0056	0.0056
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Echinococcus granulosus	tumor protein p63	0.0335	0.2029	0.2029
Echinococcus multilocularis	cysteine protease	0.0386	0.2352	0.2352
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0139	0.0139
Entamoeba histolytica	cysteine protease, putative	0.0137	0.0768	0.318
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0386	0.2352	0.2352
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Giardia lamblia	Cathepsin L precursor	0.0137	0.0768	0.2055
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0386	0.2352	0.2352
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0029	0.0029
Brugia malayi	Cathepsin L-like precursor	0.0378	0.2305	0.2305
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0137	0.0768	0.3263
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0768	0.0768
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0029	0.0029
Loa Loa (eye worm)	integrin beta-2	0.1479	0.9311	0.9311
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.0768	0.2055
Brugia malayi	Papain family cysteine protease containing protein	0.0386	0.2352	0.2352
Leishmania major	cathepsin L-like protease	0.0386	0.2352	0.6492
Brugia malayi	MH2 domain containing protein	0.0117	0.0642	0.0642
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0386	0.2352	0.6464
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0047	0.1123
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0047	0.0047
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1587	1	1
Giardia lamblia	Cysteine protease	0.0137	0.0768	0.2055
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0009	0.0038
Leishmania major	hypothetical protein, conserved	0.0025	0.0056	0.0155
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0386	0.2352	0.6492
Loa Loa (eye worm)	hypothetical protein	0.0043	0.017	0.017
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0768	0.0768
Echinococcus multilocularis	calpain A	0.0045	0.0183	0.0182
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0047	0.1123
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0386	0.2352	0.6464
Brugia malayi	Kelch motif family protein	0.0232	0.1375	0.1375
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Giardia lamblia	Cathepsin L precursor	0.0137	0.0768	0.2055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Plasmodium vivax	vivapain-3	0.0144	0.0815	0.3465
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0076	0.0076
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0112	0.0112
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0137	0.0768	0.3263
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0386	0.2352	0.6464
Schistosoma mansoni	cathepsin F (C01 family)	0.0378	0.2305	0.2305
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0047	0.1123
Loa Loa (eye worm)	hypothetical protein	0.007	0.0346	0.0345
Schistosoma mansoni	cathepsin B (C01 family)	0.0137	0.0768	0.0768
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0076	0.0076
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0047	0.0159
Onchocerca volvulus		0.0386	0.2352	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0137	0.0768	0.0768
Echinococcus granulosus	snurportin 1	0.03	0.1809	0.1809
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0386	0.2352	0.6492
Giardia lamblia	Cathepsin B precursor	0.0137	0.0768	0.2055
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0009	0.0009
Mycobacterium ulcerans	beta-lactamase	0.007	0.0346	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0137	0.0768	0.0768
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0056	0.0056
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0029	0.0086
Giardia lamblia	Cathepsin L precursor	0.0137	0.0768	0.2055
Onchocerca volvulus		0.0386	0.2352	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0137	0.0768	0.2055
Onchocerca volvulus	Cathepsin F homolog	0.0386	0.2352	1
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Brugia malayi	Importin beta-1 subunit	0.0028	0.0076	0.0076
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0029	0.0029
Trypanosoma cruzi	cysteine protease, putative	0.0144	0.0815	0.0815
Mycobacterium tuberculosis	Conserved protein	0.007	0.0346	0.1242
Echinococcus multilocularis	calpain family protein 1, d	0.0032	0.0098	0.0098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Loa Loa (eye worm)	hypothetical protein	0.007	0.0346	0.0345
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0056	0.0202
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0047	0.0129
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0183	0.0183
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0183	0.0183
Echinococcus granulosus	cathepsin b	0.1587	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0137	0.0768	0.3263
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0378	0.2305	0.6332
Echinococcus granulosus	cysteine protease	0.0144	0.0815	0.0815
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.0346	0.0881
Plasmodium falciparum	serine repeat antigen 2	0.0137	0.0768	0.3238
Entamoeba histolytica	cysteine protease, putative	0.0386	0.2352	1
Onchocerca volvulus		0.0137	0.0768	0.3127
Mycobacterium leprae	conserved hypothetical protein	0.007	0.0346	1
Mycobacterium tuberculosis	Probable lipase LipD	0.007	0.0346	0.1242
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0212	0.0212
Brugia malayi	Cathepsin L-like precursor	0.0386	0.2352	0.2352
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0144	0.0815	0.0815
Brugia malayi	Cathepsin L-like precursor	0.0386	0.2352	0.2352
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0047	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0768	0.0768
Brugia malayi	cathepsin L precursor	0.0137	0.0768	0.0768
Entamoeba histolytica	cysteine proteinase 2	0.0144	0.0815	0.3384
Brugia malayi	Papain family cysteine protease containing protein	0.0137	0.0768	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0378	0.2305	0.2305
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0183	0.0183
Giardia lamblia	Encystation-specific protease	0.0137	0.0768	0.2055
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0183	0.0183
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0137	0.0768	0.3263
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0137	0.0768	0.3263
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0009	0.0009
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0047	0.1123
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0056	0.0155
Plasmodium falciparum	serine repeat antigen 1	0.0137	0.0768	0.3238
Brugia malayi	Papain family cysteine protease containing protein	0.0144	0.0815	0.0815
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0137	0.0768	0.0768
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0047	0.1123
Entamoeba histolytica	cysteine protease, putative	0.0137	0.0768	0.318
Entamoeba histolytica	cysteine proteinase, putative	0.0144	0.0815	0.3384
Brugia malayi	cathepsin L-like cysteine proteinase	0.0137	0.0768	0.0768
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0386	0.2352	0.6464
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0768	0.0768
Leishmania major	cathepsin L-like protease	0.0386	0.2352	0.6492
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0386	0.2352	0.6492
Plasmodium falciparum	serine repeat antigen 3	0.0137	0.0768	0.3238
Echinococcus multilocularis	cathepsin b	0.1587	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0067	0.0067
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.0642	0.0642
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.0346	0.0345
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.0346	0.0881
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0047	0.0159
Schistosoma mansoni	ran	0.0021	0.0029	0.0029
Plasmodium falciparum	serine repeat antigen 5	0.0137	0.0768	0.3238
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0144	0.0815	0.2187
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0768	0.0768
Onchocerca volvulus		0.007	0.0346	0.1296
Plasmodium falciparum	serine repeat antigen 9	0.0137	0.0768	0.3238
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0386	0.2352	0.6464
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0386	0.2352	0.6492
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0137	0.0768	0.0768
Trichomonas vaginalis	esterase, putative	0.007	0.0346	0.0881
Schistosoma mansoni	hypothetical protein	0.0166	0.0955	0.0955
Echinococcus multilocularis	snurportin 1	0.03	0.1809	0.1809
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0144	0.0815	0.2187
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.007	0.0346	0.1242
Brugia malayi	Cathepsin L-like precursor	0.0386	0.2352	0.2352
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0047	0.0076
Schistosoma mansoni	integrin beta subunit	0.0851	0.5312	0.5312
Mycobacterium tuberculosis	Conserved protein	0.007	0.0346	0.1242
Trypanosoma cruzi	cysteine peptidase, putative	0.0386	0.2352	0.2352
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0137	0.0768	0.2055
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0009	0.0009
Giardia lamblia	Cathepsin L precursor	0.0137	0.0768	0.2055
Giardia lamblia	Hypothetical protein	0.0137	0.0768	0.2055
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0047	0.1123
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0137	0.0768	0.2055
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.0346	0.0881
Onchocerca volvulus		0.0049	0.0209	0.0705
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0183	0.0183
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0768	0.0768
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.045	0.2762	1
Brugia malayi	Cathepsin L-like precursor	0.0386	0.2352	0.2352
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0232	0.1375	0.1375
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0137	0.0768	0.2055
Brugia malayi	Papain family cysteine protease containing protein	0.0137	0.0768	0.0768
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0585	0.3623	0.3623
Trichomonas vaginalis	conserved hypothetical protein	0.0137	0.0768	0.2055
Echinococcus multilocularis	cathepsin L cysteine protease	0.0386	0.2352	0.2352
Echinococcus granulosus	calpain A	0.0045	0.0183	0.0182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0137	0.0768	0.2055
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0386	0.2352	0.6464
Plasmodium vivax	serine-repeat antigen (SERA)	0.0137	0.0768	0.3263
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0183	0.0183
Giardia lamblia	Cathepsin B precursor	0.0585	0.3623	1
Entamoeba histolytica	hypothetical protein	0.0137	0.0768	0.318
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0047	0.0047
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0056	0.0239
Entamoeba histolytica	cysteine protease, putative	0.0137	0.0768	0.318
Plasmodium vivax	hypothetical protein, conserved	0.007	0.0346	0.1469
Loa Loa (eye worm)	ctsf protein	0.0386	0.2352	0.2352
Leishmania major	GTP-binding protein, putative	0.0021	0.0029	0.008
Leishmania major	cysteine peptidase A (CPA)	0.0386	0.2352	0.6492
Loa Loa (eye worm)	hypothetical protein	0.007	0.0346	0.0345
Echinococcus multilocularis	cathepsin b	0.1587	1	1
Leishmania major	cathepsin L-like protease	0.0386	0.2352	0.6492
Onchocerca volvulus	Cathepsin L homolog	0.0137	0.0768	0.3127
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0386	0.2352	0.2352
Echinococcus granulosus	beta LACTamase domain containing family member	0.007	0.0346	0.0345
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0386	0.2352	0.2352
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.0346	0.0881
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0386	0.2352	0.2352
Brugia malayi	Integrin beta pat-3 precursor	0.1479	0.9311	0.9311
Trypanosoma cruzi	major cysteine proteinase, putative	0.0137	0.0768	0.0768
Entamoeba histolytica	cysteine protease, putative	0.0144	0.0815	0.3384
Echinococcus multilocularis	cysteine protease	0.0386	0.2352	0.2352
Brugia malayi	fibroinase precursor	0.0137	0.0768	0.0768
Entamoeba histolytica	cysteine protease, putative	0.0137	0.0768	0.318
Plasmodium vivax	serine-repeat antigen (SERA)	0.0137	0.0768	0.3263
Brugia malayi	Papain family cysteine protease containing protein	0.0137	0.0768	0.0768
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0076	0.021
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0076	0.0076
Schistosoma mansoni	cathepsin C	0.0137	0.0768	0.0768
Trypanosoma cruzi	cysteine peptidase, putative	0.0386	0.2352	0.2352
Trypanosoma brucei	hypothetical protein, conserved	0.007	0.0346	0.0953
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0137	0.0768	0.2055
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.007	0.0346	0.0346
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0137	0.0768	0.0768
Echinococcus granulosus	cathepsin b	0.1587	1	1
Schistosoma mansoni	importin beta-1	0.0028	0.0076	0.0076
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0009	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0137	0.0768	0.2055
Giardia lamblia	Cathepsin B precursor	0.0137	0.0768	0.2055
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1587	1	1
Giardia lamblia	Cathepsin B precursor	0.0137	0.0768	0.2055
Brugia malayi	beta-lactamase family protein	0.007	0.0346	0.0346
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0137	0.0768	0.3263

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 833516