Detailed information for compound 842101

Basic information

Technical information
  • TDR Targets ID: 842101
  • Name: 2-amino-7,7-dimethyl-5,8-dihydropyrano[5,4-e] pyridine-3-carbonitrile
  • MW: 203.24 | Formula: C11H13N3O
  • H donors: 1 H acceptors: 2 LogP: 1.11 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc2COC(Cc2nc1N)(C)C
  • InChi: 1S/C11H13N3O/c1-11(2)4-9-8(6-15-11)3-7(5-12)10(13)14-9/h3H,4,6H2,1-2H3,(H2,13,14)
  • InChiKey: CWCCSDZPGHNWRT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • CBMicro_018835
  • Oprea1_825049
  • Oprea1_175486
  • BIM-0018782.P001
  • STK006110
  • 2-Amino-7,7-dimethyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carbonitrile
  • BAS 00338282

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis slit 2 protein 0.0009 0.0001 0.0039
Echinococcus multilocularis fat cadherin tumor suppressor 0.0009 0.0001 0.0039
Onchocerca volvulus Peroxidase homolog 0.0027 0.0145 0.0763
Brugia malayi Thioredoxin reductase 0.004 0.0244 0.1471
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0145 0.0873
Brugia malayi glutathione reductase 0.004 0.0244 0.1471
Schistosoma mansoni cell polarity protein 0.0009 0.0001 0.001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0015 0.0623
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1282 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0223 0.1345
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.004 0.162
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0248 1
Echinococcus multilocularis protein jagged 1 0.0009 0.0001 0.0039
Schistosoma mansoni notch 0.0009 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Brugia malayi nuclear hormone receptor 0.0011 0.0015 0.0088
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0223 0.8993
Echinococcus multilocularis fibropellin Ia 0.0009 0.0001 0.0039
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0145 0.0763
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0088
Echinococcus multilocularis neurogenic locus protein delta 0.0009 0.0001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.001
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0145 0.0763
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0183 0.197
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0223 0.1345
Loa Loa (eye worm) glutathione reductase 0.004 0.0244 0.1471
Echinococcus granulosus protein jagged 1 0.0009 0.0001 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0223 0.1127
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0223 0.8979
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.014 0.4894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0015 0.0088
Brugia malayi Pre-SET motif family protein 0.0219 0.165 1
Echinococcus multilocularis neurogenic locus protein delta 0.0009 0.0001 0.0039
Schistosoma mansoni septate junction protein 0.0009 0.0001 0.001
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0223 0.8979
Schistosoma mansoni cpg binding protein 0.003 0.0169 0.1814
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0015 0.0088
Loa Loa (eye worm) hypothetical protein 0.0032 0.0183 0.1104
Loa Loa (eye worm) beta-lactamase 0.0037 0.0223 0.1345
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0088
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0223 0.0183
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0015 0.0088
Echinococcus granulosus delta-like protein 1 0.0009 0.0001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0248 1
Echinococcus granulosus neurogenic locus protein delta 0.0009 0.0001 0.0039
Schistosoma mansoni cpg binding protein 0.0032 0.0182 0.1959
Onchocerca volvulus 0.0032 0.0183 0.0966
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0009 0.0001 0.000000054565
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0011 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0015 0.0077
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0183 0.7391
Schistosoma mansoni laminin gamma-3 chain 0.0009 0.0001 0.001
Schistosoma mansoni peroxidasin 0.0027 0.0145 0.156
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.004 0.162
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0015 0.0166
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0015 0.0166
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0011 0.0064
Echinococcus multilocularis neurogenic locus notch protein 0.0009 0.0001 0.0039
Schistosoma mansoni notch 0.0009 0.0001 0.001
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0011 0.0064
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0223 0.0256
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0015 0.0166
Brugia malayi hypothetical protein 0.0026 0.014 0.0841
Giardia lamblia NADH oxidase lateral transfer candidate 0.0014 0.004 1
Onchocerca volvulus 0.0037 0.0223 0.1176
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0013 0.0076
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.0642 0.0845
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.001
Brugia malayi beta-lactamase family protein 0.0037 0.0223 0.1345
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0015 0.0088
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0183 0.0657
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0183 0.197
Trichomonas vaginalis MYB, putative 0.001 0.0012 0.0002
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0223 0.8993
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.000000062394
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0015 0.0623
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.1788 0.2454
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.004 0.0432
Echinococcus multilocularis notch 0.0009 0.0001 0.0039
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0015 0.0166
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0015 0.0088
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0223 0.2398
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0223 0.1127
Brugia malayi CXXC zinc finger family protein 0.003 0.0169 0.1016
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0015 0.0088
Leishmania major hypothetical protein, conserved 0.0037 0.0223 0.8979
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.1345
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0145 0.0873
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0015 0.0623
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Onchocerca volvulus 0.003 0.0169 0.0889
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0015 0.0088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0015 0.0088
Echinococcus multilocularis protein jagged 2 0.0009 0.0001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0088
Brugia malayi hypothetical protein 0.0027 0.0145 0.0873
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0011 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0015 0.0088
Onchocerca volvulus 0.0011 0.0015 0.0077
Onchocerca volvulus Neurogenic locus notch homolog 0.0009 0.0001 0.000000054565
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0244 1
Schistosoma mansoni coup transcription factor 0.0011 0.0015 0.0166
Mycobacterium ulcerans lipase LipD 0.0037 0.0223 0.0183
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0244 0.1471
Echinococcus granulosus peroxidasin 0.0027 0.0145 0.5851
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0015 0.0623
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0015 0.0623
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.004 0.0141
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0361 0.277 0.3672
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.0721 0.0719
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0088
Onchocerca volvulus 0.0249 0.1886 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0223 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0015 0.0088
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0015 0.0623
Echinococcus granulosus notch 0.0009 0.0001 0.0039
Schistosoma mansoni peroxidasin 0.0027 0.0145 0.156
Echinococcus multilocularis neural cadherin 0.0009 0.0001 0.0039
Brugia malayi notch-like transmembrane receptor 0.0009 0.0001 0.000000062394
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0011 0.5
Leishmania major hypothetical protein, conserved 0.0026 0.014 0.4894
Echinococcus granulosus fibropellin Ia 0.0009 0.0001 0.0039
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0223 0.0256
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0169 0.1016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0015 0.0623
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0244 1
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0015 0.0623
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.014 0.4894
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0015 0.0166
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0244 0.0286
Brugia malayi steroid hormone receptor 0.0011 0.0015 0.0088
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0015 0.0166
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0145 0.0873
Mycobacterium ulcerans hypothetical protein 0.0037 0.0223 0.0183
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0443 0.4763
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0015 0.0088
Echinococcus granulosus neurogenic locus notch protein 0.0009 0.0001 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0015 0.0166
Brugia malayi ecdysteroid receptor 0.0011 0.0015 0.0088
Onchocerca volvulus 0.0037 0.0223 0.1176
Schistosoma mansoni notch 0.0009 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.1345
Schistosoma mansoni cpg binding protein 0.0032 0.0182 0.1959
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0015 0.0088
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0223 0.0256
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0011 0.5
Echinococcus granulosus neurogenic locus notch protein 0.0009 0.0001 0.0039
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0025 0.1021
Echinococcus granulosus neurogenic locus notch protein 4 0.0009 0.0001 0.0039
Echinococcus multilocularis neurogenic locus notch protein 0.0009 0.0001 0.0039
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0145 0.0873
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.014 0.4894
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0223 0.0256
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.0721 0.0957
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0015 0.0166
Brugia malayi EGF-like domain containing protein 0.0009 0.0001 0.000000062394
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.0642 0.0845
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0223 0.2398
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0009 0.0001 0.001
Echinococcus multilocularis cpg binding protein 0.0032 0.0182 0.735
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0015 0.0623
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0011 0.5
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0025 0.1021
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.0721 0.0957
Loa Loa (eye worm) histone methyltransferase 0.001 0.0014 0.0082
Echinococcus granulosus protein jagged 1 0.0009 0.0001 0.0039
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0921 0.7162 1
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0145 0.0873
Onchocerca volvulus 0.0027 0.0145 0.0763
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0223 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0015 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0015 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0015 0.0088
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0145 0.0873
Echinococcus granulosus protein jagged 2 0.0009 0.0001 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0183 0.197
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.0721 0.0957
Onchocerca volvulus Peroxidase homolog 0.0027 0.0145 0.0763
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0183 0.7391
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.0642 0.0845
Onchocerca volvulus 0.0027 0.0145 0.0763
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0015 0.0077
Onchocerca volvulus 0.0027 0.0145 0.0763
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.0642 0.0845
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.004 0.0237
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.014 0.0501
Trypanosoma brucei trypanothione reductase 0.004 0.0244 1
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.004 0.0153
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0015 0.0166
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0015 0.0077
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0014 0.0582
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.004 0.0153
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.014 0.4894
Toxoplasma gondii ABC1 family protein 0.0037 0.0223 0.0801
Leishmania major trypanothione reductase 0.004 0.0244 1
Brugia malayi Blistered cuticle protein 3 0.0027 0.0145 0.0873
Brugia malayi nuclear receptor NHR-88 0.0011 0.0015 0.0088
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.0642 0.0605
Echinococcus multilocularis protein jagged 1 0.0009 0.0001 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0223 0.1127
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0015 0.0088
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0389 0.1401
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0361 0.277 0.2741
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.165 1
Plasmodium vivax SET domain protein, putative 0.0032 0.0183 0.7027
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0015 0.0623
Echinococcus multilocularis peroxidasin 0.0027 0.0145 0.5851
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.014 0.4894
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0014 0.0582
Brugia malayi Peroxidasin 0.0027 0.0145 0.0873
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1282 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.1345
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0015 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0015 0.0088
Schistosoma mansoni slit 0.0009 0.0001 0.001
Schistosoma mansoni notch 0.0009 0.0001 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0015 0.0623
Schistosoma mansoni notch 0.0009 0.0001 0.001
Brugia malayi Pre-SET motif family protein 0.0032 0.0183 0.1104
Schistosoma mansoni hypothetical protein 0.0012 0.0025 0.0272
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0145 0.0873
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0015 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0015 0.0088
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0015 0.0623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0015 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0223 0.8979
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.014 0.4894
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0145 0.0873
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0223 0.8979
Echinococcus granulosus cpg binding protein 0.0032 0.0182 0.735
Echinococcus granulosus protein jagged 2 0.0009 0.0001 0.0039
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0145 0.0763
Plasmodium falciparum thioredoxin reductase 0.004 0.0244 1
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0088
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0223 0.0256
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0169 0.6817
Mycobacterium ulcerans beta-lactamase 0.0037 0.0223 0.0183
Brugia malayi beta-lactamase family protein 0.0037 0.0223 0.1345
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0015 0.0623
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.1345
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0015 0.0166
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0088
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0361 0.277 0.2741
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0015 0.0088
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0015 0.0623
Brugia malayi beta-lactamase 0.0037 0.0223 0.1345
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0015 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0015 0.0088
Plasmodium falciparum glutathione reductase 0.004 0.0244 1
Toxoplasma gondii thioredoxin reductase 0.004 0.0244 0.0876
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.004 0.0141
Mycobacterium tuberculosis Conserved protein 0.0037 0.0223 0.0256
Schistosoma mansoni notch 0.0009 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.1345
Loa Loa (eye worm) hypothetical protein 0.0026 0.014 0.0841
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0223 0.1127
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0223 0.1127
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0015 0.0623
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Trichomonas vaginalis esterase, putative 0.0037 0.0223 0.1127
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.0642 0.0845
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0015 0.0623
Echinococcus multilocularis neurogenic locus notch protein 4 0.0009 0.0001 0.0039
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0015 0.0623
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0012 0.0002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0223 0.0256
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0921 0.7162 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0015 0.0088
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0223 0.0256
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0145 0.0763
Mycobacterium tuberculosis Probable reductase 0.009 0.0642 0.0845
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0015 0.0088
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0183 0.7391
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0015 0.0623
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0361 0.277 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0223 0.0256
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0145 0.0873
Giardia lamblia Myb 1-like protein 0.001 0.0012 0.2763
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0183 0.197
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0145 0.0873
Echinococcus granulosus slit 2 protein 0.0009 0.0001 0.0039
Brugia malayi hypothetical protein 0.0017 0.0066 0.0395
Echinococcus granulosus neural cadherin 0.0009 0.0001 0.0039
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0145 0.0873
Onchocerca volvulus 0.0037 0.0223 0.1176
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.1345
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1282 1 1
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.001 0.0012 0.0039
Trichomonas vaginalis set domain proteins, putative 0.0249 0.1886 1
Plasmodium vivax glutathione reductase, putative 0.004 0.0244 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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