Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0064 | 0.0782 | 0.0538 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0089 | 0.2311 | 0.5 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.0066 | 0.0899 | 0.0657 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0064 | 0.0782 | 0.0538 |
Loa Loa (eye worm) | vacuolar H ATPase family member | 0.0066 | 0.0899 | 0.0657 |
Echinococcus granulosus | ATP synthase subunit beta mitochondrial | 0.0066 | 0.0899 | 0.0657 |
Echinococcus granulosus | nervana 2 | 0.0064 | 0.0782 | 0.0538 |
Echinococcus multilocularis | nervana 2 | 0.0064 | 0.0782 | 0.0538 |
Trypanosoma brucei | V-type ATPase, A subunit, putative | 0.0066 | 0.0899 | 0.0899 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0064 | 0.0782 | 0.0538 |
Schistosoma mansoni | ATP synthase beta subunit | 0.0066 | 0.0899 | 0.0657 |
Plasmodium vivax | vacuolar ATP synthase subunit b, putative | 0.0213 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.0064 | 0.0782 | 0.0538 |
Entamoeba histolytica | V-type ATPase, B subunit, putative | 0.0213 | 1 | 1 |
Echinococcus granulosus | vacuolar ATP synthase subunit b | 0.0213 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0782 | 0.0538 |
Echinococcus granulosus | nervana 2 | 0.0064 | 0.0782 | 0.0538 |
Brugia malayi | ATP synthase beta chain, mitochondrial precursor, putative | 0.0066 | 0.0899 | 0.0657 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0782 | 0.0538 |
Plasmodium falciparum | V-type proton ATPase catalytic subunit A | 0.0066 | 0.0899 | 0.0657 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0064 | 0.0782 | 0.0538 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0089 | 0.2311 | 0.2107 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0089 | 0.2311 | 0.5 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.0066 | 0.0899 | 0.0657 |
Toxoplasma gondii | vacuolar ATP synthase subunit A, putative | 0.0066 | 0.0899 | 0.0657 |
Trichomonas vaginalis | ATP synthase beta subunit, putative | 0.0066 | 0.0899 | 0.0657 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0213 | 1 | 1 |
Leishmania major | vacuolar proton translocating ATPase subunit A, putative | 0.0055 | 0.0258 | 0.0258 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0089 | 0.2311 | 0.2107 |
Chlamydia trachomatis | V-type ATP synthase subunit B | 0.0213 | 1 | 1 |
Plasmodium vivax | ATP synthase subunit beta, mitochondrial, putative | 0.0066 | 0.0899 | 0.0657 |
Leishmania major | vacuolar ATP synthase catalytic subunit A, putative | 0.0066 | 0.0899 | 0.0899 |
Trichomonas vaginalis | ATP synthase alpha subunit mitochondrial, putative | 0.0213 | 1 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0064 | 0.0782 | 0.0538 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0089 | 0.2311 | 1 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0089 | 0.2311 | 0.5 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0064 | 0.0782 | 0.0538 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0089 | 0.2311 | 0.5 |
Echinococcus granulosus | vacuolar H ATPase v1 sector subunit A | 0.0066 | 0.0899 | 0.0657 |
Trypanosoma cruzi | Vacuolar proton pump subunit B, putative | 0.0213 | 1 | 1 |
Trypanosoma brucei | ATP synthase subunit beta, mitochondrial | 0.0066 | 0.0899 | 0.0899 |
Plasmodium falciparum | ATP synthase subunit beta, mitochondrial | 0.0066 | 0.0899 | 0.0657 |
Giardia lamblia | Vacuolar ATP synthase subunit B | 0.0213 | 1 | 1 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0064 | 0.0782 | 0.0538 |
Echinococcus multilocularis | vacuolar ATP synthase subunit b | 0.0213 | 1 | 1 |
Schistosoma mansoni | ATP synthase alpha subunit vacuolar | 0.0066 | 0.0899 | 0.0657 |
Leishmania major | ATPase beta subunit, putative | 0.0066 | 0.0899 | 0.0899 |
Echinococcus multilocularis | nervana 2 | 0.0064 | 0.0782 | 0.0538 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0064 | 0.0782 | 0.0538 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0064 | 0.0782 | 0.0538 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0089 | 0.2311 | 1 |
Trypanosoma cruzi | ATP synthase subunit beta, mitochondrial, putative | 0.0066 | 0.0899 | 0.0657 |
Echinococcus multilocularis | nervana 2 | 0.0064 | 0.0782 | 0.0538 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0089 | 0.2311 | 1 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0089 | 0.2311 | 0.2107 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0064 | 0.0782 | 0.0538 |
Schistosoma mansoni | transmemberane protein | 0.0064 | 0.0782 | 0.0538 |
Trypanosoma brucei | V-type proton ATPase subunit a, putative | 0.0055 | 0.0258 | 0.0258 |
Schistosoma mansoni | ATP synthase subunit beta vacuolar | 0.0213 | 1 | 1 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0089 | 0.2311 | 0.2107 |
Leishmania major | ATPase beta subunit, putative | 0.0066 | 0.0899 | 0.0899 |
Brugia malayi | vacuolar ATP synthase catalytic subunit A, osteoclast isoform | 0.0066 | 0.0899 | 0.0657 |
Plasmodium falciparum | V-type proton ATPase subunit B | 0.0213 | 1 | 1 |
Trichomonas vaginalis | ATP synthase, putative | 0.0213 | 1 | 1 |
Toxoplasma gondii | vacuolar ATP synthase subunit b, putative | 0.0213 | 1 | 1 |
Loa Loa (eye worm) | vacuolar ATP synthase subunit B | 0.0213 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.0064 | 0.0782 | 0.0538 |
Plasmodium vivax | vacuolar ATP synthase catalytic subunit A, putative | 0.0066 | 0.0899 | 0.0657 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0089 | 0.2311 | 0.2107 |
Echinococcus multilocularis | ATP synthase subunit beta, mitochondrial | 0.0066 | 0.0899 | 0.0657 |
Leishmania major | vacuolar ATP synthase subunit b, putative | 0.0213 | 1 | 1 |
Leishmania major | vacuolar proton-ATPase-like protein, putative | 0.0055 | 0.0258 | 0.0258 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0064 | 0.0782 | 0.0538 |
Echinococcus multilocularis | nervana 2 | 0.0064 | 0.0782 | 0.0538 |
Echinococcus multilocularis | vacuolar H+ ATPase v1 sector subunit A | 0.0066 | 0.0899 | 0.0657 |
Toxoplasma gondii | ATP synthase beta subunit ATP-B | 0.0066 | 0.0899 | 0.0657 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0213 | 1 | 1 |
Entamoeba histolytica | V-type ATPase, A subunit, putative | 0.0066 | 0.0899 | 0.0657 |
Giardia lamblia | Vacuolar ATP synthase catalytic subunit A | 0.0066 | 0.0899 | 0.0657 |
Trypanosoma brucei | Vacuolar proton pump subunit B, putative | 0.0213 | 1 | 1 |
Trypanosoma cruzi | V-type proton ATPase subunit B, putative | 0.0213 | 1 | 1 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0089 | 0.2311 | 0.2107 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0064 | 0.0782 | 0.0538 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency ratio (binding) | = 1.4 | Inhibition of V-ATPase-driven proton transport in membrane vesicles derived from bovine chromaffin granules (bCG); Potency ratio expressed as IC50 of compound/IC50 of baf A1 | ChEMBL. | 9599238 |
Potency ratio (binding) | = 2 | Inhibition of V-ATPase-driven proton transport in membrane vesicles derived from chicken osteoclasts (cOc); Potency ratio expressed as IC50 of compound/IC50 of baf A1 | ChEMBL. | 9599238 |
Potency ratio (binding) | = 1.4 | Inhibition of V-ATPase-driven proton transport in membrane vesicles derived from bovine chromaffin granules (bCG); Potency ratio expressed as IC50 of compound/IC50 of baf A1 | ChEMBL. | 9599238 |
Potency ratio (binding) | = 2 | Inhibition of V-ATPase-driven proton transport in membrane vesicles derived from chicken osteoclasts (cOc); Potency ratio expressed as IC50 of compound/IC50 of baf A1 | ChEMBL. | 9599238 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.