TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 414.519 | Formula: C25H22N2O2S
H donors: 2 H acceptors: 2 LogP: 5.04 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)CNC(=O)c1ccc2c(c1)[nH]c(=O)c(=Cc1ccc(cc1)C)s2
InChi: 1S/C25H22N2O2S/c1-16-3-7-18(8-4-16)13-23-25(29)27-21-14-20(11-12-22(21)30-23)24(28)26-15-19-9-5-17(2)6-10-19/h3-14H,15H2,1-2H3,(H,26,28)(H,27,29)/b23-13+
InChiKey: YPNXFRQRXGCQSR-YDZHTSKRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0227	0.4477	0.4477
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0029	0.0361	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0492	1	1
Brugia malayi	nuclear receptor NHR-88	0.0029	0.0361	0.0326
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0084	0.1495	0.3237
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.0713	0.1941
Schistosoma mansoni	RAR-like nuclear receptor	0.0029	0.0361	0.0712
Schistosoma mansoni	chromatin regulatory protein sir2	0.0084	0.1495	0.3198
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0156	0.0087
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0077	0.1356	0.4086
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0293
Echinococcus granulosus	thymidylate synthase	0.0162	0.313	0.6799
Loa Loa (eye worm)	hypothetical protein	0.0158	0.3039	0.3039
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0073	0.1274	0.3814
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0073	0.1274	0.1243
Entamoeba histolytica	hypothetical protein	0.0076	0.1334	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0029	0.0361	0.0361
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0073	0.1274	0.2755
Echinococcus multilocularis	ecdysone induced protein 78C	0.0029	0.0361	0.0765
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0295	0.1368
Echinococcus multilocularis	muscleblind protein	0.0158	0.3039	0.6601
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0156	0.5
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0295	0.026
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0029	0.0361	0.0765
Onchocerca volvulus		0.0026	0.0295	0.026
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.1999	0.197
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0029	0.0361	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0158	0.3039	0.3039
Onchocerca volvulus		0.0492	1	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0361	0.0361
Brugia malayi	steroid hormone receptor	0.0029	0.0361	0.0326
Schistosoma mansoni	lamin	0.0026	0.0293	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0015	0.005	0.005
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0039	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0029	0.0361	0.0361
Brugia malayi	intermediate filament protein	0.0026	0.0293	0.0258
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0029	0.0361	0.0712
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0085	0.1509	0.3267
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0361	0.0361
Schistosoma mansoni	retinoic acid receptor RXR	0.0029	0.0361	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0361	0.0361
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.0048	0.0083
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0029	0.0361	0.0326
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0233	0.4599	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0076	0.1334	0.2886
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0293	0.0563
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0014	0.0036	0.0057
Schistosoma mansoni	netrin receptor unc5	0.0014	0.0048	0.0026
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.013	0.0262
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0076	0.1334	0.2886
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0295	0.0549
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0029	0.0361	0.0361
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.1274	0.3814
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.1356	0.8977
Echinococcus multilocularis	Ankyrin	0.0015	0.005	0.0088
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.013	0.0262
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0295	0.1368
Onchocerca volvulus		0.0162	0.313	0.3105
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0046	0.0713	0.4265
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.1286	0.1255
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0134	0.0012
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0016	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1286	0.1286
Loa Loa (eye worm)	acetyltransferase	0.0158	0.3032	0.3032
Loa Loa (eye worm)	DR-78	0.0014	0.0036	0.0036
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.0071	0.0076
Giardia lamblia	Histone acetyltransferase GCN5	0.0042	0.0632	0.3675
Echinococcus multilocularis	muscleblind protein 1	0.0158	0.3039	0.6601
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.013	0.5
Schistosoma mansoni	ap endonuclease	0.0018	0.013	0.0206
Brugia malayi	hypothetical protein	0.0076	0.1334	0.1303
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0295	0.0549
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0295	0.0549
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0162	0.313	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0014	0.0036	0.0057
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.1999	0.197
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0029	0.0361	0.0361
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0293	0.0258
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0295	0.0549
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0158	0.3032	0.6586
Echinococcus granulosus	FTZ F1 alpha	0.0029	0.0361	0.0765
Schistosoma mansoni	thyroid hormone receptor	0.0029	0.0361	0.0712
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0084	0.1495	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0029	0.0361	0.0326
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0459	0.0978
Schistosoma mansoni	thyroid hormone receptor	0.0029	0.0361	0.0712
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0074	0.1292	0.2794
Schistosoma mansoni	hypothetical protein	0.0034	0.0459	0.0927
Echinococcus granulosus	ecdysone induced protein 78C	0.0029	0.0361	0.0765
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0029	0.0361	0.0765
Entamoeba histolytica	acetyltransferase, GNAT family	0.0042	0.0632	0.4167
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0071	0.0035
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.013	0.0094
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0029	0.0361	0.0712
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.1274	0.3814
Brugia malayi	hypothetical protein	0.0016	0.0071	0.0035
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0029	0.0361	0.0326
Schistosoma mansoni	jun-related protein	0.0069	0.1179	0.2504
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0029	0.0361	0.0765
Echinococcus granulosus	transcription factor Dp 1	0.0042	0.0631	0.1353
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0156	0.0087
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0029	0.0361	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Brugia malayi	nuclear receptor RXR	0.0016	0.0071	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.002	0.0156	0.0156
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0029	0.0361	0.0326
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0029	0.0361	0.0712
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0014	0.0036	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0283	0.0283
Echinococcus multilocularis	thymidylate synthase	0.0162	0.313	0.6799
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0134	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0029	0.0361	0.0326
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.005	0.0031
Echinococcus granulosus	thyroid hormone receptor alpha	0.0014	0.0036	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0071	0.0071
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.0713	0.1531
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0295	0.0549
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0162	0.313	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0071	0.0071
Brugia malayi	acetyltransferase, GNAT family protein	0.0158	0.3032	0.3007
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0295	0.0549
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0029	0.0361	0.0326
Echinococcus granulosus	death domain containing protein	0.0014	0.0048	0.0083
Loa Loa (eye worm)	thymidylate synthase	0.0162	0.313	0.313
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0361	0.0361
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0085	0.1509	0.3267
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0014	0.0036	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0361	0.0361
Brugia malayi	Uncoordinated protein 44	0.0014	0.0048	0.0012
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0029	0.0361	0.0765
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0295	0.0549
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0084	0.1495	0.3237
Onchocerca volvulus		0.0026	0.0293	0.0258
Schistosoma mansoni	lamin	0.0026	0.0293	0.0563
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0293	0.0293
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0029	0.0361	0.0765
Brugia malayi	hypothetical protein	0.0016	0.0071	0.0035
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.1999	0.1999
Echinococcus granulosus	lamin dm0	0.0026	0.0293	0.0617
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0073	0.1274	0.3814
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0016	0.0071	0.0076
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0459	0.0459
Brugia malayi	bZIP transcription factor family protein	0.0085	0.1509	0.1478
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0071	0.0071
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.013	0.5
Schistosoma mansoni	hypothetical protein	0.0034	0.0459	0.0927
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0084	0.1495	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0029	0.0361	0.0326
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0029	0.0361	0.0326
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0084	0.1495	0.1465
Onchocerca volvulus		0.0026	0.0293	0.0258
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0293	0.0293
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0016	0.0071	0.0133
Brugia malayi	hypothetical protein	0.0077	0.1356	0.1324
Echinococcus multilocularis	nuclear receptor nhr 48	0.0014	0.0036	0.0057
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0029	0.0361	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0361	0.0361
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0295	0.026
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0459	0.0978
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0029	0.0361	0.0361
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0029	0.0361	0.0326
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0029	0.0361	0.0765
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0162	0.313	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0029	0.0361	0.0765
Schistosoma mansoni	hypothetical protein	0.0069	0.1179	0.2504
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0048	0.0083
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0029	0.0361	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0492	1	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1461	0.1461
Echinococcus granulosus	lamin	0.0026	0.0293	0.0617
Echinococcus granulosus	Ankyrin	0.0015	0.005	0.0088
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0233	0.4599	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0046	0.0713	0.4265
Echinococcus multilocularis	jun protein	0.0085	0.1509	0.3267
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0084	0.1495	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0295	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0029	0.0361	0.0712
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0162	0.313	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0029	0.0361	0.0326
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0029	0.0361	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1999	0.1999
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0029	0.0361	0.0765
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0295	0.0549
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0459	0.0424
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0295	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0295	0.0295
Schistosoma mansoni	nuclear hormone receptor	0.0029	0.0361	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Loa Loa (eye worm)	steroid hormone receptor	0.0029	0.0361	0.0361
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0014	0.0036	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0295	0.026
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0361	0.0361
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0134	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0295	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0029	0.0361	0.0361
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.0713	0.1941
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0295	0.1368
Loa Loa (eye worm)	hypothetical protein	0.002	0.0156	0.0156
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.0156	0.0087
Echinococcus granulosus	muscleblind protein	0.0158	0.3039	0.6601
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0048	0.0083
Loa Loa (eye worm)	runx1	0.0062	0.1032	0.1032
Brugia malayi	Muscleblind-like protein	0.0158	0.3039	0.3014
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1266	0.1266
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0048	0.0048
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0014	0.0036	0.0036
Brugia malayi	thymidylate synthase	0.0162	0.313	0.3105
Echinococcus multilocularis	FTZ F1 alpha	0.0029	0.0361	0.0765
Onchocerca volvulus		0.0029	0.0361	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0039	0.0039
Schistosoma mansoni	transcription factor LCR-F1	0.0076	0.1334	0.2845
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0048	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0029	0.0361	0.0326
Brugia malayi	hypothetical protein	0.0066	0.1131	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1495	0.1495
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0459	0.0978
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0073	0.1274	0.9502
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0153	0.294	0.6386
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0295	0.0549
Onchocerca volvulus		0.0066	0.1131	0.1098
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0048	0.0048
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0029	0.0361	0.0712
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0048	0.0026
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0295	0.0549
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0048	0.0012
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0084	0.1495	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0295	0.0549
Echinococcus granulosus	hormone sensitive lipase	0.0233	0.4599	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0029	0.0361	0.0326
Loa Loa (eye worm)	nuclear hormone receptor	0.0014	0.0036	0.0036
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.0713	0.1941
Onchocerca volvulus	Netrin receptor homolog	0.0014	0.0048	0.0012
Echinococcus multilocularis	musashi	0.0026	0.0293	0.0617
Schistosoma mansoni	hypothetical protein	0.0074	0.1286	0.274
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0158	0.3032	0.6567
Echinococcus granulosus	nuclear receptor nhr 48	0.0014	0.0036	0.0057
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0162	0.313	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0029	0.0361	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0013	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0233	0.4599	0.4599
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0029	0.0361	0.0765
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0029	0.0361	0.0765
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0074	0.1292	0.2794
Echinococcus multilocularis	Protein lozenge	0.0062	0.1032	0.2228
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0459	0.0459
Echinococcus multilocularis	transcription factor Dp 1	0.0042	0.0631	0.1353
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0029	0.0361	0.0765
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0134	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Schistosoma mansoni	hypothetical protein	0.0076	0.1334	0.2845
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0029	0.0361	0.0765
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0162	0.313	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0295	0.0549
Brugia malayi	Death domain containing protein	0.0014	0.0048	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0071	0.0071
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0048	0.0083
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0084	0.1495	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0459	0.0927
Onchocerca volvulus	Bile acid receptor homolog	0.0029	0.0361	0.0326
Echinococcus multilocularis	hormone sensitive lipase	0.0233	0.4599	1
Entamoeba histolytica	hypothetical protein	0.0076	0.1334	1
Schistosoma mansoni	coup transcription factor	0.0029	0.0361	0.0712
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0156	0.0087
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0459	0.0424
Entamoeba histolytica	hypothetical protein	0.0076	0.1334	1
Mycobacterium tuberculosis	Hypothetical protein	0.0077	0.1356	0.4086
Schistosoma mansoni	hypothetical protein	0.0034	0.0459	0.0927
Brugia malayi	follicle stimulating hormone receptor	0.0227	0.4477	0.4457
Schistosoma mansoni	lozenge	0.0062	0.1032	0.2183
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0014	0.0036	0.0057
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0162	0.313	0.678
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0073	0.1274	0.2714
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.013	0.013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0029	0.0361	0.0361
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0162	0.313	1
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0073	0.1274	0.2755
Echinococcus granulosus	jun protein	0.0085	0.1509	0.3267
Echinococcus multilocularis	lamin dm0	0.0026	0.0293	0.0617
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0459	0.0978
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0014	0.0036	0.0057
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0162	0.313	1
Mycobacterium ulcerans	thymidylate synthase	0.0162	0.313	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0014	0.0036	0.0057
Brugia malayi	ecdysteroid receptor	0.0029	0.0361	0.0326
Echinococcus granulosus	intermediate filament protein	0.0026	0.0293	0.0617
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0029	0.0361	0.0326
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0014	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.002	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.002	0.0156	0.0156
Echinococcus multilocularis	lamin	0.0026	0.0293	0.0617
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0459	0.0978
Brugia malayi	photoreceptor-specific nuclear receptor	0.0029	0.0361	0.0326
Loa Loa (eye worm)	hypothetical protein	0.002	0.0156	0.0156
Brugia malayi	nuclear hormone receptor	0.0029	0.0361	0.0326
Entamoeba histolytica	hypothetical protein	0.0076	0.1334	1
Brugia malayi	Steroid receptor seven-up type 2	0.0029	0.0361	0.0326
Schistosoma mansoni	ap endonuclease	0.0018	0.013	0.0206
Schistosoma mansoni	hypothetical protein	0.0014	0.0048	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0361	0.0361
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0016	0.0071	0.0133
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0071	0.0035
Echinococcus granulosus	GPCR family 2	0.0034	0.0459	0.0978
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0233	0.4599	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0042	0.0632	0.1673
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0014	0.0036	0.0057
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0073	0.1274	0.1274

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 834942