Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | ATP synthase subunit beta, mitochondrial | 0.0059 | 0.0756 | 0.0832 |
Trichomonas vaginalis | vacuolar proton ATPase, putative | 0.0047 | 0.0395 | 0.0835 |
Toxoplasma gondii | vacuolar ATP synthase subunit b, putative | 0.0192 | 0.4736 | 1 |
Trypanosoma cruzi | V-type proton ATPase subunit B, putative | 0.0192 | 0.4736 | 1 |
Brugia malayi | vacuolar ATP synthase subunit B | 0.0192 | 0.4736 | 0.4519 |
Plasmodium falciparum | ATP synthase F1, alpha subunit | 0.0086 | 0.1555 | 0.2671 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0075 | 0.1239 | 0.1944 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1239 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 1 | 1 |
Schistosoma mansoni | ATP synthase beta subunit | 0.0059 | 0.0756 | 0.0376 |
Schistosoma mansoni | transmemberane protein | 0.0075 | 0.1239 | 0.0878 |
Mycobacterium tuberculosis | Probable ATP synthase alpha chain AtpA | 0.0086 | 0.1555 | 0.5 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0192 | 0.4736 | 1 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.0059 | 0.0756 | 0.0832 |
Plasmodium vivax | ATP synthase alpha chain, putative | 0.0086 | 0.1555 | 0.2671 |
Entamoeba histolytica | vacuolar proton ATPase subunit, putative | 0.0047 | 0.0395 | 0.0835 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit alpha | 0.0086 | 0.1555 | 1 |
Leishmania major | ATPase beta subunit, putative | 0.0059 | 0.0756 | 0.0832 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 1 | 1 |
Echinococcus multilocularis | ATP synthase subunit beta, mitochondrial | 0.0059 | 0.0756 | 0.0832 |
Leishmania major | ATPase alpha subunit | 0.0052 | 0.0545 | 0.0344 |
Echinococcus multilocularis | nervana 2 | 0.0075 | 0.1239 | 0.1944 |
Chlamydia trachomatis | V-type ATP synthase subunit B | 0.0192 | 0.4736 | 1 |
Schistosoma mansoni | ATP synthase subunit beta vacuolar | 0.0192 | 0.4736 | 0.4519 |
Leishmania major | vacuolar ATP synthase subunit b, putative | 0.0192 | 0.4736 | 1 |
Entamoeba histolytica | vacuolar proton ATPase subunit, putative | 0.0047 | 0.0395 | 0.0835 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0075 | 0.1239 | 0.1944 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0075 | 0.1239 | 0.1944 |
Giardia lamblia | Vacuolar ATP synthase catalytic subunit A | 0.0059 | 0.0756 | 0.0832 |
Schistosoma mansoni | ATP synthase alpha subunit mitochondrial | 0.0086 | 0.1555 | 0.1207 |
Loa Loa (eye worm) | vacuolar ATP synthase subunit B | 0.0192 | 0.4736 | 0.4519 |
Echinococcus granulosus | nervana 2 | 0.0075 | 0.1239 | 0.1944 |
Trypanosoma brucei | Vacuolar proton pump subunit B, putative | 0.0192 | 0.4736 | 1 |
Echinococcus multilocularis | ATP synthase subunit alpha, mitochondrial | 0.0086 | 0.1555 | 0.2671 |
Brugia malayi | ATP synthase beta chain, mitochondrial precursor, putative | 0.0059 | 0.0756 | 0.0376 |
Entamoeba histolytica | V-type ATPase, A subunit, putative | 0.0059 | 0.0756 | 0.1597 |
Trichomonas vaginalis | ATP synthase beta subunit, putative | 0.0059 | 0.0756 | 0.1597 |
Schistosoma mansoni | ATP synthase alpha subunit vacuolar | 0.0059 | 0.0756 | 0.0376 |
Mycobacterium tuberculosis | Probable ATP synthase beta chain AtpD | 0.0086 | 0.1555 | 0.5 |
Echinococcus multilocularis | nervana 2 | 0.0075 | 0.1239 | 0.1944 |
Toxoplasma gondii | ATP synthase beta subunit ATP-B | 0.0059 | 0.0756 | 0.0832 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0052 | 0.0545 | 0.0344 |
Echinococcus granulosus | nervana 2 | 0.0075 | 0.1239 | 0.1944 |
Entamoeba histolytica | V-type ATPase, B subunit, putative | 0.0192 | 0.4736 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0075 | 0.1239 | 0.1944 |
Echinococcus granulosus | nervana 2 | 0.0075 | 0.1239 | 0.1944 |
Loa Loa (eye worm) | vacuolar H ATPase family member | 0.0059 | 0.0756 | 0.0376 |
Trichomonas vaginalis | vacuolar proton ATPase subunit A4, putative | 0.0047 | 0.0395 | 0.0835 |
Trypanosoma cruzi | ATP synthase subunit beta, mitochondrial, putative | 0.0059 | 0.0756 | 0.0832 |
Trichomonas vaginalis | ATP synthase alpha subunit mitochondrial, putative | 0.0192 | 0.4736 | 1 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0075 | 0.1239 | 0.1944 |
Trypanosoma brucei | ATP synthase F1, alpha subunit | 0.0052 | 0.0545 | 0.0344 |
Brugia malayi | ATP synthase alpha chain, mitochondrial precursor, putative | 0.0086 | 0.1555 | 0.1207 |
Trypanosoma cruzi | Vacuolar proton pump subunit B, putative | 0.0192 | 0.4736 | 1 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0075 | 0.1239 | 0.0878 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0369 | 1 | 1 |
Echinococcus multilocularis | vacuolar ATP synthase subunit b | 0.0192 | 0.4736 | 1 |
Echinococcus granulosus | vacuolar H ATPase v1 sector subunit A | 0.0059 | 0.0756 | 0.0832 |
Leishmania major | ATPase beta subunit, putative | 0.0059 | 0.0756 | 0.0832 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.8667 | 0.8612 |
Echinococcus granulosus | nervana 2 | 0.0075 | 0.1239 | 0.1944 |
Plasmodium falciparum | V-type proton ATPase catalytic subunit A | 0.0059 | 0.0756 | 0.0832 |
Echinococcus granulosus | vacuolar ATP synthase subunit b | 0.0192 | 0.4736 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0075 | 0.1239 | 0.1944 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE BETA CHAIN ATPD | 0.0086 | 0.1555 | 0.5 |
Trichomonas vaginalis | ATP synthase, putative | 0.0192 | 0.4736 | 1 |
Leishmania major | vacuolar ATP synthase catalytic subunit A, putative | 0.0059 | 0.0756 | 0.0832 |
Plasmodium vivax | vacuolar ATP synthase subunit b, putative | 0.0192 | 0.4736 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0075 | 0.1239 | 0.1944 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0075 | 0.1239 | 0.1944 |
Trichomonas vaginalis | vacuolar proton ATPase, putative | 0.0047 | 0.0395 | 0.0835 |
Trypanosoma brucei | RNA helicase, putative | 0.0084 | 0.1502 | 0.2549 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1239 | 0.0878 |
Plasmodium vivax | ATP synthase subunit beta, mitochondrial, putative | 0.0059 | 0.0756 | 0.0832 |
Onchocerca volvulus | ATP synthase subunit alpha, mitochondrial homolog | 0.0086 | 0.1555 | 1 |
Echinococcus granulosus | ATP synthase subunit alpha mitochondrial | 0.0086 | 0.1555 | 0.2671 |
Plasmodium falciparum | V-type proton ATPase subunit B | 0.0192 | 0.4736 | 1 |
Toxoplasma gondii | vacuolar ATP synthase subunit A, putative | 0.0059 | 0.0756 | 0.0832 |
Treponema pallidum | V-type ATP synthase subunit B | 0.0192 | 0.4736 | 1 |
Plasmodium vivax | vacuolar ATP synthase catalytic subunit A, putative | 0.0059 | 0.0756 | 0.0832 |
Trypanosoma cruzi | V-type ATPase, A subunit, putative | 0.0059 | 0.0756 | 0.0832 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0075 | 0.1239 | 0.1944 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0075 | 0.1239 | 0.0878 |
Giardia lamblia | Vacuolar ATP synthase subunit B | 0.0192 | 0.4736 | 1 |
Echinococcus multilocularis | vacuolar H+ ATPase v1 sector subunit A | 0.0059 | 0.0756 | 0.0832 |
Brugia malayi | vacuolar ATP synthase catalytic subunit A, osteoclast isoform | 0.0059 | 0.0756 | 0.0376 |
Plasmodium falciparum | ATP synthase subunit beta, mitochondrial | 0.0059 | 0.0756 | 0.0832 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0075 | 0.1239 | 0.0878 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0075 | 0.1239 | 0.0878 |
Echinococcus granulosus | ATP synthase subunit beta mitochondrial | 0.0059 | 0.0756 | 0.0832 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.1502 | 0.1152 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE ALPHA CHAIN ATPA | 0.0086 | 0.1555 | 0.5 |
Leishmania major | ATPase alpha subunit | 0.0052 | 0.0545 | 0.0344 |
Trypanosoma brucei | V-type ATPase, A subunit, putative | 0.0059 | 0.0756 | 0.0832 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit alpha | 0.0086 | 0.1555 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0075 | 0.1239 | 0.1944 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Clearance (ADMET) | = 19 ml min-1 kg-1 | Compound was evaluated for Blood clearance in rat | ChEMBL. | 10794704 |
F (ADMET) | = 43 % | Oral bioavailability in rat | ChEMBL. | 10794704 |
Log Ki (binding) | < 5.2 | Binding activity against human 5-hydroxytryptamine 1B receptor | ChEMBL. | 10794704 |
Log Ki (binding) | = 5.9 | Binding activity against human 5-hydroxytryptamine 1D receptor | ChEMBL. | 10794704 |
Log Ki (binding) | = 6 | Binding affinity for human Dopamine receptor D2 expressed in CHO cells | ChEMBL. | 10794704 |
Log Ki (binding) | = 8 | Binding affinity for human Dopamine receptor D3 expressed in CHO cells | ChEMBL. | 10794704 |
pKb (functional) | = 6.5 | Antagonistic activity against CHO cells expressing human Dopamine receptor D2 | ChEMBL. | 10794704 |
pKb (functional) | = 8.4 | Antagonistic activity against CHO cells expressing human Dopamine receptor D3 | ChEMBL. | 10794704 |
T1/2 (ADMET) | = 2 hr | Compound was evaluated for its Half life in rat | ChEMBL. | 10794704 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.