Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0104 | 0.0187 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0104 | 0.0187 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0078 | 0.3151 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0104 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0104 | 0.0227 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0104 | 0.0227 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.1489 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0104 | 0.0227 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.1284 | 0.1204 |
Onchocerca volvulus | 0.001 | 0.0104 | 0.0039 | |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0104 | 0.0227 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.5107 | 0.9212 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1284 | 0.8533 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0078 | 0.3151 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.1284 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.1284 | 0.1204 |
Onchocerca volvulus | 0.0036 | 0.1284 | 0.3898 | |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.1284 | 0.1204 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0104 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1284 | 0.2818 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.1489 | 0.3268 |
Onchocerca volvulus | 0.0036 | 0.1284 | 0.3898 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1924 | 0.3767 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.1489 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.1284 | 0.1204 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0398 | 0.0719 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0104 | 0.0227 |
Brugia malayi | beta-lactamase | 0.0036 | 0.1284 | 0.2818 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.1284 | 0.8533 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1924 | 0.347 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.1284 | 0.3898 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0104 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1284 | 0.2818 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0104 | 0.0227 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0078 | 0.3151 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.1489 | 0.4568 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0104 | 0.0227 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.1489 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0398 | 0.0719 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.1284 | 0.1204 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.1284 | 0.3898 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0104 | 0.0187 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.001 | 0.0092 | 0.0201 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0398 | 0.0719 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1924 | 0.4222 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0092 | 0.0201 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0104 | 0.0187 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0104 | 0.0203 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.1489 | 0.2686 |
Brugia malayi | MH2 domain containing protein | 0.0109 | 0.4557 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1284 | 0.8533 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0104 | 0.0203 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0078 | 0.3151 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1284 | 0.2818 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1924 | 0.347 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0104 | 0.0203 |
Schistosoma mansoni | zinc binding dehydrogenase | 0.001 | 0.0092 | 0.0165 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.1284 | 0.1204 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0104 | 0.0039 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.1489 | 0.4568 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0104 | 0.0203 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.5544 | 1 |
Brugia malayi | Alcohol dehydrogenase class III | 0.0078 | 0.3151 | 0.6915 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0078 | 0.3151 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0104 | 0.0227 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0104 | 0.0187 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.1489 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1247 | 0.2737 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0104 | 0.0227 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.1284 | 0.8533 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.1489 | 0.2916 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.001 | 0.0092 | 0.0201 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0398 | 0.078 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0104 | 0.0187 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0104 | 0.0203 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0104 | 0.0039 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.1284 | 0.2818 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.1284 | 0.8533 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0104 | 0.0227 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.1284 | 0.3898 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.1284 | 0.8533 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.1284 | 0.3898 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0104 | 0.0227 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0078 | 0.3151 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0104 | 0.0227 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1979 | 0.4343 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0104 | 0.0203 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0104 | 0.0227 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0104 | 0.0187 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1924 | 0.347 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0104 | 0.0187 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0104 | 0.0187 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.1284 | 0.1204 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.1489 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0132 | 0.5544 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0104 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0104 | 0.0227 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1924 | 0.347 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.1284 | 0.2316 |
Echinococcus multilocularis | mitochondrial trans 2 enoyl coenzyme A reductase | 0.001 | 0.0092 | 0.0165 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.1284 | 0.2316 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1924 | 0.347 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1924 | 0.4222 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1284 | 0.2818 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0078 | 0.3151 | 0.3088 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0104 | 0.0227 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.1489 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0037 | 0.1298 | 0.3944 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.1284 | 0.3898 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.1489 | 0.2686 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0398 | 0.0719 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1979 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1979 | 0.4343 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1247 | 0.225 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.1284 | 0.2818 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.1284 | 0.8533 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0.1489 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0104 | 0.0187 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0078 | 0.3151 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0104 | 0.0227 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0104 | 0.0227 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.1284 | 0.3898 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0104 | 0.0227 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0037 | 0.1298 | 0.1218 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0398 | 0.0874 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0104 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0092 | 0.0201 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0104 | 0.0187 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0398 | 0.078 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0104 | 0.0039 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.1284 | 0.8533 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0398 | 0.0719 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0104 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0104 | 0.0227 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0104 | 0.0187 |
Onchocerca volvulus | 0.0036 | 0.1284 | 0.3898 | |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0398 | 0.0719 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0104 | 0.0227 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0104 | 0.0203 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0104 | 0.0187 |
Schistosoma mansoni | thyroid hormone receptor | 0.0132 | 0.5544 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.1284 | 0.2316 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0104 | 0.0227 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0069 | 0.2726 | 0.2659 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.1284 | 0.2818 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0104 | 0.0187 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.1284 | 0.1204 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0104 | 0.0203 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.1284 | 0.2818 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0398 | 0.078 |
Brugia malayi | Inositol-1 | 0.0041 | 0.1489 | 0.3268 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.5107 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.5107 | 0.9212 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.1284 | 0.1204 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.1489 | 0.2686 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1247 | 0.2737 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1284 | 0.2818 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0398 | 0.0874 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1284 | 0.8533 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.1284 | 0.8533 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0104 | 0.0203 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0104 | 0.0187 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0104 | 0.0227 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0104 | 0.0187 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0104 | 0.0227 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0109 | 0.4557 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0104 | 0.0227 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0104 | 0.0227 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.1284 | 0.1204 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0078 | 0.3151 | 0.6915 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1979 | 0.4343 |
Echinococcus granulosus | mitochondrial trans 2 enoyl coenzyme A reductase | 0.001 | 0.0092 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1284 | 0.2818 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0104 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0092 | 0.0201 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.1489 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0104 | 0.0227 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.1284 | 0.3898 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0104 | 0.0227 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.1284 | 0.2818 |
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0069 | 0.2726 | 0.2659 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0109 | 0.4557 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0398 | 0.0719 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0104 | 0.0227 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0078 | 0.3151 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0104 | 0.0227 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0398 | 0.0874 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1924 | 0.3767 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.1489 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.1284 | 0.3898 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.1284 | 0.2514 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0104 | 0.0187 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0078 | 0.3151 | 0.5684 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0104 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0104 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0398 | 0.0874 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.