Detailed information for compound 840843

Basic information

Technical information
  • TDR Targets ID: 840843
  • Name: 2-phenyl-1-[4-(phenylmethyl)piperazin-1-yl]et hanone
  • MW: 294.391 | Formula: C19H22N2O
  • H donors: 0 H acceptors: 1 LogP: 2.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)Cc1ccccc1)Cc1ccccc1
  • InChi: 1S/C19H22N2O/c22-19(15-17-7-3-1-4-8-17)21-13-11-20(12-14-21)16-18-9-5-2-6-10-18/h1-10H,11-16H2
  • InChiKey: RFJPGRQJVLXFBM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-phenyl-1-[4-(phenylmethyl)-1-piperazinyl]ethanone
  • 1-[4-(benzyl)piperazin-1-yl]-2-phenyl-ethanone
  • STK130465
  • Oprea1_115298
  • CBMicro_019283
  • BIM-0019201.P001
  • Oprea1_220876
  • Maybridge1_006921

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major trypanothione reductase 0.0051 0.0164 0.3167
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.044 0.0921
Trichomonas vaginalis esterase, putative 0.0133 0.0513 1
Brugia malayi hypothetical protein 0.0066 0.023 0.1323
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.0494 0.1036
Mycobacterium leprae Probable lipase LipE 0.0133 0.0513 0.0171
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0052 0.101
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0017 0.0074
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0017 0.0094
Mycobacterium tuberculosis Probable lipase LipE 0.0133 0.0513 0.1075
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0005 0.0018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0053 0.0174 0.0996
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0017 0.0074
Loa Loa (eye worm) hypothetical protein 0.0033 0.0088 0.0504
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0017 0.0094
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0016 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0017 0.0094
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0013 0.0005 0.0004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0852 0.3553 0.7475
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0001 0.0019
Mycobacterium ulcerans beta-lactamase 0.0133 0.0513 0.1035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0024 0.0417
Loa Loa (eye worm) hypothetical protein 0.0133 0.0513 0.2953
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0017 0.0074
Loa Loa (eye worm) hypothetical protein 0.0422 0.1735 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0019
Mycobacterium ulcerans putative regulatory protein 0.1135 0.4752 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0103 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0017 0.0094
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0086 0.0313 0.1802
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0133 0.0513 0.2953
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0017 0.0317
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0486
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0014 0.0058
Trichomonas vaginalis hypothetical protein 0.0012 0.0001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0094
Echinococcus granulosus mixed lineage leukemia protein mll 0.0013 0.0005 0.0018
Echinococcus multilocularis lamin dm0 0.0033 0.0088 0.0087
Mycobacterium tuberculosis Probable reductase 0.0116 0.044 0.0921
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0017 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0052 0.101
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0013 0.0002 0.0084
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0017 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0017 0.0094
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0017 0.0016
Brugia malayi hypothetical protein 0.002 0.0034 0.0191
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0043 0.0131 0.2525
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0052 0.101
Brugia malayi intermediate filament protein 0.0033 0.0088 0.0501
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0017 0.0074
Schistosoma mansoni lamin 0.0033 0.0088 0.0394
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0001 0.0019
Brugia malayi SET domain containing protein 0.0013 0.0006 0.0028
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0164 0.3186
Schistosoma mansoni cpg binding protein 0.0056 0.0186 0.0841
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0043 0.0131 0.0752
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0133 0.0513 0.2953
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0103 0.0102
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0088 0.0501
Echinococcus granulosus chromobox protein 1 0.0075 0.0266 0.1201
Echinococcus granulosus survival motor neuron protein 1 0.0422 0.1735 0.7864
Brugia malayi CHD4 protein 0.0015 0.0014 0.0074
Schistosoma mansoni hypothetical protein 0.0135 0.052 0.2354
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0001 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0017 0.0094
Toxoplasma gondii histone lysine methyltransferase SET1 0.0101 0.0374 0.7293
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0072
Toxoplasma gondii ABC1 family protein 0.0133 0.0513 1
Brugia malayi hypothetical protein 0.012 0.0458 0.2636
Leishmania major hypothetical protein, conserved 0.002 0.0034 0.062
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0017 0.0074
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0014 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0024 0.0417
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0024 0.0417
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0266 0.5182
Brugia malayi cytoplasmic intermediate filament protein 0.0018 0.0023 0.0129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0052 0.101
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0017 0.0094
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.014 0.2718
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0017 0.0074
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0001 0.0019
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0024 0.0131
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0094
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0024 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0019
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0014 0.0074
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0043 0.0131 0.0591
Brugia malayi nuclear receptor NHR-88 0.0016 0.0017 0.0094
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0028 0.0551
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0164 0.3167
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0043 0.0131 0.2525
Schistosoma mansoni microtubule-associated protein tau 0.0534 0.2206 1
Mycobacterium ulcerans esterase/lipase LipP 0.0133 0.0513 0.1035
Brugia malayi beta-lactamase family protein 0.0133 0.0513 0.2953
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0075 0.1459
Brugia malayi Heterochromatin protein 1 0.0075 0.0266 0.1528
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0184 0.0729 0.42
Echinococcus multilocularis geminin 0.0135 0.052 0.0519
Brugia malayi steroid hormone receptor 0.0016 0.0017 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0019
Schistosoma mansoni hypothetical protein 0.0086 0.0313 0.1417
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0017 0.0094
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0017 0.0074
Loa Loa (eye worm) hypothetical protein 0.012 0.0458 0.2636
Schistosoma mansoni hypothetical protein 0.0316 0.1287 0.5831
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0024 0.0442
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0024 0.0442
Mycobacterium ulcerans hypothetical protein 0.1135 0.4752 1
Schistosoma mansoni cpg binding protein 0.0056 0.0186 0.0841
Echinococcus granulosus chromobox protein 1 0.0075 0.0266 0.1201
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0017 0.0016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.044 0.0921
Onchocerca volvulus 0.0033 0.0088 0.1695
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0024 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0127 0.2469
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0017 0.0094
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0017 0.0074
Schistosoma mansoni cpg binding protein 0.0053 0.0174 0.0783
Mycobacterium tuberculosis Conserved protein 0.0133 0.0513 0.1075
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0024 0.0417
Entamoeba histolytica hypothetical protein 0.0066 0.023 1
Toxoplasma gondii thioredoxin reductase 0.0051 0.0164 0.3186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0024 0.0417
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0017 0.0074
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0017 0.0074
Brugia malayi beta-lactamase 0.0133 0.0513 0.2953
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0094
Loa Loa (eye worm) hypothetical protein 0.0133 0.0513 0.2953
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0164 0.0163
Brugia malayi follicle stimulating hormone receptor 0.0184 0.0729 0.42
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0024 0.0417
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0017 0.0094
Schistosoma mansoni chromobox protein 0.0075 0.0266 0.1201
Plasmodium falciparum glutathione reductase 0.0051 0.0164 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0024 0.0442
Brugia malayi ecdysteroid receptor 0.0016 0.0017 0.0094
Brugia malayi glutathione reductase 0.0051 0.0164 0.0941
Mycobacterium ulcerans two component transcriptional regulatory protein DevR 0.1135 0.4752 1
Echinococcus multilocularis lamin 0.0033 0.0088 0.0087
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0127 0.2455
Onchocerca volvulus 0.0133 0.0513 1
Entamoeba histolytica hypothetical protein 0.0066 0.023 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0113 0.0425 0.1924
Schistosoma mansoni hypothetical protein 0.0066 0.023 0.104
Mycobacterium tuberculosis Probable transcriptional regulatory protein 0.1135 0.4752 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0133 0.0513 0.1075
Mycobacterium tuberculosis Probable lipase LipD 0.0133 0.0513 0.1075
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0066 0.023 0.0229
Echinococcus granulosus cpg binding protein 0.0056 0.0186 0.0841
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0131 0.2545
Onchocerca volvulus 0.0013 0.0006 0.0096
Mycobacterium tuberculosis Probable transcriptional regulatory protein (probably LuxR/UhpA-family) 0.1135 0.4752 1
Mycobacterium tuberculosis Probable esterase LipL 0.0133 0.0513 0.1075
Brugia malayi Isocitrate dehydrogenase 0.0013 0.0002 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0024 0.0417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0103 0.0464
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0017 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0133 0.0513 1
Schistosoma mansoni hypothetical protein 0.0135 0.052 0.2354
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0094
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0013 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0094
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0266 0.5182
Plasmodium vivax hypothetical protein, conserved 0.0133 0.0513 1
Onchocerca volvulus 0.0133 0.0513 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0088 0.0394
Mycobacterium tuberculosis Conserved protein 0.0133 0.0513 0.1075
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0017 0.0016
Plasmodium falciparum thioredoxin reductase 0.0018 0.0024 0.1389
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0034 0.0646
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0005 0.0004
Echinococcus multilocularis microtubule associated protein 2 0.0534 0.2206 0.2205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0017 0.0094
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0024 0.0103
Mycobacterium ulcerans hypothetical protein 0.0133 0.0513 0.1035
Echinococcus multilocularis chromobox protein 1 0.0075 0.0266 0.0265
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0043 0.0131 1
Leishmania major hypothetical protein, conserved 0.0133 0.0513 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0094
Mycobacterium ulcerans nitrate/nitrite response regulator protein NarL 0.1135 0.4752 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0017 0.0094
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.0034 0.0646
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0017 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0017 0.0094
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0024 0.0461
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0133 0.0513 0.1035
Brugia malayi isocitrate dehydrogenase 0.0013 0.0002 0.0008
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0034 0.2027
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0075 0.1459
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0088 0.0501
Trichomonas vaginalis D-aminoacylase, putative 0.0133 0.0513 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0043 0.0131 0.013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0103 0.0464
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0043 0.0131 0.0228
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0042 0.0127 0.0725
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0266 0.1528
Schistosoma mansoni ap endonuclease 0.0043 0.0131 0.0591
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0094
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0024 0.0417
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0006 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0127 0.2469
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.0494 0.1036
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0019
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0024 0.0103
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0133 0.0513 0.2953
Loa Loa (eye worm) hypothetical protein 0.0133 0.0513 0.2953
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0036 0.0103 0.059
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0131 0.256
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0164 0.0341
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0066 0.023 0.104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0103 0.0464
Schistosoma mansoni coup transcription factor 0.0016 0.0017 0.0074
Mycobacterium ulcerans lipase LipD 0.0133 0.0513 0.1035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0017 0.0094
Schistosoma mansoni transcription factor LCR-F1 0.0066 0.023 0.104
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0002 0.0001
Echinococcus granulosus microtubule associated protein 2 0.0534 0.2206 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0052 0.101
Trichomonas vaginalis D-aminoacylase, putative 0.0133 0.0513 1
Loa Loa (eye worm) glutathione reductase 0.0051 0.0164 0.0941
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0017 0.0074
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0034 0.2027
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0019
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0024 0.0417
Plasmodium falciparum glutathione reductase 0.0018 0.0024 0.1389
Trypanosoma cruzi hypothetical protein, conserved 0.0133 0.0513 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0013 0.0002 0.0006
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0024 0.0417
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.0034 0.062
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0133 0.0513 0.2323
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0019
Brugia malayi hypothetical protein 0.0013 0.0004 0.0017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0024 0.0417
Echinococcus granulosus lamin 0.0033 0.0088 0.0394
Toxoplasma gondii exonuclease III APE 0.0043 0.0131 0.2545
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.0002 0.0027
Mycobacterium tuberculosis Conserved protein 0.0133 0.0513 0.1075
Echinococcus granulosus geminin 0.0135 0.052 0.2354
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0088 0.0501
Brugia malayi hypothetical protein 0.0422 0.1735 1
Onchocerca volvulus 0.012 0.0458 0.8927
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.0494 0.0127
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0133 0.0513 0.1075
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0043 0.0131 0.799
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.044 0.0921
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0164 0.0941
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0017 0.0094
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0014 0.0058
Onchocerca volvulus 0.0086 0.0313 0.61
Brugia malayi chromobox protein homolog 3 0.0042 0.0127 0.0725
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0024 0.0417
Trichomonas vaginalis penicillin-binding protein, putative 0.0133 0.0513 1
Mycobacterium leprae PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN 0.1135 0.4752 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0103 0.0464
Mycobacterium tuberculosis Probable transcriptional regulatory protein (LuxR-family) 0.1135 0.4752 1
Brugia malayi exodeoxyribonuclease III family protein 0.0043 0.0131 0.0752
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0133 0.0513 0.2323
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0024 0.0442
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0017 0.0094
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0017 0.0094
Trichomonas vaginalis Heterochromatin protein, putative 0.0012 0.0001 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0019
Onchocerca volvulus 0.0016 0.0017 0.0317
Plasmodium vivax glutathione reductase, putative 0.0051 0.0164 0.3186
Loa Loa (eye worm) hypothetical protein 0.0133 0.0513 0.2953
Mycobacterium tuberculosis Possible two component transcriptional regulatory protein (probably LuxR-family) 0.1135 0.4752 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0088 0.0394
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0043 0.0131 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0028 0.0551
Mycobacterium leprae conserved hypothetical protein 0.0133 0.0513 0.0171
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0043 0.0131 0.5683
Toxoplasma gondii isocitrate dehydrogenase 0.0013 0.0002 0.0027
Echinococcus multilocularis isocitrate dehydrogenase 0.0013 0.0002 0.0001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0017 0.0016
Mycobacterium tuberculosis Probable hydrolase 0.0133 0.0513 0.1075
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0024 0.0045
Entamoeba histolytica hypothetical protein 0.0066 0.023 1
Brugia malayi CXXC zinc finger family protein 0.0053 0.0174 0.0996
Plasmodium falciparum thioredoxin reductase 0.0051 0.0164 1
Onchocerca volvulus 0.0133 0.0513 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0024 0.0417
Loa Loa (eye worm) hypothetical protein 0.0033 0.0088 0.0501
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0013 0.0005 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0025 0.0479
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.0494 0.1036
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0094
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0002 0.0001
Entamoeba histolytica hypothetical protein 0.0066 0.023 1
Brugia malayi beta-lactamase family protein 0.0133 0.0513 0.2953
Loa Loa (eye worm) histone methyltransferase 0.0016 0.0019 0.0102
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0017 0.0074
Echinococcus multilocularis beta LACTamase domain containing family member 0.0133 0.0513 0.0512
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0034 0.062
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0013 0.0002 0.0006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0024 0.0417
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0052 0.101
Onchocerca volvulus 0.0033 0.0088 0.1706
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0017 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0017 0.0094
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0013 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0133 0.0513 0.2953
Mycobacterium ulcerans two component transcriptional regulator 0.1135 0.4752 1
Echinococcus multilocularis chromobox protein 1 0.0075 0.0266 0.0265
Echinococcus granulosus beta LACTamase domain containing family member 0.0133 0.0513 0.2323
Loa Loa (eye worm) beta-lactamase 0.0133 0.0513 0.2953
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0052 0.101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0017 0.0094
Schistosoma mansoni lamin 0.0033 0.0088 0.0394
Echinococcus multilocularis dnaJ subfamily B 0.0316 0.1287 0.1286
Trichomonas vaginalis ap endonuclease, putative 0.0043 0.0131 0.256
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.044 0.0921
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0001 0.0019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0019 0.0018
Trichomonas vaginalis chromobox protein, putative 0.0045 0.014 0.2732
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0133 0.0513 0.1075
Mycobacterium tuberculosis Possible nitrate/nitrite response transcriptional regulatory protein NarL 0.1135 0.4752 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0024 0.1389
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0017 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0017 0.0094
Echinococcus multilocularis cpg binding protein 0.0056 0.0186 0.0185
Trypanosoma brucei trypanothione reductase 0.0051 0.0164 0.3167
Trichomonas vaginalis chromobox protein, putative 0.0045 0.014 0.2732
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0043 0.0131 0.0272
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0017 0.0074
Trypanosoma brucei hypothetical protein, conserved 0.0133 0.0513 1
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0017 0.0074
Treponema pallidum exodeoxyribonuclease (exoA) 0.0043 0.0131 1
Onchocerca volvulus 0.0053 0.0174 0.3371
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0018 0.0023 0.0129
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0087
Brugia malayi Thioredoxin reductase 0.0051 0.0164 0.0941
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0016 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0017 0.0016
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0024 0.0461
Loa Loa (eye worm) isocitrate dehydrogenase 0.0013 0.0002 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0043 0.0131 0.2525
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0036 0.0103 0.059
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0004 0.0017
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0017 0.0074
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0052 0.101
Echinococcus multilocularis survival motor neuron protein 1 0.0422 0.1735 0.1734
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0024 0.0417
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0024 0.0417
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0103 0.0102
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0017 0.0074
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0017 0.0317
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0018 0.0096
Trichomonas vaginalis chromobox protein, putative 0.0012 0.0001 0.0019
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0024 0.1389
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0164 0.074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0017 0.0094
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.044 0.0921
Schistosoma mansoni ap endonuclease 0.0043 0.0131 0.0591
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0004 0.0017
Schistosoma mansoni chromobox protein 0.0075 0.0266 0.1201
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0013 0.0002 0.0027
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0019 0.008
Echinococcus multilocularis musashi 0.0033 0.0088 0.0087
Echinococcus granulosus lamin dm0 0.0033 0.0088 0.0394
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0191
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0043 0.0131 0.2525
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0017 0.0094
Trichomonas vaginalis D-aminoacylase, putative 0.0133 0.0513 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0017 0.0094
Trichomonas vaginalis penicillin-binding protein, putative 0.0133 0.0513 1
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0034 0.062
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0017 0.0074
Onchocerca volvulus 0.0033 0.0088 0.1695
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0017 0.0074
Mycobacterium tuberculosis Possible transcriptional regulatory protein 0.1135 0.4752 1
Brugia malayi nuclear hormone receptor 0.0016 0.0017 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0017 0.0094
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0024 0.5
Schistosoma mansoni survival motor neuron protein 0.0086 0.0313 0.1417
Echinococcus granulosus dnaJ subfamily B 0.0316 0.1287 0.5831
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0001 0.0019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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