Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Onchocerca volvulus | 0.0134 | 0.4217 | 0.5 | |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0116 | 0.3358 | 0.5 |
Loa Loa (eye worm) | pyridoxal-dependent decarboxylase | 0.0134 | 0.4217 | 0.3445 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0116 | 0.3358 | 0.4303 |
Trichomonas vaginalis | diaminopimelate decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Mycobacterium ulcerans | diaminopimelate decarboxylase LysA | 0.0134 | 0.4217 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0103 | 0.271 | 0.6428 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0116 | 0.3358 | 0.4303 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0052 | 0.0188 | 0.0446 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0116 | 0.3358 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0116 | 0.3358 | 0.8757 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0122 | 0.3668 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0116 | 0.3358 | 0.2472 |
Brugia malayi | FAD binding domain containing protein | 0.0116 | 0.3358 | 0.2472 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0116 | 0.3358 | 0.8757 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Leishmania major | p450 reductase, putative | 0.0116 | 0.3358 | 0.4303 |
Chlamydia trachomatis | sulfite reductase | 0.0072 | 0.1178 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0251 | 1 | 1 |
Trichomonas vaginalis | ornithine decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.0134 | 0.4217 | 1 |
Giardia lamblia | Ornithine decarboxylase | 0.0134 | 0.4217 | 1 |
Mycobacterium tuberculosis | Diaminopimelate decarboxylase LysA (DAP decarboxylase) | 0.0134 | 0.4217 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.3358 | 0.2472 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0072 | 0.1178 | 0.2173 |
Leishmania major | ornithine decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Mycobacterium leprae | PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP DECARBOXYLASE) | 0.0052 | 0.0188 | 0.5 |
Trichomonas vaginalis | pyridoxal-dependent decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0116 | 0.3358 | 0.5 |
Toxoplasma gondii | diaminopimelate decarboxylase | 0.0134 | 0.4217 | 1 |
Trypanosoma brucei | ornithine decarboxylase | 0.0134 | 0.4217 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0116 | 0.3358 | 0.5 |
Brugia malayi | Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein | 0.0134 | 0.4217 | 0.3445 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0251 | 1 | 1 |
Entamoeba histolytica | ornithine decarboxylase, putative | 0.0134 | 0.4217 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0059 | 0.053 | 0.0136 |
Schistosoma mansoni | lipoxygenase | 0.0122 | 0.3668 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0116 | 0.3358 | 0.8757 |
Brugia malayi | flavodoxin family protein | 0.0116 | 0.3358 | 0.2472 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0116 | 0.3358 | 0.7965 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.0134 | 0.4217 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0116 | 0.3358 | 0.8757 |
Schistosoma mansoni | lipoxygenase | 0.0086 | 0.1859 | 0.4315 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0116 | 0.3358 | 0.9027 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0122 | 0.3668 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.