Detailed information for compound 846299

Basic information

Technical information
  • TDR Targets ID: 846299
  • Name: (6-ethoxy-4-phenylsulfonylquinolin-3-yl)-(4-m ethoxyphenyl)methanone
  • MW: 447.503 | Formula: C25H21NO5S
  • H donors: 0 H acceptors: 4 LogP: 4.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc2c(c1)c(c(cn2)C(=O)c1ccc(cc1)OC)S(=O)(=O)c1ccccc1
  • InChi: 1S/C25H21NO5S/c1-3-31-19-13-14-23-21(15-19)25(32(28,29)20-7-5-4-6-8-20)22(16-26-23)24(27)17-9-11-18(30-2)12-10-17/h4-16H,3H2,1-2H3
  • InChiKey: UFLUXDLBJUASBA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (6-ethoxy-4-phenylsulfonyl-3-quinolyl)-(4-methoxyphenyl)methanone
  • (6-ethoxy-4-phenylsulfonyl-quinolin-3-yl)-(4-methoxyphenyl)methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) transcription factor SMAD2 0.0267 0.1281 0.4721
Loa Loa (eye worm) MH2 domain-containing protein 0.0267 0.1281 0.4721
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0107 0.0476 1
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.1245 1
Schistosoma mansoni heat shock protein 0.0073 0.0303 0.0432
Leishmania major cAMP-specific phosphodiesterase, putative 0.0067 0.0274 0.285
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0012 0.0005
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0039 0.0132 0.3156
Trypanosoma cruzi trypanothione reductase, putative 0.0098 0.0428 0.8999
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0015 0.0011 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0044 0.0157 0.0212
Toxoplasma gondii thioredoxin reductase 0.0098 0.0428 0.1544
Plasmodium falciparum phosphodiesterase delta, putative 0.0067 0.0274 0.6407
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0274 0.2179
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0017 0.007
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0141 0.1107
Treponema pallidum hypothetical protein 0.0031 0.009 0.008
Schistosoma mansoni cathepsin D (A01 family) 0.0077 0.0326 0.0466
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0067 0.0274 0.038
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0259 0.037
Brugia malayi Probable DNA topoisomerase II 0.0015 0.0011 0.0046
Plasmodium vivax heat shock protein 90, putative 0.003 0.0086 0.2017
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0274 0.5766
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0107 0.1109
Plasmodium vivax multidomain scavenger receptor, putative 0.0065 0.0263 0.6146
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0039 0.0132 0.3156
Echinococcus granulosus Smad4 0.0018 0.0028 0.0027
Schistosoma mansoni rab6-interacting 0.0065 0.0263 0.0376
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0028 0.0041
Loa Loa (eye worm) hypothetical protein 0.0067 0.0274 0.1011
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0322 0.807
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.004 0.0045
Giardia lamblia Heat shock protein HSP 90-alpha 0.0073 0.0303 0.1115
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0021 0.004 0.0045
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0044 0.0157 0.0224
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0552 0.2714 0.3869
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0107 0.0107
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0396 1
Trypanosoma brucei Heat shock protein 83, putative 0.0073 0.0303 0.6356
Leishmania major hypothetical protein, conserved 0.0067 0.0274 0.285
Schistosoma mansoni amyloid beta A4 protein related 0.0066 0.0271 0.0386
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0067 0.0274 0.6407
Echinococcus granulosus snurportin 1 0.0303 0.1462 0.2078
Loa Loa (eye worm) hypothetical protein 0.008 0.0339 0.125
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Schistosoma mansoni nuclear hormone receptor 0.0021 0.004 0.0058
Leishmania major calcium channel protein, putative,ion transporter, putative 0.004 0.0138 0.1432
Leishmania major importin beta-1 subunit, putative 0.0023 0.0052 0.0542
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.1462 0.5386
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0322 0.1185
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0107 0.0476 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0042 0.0872
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.004 0.0045
Brugia malayi Nuclear hormone receptor E75 0.0021 0.004 0.017
Plasmodium vivax heat shock protein 86, putative 0.0073 0.0303 0.7063
Entamoeba histolytica hypothetical protein 0.0023 0.005 0.1018
Plasmodium falciparum DNA gyrase subunit B 0.0015 0.0011 0.0255
Trichomonas vaginalis heat shock protein, putative 0.0073 0.0303 0.2405
Brugia malayi Blistered cuticle protein 3 0.0228 0.1086 0.4572
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0157 0.0224
Schistosoma mansoni chromobox protein 0.0067 0.0275 0.0393
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0037 0.0156
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.005 0.0039
Loa Loa (eye worm) voltage-dependent calcium channel 0.0022 0.0047 0.0171
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0295 0.041
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0139 0.0512
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0053 0.0223
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0058 0.0228 0.0303
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0034 0.0126
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0141 0.1107
Echinococcus granulosus heat shock protein 90 0.0073 0.0303 0.042
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0171
Schistosoma mansoni hypothetical protein 0.008 0.0339 0.0485
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0044 0.0157 0.0224
Loa Loa (eye worm) MBCTL1 0.0107 0.0476 0.1753
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0067 0.0274 0.038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0107 0.2245
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Loa Loa (eye worm) hypothetical protein 0.0067 0.0274 0.1011
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0015 0.0011 0.0003
Trypanosoma brucei unspecified product 0.0028 0.0078 0.1634
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.0341 0.0487
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0107 0.0828
Echinococcus multilocularis endoplasmin 0.0058 0.0228 0.0313
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0037 0.004
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Loa Loa (eye worm) hypothetical protein 0.0095 0.0416 0.1534
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0015 0.0011 0.0011
Giardia lamblia Pms1-like protein 0.0015 0.0011 0.004
Echinococcus granulosus amyloid beta A4 protein 0.0066 0.0271 0.0374
Brugia malayi aspartic protease BmAsp-2, identical 0.0018 0.0028 0.012
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0037 0.0865
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0037 0.004
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.004 0.0272
Leishmania major ferric reductase, putative 0.0107 0.0476 0.4943
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.1245 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0078 0.1634
Mycobacterium ulcerans aldehyde dehydrogenase 0.0204 0.0963 0.0963
Loa Loa (eye worm) aspartyl protease 6 0.0018 0.0028 0.0105
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0095 0.0416 0.0594
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0484 0.2376 0.8754
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.5766
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0095 0.0416 0.0583
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0067 0.0274 0.0392
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0206 0.4338
Onchocerca volvulus Bile acid receptor homolog 0.0044 0.0157 0.1347
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0107 0.1109
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Brugia malayi hypothetical protein 0.0065 0.0263 0.1108
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0039 0.0132 0.1035
Toxoplasma gondii heat shock protein 90, putative 0.0073 0.0303 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0044 0.0157 0.0661
Plasmodium falciparum plasmepsin III 0.0018 0.0028 0.0664
Schistosoma mansoni smad1 5 8 and 0.0018 0.0028 0.004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0028 0.0194
Echinococcus granulosus dna polymerase eta 0.0068 0.0277 0.0383
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0841 0.6746
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.0103 0.2411
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0021 0.004 0.0058
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0955 0.3521
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0396 0.3158
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0248 0.1184 0.164
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.0103 0.2169
Echinococcus granulosus RUN 0.0065 0.0263 0.0364
Leishmania major hypothetical protein, conserved 0.0054 0.0206 0.2144
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0042 0.0153
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0053 0.0076
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Plasmodium falciparum plasmepsin I 0.0077 0.0326 0.7609
Trypanosoma brucei hypothetical protein, conserved 0.0067 0.0274 0.5766
Leishmania major mitochondrial DNA topoisomerase II 0.0015 0.0011 0.0114
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0059 0.0235 0.099
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0274 0.5766
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0395 0.0564
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0088 0.0318
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0016 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0164 0.1288
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0067 0.0274 0.5766
Trichomonas vaginalis set domain proteins, putative 0.023 0.1095 0.8793
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0107 0.2245
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0107 0.0476 0.2002
Schistosoma mansoni ap endonuclease 0.004 0.0139 0.0199
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0795 0.6374
Schistosoma mansoni kinase 0.0046 0.017 0.0243
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0141 0.0141
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0105
Toxoplasma gondii hypothetical protein 0.0017 0.0022 0.0081
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0024
Onchocerca volvulus 0.0065 0.0263 0.2327
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0139 0.2921
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0015 0.0011 0.0003
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0204 0.0963 0.1365
Loa Loa (eye worm) hypothetical protein 0.0107 0.0476 0.1753
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0206 0.4338
Loa Loa (eye worm) hypothetical protein 0.0031 0.0094 0.0345
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.008 0.0339 0.1428
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0223 0.1059 0.1465
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0157 0.0661
Trichomonas vaginalis ran, putative 0.0021 0.0042 0.0302
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0044 0.0157 0.0224
Echinococcus multilocularis chromobox protein 1 0.0067 0.0275 0.0381
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0139 0.1444
Plasmodium vivax heat shock protein, putative 0.003 0.0086 0.2017
Brugia malayi Importin beta-1 subunit 0.0028 0.0079 0.0334
Echinococcus multilocularis RUN 0.0065 0.0263 0.0364
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0157 0.0212
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0028 0.0027
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0107 0.2245
Echinococcus granulosus lamin dm0 0.0031 0.0094 0.0121
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0322 0.334
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0274 0.2179
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0137
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.005 0.0181
Leishmania major DNA topoisomerase ii 0.0015 0.0011 0.0114
Echinococcus granulosus smad 0.0018 0.0028 0.0027
Brugia malayi glutathione reductase 0.0098 0.0428 0.1803
Onchocerca volvulus 0.0018 0.0028 0.0162
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0042 0.0175
Plasmodium falciparum heat shock protein 90, putative 0.003 0.0086 0.2017
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0067 0.0274 0.1155
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0076 0.0096
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0552 0.2714 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.005 0.005
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0067 0.0274 0.1155
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0059 0.0447
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0235 0.0866
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0164 0.1288
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0021 0.004 0.0045
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0009 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0067 0.0274 0.5766
Entamoeba histolytica heat shock protein 90, putative 0.0073 0.0303 0.7574
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0578
Schistosoma mansoni endoplasmin 0.0073 0.0303 0.0432
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.004 0.0045
Giardia lamblia Hypothetical protein 0.0067 0.0274 0.1011
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Trichomonas vaginalis MYB, putative 0.0039 0.0133 0.1042
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0263 0.0364
Schistosoma mansoni rab6-interacting 0.0065 0.0263 0.0376
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0039 0.0133 0.0481
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0021 0.0087
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0159 0.0215
Brugia malayi hypothetical protein 0.0021 0.004 0.017
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0044 0.0157 0.0212
Echinococcus granulosus lamin 0.0031 0.0094 0.0121
Echinococcus multilocularis muscleblind protein 0.0298 0.1435 0.204
Echinococcus granulosus dna polymerase kappa 0.0041 0.0141 0.019
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0034 0.0036
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0028 0.0041
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0052 0.0388
Schistosoma mansoni zinc finger protein 0.0021 0.004 0.0058
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1435 0.7163 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0126 0.0466
Brugia malayi nuclear receptor NHR-67 0.0021 0.004 0.017
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0015 0.0011 0.0056
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0062 0.0259
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0206 0.4821
Echinococcus multilocularis chromobox protein 1 0.0067 0.0275 0.0381
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0028 0.0103
Trypanosoma brucei heat shock protein, putative 0.0073 0.0303 0.6356
Brugia malayi photoreceptor-specific nuclear receptor 0.0044 0.0157 0.0661
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0015 0.0011 0.0046
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0095 0.0416 0.0583
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0141 0.1198
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.0141 0.0595
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0094 0.0345
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0552 0.2714 0.3869
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0088 0.0126
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0195
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0044 0.0157 0.0212
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0052 0.0388
Loa Loa (eye worm) hypothetical protein 0.0121 0.0547 0.2014
Schistosoma mansoni nuclear receptor 0.0021 0.004 0.0058
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0015 0.0011 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0044 0.0157 0.0661
Schistosoma mansoni apoptosis regulator bax 0.008 0.0339 0.0485
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0157 0.0661
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0021 0.004 0.0045
Plasmodium falciparum glutathione reductase 0.0034 0.0107 0.2494
Trichomonas vaginalis receptor histidine kinase, putative 0.0015 0.0011 0.0056
Loa Loa (eye worm) mbt repeat family protein 0.0094 0.041 0.1511
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0037 0.0137
Onchocerca volvulus 0.0044 0.0157 0.1347
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0067 0.0274 0.1155
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0396 0.8318
Entamoeba histolytica Ran family GTPase 0.0021 0.0042 0.0795
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0042 0.0153
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0052 0.0388
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0015 0.0011 0.023
Echinococcus multilocularis heat shock protein 90 0.0058 0.0228 0.0313
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0321 0.1551 0.2206
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Plasmodium vivax glutathione reductase, putative 0.0098 0.0428 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Echinococcus granulosus sodium channel protein 0.004 0.0138 0.0185
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0067 0.0274 0.5766
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0009 0.0013
Trypanosoma brucei heat shock protein, putative 0.0073 0.0303 0.6356
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0139 0.1088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0088 0.0126
Brugia malayi hypothetical protein 0.0036 0.012 0.0503
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0107 0.2245
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1998 1 1
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0024
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0223 0.1059 0.1465
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0274 0.5766
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0395 0.0552
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0107 0.2245
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0067 0.0274 0.5766
Leishmania major trypanothione reductase 0.0098 0.0428 0.4448
Schistosoma mansoni smad1 5 8 and 0.0018 0.0028 0.004
Trichomonas vaginalis pc-MYB2, putative 0.0039 0.0132 0.1035
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0126 0.0986
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0575 0.0821
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0223 0.1059 0.1465
Echinococcus granulosus muscleblind protein 0.0298 0.1435 0.204
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0059 0.0447
Echinococcus granulosus microtubule associated protein 2 0.1403 0.7001 1
Schistosoma mansoni retinoic acid receptor RXR 0.0044 0.0157 0.0224
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0396 0.3158
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.026 0.1245 0.5241
Onchocerca volvulus 0.0018 0.0028 0.0162
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0395 0.1455
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0028 0.0027
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0067 0.0274 0.038
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.0341 0.1435
Brugia malayi nuclear receptor NHR-88 0.0021 0.004 0.017
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Echinococcus granulosus nuclear receptor nhr 48 0.0021 0.004 0.0045
Trichomonas vaginalis heat shock protein, putative 0.003 0.0086 0.0664
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0139 0.2921
Echinococcus multilocularis histone acetyltransferase MYST2 0.0107 0.0476 0.0668
Loa Loa (eye worm) apoptosis regulator protein 0.008 0.0339 0.125
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0059 0.0447
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0037 0.0778
Giardia lamblia hypothetical protein 0.0067 0.0274 0.1011
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0028 0.0103
Trypanosoma cruzi Heat shock protein 83, putative 0.0073 0.0303 0.6356
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Toxoplasma gondii Hsp90 domain-containing protein 0.003 0.0086 0.0312
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0015 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0058 0.0228 0.2367
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0077 0.0326 0.1175
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Toxoplasma gondii DNA topoisomerase 2, putative 0.0015 0.0011 0.0039
Brugia malayi Augmenter of liver regeneration 0.0033 0.0103 0.0435
Onchocerca volvulus 0.0094 0.041 0.3682
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.005 0.0039
Schistosoma mansoni Smad4 0.0018 0.0028 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0395 0.0552
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0059 0.0447
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0195
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0067 0.0274 0.0392
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0053 0.0063
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0841 0.6746
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0067 0.0274 0.2179
Onchocerca volvulus 0.0021 0.004 0.0272
Trypanosoma brucei unspecified product 0.0041 0.0141 0.2971
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0033 0.0103 0.2169
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.005 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0157 0.0212
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0141 0.2971
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0295 0.1088
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0067 0.0274 0.5766
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0139 0.0179
Plasmodium falciparum thioredoxin reductase 0.0098 0.0428 1
Onchocerca volvulus 0.003 0.0085 0.0686
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0141 0.1102
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1998 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0021 0.004 0.0045
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0037 0.0266
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0039 0.0132 0.3156
Schistosoma mansoni DNA polymerase eta 0.0068 0.0277 0.0395
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0067 0.0274 0.5766
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0044 0.0157 0.0212
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0079 0.0101
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0021 0.004 0.0058
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0017 0.0011
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.004 0.0045
Schistosoma mansoni memapsin-2 (A01 family) 0.0018 0.0028 0.0041
Echinococcus multilocularis geminin 0.0686 0.3391 0.4837
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.004 0.0045
Leishmania major DNA polymerase eta, putative 0.0068 0.0277 0.2874
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0023 0.0155
Trypanosoma cruzi heat shock protein 85, putative 0.0073 0.0303 0.6356
Schistosoma mansoni ets-related 0.0216 0.1026 0.1465
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.0277 0.5814
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0039 0.0133 0.1042
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0206 0.4338
Echinococcus multilocularis nuclear receptor nhr 48 0.0021 0.004 0.0045
Schistosoma mansoni ap endonuclease 0.004 0.0139 0.0199
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Echinococcus multilocularis dna polymerase eta 0.0068 0.0277 0.0383
Echinococcus granulosus GPCR family 2 0.0016 0.0017 0.0011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0016 0.001
Brugia malayi hypothetical protein 0.0018 0.0028 0.012
Echinococcus granulosus thioredoxin glutathione reductase 0.0098 0.0428 0.06
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0204 0.0963 0.1365
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0086 0.1815
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0021 0.0076
Brugia malayi MH2 domain containing protein 0.0018 0.0028 0.0118
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0195
Brugia malayi Thioredoxin reductase 0.0098 0.0428 0.1803
Plasmodium vivax importin-beta 2, putative 0.0028 0.0079 0.185
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Trypanosoma brucei heat shock protein 90, putative 0.0073 0.0303 0.6356
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0314
Trypanosoma brucei developmentally regulated phosphoprotein 0.0015 0.0011 0.023
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0263 0.0364
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0017 0.007
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0042 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0274 0.5766
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0042 0.0969
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0058 0.0228 0.0217
Trichomonas vaginalis receptor histidine kinase, putative 0.0015 0.0011 0.0056
Loa Loa (eye worm) hypothetical protein 0.008 0.0341 0.1256
Brugia malayi nuclear receptor NHR-88 0.0044 0.0157 0.0661
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0028 0.0041
Echinococcus multilocularis Smad4 0.0018 0.0028 0.0027
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0067 0.0274 0.0392
Plasmodium falciparum plasmepsin IV 0.0077 0.0326 0.7609
Echinococcus multilocularis musashi 0.0031 0.0094 0.0121
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0135 0.0488
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Loa Loa (eye worm) hypothetical protein 0.0298 0.1435 0.5289
Echinococcus multilocularis bloom syndrome protein 0.002 0.0037 0.004
Mycobacterium ulcerans putative regultory protein 0.0015 0.0011 0.0011
Leishmania major DNA polymerase eta, putative 0.004 0.0135 0.1405
Loa Loa (eye worm) heat shock protein 90 0.0073 0.0303 0.1115
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0107 0.2494
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0139 0.0128
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0141 0.0202
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.0141 0.0182
Brugia malayi hypothetical protein 0.0021 0.004 0.017
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0086 0.196
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0044 0.0157 0.0661
Plasmodium falciparum plasmepsin II 0.0077 0.0326 0.7609
Plasmodium vivax aspartyl proteinase, putative 0.0077 0.0326 0.7609
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0259 0.0954
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0098 0.0428 0.0584
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0204 0.0963 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.004 0.017
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0037 0.0266
Schistosoma mansoni gabp alpha 0.0071 0.0295 0.0422
Giardia lamblia DINP protein human, muc B family 0.0041 0.0141 0.0521
Loa Loa (eye worm) Smad1 0.0018 0.0028 0.0103
Brugia malayi Eukaryotic aspartyl protease family protein 0.0018 0.0028 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0396 0.0566
Onchocerca volvulus Protein ultraspiracle homolog 0.0044 0.0157 0.1347
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0015 0.0011 0.0011
Echinococcus multilocularis Polycystic kidney disease protein 0.0065 0.0263 0.0364
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0077 0.0326 0.0453
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0067 0.0274 0.038
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0396 0.3158
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0015 0.0011 0.0056
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0044 0.0157 0.0224
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0035
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0507 0.183
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0292
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0107 0.1109
Schistosoma mansoni RAR-like nuclear receptor 0.0044 0.0157 0.0224
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0395 0.0552
Echinococcus granulosus intermediate filament protein 0.0031 0.0094 0.0121
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0028 0.0041
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0053 0.0076
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0015 0.0011 0.023
Plasmodium vivax SET domain protein, putative 0.003 0.0088 0.2057
Mycobacterium ulcerans DNA gyrase subunit B 0.0015 0.0011 0.0011
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0037 0.004
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0037 0.0156
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.004 0.017
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0086 0.0696
Schistosoma mansoni aldehyde dehydrogenase 0.0204 0.0963 0.1375
Schistosoma mansoni hypothetical protein 0.0686 0.3391 0.4843
Schistosoma mansoni hypothetical protein 0.0413 0.2015 0.2878
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0274 0.5766
Leishmania major DNA polymerase kappa, putative 0.0041 0.0141 0.1469
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0079 0.0286
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.011 0.0462
Echinococcus granulosus histone acetyltransferase MYST2 0.0107 0.0476 0.0668
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0028 0.0041
Trichomonas vaginalis pc-MYB2, putative 0.0039 0.0132 0.1035
Plasmodium vivax DNA topoisomerase II, putative 0.0015 0.0011 0.0255
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0045
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Echinococcus multilocularis voltage dependent calcium channel 0.0095 0.0416 0.0583
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.019 0.0701
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0141 0.1102
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0067 0.0274 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.3882 0.5539
Mycobacterium ulcerans aldehyde dehydrogenase 0.0204 0.0963 0.0963
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0044 0.0157 0.1347
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.6407
Giardia lamblia Kinase, PLK 0.0091 0.0396 0.1459
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0107 0.2245
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0275 0.1015
Giardia lamblia Grp94/Hsp90 0.0058 0.0228 0.084
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0095 0.0416 0.0583
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0157 0.0661
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.0103 0.2169
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0052 0.1097
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0016 0.001
Mycobacterium leprae conserved hypothetical protein 0.0023 0.005 0.0055
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0015 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0578
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0139 0.2921
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0012 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.0044 0.0157 0.0661
Trypanosoma cruzi DNA topoisomerase II, putative 0.0015 0.0011 0.023
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0058 0.007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.012 0.0158
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.005 0.1053
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0067 0.0274 0.5766
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0067 0.0274 0.2179
Loa Loa (eye worm) hypothetical protein 0.0065 0.0263 0.097
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Trichomonas vaginalis sensor histidine kinase, putative 0.0015 0.0011 0.0056
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0578
Leishmania major hypothetical protein, conserved 0.0033 0.0103 0.1072
Loa Loa (eye worm) RecQ helicase 0.002 0.0037 0.0137
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0139 0.0585
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0248 0.1184 0.164
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0039 0.0132 0.3156
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0195
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0107 0.0096
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0396 0.4112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0157 0.0661
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0067 0.0274 0.038
Brugia malayi CHD4 protein 0.0014 0.0009 0.0037
Loa Loa (eye worm) doublecortin family protein 0.0065 0.0263 0.097
Schistosoma mansoni smad 0.0018 0.0028 0.004
Schistosoma mansoni steroid hormone receptor ad4bp 0.0044 0.0157 0.0224
Mycobacterium ulcerans two component sensor kinase MprB 0.0015 0.0011 0.0011
Echinococcus multilocularis voltage dependent calcium channel 0.0095 0.0416 0.0583
Echinococcus granulosus FTZ F1 alpha 0.0044 0.0157 0.0212
Brugia malayi Pre-SET motif family protein 0.0202 0.0955 0.4022
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Echinococcus granulosus tar DNA binding protein 0.0064 0.0259 0.0358
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0067 0.0274 0.1155
Plasmodium falciparum thioredoxin reductase 0.0034 0.0107 0.2494
Echinococcus multilocularis sodium channel protein 0.0077 0.0324 0.0451
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0139 0.0512
Leishmania major GTP-binding protein, putative 0.0021 0.0042 0.0431
Schistosoma mansoni hypothetical protein 0.058 0.2858 0.4082
Trichomonas vaginalis MYB72, putative 0.0039 0.0132 0.1035
Trypanosoma cruzi heat shock protein, putative 0.003 0.0086 0.1815
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0484 0.2376 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0263 0.0364
Mycobacterium ulcerans heat shock protein 90 0.0058 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0578
Onchocerca volvulus 0.0031 0.0094 0.0764
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0016 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0556 0.2738 0.9872
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0067 0.0274 0.038
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0015 0.0011 0.0039
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0044 0.0157 0.0212
Schistosoma mansoni lamin 0.0031 0.0094 0.0134
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0095 0.0416 0.1752
Brugia malayi intermediate filament protein 0.0031 0.0094 0.0395
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Brugia malayi nuclear receptor RXR 0.0023 0.0053 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0044 0.0157 0.0578
Plasmodium falciparum endoplasmin, putative 0.0045 0.0161 0.3758
Schistosoma mansoni smad1 5 8 and 0.0018 0.0028 0.004
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.005 0.005
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0067 0.0274 0.285
Echinococcus multilocularis ecdysone induced protein 78C 0.0044 0.0157 0.0212
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0107 0.2245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0044 0.0157 0.0578
Onchocerca volvulus 0.0041 0.0144 0.1223
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Brugia malayi heat shock protein 90 0.0073 0.0303 0.1273
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0015 0.0011 0.0056
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.0341 0.0475
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Echinococcus multilocularis SAM and MBT domain containing protein 0.0094 0.041 0.0574
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0795 0.6374
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.005 0.0181
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0095 0.0416 0.0583
Trypanosoma brucei heat shock protein, putative 0.0073 0.0303 0.6356
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0044 0.0157 0.0212
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Trichomonas vaginalis endoplasmin, putative 0.0045 0.0161 0.1265
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0037 0.0865
Schistosoma mansoni voltage-gated cation channel 0.0095 0.0416 0.0594
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0107 0.0476 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.008 0.0339 0.0473
Brugia malayi RNA binding protein 0.0064 0.0259 0.109
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0033 0.0103 0.2169
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0223 0.1059 0.1465
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0018 0.0028 0.0105
Echinococcus granulosus chromobox protein 1 0.0067 0.0275 0.0381
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0396 0.1667
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.0141 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0078 0.1634
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0086 0.0111
Plasmodium falciparum LCCL domain-containing protein 0.0065 0.0263 0.6146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0195
Trichomonas vaginalis C-MYB, putative 0.0039 0.0132 0.1035
Loa Loa (eye worm) hypothetical protein 0.0068 0.0277 0.102
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0795 0.6374
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0042 0.015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0157 0.0661
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0552 0.2714 0.3876
Loa Loa (eye worm) PDE1B protein 0.0067 0.0274 0.1011
Schistosoma mansoni hypothetical protein 0.008 0.0339 0.0485
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0139 0.0186
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0015 0.0011 0.0011
Brugia malayi chromobox protein homolog 3 0.0038 0.0126 0.0532
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0563 0.2773 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0322 0.0447
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0039 0.0132 0.1035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0059 0.0447
Plasmodium falciparum plasmepsin VI 0.0077 0.0326 0.7609
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0484 0.2376 0.3385
Trypanosoma brucei heat shock protein 90, putative 0.0073 0.0303 0.6356
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0067 0.0274 0.038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.004
Loa Loa (eye worm) blistered cuticle protein 3 0.0228 0.1086 0.4002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0139 0.3246
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.6407
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0061
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0141 0.2971
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.008 0.0339 0.0485
Brugia malayi hypothetical protein 0.0054 0.0206 0.0869
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0206 0.4821
Toxoplasma gondii heat shock protein HSP90 0.0073 0.0303 0.1091
Brugia malayi kinase, mitochondrial precursor 0.0015 0.0011 0.0046
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Plasmodium falciparum plasmepsin VII 0.0018 0.0028 0.0664
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0107 0.2494
Echinococcus granulosus polycomb protein SCMH1 0.0094 0.041 0.0574
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0015 0.0011 0.0003
Leishmania major hypothetical protein, conserved 0.0067 0.0274 0.285
Trichomonas vaginalis C-MYB, putative 0.0039 0.0132 0.1035
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0028 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0028 0.0194
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.6407
Brugia malayi mbt repeat family protein 0.0094 0.041 0.1726
Loa Loa (eye worm) nuclear receptor NHR-67 0.0021 0.004 0.0149
Schistosoma mansoni heat shock protein 0.0073 0.0303 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0274 0.2179
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0062 0.0259
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0039 0.0132 0.3156
Treponema pallidum heat shock protein 90 0.0058 0.0228 0.0217
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0141 0.019
Echinococcus multilocularis thioredoxin glutathione reductase 0.0098 0.0428 0.06
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0295 0.041
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Mycobacterium ulcerans aldehyde dehydrogenase 0.0204 0.0963 0.0963
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0039 0.0132 0.1035
Loa Loa (eye worm) DR-78 0.0021 0.004 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0044 0.0157 0.0578
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0077 0.0326 0.2594
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0107 0.2494
Trypanosoma brucei heat shock protein, putative 0.0073 0.0303 0.6356
Echinococcus granulosus dnaJ subfamily B 0.0413 0.2015 0.2869
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0107 0.0828
Brugia malayi Muscleblind-like protein 0.0298 0.1435 0.6041
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0157 0.0661
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0107 0.0107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0157 0.0212
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0015 0.0011 0.0255
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0079 0.1665
Loa Loa (eye worm) calcium channel 0.0095 0.0416 0.1534
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0379 0.1844 0.2625
Plasmodium vivax aspartyl protease, putative 0.0018 0.0028 0.0664
Brugia malayi SET domain containing protein 0.0013 0.0004 0.0016
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0077 0.0326 0.0453
Plasmodium falciparum plasmepsin IX 0.0018 0.0028 0.0664
Loa Loa (eye worm) X11 protein 0.0066 0.0271 0.0997
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0039 0.0132 0.1035
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.6407
Schistosoma mansoni sex comb on midleg homolog 0.0094 0.041 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0157 0.0661
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0795 0.6374
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0015 0.0011 0.0011
Trypanosoma brucei heat shock protein, putative 0.0073 0.0303 0.6356
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0396 0.355
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.0103 0.0372
Brugia malayi Heterochromatin protein 1 0.0067 0.0275 0.1159
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0107 0.1109
Schistosoma mansoni cpg binding protein 0.0059 0.0235 0.0336
Mycobacterium tuberculosis Probable oxidoreductase 0.0248 0.1184 0.164
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0067 0.0274 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0071 0.0539
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.0141 0.0202
Trypanosoma cruzi heat shock protein 90, putative 0.0073 0.0303 0.6356
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0259 0.037
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0039 0.0133 0.1042
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0058 0.0228 0.0303
Schistosoma mansoni hypothetical protein 0.0303 0.1462 0.2088
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0141 0.0182
Brugia malayi hypothetical protein 0.0018 0.0028 0.012
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Brugia malayi Pre-SET motif family protein 0.003 0.0088 0.0371
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0105
Brugia malayi MH2 domain containing protein 0.0267 0.1281 0.5393
Trypanosoma cruzi heat shock protein 85, putative 0.0058 0.0228 0.4789
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0044 0.0157 0.0212
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0059 0.0233 0.4896
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0033 0.0103 0.0135
Loa Loa (eye worm) hypothetical protein 0.0094 0.041 0.1511
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0015 0.0011 0.023
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.005 0.117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0044 0.0157 0.0578
Brugia malayi CXXC zinc finger family protein 0.0059 0.0235 0.0989
Brugia malayi ImpB/MucB/SamB family protein 0.0068 0.0277 0.1165
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Schistosoma mansoni heat shock protein 0.003 0.0086 0.0123
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0015 0.0011 0.023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Brugia malayi ecdysone receptor 0.0021 0.004 0.017
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0037 0.0778
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Brugia malayi hypothetical protein 0.0023 0.0053 0.0223
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0274 0.5766
Echinococcus multilocularis lamin 0.0031 0.0094 0.0121
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0058 0.0228 0.0313
Schistosoma mansoni importin beta-1 0.0028 0.0079 0.0113
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0015 0.0011 0.0003
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0126 0.1065
Schistosoma mansoni DNA helicase recq1 0.002 0.0037 0.0053
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0095 0.0416 0.0583
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0107 0.2245
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0135 0.2843
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0396 0.3158
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0037 0.0266
Echinococcus multilocularis snurportin 1 0.0303 0.1462 0.2078
Schistosoma mansoni endoplasmin 0.0073 0.0303 0.0432
Echinococcus granulosus endoplasmin 0.0058 0.0228 0.0313
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0141 0.0141
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0067 0.0274 0.5766
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.026 0.1245 0.4588
Treponema pallidum NADH oxidase 0.0034 0.0107 0.0096
Plasmodium falciparum plasmepsin X 0.0018 0.0028 0.0664
Brugia malayi Hsp90 protein 0.003 0.0086 0.0364
Plasmodium falciparum heat shock protein 90, putative 0.003 0.0086 0.2017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0107 0.2245
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0028 0.0027
Plasmodium falciparum heat shock protein 90 0.0073 0.0303 0.7063
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0039 0.0132 0.1035
Onchocerca volvulus 0.023 0.1095 1
Schistosoma mansoni sex comb on midleg homolog 0.0094 0.041 0.0586
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0259 0.109
Loa Loa (eye worm) hepatopoietin HPO2 0.0033 0.0103 0.038
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0015 0.0011 0.0011
Schistosoma mansoni nuclear receptor 0.0021 0.004 0.0058
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0139 0.3246
Schistosoma mansoni lipoxygenase 0.0321 0.1551 0.2215
Echinococcus granulosus Polycystic kidney disease protein 0.0065 0.0263 0.0364
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0322 0.0459
Schistosoma mansoni chromobox protein 0.0067 0.0275 0.0393
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0067 0.0274 0.0392
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0396 0.3158
Echinococcus granulosus ecdysone induced protein 78C 0.0044 0.0157 0.0212
Echinococcus multilocularis amyloid beta A4 protein 0.0066 0.0271 0.0374
Echinococcus multilocularis smad 0.0018 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0042 0.0872
Loa Loa (eye worm) hypothetical protein 0.0064 0.0257 0.0949
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0161 0.1265
Mycobacterium ulcerans two component regulator - sensor kinase 0.0015 0.0011 0.0011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0107 0.0096
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0552 0.2714 0.3869
Plasmodium vivax thioredoxin reductase, putative 0.0098 0.0428 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.004 0.0045
Schistosoma mansoni lipoxygenase 0.0204 0.0963 0.1375
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1435 0.7163 1
Schistosoma mansoni intermediate filament proteins 0.0031 0.0094 0.0134
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.1245 1
Plasmodium vivax aspartyl protease, putative 0.0018 0.0028 0.0664
Loa Loa (eye worm) heat shock protein 75 0.003 0.0086 0.0318
Brugia malayi nuclear receptor RXR 0.0021 0.004 0.017
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0396 0.1459
Trypanosoma brucei DNA topoisomerase ii 0.0015 0.0011 0.023
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.004 0.017
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0067 0.0274 0.0392
Mycobacterium tuberculosis Probable reductase 0.0223 0.1059 0.1465
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1998 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Plasmodium falciparum plasmepsin V 0.0018 0.0028 0.0664
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0094 0.041 0.3682
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0067 0.0274 0.6407
Trypanosoma cruzi heat shock protein 85, putative 0.0073 0.0303 0.6356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0044 0.0157 0.0578
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0015 0.0011 0.0039
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.0795 0.7231
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0037 0.0385
Trichomonas vaginalis DNA topoisomerase II, putative 0.0015 0.0011 0.0056
Trichomonas vaginalis heat shock protein, putative 0.0058 0.0228 0.1804
Brugia malayi Nuclear hormone receptor E75 0.0021 0.004 0.017
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0017 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0259 0.037
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0028 0.0027
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.005 0.117
Echinococcus granulosus importin subunit beta 1 0.0028 0.0079 0.0101
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0042 0.0047
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.0141 0.1469
Entamoeba histolytica hypothetical protein 0.0023 0.0052 0.1072
Echinococcus multilocularis heat shock protein 90 0.0073 0.0303 0.042
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0563 0.2773 0.2766
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0259 0.0358
Giardia lamblia Heat shock protein HSP 90-alpha 0.0058 0.0228 0.084
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0396 0.0554
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0795 0.6374
Loa Loa (eye worm) hypothetical protein 0.0552 0.2714 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0139 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0044 0.0157 0.0661
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0071 0.0539
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.5766
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0552 0.2714 0.3869
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0015 0.0011 0.023
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0067 0.0274 0.5766
Toxoplasma gondii aspartyl protease 0.0018 0.0028 0.0103
Brugia malayi MH1 domain containing protein 0.0018 0.0028 0.0118
Schistosoma mansoni lamin 0.0031 0.0094 0.0134
Plasmodium vivax plasmepsin IV, putative 0.0077 0.0326 0.7609
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0159 0.0215
Echinococcus multilocularis thyroid hormone receptor alpha 0.0044 0.0157 0.0212
Toxoplasma gondii exonuclease III APE 0.004 0.0139 0.0501
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0017 0.0011
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0322 0.6757
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0067 0.0274 0.5766
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0107 0.0476 0.0668
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0044 0.0157 0.0578
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0204 0.0963 0.1331
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0107 0.0096
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.2821
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0321 0.1551 0.2206
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0157 0.0212
Schistosoma mansoni cpg binding protein 0.0063 0.0252 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0126 0.0986
Brugia malayi Pepsin A precursor 0.0018 0.0028 0.012
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0396 0.8318
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0259 0.037
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0037 0.0134
Trypanosoma brucei unspecified product 0.0028 0.0078 0.1634
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0086 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0395 0.0564
Loa Loa (eye worm) thioredoxin reductase 0.0098 0.0428 0.1578
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0795 0.6374
Echinococcus multilocularis FTZ F1 alpha 0.0044 0.0157 0.0212
Plasmodium falciparum importin beta, putative 0.0028 0.0079 0.185
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0033 0.0103 0.2411
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0053 0.0223
Trypanosoma brucei heat shock protein, putative 0.0073 0.0303 0.6356
Schistosoma mansoni hypothetical protein 0.0024 0.0058 0.0082
Onchocerca volvulus 0.0065 0.0263 0.2327
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0077 0.0326 0.0466
Echinococcus multilocularis lamin dm0 0.0031 0.0094 0.0121
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0157 0.0224
Echinococcus granulosus chromobox protein 1 0.0067 0.0275 0.0381
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.019 0.08
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0059 0.0447
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0083
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0322 0.0447
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0322 0.6757
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0088 0.0113
Toxoplasma gondii aspartyl protease ASP1 0.0077 0.0326 0.1175
Schistosoma mansoni ran 0.0021 0.0042 0.0059
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0107 0.0107
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0077 0.0324 0.0451
Brugia malayi aspartic protease BmAsp-1, identical 0.0018 0.0028 0.012
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0088 0.0113
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.008 0.0339 0.0473
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Echinococcus granulosus geminin 0.0686 0.3391 0.4837
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0248 0.1184 0.164
Brugia malayi tailless protein 0.0021 0.004 0.017
Echinococcus granulosus cpg binding protein 0.0063 0.0252 0.0348
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0037 0.0137
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0059 0.0447
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0021 0.004 0.0149
Schistosoma mansoni cathepsin D (A01 family) 0.0077 0.0326 0.0466
Echinococcus multilocularis cpg binding protein 0.0063 0.0252 0.0348
Brugia malayi hypothetical protein 0.0023 0.0053 0.0223
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0578
Schistosoma mansoni hypothetical protein 0.0686 0.3391 0.4843
Brugia malayi nuclear hormone receptor 0.0044 0.0157 0.0661
Loa Loa (eye worm) nuclear hormone receptor 0.0021 0.004 0.0149
Plasmodium vivax endoplasmin, putative 0.0073 0.0303 0.7063
Schistosoma mansoni myelin transcription factor 1 myt1 0.0107 0.0476 0.068
Schistosoma mansoni hypothetical protein 0.0065 0.0263 0.0376
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0395 0.1662
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0107 0.045
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0034 0.0036
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0484 0.2376 0.3385
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.005 0.0521
Trypanosoma cruzi heat shock protein 85, putative 0.0073 0.0303 0.6356
Brugia malayi mbt repeat family protein 0.0094 0.041 0.1726
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0396 0.0554
Trypanosoma brucei heat shock protein, putative 0.0073 0.0303 0.6356
Onchocerca volvulus 0.0021 0.004 0.0272
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0206 0.0745
Plasmodium falciparum DNA topoisomerase 2 0.0015 0.0011 0.0255
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0067 0.0274 0.038
Brugia malayi ecdysteroid receptor 0.0044 0.0157 0.0661
Schistosoma mansoni DNA topoisomerase II 0.0015 0.0011 0.0016
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0107 0.0476 0.0668
Loa Loa (eye worm) TOPoisomerase family member 0.0015 0.0011 0.004
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0094 0.0345
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0259 0.0954
Schistosoma mansoni polycystin 1-related 0.0065 0.0263 0.0376
Brugia malayi Smad1 0.0018 0.0028 0.0118
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0322 0.6757
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0259 0.037
Plasmodium vivax aspartyl protease, putative 0.0018 0.0028 0.0664
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0094 0.041 0.0586
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0223 0.1059 0.1465
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Schistosoma mansoni hypothetical protein 0.0034 0.011 0.0157
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0067 0.0274 0.0392
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0015 0.0011 0.023
Toxoplasma gondii Erv1 / Alr family protein 0.0033 0.0103 0.0372
Echinococcus granulosus bloom syndrome protein 0.002 0.0037 0.004
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0044 0.0157 0.0212
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0563 0.2773 0.2773
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.008 0.0339 0.0473
Brugia malayi hypothetical protein 0.0035 0.0111 0.0466
Toxoplasma gondii aspartyl protease ASP3 0.0018 0.0028 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Plasmodium vivax DNA gyrase subunit B, putative 0.0015 0.0011 0.0255
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0157 0.0224
Loa Loa (eye worm) endoplasmin 0.0073 0.0303 0.1115
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0015 0.0011 0.0003
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.2179
Schistosoma mansoni hypothetical protein 0.0016 0.0017 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Echinococcus granulosus heat shock protein 90 0.0058 0.0228 0.0313
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.012 0.0158
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0059 0.0447
Brugia malayi Doublecortin family protein 0.0065 0.0263 0.1108
Toxoplasma gondii aldehyde dehydrogenase 0.0204 0.0963 0.3472
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.008 0.0339 0.0473
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0033 0.0103 0.0135
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0037 0.0156
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0053 0.0063
Loa Loa (eye worm) RNA binding protein 0.0064 0.0259 0.0954
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0395 0.0564
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0039 0.0132 0.1035
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0067 0.0274 0.1155
Plasmodium falciparum phosphodiesterase gamma, putative 0.0067 0.0274 0.6407
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.2015 0.2869
Echinococcus granulosus heat shock protein 0.0073 0.0303 0.042
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0035
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.2821
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0275 0.2186
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0141 0.2971
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0149
Brugia malayi nuclear hormone receptor 0.0021 0.004 0.017
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0107 0.0385
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0322 0.1354
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.2821
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0578
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.1245 1
Plasmodium falciparum glutathione reductase 0.0098 0.0428 1
Entamoeba histolytica heat shock protein 90, putative 0.0073 0.0303 0.7574
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0067 0.0274 0.5766
Trypanosoma cruzi heat shock protein 90, putative 0.0058 0.0228 0.4789
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0139 0.0186
Plasmodium vivax phosphodiesterase gamma, putative 0.0067 0.0274 0.6407
Brugia malayi Ets-domain containing protein 0.0071 0.0295 0.1243
Brugia malayi RNA, U transporter 1 0.0081 0.0343 0.1442
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0578
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0067 0.0274 0.2179
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0795 0.6374
Schistosoma mansoni loxhd1 0.0065 0.0263 0.0376
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0072 0.0299 0.1076
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0017 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0044 0.0157 0.0661
Brugia malayi steroid hormone receptor 0.0044 0.0157 0.0661
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0015 0.0011 0.0056
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0325
Loa Loa (eye worm) hypothetical protein 0.0034 0.011 0.0405
Schistosoma mansoni aldehyde dehydrogenase 0.0204 0.0963 0.1375
Trypanosoma brucei polo-like protein kinase 0.0091 0.0396 0.8318
Leishmania major developmentally regulated phosphoprotein-like protein 0.0015 0.0011 0.0114
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0275 0.2186
Echinococcus multilocularis muscleblind protein 1 0.0298 0.1435 0.204
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0044 0.0157 0.0661
Brugia malayi Endoplasmin precursor 0.0073 0.0303 0.1273
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0067 0.0274 0.0392
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0015 0.0011 0.0011
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0042 0.0872
Loa Loa (eye worm) hypothetical protein 0.0054 0.0206 0.0761
Loa Loa (eye worm) glutathione reductase 0.0098 0.0428 0.1578
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0396 0.3158
Brugia malayi MH1 domain containing protein 0.0018 0.0028 0.0118
Onchocerca volvulus 0.008 0.0341 0.3043
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0017 0.0061
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.1245 1
Onchocerca volvulus Dual oxidase homolog 0.0228 0.1086 0.9915
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.0141 0.019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0107 0.2245
Onchocerca volvulus 0.0031 0.0094 0.0764
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0107 0.0134
Trichomonas vaginalis heat shock protein, putative 0.0058 0.0228 0.1804
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.005 0.0039
Echinococcus granulosus SAM and MBT domain containing protein 0.0094 0.041 0.0574
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0044 0.0157 0.0661
Schistosoma mansoni pyruvate dehydrogenase 0.0015 0.0011 0.0016
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.004 0.0272
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0396 0.3158
Loa Loa (eye worm) fli-1 protein 0.0216 0.1026 0.378
Trichomonas vaginalis MYB3r3, putative 0.0039 0.0132 0.1035
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0088 0.0113
Schistosoma mansoni nuclear receptor nhr-48 0.0021 0.004 0.0058
Loa Loa (eye worm) hypothetical protein 0.005 0.019 0.0701
Entamoeba histolytica hypothetical protein 0.0036 0.012 0.2821
Loa Loa (eye worm) hypothetical protein 0.0031 0.0091 0.0335
Brugia malayi TAR-binding protein 0.0064 0.0259 0.109
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0028 0.0041
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0379 0.1844 0.2625
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0028 0.004
Brugia malayi Fli-1 protein 0.0216 0.1026 0.4318
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0044 0.0157 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0044 0.0157 0.0578
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0037 0.004
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0018 0.0028 0.0103
Schistosoma mansoni microtubule-associated protein tau 0.1403 0.7001 1
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0206 0.4821
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0079 0.1665
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0067 0.0274 0.038
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0015 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.0077 0.0326 0.1201
Schistosoma mansoni cpg binding protein 0.0063 0.0252 0.036
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0086 0.0111
Giardia lamblia Myb 1-like protein 0.0039 0.0133 0.0491
Brugia malayi conserved hypotetical protein 0.0021 0.004 0.017
Trypanosoma brucei DNA polymerase eta, putative 0.0068 0.0277 0.5814
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Schistosoma mansoni hypothetical protein 0.0036 0.012 0.0171
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0059 0.0233 0.4896
Onchocerca volvulus 0.0059 0.0235 0.2066
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0094 0.0395
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0011 0.0255
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0053 0.0195
Leishmania major heat shock protein 83-1 0.0073 0.0303 0.3142
Schistosoma mansoni DNA helicase recq5 0.002 0.0037 0.0053
Mycobacterium tuberculosis Probable dehydrogenase 0.0223 0.1059 0.1465
Echinococcus granulosus voltage dependent calcium channel 0.0022 0.0047 0.0054
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0139 0.0128
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.0141 0.3389
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0067 0.0274 0.0392
Plasmodium vivax aspartyl proteinase, putative 0.0018 0.0028 0.0664
Loa Loa (eye worm) hypothetical protein 0.0044 0.0157 0.0578
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0095 0.0416 0.0594
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Brugia malayi hypothetical protein 0.0064 0.0257 0.1084
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0144 0.0205
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0044 0.0157 0.0212
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0015 0.0011 0.023
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0067 0.0274 0.0392
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0095 0.0416 0.0583
Leishmania major hypothetical protein, conserved 0.0015 0.0011 0.0114
Loa Loa (eye worm) hypothetical protein 0.0067 0.0274 0.1011
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0067 0.0274 0.2179
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0067 0.0274 0.1155
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0107 0.2245
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Trichomonas vaginalis heat shock protein, putative 0.0058 0.0228 0.1804
Echinococcus multilocularis GPCR, family 2 0.0016 0.0017 0.0011
Schistosoma mansoni ran 0.0021 0.0042 0.0059
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0018 0.0028 0.0041
Loa Loa (eye worm) hypothetical protein 0.0061 0.0243 0.0896
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0078 0.1634
Entamoeba histolytica hypothetical protein 0.0031 0.009 0.2066
Echinococcus multilocularis polycomb protein SCMH1 0.0094 0.041 0.0574
Loa Loa (eye worm) steroid hormone receptor 0.0044 0.0157 0.0578
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0058 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0141 0.2971
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0107 0.014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0395 0.0552
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0157 0.0224
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.004 0.017
Plasmodium falciparum plasmepsin VIII, putative 0.0018 0.0028 0.0664
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0067 0.0274 0.038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0016 0.0023
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0095 0.0416 0.0583
Trypanosoma brucei trypanothione reductase 0.0098 0.0428 0.8999
Echinococcus multilocularis heat shock protein 0.0073 0.0303 0.042
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0563 0.2773 0.3863
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0067 0.0274 0.099
Entamoeba histolytica recQ family helicase, putative 0.002 0.0037 0.0679
Leishmania major heat shock protein, putative 0.003 0.0086 0.0897
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0067 0.0274 0.6407
Toxoplasma gondii transporter, cation channel family protein 0.0022 0.0047 0.0168
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0139 0.3328
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0107 0.2245
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.019 0.08
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0107 0.0394
Schistosoma mansoni nuclear hormone receptor 0.0021 0.004 0.0058
Echinococcus multilocularis microtubule associated protein 2 0.1403 0.7001 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0107 0.0385
Trypanosoma brucei heat shock protein, putative 0.0073 0.0303 0.6356
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0037 0.0134
Trypanosoma cruzi heat shock protein 90, putative 0.0043 0.0152 0.3204
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0263 0.0364
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0033 0.0138
Brugia malayi Ets-domain containing protein 0.0071 0.0295 0.1243
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0077 0.0326 0.1201
Loa Loa (eye worm) hypothetical protein 0.0065 0.0263 0.097
Loa Loa (eye worm) hypothetical protein 0.0298 0.1435 0.5289
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0067 0.0274 0.5766
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0088 0.0126
Schistosoma mansoni hypothetical protein 0.008 0.0339 0.0485
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0067 0.0274 0.038
Brugia malayi MH2 domain containing protein 0.0018 0.0028 0.0118
Trypanosoma cruzi DNA topoisomerase II, putative 0.0015 0.0011 0.023
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0042 0.0969
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.0341 0.0475
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.012 0.0171
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0107 0.2494
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0107 0.0153
Brugia malayi hypothetical protein 0.0065 0.0263 0.1108
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0067 0.0274 0.1011
Plasmodium vivax plasmepsin V, putative 0.0018 0.0028 0.0664
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0107 0.014
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.0141 0.0521
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0107 0.2245
Echinococcus granulosus voltage dependent calcium channel 0.0095 0.0416 0.0583
Schistosoma mansoni coup transcription factor 0.0044 0.0157 0.0224
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0139 0.0139

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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