Detailed information for compound 839728

Basic information

Technical information
  • TDR Targets ID: 839728
  • Name: 3-(2,4-dichlorophenoxy)-3-phenyl-2-benzofuran -1-one
  • MW: 371.213 | Formula: C20H12Cl2O3
  • H donors: 0 H acceptors: 1 LogP: 5.88 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)OC1(OC(=O)c2c1cccc2)c1ccccc1
  • InChi: 1S/C20H12Cl2O3/c21-14-10-11-18(17(22)12-14)24-20(13-6-2-1-3-7-13)16-9-5-4-8-15(16)19(23)25-20/h1-12H
  • InChiKey: LALFUOOYRZJLJF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(2,4-dichlorophenoxy)-3-phenyl-isobenzofuran-1-one
  • 3-(2,4-dichlorophenoxy)-3-phenyl-1-isobenzofuranone
  • AK-968/36802017
  • Oprea1_792775
  • BIM-0020195.P001
  • CBMicro_020365

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0005 0.0005 0.0005
Brugia malayi Fli-1 protein 0.0223 0.1586 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0008 0.0022 0.0107
Schistosoma mansoni hypothetical protein 0.0025 0.0152 0.0167
Echinococcus granulosus Niemann Pick C1 protein 0.0073 0.0499 0.0564
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0018 0.0096 0.009
Toxoplasma gondii ATPase, AAA family protein 0.0007 0.0021 0.0608
Mycobacterium tuberculosis Probable transcriptional regulatory protein (LuxR-family) 0.138 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0107
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0008 0.0022 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0196 1
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0007 0.0021 0.0608
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0008 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0099
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0096 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0008 0.0022 0.1446
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0005 0.0006 0.0001
Schistosoma mansoni cpg binding protein 0.0021 0.0123 0.0134
Echinococcus granulosus expressed conserved protein 0.0069 0.0467 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0008 0.0022 0.0107
Echinococcus multilocularis sterol regulatory element binding protein 0.0031 0.0196 0.0217
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.0063 0.0063
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0012 0.0053 0.0301
Loa Loa (eye worm) hypothetical protein 0.0018 0.0096 0.0572
Brugia malayi hypothetical protein 0.0027 0.0162 0.0992
Schistosoma mansoni topbp1 0.0007 0.0021 0.0018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0008 0.0022 0.0019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0012 0.0053 0.0054
Echinococcus multilocularis microtubule associated protein 2 0.1211 0.8773 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0096 0.009
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0096 0.0572
Brugia malayi Niemann-Pick C1 protein precursor 0.0073 0.0499 0.3126
Schistosoma mansoni gabp alpha 0.0073 0.0501 0.0565
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0007 0.0021 0.0016
Brugia malayi hypothetical protein 0.0007 0.0021 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0022 0.0107
Schistosoma mansoni steroid hormone receptor ad4bp 0.0008 0.0022 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0096 0.009
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0045 0.0251
Echinococcus granulosus mixed lineage leukemia protein mll 0.0005 0.0006 0.0001
Brugia malayi steroid hormone receptor 0.0008 0.0022 0.0107
Onchocerca volvulus 0.0007 0.0021 0.1326
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0045 0.0045
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0007 0.0021 0.0934
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0005 0.0005 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0099
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0045 0.0045
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.0006 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0008 0.0022 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0008 0.0022 0.0107
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0008 0.0022 0.0019
Brugia malayi Steroid receptor seven-up type 2 0.0008 0.0022 0.0107
Loa Loa (eye worm) hypothetical protein 0.0013 0.0063 0.0367
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0107
Toxoplasma gondii histone lysine methyltransferase SET1 0.004 0.0261 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0012 0.0053 0.0301
Schistosoma mansoni ets-related 0.0011 0.0045 0.0045
Echinococcus multilocularis dnaJ subfamily B 0.0304 0.2177 0.2477
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0096 0.0572
Loa Loa (eye worm) hypothetical protein 0.0018 0.0096 0.0572
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0005 0.0005 0.0005
Mycobacterium tuberculosis Probable transcriptional regulatory protein 0.138 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0012 0.0053 0.0054
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0007 0.0021 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0021 0.0934
Brugia malayi hypothetical protein 0.0007 0.0021 0.0099
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0007 0.0021 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0008 0.0022 0.0107
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0107
Schistosoma mansoni transcription factor LCR-F1 0.0027 0.0162 0.0179
Echinococcus multilocularis GPCR, family 2 0.0012 0.0053 0.0054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0022 0.0019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0012 0.0053 0.0054
Brugia malayi nuclear receptor NHR-88 0.0008 0.0022 0.0107
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0013 0.0063 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0008 0.0022 0.0019
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0005 0.0005 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0021 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0005 0.0005 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0058 0.0058
Echinococcus granulosus ecdysone induced protein 78C 0.0008 0.0022 0.0019
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0045 0.0045
Brugia malayi Ets-domain containing protein 0.0073 0.0501 0.3134
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0501 0.3134
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0005 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0013 0.0063 0.0367
Brugia malayi CXXC zinc finger family protein 0.0021 0.0123 0.0744
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0008 0.0022 0.0107
Echinococcus multilocularis protein dispatched 1 0.0036 0.0228 0.0254
Brugia malayi Ets-domain containing protein 0.0011 0.0045 0.0251
Echinococcus granulosus dnaJ subfamily B 0.0304 0.2177 0.2477
Plasmodium falciparum replication factor C subunit 1, putative 0.0007 0.0021 0.2682
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.0096 0.183
Loa Loa (eye worm) fli-1 protein 0.0223 0.1586 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0005 0.0005 0.0005
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0096 0.009
Mycobacterium ulcerans two component transcriptional regulatory protein DevR 0.138 1 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0013 0.0063 1
Entamoeba histolytica hypothetical protein 0.0027 0.0162 0.3171
Schistosoma mansoni hypothetical protein 0.003 0.0188 0.0208
Loa Loa (eye worm) hypothetical protein 0.0013 0.0063 0.0367
Entamoeba histolytica hypothetical protein 0.0027 0.0162 0.3171
Trypanosoma cruzi FHA domain containing protein, putative 0.0007 0.0021 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0022 0.0019
Mycobacterium ulcerans two component transcriptional regulator 0.138 1 1
Schistosoma mansoni hypothetical protein 0.0012 0.0053 0.0054
Schistosoma mansoni hypothetical protein 0.0011 0.0045 0.0045
Brugia malayi CHE-14 protein 0.0031 0.0196 0.1206
Schistosoma mansoni chromosome transmission fidelity factor 0.0007 0.0021 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0021 0.0934
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0022 0.0107
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0074 0.0508 0.0573
Loa Loa (eye worm) hypothetical protein 0.0025 0.0152 0.0927
Schistosoma mansoni hypothetical protein 0.0012 0.0053 0.0054
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.0006 0.0001
Giardia lamblia Replication factor C, subunit 1 0.0007 0.0021 0.5
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0045 0.0045
Mycobacterium ulcerans acyl-CoA synthetase 0.0018 0.0096 0.009
Schistosoma mansoni cpg binding protein 0.0023 0.0132 0.0144
Loa Loa (eye worm) hypothetical protein 0.0013 0.0063 0.0367
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0018 0.0096 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0008 0.0022 0.0107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0022 0.0019
Schistosoma mansoni hypothetical protein 0.0012 0.0053 0.0054
Mycobacterium ulcerans nitrate/nitrite response regulator protein NarL 0.138 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0123 0.0744
Onchocerca volvulus Bile acid receptor homolog 0.0008 0.0022 0.1446
Brugia malayi DKFZp564C0469 protein 0.0007 0.0021 0.0099
Echinococcus multilocularis thyroid hormone receptor alpha 0.0008 0.0022 0.0019
Trichomonas vaginalis replication factor C large subunit, putative 0.0007 0.0021 0.0934
Echinococcus multilocularis ets variant gene 4 0.0011 0.0045 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0096 1
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0063 1
Echinococcus multilocularis cpg binding protein 0.0023 0.0132 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0008 0.0022 0.0107
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0045 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0058 0.0058
Brugia malayi ecdysteroid receptor 0.0008 0.0022 0.0107
Echinococcus multilocularis Niemann Pick C1 protein 0.0073 0.0499 0.0564
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0251
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0008 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0196 0.1206
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0022 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0022 0.0107
Echinococcus granulosus microtubule associated protein 2 0.1211 0.8773 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0005 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0247 0.1531
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.0301
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0022 0.0107
Brugia malayi topoisomerase 0.0007 0.0021 0.0099
Entamoeba histolytica hypothetical protein 0.0027 0.0162 0.3171
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0007 0.0021 1
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0501 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0021 0.0934
Leishmania major 4-coumarate:coa ligase-like protein 0.0018 0.0096 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0007 0.0021 0.0315
Schistosoma mansoni cpg binding protein 0.0023 0.0132 0.0144
Brugia malayi Ets-domain containing protein 0.0073 0.0501 0.3134
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0821 0.5935 0.6764
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0096 0.0572
Echinococcus granulosus cpg binding protein 0.0023 0.0132 0.0144
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0007 0.0021 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0016 0.0012
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0016 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0022 0.0107
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0027 0.0162 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0008 0.0022 0.0107
Onchocerca volvulus 0.0021 0.0123 1
Brugia malayi latrophilin 2 splice variant baaae 0.0025 0.0152 0.0927
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0008 0.0022 0.0019
Brugia malayi Pax transcription activation domain interacting protein 0.0007 0.0021 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0022 0.0107
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0099
Plasmodium vivax replication factor C subunit 1, putative 0.0007 0.0021 0.2682
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0045 0.0045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0027 0.0162 0.0179
Mycobacterium tuberculosis Probable transcriptional regulatory protein (probably LuxR/UhpA-family) 0.138 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0005 0.0005 0.0005
Loa Loa (eye worm) steroid hormone receptor 0.0008 0.0022 0.0107
Brugia malayi transcription factor E74 isoform 0.0011 0.0045 0.0251
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0045 0.0251
Onchocerca volvulus 0.0008 0.0022 0.1446
Schistosoma mansoni coup transcription factor 0.0008 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0237 0.1466
Schistosoma mansoni topbp1 0.0007 0.0021 0.0018
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0008 0.0022 0.0107
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0007 0.0021 0.0934
Mycobacterium ulcerans hypothetical protein 0.138 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0107
Echinococcus multilocularis protein C ets 2 0.0011 0.0045 0.0045
Echinococcus multilocularis expressed conserved protein 0.0069 0.0467 0.0527
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0045 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.0297 0.0332
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0008 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0107
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0045 0.0251
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0008 0.0022 0.0019
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0501 0.0565
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0007 0.0021 0.0099
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0045 0.0045
Entamoeba histolytica acyl-CoA synthetase, putative 0.0018 0.0096 0.183
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0012 0.0053 0.0054
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0018 0.0096 0.009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0096 0.009
Schistosoma mansoni hypothetical protein 0.0027 0.0162 0.0179
Entamoeba histolytica hypothetical protein 0.0027 0.0162 0.3171
Schistosoma mansoni retinoic acid receptor RXR 0.0008 0.0022 0.0019
Schistosoma mansoni ets-related 0.0223 0.1586 0.1803
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0073 0.0499 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0008 0.0022 0.1446
Echinococcus multilocularis nibrin 0.0007 0.0021 0.0018
Schistosoma mansoni patched 1 0.0031 0.0196 0.0217
Onchocerca volvulus 0.0018 0.0096 0.7697
Schistosoma mansoni elf1 0.0011 0.0045 0.0045
Echinococcus granulosus Protein patched homolog 1 0.0031 0.0196 0.0217
Mycobacterium tuberculosis Possible nitrate/nitrite response transcriptional regulatory protein NarL 0.138 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0107
Mycobacterium ulcerans putative regulatory protein 0.138 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0008 0.0022 0.0019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0006 0.0001
Echinococcus multilocularis protein patched 0.0031 0.0196 0.0217
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0008 0.0022 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0096 0.0096
Mycobacterium tuberculosis Possible two component transcriptional regulatory protein (probably LuxR-family) 0.138 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0037 0.0237 0.1466
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0008 0.0022 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0021 0.0934
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0251
Echinococcus granulosus replication factor c subunit 1 0.0007 0.0021 0.0018
Mycobacterium tuberculosis Possible transcriptional regulatory protein 0.138 1 1
Schistosoma mansoni hypothetical protein 0.003 0.0188 0.0208
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.0727 0.0824
Loa Loa (eye worm) hypothetical protein 0.0018 0.0096 0.0572
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0045 0.0251
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0045 0.0251
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0045 0.0045
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0045 0.0045
Echinococcus granulosus GPCR family 2 0.0012 0.0053 0.0054
Echinococcus granulosus protein C ets 2 0.0011 0.0045 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0008 0.0022 0.0107
Trichomonas vaginalis antibiotic synthetase, putative 0.0005 0.0005 0.0127
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0099
Schistosoma mansoni hypothetical protein 0.003 0.0188 0.0208
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0022 0.0019
Schistosoma mansoni hypothetical protein 0.003 0.0188 0.0208
Brugia malayi photoreceptor-specific nuclear receptor 0.0008 0.0022 0.0107
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0013 0.0063 0.0058
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0031 0.0196 0.1206
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.0015 0.0062
Brugia malayi Latrophilin receptor protein 2 0.0012 0.0053 0.0301
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0045 0.0045
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0007 0.0021 0.0934
Loa Loa (eye worm) hypothetical protein 0.0013 0.0063 0.0367
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0037 0.0237 0.1466
Entamoeba histolytica acyl-coA synthetase, putative 0.0018 0.0096 0.183
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0016 0.0066
Brugia malayi nuclear hormone receptor 0.0008 0.0022 0.0107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0063 0.0423 0.2645
Echinococcus multilocularis ecdysone induced protein 78C 0.0008 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0099
Echinococcus granulosus sterol regulatory element binding protein 0.0031 0.0196 0.0217
Schistosoma mansoni RAR-like nuclear receptor 0.0008 0.0022 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0022 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0008 0.0022 0.0107
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0008 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0107
Trichomonas vaginalis antibiotic synthetase, putative 0.0005 0.0005 0.0127
Brugia malayi Calcitonin receptor-like protein seb-1 0.0037 0.0237 0.1466
Schistosoma mansoni ets 0.0011 0.0045 0.0045
Schistosoma mansoni microtubule-associated protein tau 0.1211 0.8773 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0022 0.0107
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0099
Loa Loa (eye worm) hypothetical protein 0.0073 0.0499 0.3126
Treponema pallidum DNA ligase (lig) 0.0007 0.0021 0.5
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0022 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0096 0.009
Echinococcus granulosus FTZ F1 alpha 0.0008 0.0022 0.0019
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.0727 0.0824
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0007 0.0021 0.0934
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0005 0.0005 0.0005
Echinococcus granulosus nibrin 0.0007 0.0021 0.0018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0058 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0007 0.0021 1
Schistosoma mansoni hypothetical protein 0.0304 0.2177 0.2477
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0008 0.0022 0.0019
Schistosoma mansoni hypothetical protein 0.0011 0.0045 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0008 0.0022 0.0107
Echinococcus multilocularis replication factor c subunit 1 0.0007 0.0021 0.0018
Schistosoma mansoni DNA ligase IV 0.0007 0.0021 0.0018
Entamoeba histolytica hypothetical protein 0.0007 0.0021 0.0315
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0005 0.0005 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.0008 0.0022 0.0019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0008 0.0022 0.0107
Mycobacterium ulcerans hypothetical protein 0.0018 0.0096 0.009
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0045 0.0045
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0018 0.0096 0.009
Schistosoma mansoni hypothetical protein 0.0012 0.0053 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0021 0.0934

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.