Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | DNA polymerase III beta clamp subunit | 0.0548 | 0.5 | 0.5 |
Mycobacterium leprae | Probable DNA polymerase III, [beta] subunit DnaN | 0.0548 | 0.5 | 0.5 |
Treponema pallidum | DNA polymerase III, subunit beta (dnaN) | 0.0548 | 0.5 | 0.5 |
Mycobacterium ulcerans | DNA polymerase III subunit beta | 0.0548 | 0.5 | 0.5 |
Mycobacterium tuberculosis | DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase) | 0.0548 | 0.5 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.