Detailed information for compound 835895

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 231.171 | Formula: C10H8F3NO2
  • H donors: 2 H acceptors: 2 LogP: 1.99 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=CC=Nc1ccccc1O)C(F)(F)F
  • InChi: 1S/C10H8F3NO2/c11-10(12,13)9(16)5-6-14-7-3-1-2-4-8(7)15/h1-6,15-16H
  • InChiKey: DDKPDWIRDHROKT-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0285 0.0459
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0081 0.3391 0.3875
Echinococcus granulosus dna polymerase eta 0.0061 0.2497 0.4027
Trypanosoma cruzi DNA damage repair protein, putative 0.0011 0.0236 0.0608
Loa Loa (eye worm) hypothetical protein 0.0055 0.2215 0.2531
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0285 0.0325
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0063 0.2605 0.2976
Chlamydia trachomatis metal transport ATPase 0.0017 0.049 1
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0054 0.2168 0.2168
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0092 0.3881 1
Brugia malayi Muscleblind-like protein 0.0143 0.6201 0.7086
Echinococcus granulosus calcium transporting atpase 0.0081 0.3391 0.5469
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0043 0.1679 0.4325
Leishmania major DNA damage repair protein, putative 0.0011 0.0236 0.0608
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0871 0.2569
Toxoplasma gondii thioredoxin reductase 0.0036 0.1358 0.3499
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0285 0.0734
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0285 0.5
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0043 0.1679 0.2707
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0285 0.0734
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0285 0.0134
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0199 0.8752 1
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0017 0.049 0.1262
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0043 0.1679 0.7741
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0285 0.084
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.1342 0.3457
Treponema pallidum cation-transporting ATPase, P-type 0.0017 0.049 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.049 0.056
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0092 0.388 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0092 0.3881 0.3881
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.1012 0.1632
Leishmania major calcium-transporting ATPase, putative 0.0043 0.1679 0.4325
Echinococcus granulosus bloom syndrome protein 0.0023 0.0758 0.1222
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0017 0.049 0.079
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0285 0.084
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0082 0.3462 0.8837
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0758 0.1222
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0236 0.0695
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0285 0.0734
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0871 0.2569
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.1391 0.2244
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0017 0.049 0.079
Mycobacterium tuberculosis Probable dehydrogenase 0.0082 0.3462 0.8837
Trypanosoma cruzi P-type H+-ATPase, putative 0.0034 0.1276 0.3289
Trypanosoma cruzi DNA damage repair protein, putative 0.0011 0.0236 0.0608
Loa Loa (eye worm) glutathione reductase 0.0036 0.1358 0.1552
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0011 0.0205 0.0529
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0043 0.1679 0.3374
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0017 0.049 0.2259
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0043 0.1679 0.2707
Trypanosoma brucei calcium-translocating P-type ATPase 0.0081 0.3391 1
Plasmodium vivax SET domain protein, putative 0.0028 0.1012 0.2607
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0272 0.0272
Schistosoma mansoni atpase class VI type 11c 0.0011 0.0205 0.0413
Trichomonas vaginalis cation-transporting ATPase, putative 0.0034 0.1276 0.1276
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0758 0.0758
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0026 0.0892 0.2298
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0082 0.3462 0.8837
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0054 0.2168 0.2168
Loa Loa (eye worm) hypothetical protein 0.0017 0.049 0.056
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0054 0.2168 0.5587
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0146 0.0235
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0285 0.0734
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0092 0.3881 0.6259
Schistosoma mansoni ATPase 0.0092 0.3881 0.7801
Mycobacterium ulcerans metal cation transporter ATPase p-type CtpE 0.0017 0.049 0.0697
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0092 0.3881 0.6259
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0285 0.0734
Plasmodium falciparum glutathione reductase 0.0013 0.0285 0.0734
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0092 0.3881 1
Brugia malayi polk-prov protein 0.0011 0.0236 0.0269
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0285 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1391 0.4103
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.1391 0.1391
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.1391 0.3078
Giardia lamblia DNA damage repair protein 0.0011 0.0236 0.1087
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1391 0.3585
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0017 0.049 0.2259
Echinococcus granulosus Na:K ATPase alpha subunit 0.0043 0.1679 0.2707
Loa Loa (eye worm) hypothetical protein 0.0061 0.2497 0.2854
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0024 0.0787 0.2027
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0082 0.3462 0.8837
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0146 0.0235
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0272 0.0702
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0011 0.0205 0.0529
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0024 0.0787 0.3628
Loa Loa (eye worm) RecQ helicase 0.0023 0.0758 0.0866
Mycobacterium ulcerans cation transporter p-type ATPase D CtpD 0.0017 0.049 0.0697
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0964 0.1555
Mycobacterium ulcerans cation-transporter p-type ATPase B CtpB 0.0017 0.049 0.0697
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0024 0.0787 0.0899
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.138 0.2225
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0092 0.3881 1
Trypanosoma cruzi cation-transporting ATPase, putative 0.0017 0.049 0.1262
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1391 0.4103
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.1012 0.1632
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.1012 0.2034
Trypanosoma brucei unspecified product 0.0025 0.0871 0.2569
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0285 0.0734
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0272 0.0702
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0017 0.049 0.056
Loa Loa (eye worm) hypothetical protein 0.0054 0.2168 0.2478
Loa Loa (eye worm) hypothetical protein 0.0143 0.6201 0.7086
Leishmania major P-type ATPase, putative 0.0043 0.1679 0.4325
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.003 0.1097 0.5061
Loa Loa (eye worm) hypothetical protein 0.0017 0.049 0.056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0502 0.0574
Schistosoma mansoni DNA helicase recq1 0.0009 0.0146 0.0293
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0017 0.049 0.1262
Loa Loa (eye worm) E1-E2 ATPase 0.0034 0.1276 0.1458
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0285 0.0734
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0539 0.1083
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0082 0.3462 0.8837
Loa Loa (eye worm) hypothetical protein 0.0011 0.0236 0.0269
Echinococcus multilocularis cation transporting ATPase 13A3 0.0017 0.049 0.079
Trypanosoma brucei calcium-transporting ATPase, putative 0.0026 0.0892 0.263
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0037 0.1382 0.2631
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.1012 0.2034
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0285 0.0734
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0134 0.0153
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0285 0.0734
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.1391 0.317
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0285 0.084
Leishmania major DNA polymerase kappa, putative 0.0037 0.1391 0.3585
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0285 0.1314
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0057 0.232 0.5979
Brugia malayi Membrane calcium atpase protein 3 0.0043 0.1679 0.1918
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.1391 0.4103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1391 0.3585
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.1391 0.4103
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0285 0.0572
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0043 0.1679 0.3374
Treponema pallidum NADH oxidase 0.0013 0.0285 0.2792
Loa Loa (eye worm) hypothetical protein 0.0092 0.3881 0.4435
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0017 0.049 0.0984
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0272 0.0803
Loa Loa (eye worm) hypothetical protein 0.0115 0.4962 0.567
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0146 0.0167
Brugia malayi hypothetical protein 0.0011 0.0205 0.0235
Trypanosoma brucei cation-transporting ATPase, putative 0.0017 0.049 0.1444
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0054 0.2168 0.5301
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0146 0.0235
Mycobacterium ulcerans cation transporter p-type ATPase a CtpA 0.0017 0.049 0.0697
Loa Loa (eye worm) hypothetical protein 0.0028 0.1012 0.1156
Plasmodium vivax DNA repair protein REV1, putative 0.0011 0.0236 0.0608
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0081 0.3391 0.6817
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0024 0.0787 0.2027
Trypanosoma cruzi proton motive ATPase 1, putative 0.0011 0.0205 0.0529
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.1391 0.159
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0017 0.049 0.049
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0285 0.0734
Loa Loa (eye worm) hypothetical protein 0.0143 0.6201 0.7086
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0011 0.0205 0.0529
Plasmodium falciparum glutathione reductase 0.0036 0.1358 0.3499
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0054 0.2168 0.2168
Loa Loa (eye worm) hypothetical protein 0.0009 0.0146 0.0167
Toxoplasma gondii cation-transporting atpase family protein 0.0011 0.0205 0.0529
Brugia malayi calcium ATPase 0.0024 0.0787 0.0899
Trypanosoma brucei chrX additional, unordered contigs 0.0011 0.0236 0.0695
Echinococcus multilocularis phosphoserine phosphatase 0.0011 0.0205 0.0331
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0054 0.2168 0.2168
Leishmania major trypanothione reductase 0.0036 0.1358 0.3499
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0285 0.0734
Leishmania major calcium motive p-type ATPase, putative 0.0043 0.1679 0.4325
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0285 0.0734
Toxoplasma gondii P-type ATPase PMA1 0.0034 0.1276 0.3289
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0017 0.049 0.1262
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.003 0.1097 0.5061
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0017 0.049 0.049
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1391 0.3585
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0011 0.0205 0.0529
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0081 0.3391 0.6817
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0285 0.0734
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0037 0.1382 0.1579
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0412 0.1062
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0043 0.1679 0.7741
Giardia lamblia DINP protein human, muc B family 0.0037 0.1391 0.6417
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.049 0.049
Plasmodium falciparum thioredoxin reductase 0.0013 0.0285 0.0734
Plasmodium vivax P-type ATPase4, putative 0.0092 0.3881 1
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0043 0.1679 0.4325
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0758 0.0758
Trypanosoma brucei copper-transporting ATPase-like protein, putative 0.0017 0.049 0.1444
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0011 0.0205 0.0529
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.1391 0.317
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0285 0.0734
Plasmodium falciparum calcium-transporting ATPase 0.0081 0.3391 0.8738
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0043 0.1679 0.2707
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.1012 0.2034
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.003 0.1097 0.1254
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.138 0.2225
Brugia malayi Pre-SET motif family protein 0.0199 0.8752 1
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0285 0.0734
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1391 0.4103
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0024 0.0787 0.0899
Brugia malayi Na,K-ATPase alpha subunit 0.0054 0.2168 0.2478
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0037 0.1382 0.1579
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0146 0.0376
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.1391 0.159
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0024 0.0787 0.2027
Giardia lamblia Phospholipid-transporting ATPase IA, putative 0.0017 0.049 0.2259
Onchocerca volvulus 0.0028 0.1012 0.1012
Leishmania major DNA polymerase eta, putative 0.0036 0.1342 0.3457
Schistosoma mansoni cation-transporting ATPase 0.0017 0.049 0.0984
Plasmodium vivax copper-transporting ATPase, putative 0.0017 0.049 0.1262
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0236 0.0608
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0017 0.049 0.049
Echinococcus multilocularis dna polymerase kappa 0.0037 0.1391 0.2244
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0236 0.0695
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0236 0.0695
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0043 0.1679 0.4949
Trichomonas vaginalis cation-transporting ATPase, putative 0.0092 0.3881 0.3881
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0236 0.0608
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0043 0.1679 0.1679
Echinococcus granulosus cation transporting ATPase 13A1 0.0017 0.049 0.079
Echinococcus granulosus dna polymerase kappa 0.0037 0.1391 0.2244
Echinococcus multilocularis calcium transporting atpase 0.0081 0.3391 0.5469
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0285 0.0734
Echinococcus granulosus phospholipid transporting ATPase VA 0.0011 0.0205 0.0331
Plasmodium vivax calcium-transporting ATPase, putative 0.0092 0.3881 1
Schistosoma mansoni type V p-type atpase isoform 0.0017 0.049 0.0984
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1391 0.4103
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0146 0.0167
Plasmodium vivax cation transporting ATPase, putative 0.0017 0.049 0.1262
Plasmodium vivax glutathione reductase, putative 0.0036 0.1358 0.3499
Schistosoma mansoni DNA polymerase IV / kappa 0.0011 0.0236 0.0474
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.1342 0.3457
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0054 0.2168 0.3496
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0081 0.3391 0.6817
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.1391 0.1391
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0285 0.0734
Trypanosoma brucei unspecified product 0.0025 0.0871 0.2569
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0011 0.0205 0.0331
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0285 0.084
Echinococcus multilocularis cation transporting ATPase 13A1 0.0017 0.049 0.079
Trypanosoma cruzi P-type H+-ATPase, putative 0.0024 0.0787 0.2027
Trichomonas vaginalis set domain proteins, putative 0.0226 1 1
Mycobacterium tuberculosis Cation transporter P-type ATPase a CtpA 0.0017 0.049 0.057
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.1391 0.3585
Echinococcus multilocularis phosphoserine phosphatase 0.0011 0.0205 0.0331
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0285 0.5
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0054 0.2168 0.6393
Plasmodium vivax thioredoxin reductase, putative 0.0036 0.1358 0.3499
Schistosoma mansoni ATPase 0.0092 0.3881 0.7801
Plasmodium falciparum thioredoxin reductase 0.0036 0.1358 0.3499
Brugia malayi E1-E2 ATPase family protein 0.0034 0.1276 0.1458
Brugia malayi glutathione reductase 0.0036 0.1358 0.1552
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0054 0.2168 0.2168
Leishmania major P-type H -ATPase, putative 0.0034 0.1276 0.3289
Giardia lamblia Copper-transporting P-type ATPase 0.0017 0.049 0.2259
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0631 0.1627
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0043 0.1679 0.3374
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.1391 0.2797
Mycobacterium ulcerans metal cation transporter p-type ATPase, CtpV 0.0017 0.049 0.0697
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0092 0.388 1
Echinococcus multilocularis phosphoserine phosphatase 0.0011 0.0205 0.0331
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0054 0.2168 0.6393
Echinococcus granulosus cation transporting ATPase 13A3 0.0017 0.049 0.079
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0285 0.0285
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0017 0.049 0.2259
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0092 0.388 1
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0037 0.1382 0.3051
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.1391 0.2797
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0054 0.2168 0.5587
Toxoplasma gondii P-type ATPase4, putative 0.0054 0.2168 0.5587
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0054 0.2168 1
Trypanosoma brucei P-type H+-ATPase, putative 0.0034 0.1276 0.3764
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1391 0.3585
Leishmania major proton motive ATPase, putative 0.0017 0.049 0.1262
Brugia malayi calcium ATPase 0.002 0.0608 0.0694
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1391 0.4103
Echinococcus multilocularis phosphoserine phosphatase 0.0011 0.0205 0.0331
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0092 0.3881 0.6259
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.1012 0.1632
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0134 0.0153
Loa Loa (eye worm) hypothetical protein 0.0024 0.0787 0.0899
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.1391 0.2244
Brugia malayi Thioredoxin reductase 0.0036 0.1358 0.1552
Echinococcus granulosus muscleblind protein 0.0143 0.6201 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0036 0.1358 0.2985
Trypanosoma brucei P-type H+-ATPase, putative 0.0034 0.1276 0.3764
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0146 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1391 0.4103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.1012 0.2034
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0043 0.1679 0.2707
Leishmania major DNA polymerase eta, putative 0.0061 0.2497 0.6435
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0017 0.049 0.1262
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0054 0.2168 1
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0758 0.0866
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0043 0.1679 0.2707
Plasmodium falciparum DNA repair protein REV1, putative 0.0011 0.0236 0.0608
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1391 0.4103
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0037 0.1382 0.3143
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase A CtpF 0.0038 0.1429 0.3181
Trypanosoma brucei unspecified product 0.0037 0.1391 0.4103
Leishmania major copper-transporting ATPase-like protein, putative 0.0017 0.049 0.1262
Schistosoma mansoni copper ABC transporter ATPase 0.0017 0.049 0.0984
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0054 0.2168 0.6393
Onchocerca volvulus 0.0054 0.2168 0.2168
Echinococcus multilocularis muscleblind protein 0.0143 0.6201 1
Loa Loa (eye worm) calcium ATPase 0.003 0.1097 0.1254
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0054 0.2168 0.2478
Mycobacterium tuberculosis Probable oxidoreductase 0.0092 0.388 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0892 0.1019
Echinococcus multilocularis phosphoserine phosphatase 0.0011 0.0205 0.0331
Schistosoma mansoni DNA helicase recq5 0.0009 0.0146 0.0293
Brugia malayi E1-E2 ATPase family protein 0.0017 0.049 0.056
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.1391 0.3078
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0054 0.2168 0.2168
Echinococcus granulosus copper transporting ATPase 1 0.0017 0.049 0.079
Brugia malayi Pre-SET motif family protein 0.0028 0.1012 0.1156
Plasmodium falciparum copper-transporting ATPase 0.0017 0.049 0.1262
Mycobacterium tuberculosis Probable cation transporter P-type ATPase D CtpD 0.0017 0.049 0.057
Mycobacterium ulcerans metal cation-transporting p-type ATPase CtpC 0.0017 0.049 0.0697
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0146 0.0235
Trypanosoma cruzi copper-transporting ATPase, putative 0.0011 0.0205 0.0529
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0054 0.2168 0.3496
Trypanosoma brucei DNA damage repair protein, putative 0.0011 0.0236 0.0695
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0054 0.2168 0.5587
Schistosoma mansoni phosphoserine phosphatase 0.0011 0.0205 0.0413
Mycobacterium tuberculosis Probable reductase 0.0082 0.3462 0.8837
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.042 0.1083
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0017 0.049 0.056
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0146 0.0376
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0054 0.2168 0.5587
Trypanosoma cruzi DNA polymerase eta, putative 0.0061 0.2497 0.6435
Trichomonas vaginalis cation-transporting ATPase, putative 0.0054 0.2168 0.2168
Leishmania major calcium-translocating P-type ATPase 0.0092 0.3881 1
Leishmania major P-type H -ATPase, putative 0.0034 0.1276 0.3289
Mycobacterium tuberculosis Probable metal cation transporter P-type ATPase CtpV 0.0017 0.049 0.057
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0272 0.1257
Loa Loa (eye worm) thioredoxin reductase 0.0036 0.1358 0.1552
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.1358 0.3499
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0011 0.0236 0.0608
Echinococcus granulosus cation transporting atpase worm 0.0017 0.049 0.079
Trypanosoma brucei DNA polymerase eta, putative 0.0061 0.2497 0.7364
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0236 0.0608
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0043 0.1679 0.4325
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0146 0.0673
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1391 0.4103
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0285 0.0285
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0082 0.3462 0.8767
Schistosoma mansoni cation-transporting atpase worm 0.0017 0.049 0.0984
Echinococcus multilocularis phosphoserine phosphatase 0.0011 0.0205 0.0331
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.1012 0.2607
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0017 0.049 0.2259
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0092 0.3881 1
Trypanosoma brucei DNA damage repair protein, putative 0.0011 0.0236 0.0695
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0054 0.2168 1
Mycobacterium tuberculosis Probable metal cation transporter ATPase P-type CtpE 0.0017 0.049 0.057
Echinococcus multilocularis dna polymerase eta 0.0061 0.2497 0.4027
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0054 0.2168 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1391 0.4103
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0871 0.2569
Echinococcus multilocularis copper transporting ATPase 1 0.0017 0.049 0.079
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0054 0.2168 0.5587
Trypanosoma cruzi P-type H+-ATPase, putative 0.0034 0.1276 0.3289
Schistosoma mansoni cation-transporting atpase worm 0.0017 0.049 0.0984
Schistosoma mansoni DNA polymerase eta 0.0061 0.2497 0.502
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1391 0.4103
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.1391 0.4103
Trypanosoma brucei trypanothione reductase 0.0036 0.1358 0.4004
Echinococcus multilocularis cation transporting atpase worm 0.0017 0.049 0.079
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0285 0.0459
Echinococcus multilocularis muscleblind protein 1 0.0143 0.6201 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.1391 0.6417
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0285 0.0734
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0285 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0236 0.0695
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0285 0.0734
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.2497 0.2854
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0063 0.2605 0.2976
Loa Loa (eye worm) hypothetical protein 0.002 0.0608 0.0694
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0146 0.0167
Leishmania major DNA polymerase kappa, putative 0.0011 0.0236 0.0608
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0054 0.2168 1
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0054 0.2168 0.4358
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0092 0.3881 0.6259

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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