TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 456.364 | Formula: C16H20N6O10
H donors: 8 H acceptors: 12 LogP: -2.7 Rotable bonds: 9
Rule of 5 violations (Lipinski): 3
SMILES: OCC1OC([C@H]([C@@H]1O)O)n1nc(c2c1nc(N)nc2O)C(=O)N[C@H](C(=O)O)CCC(=O)O
InChi: 1S/C16H20N6O10/c17-16-19-11-7(12(28)20-16)8(13(29)18-4(15(30)31)1-2-6(24)25)21-22(11)14-10(27)9(26)5(3-23)32-14/h4-5,9-10,14,23,26-27H,1-3H2,(H,18,29)(H,24,25)(H,30,31)(H3,17,19,20,28)/t4-,5?,9-,10?,14?/m0/s1
InChiKey: UQYNDRQWVKEPEB-BPBVSYRNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Papain family cysteine protease containing protein	0.016	0.1367	0.1367
Entamoeba histolytica	cysteine protease, putative	0.016	0.1367	1
Echinococcus granulosus	cathepsin l1	0.0115	0.0813	0.0813
Echinococcus multilocularis	cathepsin L cysteine protease	0.016	0.1367	0.1367
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0676	0.0676
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Onchocerca volvulus		0.0073	0.029	0.2125
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0117	0.0841	0.0841
Entamoeba histolytica	cysteine proteinase, putative	0.016	0.1367	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Trypanosoma cruzi	cysteine peptidase, putative	0.0094	0.0554	0.0554
Brugia malayi	cathepsin L-like precursor	0.0115	0.0813	0.0813
Trypanosoma cruzi	cysteine peptidase, putative	0.016	0.1367	0.1367
Echinococcus multilocularis	cathepsin b	0.0853	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0853	1	1
Brugia malayi	Cathepsin L-like precursor	0.016	0.1367	0.1367
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.016	0.1367	0.1367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1367	0.3201
Toxoplasma gondii	cathepsin CPL	0.016	0.1367	0.4419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.016	0.1367	0.4419
Entamoeba histolytica	cysteine proteinase, putative	0.0094	0.0554	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.0813	0.2627
Echinococcus granulosus	cathepsin l1	0.016	0.1367	0.1367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1367	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0298	0.3093	1
Giardia lamblia	Cathepsin B precursor	0.0298	0.3093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Echinococcus granulosus	cathepsin L cysteine protease	0.0094	0.0554	0.0554
Loa Loa (eye worm)	calpain family protein 1	0.0086	0.0456	0.0456
Onchocerca volvulus		0.0115	0.0813	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0637	0.0637
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0298	0.3093	0.3093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1367	0.3201
Echinococcus granulosus	cathepsin L cysteine proteinase	0.016	0.1367	0.1367
Brugia malayi	Papain family cysteine protease containing protein	0.0094	0.0554	0.0554
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1367	0.3201
Entamoeba histolytica	cysteine proteinase 2	0.0094	0.0554	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.016	0.1367	0.4419
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0298	0.3093	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0298	0.3093	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0456	0.0456
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.016	0.1367	0.4419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.016	0.1367	0.4419
Echinococcus granulosus	cathepsin L	0.0094	0.0554	0.0554
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Entamoeba histolytica	cysteine proteinase 1, putative	0.0094	0.0554	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1367	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.016	0.1367	1
Echinococcus multilocularis	cathepsin b	0.0853	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0094	0.0554	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1367	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.016	0.1367	0.4419
Echinococcus multilocularis	cathepsin L cysteine protease	0.016	0.1367	0.1367
Loa Loa (eye worm)	cathepsin B	0.0298	0.3093	0.3093
Loa Loa (eye worm)	hypothetical protein	0.016	0.1367	0.1367
Brugia malayi	Cathepsin L-like precursor	0.016	0.1367	0.1367
Entamoeba histolytica	cysteine proteinase, putative	0.0115	0.0813	0.5946
Onchocerca volvulus	Cathepsin L homolog	0.016	0.1367	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Onchocerca volvulus		0.016	0.1367	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0637	0.0637
Schistosoma mansoni	cathepsin F (C01 family)	0.0115	0.0813	0.0813
Plasmodium vivax	vivapain-3	0.0094	0.0554	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.016	0.1367	0.4419
Brugia malayi	Papain family cysteine protease containing protein	0.0094	0.0554	0.0554
Onchocerca volvulus	Cathepsin L homolog	0.016	0.1367	1
Entamoeba histolytica	cysteine proteinase, putative	0.0094	0.0554	0.4054
Echinococcus granulosus	cathepsin b	0.0853	1	1
Brugia malayi	Cathepsin L-like precursor	0.016	0.1367	0.1367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Onchocerca volvulus		0.016	0.1367	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.016	0.1367	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0853	1	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0101	0.0637	0.0637
Echinococcus granulosus	cathepsin b	0.0853	1	1
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Giardia lamblia	Cathepsin B precursor	0.0298	0.3093	1
Plasmodium vivax	vivapain-2	0.016	0.1367	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0115	0.0813	0.2627
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1367	0.3201
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0853	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0094	0.0554	0.4054
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.016	0.1367	0.1367
Echinococcus granulosus	cysteine protease	0.0094	0.0554	0.0554
Trypanosoma cruzi	cysteine peptidase, putative	0.016	0.1367	0.1367
Trypanosoma cruzi	cruzipain precursor, putative	0.016	0.1367	0.1367
Giardia lamblia	Cathepsin B precursor	0.0298	0.3093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0094	0.0554	0.1791
Onchocerca volvulus		0.016	0.1367	1
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0813	0.0813
Echinococcus multilocularis	cysteine protease	0.016	0.1367	0.1367
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0123	0.0907	0.0907
Schistosoma mansoni	cathepsin F (C01 family)	0.016	0.1367	0.1367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0123	0.0907	0.0907
Trypanosoma cruzi	cysteine protease, putative	0.0094	0.0554	0.0554
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.016	0.1367	0.4419
Echinococcus multilocularis	cysteine protease	0.016	0.1367	0.1367
Onchocerca volvulus		0.0101	0.0637	0.4663
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Entamoeba histolytica	cysteine proteinase, putative	0.016	0.1367	1
Loa Loa (eye worm)	ctsf protein	0.016	0.1367	0.1367
Loa Loa (eye worm)	fibroinase	0.016	0.1367	0.1367
Plasmodium vivax	unspecified product	0.0094	0.0554	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0094	0.0554	0.0554
Toxoplasma gondii	cathepsin B	0.0298	0.3093	1
Onchocerca volvulus	Cathepsin F homolog	0.016	0.1367	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0123	0.0907	0.0907
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.016	0.1367	0.1367
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0115	0.0813	0.0813
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.016	0.1367	0.4419
Plasmodium vivax	vivapain-2	0.016	0.1367	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0853	1	1
Loa Loa (eye worm)	hypothetical protein	0.0853	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.016	0.1367	0.4419
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.016	0.1367	1
Brugia malayi	calpain family protein 1	0.0117	0.0841	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0813	0.0813
Loa Loa (eye worm)	calpain family protein 1	0.0117	0.0841	0.0841
Onchocerca volvulus		0.009	0.0498	0.3647
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0115	0.0813	0.0813
Onchocerca volvulus		0.016	0.1367	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.029	0.029
Brugia malayi	Cathepsin L-like precursor	0.016	0.1367	0.1367
Echinococcus multilocularis	cathepsin L	0.0094	0.0554	0.0554
Brugia malayi	Cathepsin L-like precursor	0.0115	0.0813	0.0813
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0298	0.3093	0.3093
Brugia malayi	calpain family protein 1	0.0117	0.0841	0.0841
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0094	0.0554	0.0554
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.016	0.1367	0.1367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1367	0.3201
Brugia malayi	Trypsin family protein	0.0101	0.0637	0.0637
Brugia malayi	Cathepsin L-like precursor	0.0115	0.0813	0.0813
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1367	0.3201
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0094	0.0554	0.0554
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0101	0.0637	0.0637
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0094	0.0554	0.0554
Loa Loa (eye worm)	cysteine protease	0.016	0.1367	0.1367
Echinococcus granulosus	calpain A	0.0123	0.0907	0.0907
Brugia malayi	Cathepsin L-like precursor	0.016	0.1367	0.1367
Plasmodium vivax	vivapain-1	0.0094	0.0554	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.016	0.1367	0.1367
Echinococcus multilocularis	calpain family protein 1, d	0.0086	0.0456	0.0456
Brugia malayi	Cathepsin L-like precursor	0.016	0.1367	0.1367
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0123	0.0907	0.0907
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.016	0.1367	0.1367
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0841	0.0841
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1367	0.3201
Onchocerca volvulus		0.016	0.1367	1
Schistosoma mansoni	cathepsin F (C01 family)	0.016	0.1367	0.1367
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0094	0.0554	0.0554
Echinococcus granulosus	cathepsin l cysteine peptidase	0.016	0.1367	0.1367
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.016	0.1367	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0813	0.0813
Trypanosoma cruzi	cysteine proteinase, putative	0.0094	0.0554	0.0554
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.016	0.1367	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.016	0.1367	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0094	0.0554	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0853	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0094	0.0554	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0094	0.0554	0.1791
Onchocerca volvulus		0.016	0.1367	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.016	0.1367	0.4419
Echinococcus multilocularis	calpain A	0.0123	0.0907	0.0907
Onchocerca volvulus		0.016	0.1367	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Incorporation (functional)	= 6506	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Phytohemagglutinin at a concentration of 0.25 ug with out compound	ChEMBL.	2754713
Incorporation (functional)	= 8002	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Phytohemagglutinin at a concentration of 0.25 ug with compound at 0.1 microM	ChEMBL.	2754713
Incorporation (functional)	= 12995	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Phytohemagglutinin at a concentration of 0.25 ug with compound at 1 uM	ChEMBL.	2754713
Incorporation (functional)	= 13781	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Phytohemagglutinin at a concentration of 0.25 ug with compound at 400 uM	ChEMBL.	2754713
Incorporation (functional)	= 14187	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Phytohemagglutinin at a concentration of 0.25 ug with compound at 50 microM	ChEMBL.	2754713
Incorporation (functional)	= 16224	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Phytohemagglutinin at a concentration of 0.25 ug with compound at 10 microM	ChEMBL.	2754713
Incorporation (functional)	= 26393	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Concanavalin A (Con A) at a concentration of 0.5 ug with out compound	ChEMBL.	2754713
Incorporation (functional)	= 40443	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Pokeweed mitogen at a concentration of 1/1250 ug with out compound	ChEMBL.	2754713
Incorporation (functional)	= 41114	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Concanavalin A (Con A) at a concentration of 0.5 ug with compound at 50 uM	ChEMBL.	2754713
Incorporation (functional)	= 43786	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Concanavalin A (Con A) at a concentration of 0.5 ug with compound at 0.1 uM	ChEMBL.	2754713
Incorporation (functional)	= 44427	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Phytohemagglutinin at a concentration of 1 ug with compound at 400 uM	ChEMBL.	2754713
Incorporation (functional)	= 45681	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Concanavalin A at a concentration of 0.5 ug with compound at 400 uM	ChEMBL.	2754713
Incorporation (functional)	= 47573	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Concanavalin A (Con A) at a concentration of 0.5 ug with compound at 10 uM	ChEMBL.	2754713
Incorporation (functional)	= 49105	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Pokeweed mitogen at a concentration of 1/1250 ug with compound at 10 microM	ChEMBL.	2754713
Incorporation (functional)	= 49176	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Phytohemagglutinin at a concentration of 1 ug with compound at 0.1 uM	ChEMBL.	2754713
Incorporation (functional)	= 49196	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Concanavalin A (Con A) at a concentration of 0.5 ug with compound at 1 uM	ChEMBL.	2754713
Incorporation (functional)	= 49556	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Pokeweed mitogen at a concentration of 1/1250 ug with compound at 400 uM	ChEMBL.	2754713
Incorporation (functional)	= 50246	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Phytohemagglutinin at a concentration of 1 ug with compound at 50 uM	ChEMBL.	2754713
Incorporation (functional)	= 50330	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Phytohemagglutinin at a concentration of 1 ug with compound at 1 uM	ChEMBL.	2754713
Incorporation (functional)	= 50830	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Phytohemagglutinin at a concentration of 1 ug with compound at 10 uM	ChEMBL.	2754713
Incorporation (functional)	= 51918	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Pokeweed mitogen at a concentration of 1/1250 ug with compound at 0.1 uM	ChEMBL.	2754713
Incorporation (functional)	= 53140	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Pokeweed mitogen at a concentration of 1/1250 ug with compound at 50 uM	ChEMBL.	2754713
Incorporation (functional)	= 56187	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Pokeweed mitogen at a concentration of 1/1250 ug with compound at 1 uM	ChEMBL.	2754713
Incorporation (functional)	= 56641	Mitogen-induced human lymphocyte proliferation measured by incorporation of [3H]-thymidine in lymphocytes with Phytohemagglutinin at a concentration of 1 ug with out compound	ChEMBL.	2754713

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 187748

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 84007