TDR Targets

Basic information

Technical information

TDR Targets ID: 846697
Name: N,N-dimethyl-5,7-dinitroquinolin-8-amine
MW: 262.221 | Formula: C11H10N4O4
H donors: 0 H acceptors: 5 LogP: 1.97 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1cc([N+](=O)[O-])c(c2c1cccn2)N(C)C
InChi: 1S/C11H10N4O4/c1-13(2)11-9(15(18)19)6-8(14(16)17)7-4-3-5-12-10(7)11/h3-6H,1-2H3
InChiKey: AEEHUYPODDIQHA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N,N-dimethyl-5,7-dinitro-quinolin-8-amine
N,N-dimethyl-5,7-dinitro-8-quinolinamine
(5,7-dinitro-8-quinolyl)-dimethyl-amine
Oprea1_511836
CBMicro_019601
BIM-0019538.P001
ZINC03880734

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0092	0.5193	0.5193
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0092	0.5193	0.5193
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0092	0.5193	1
Brugia malayi	Cathepsin L-like precursor	0.0092	0.5193	0.5193
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.2589	0.2606
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0092	0.5193	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2792	0.2792
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0092	0.5193	1
Leishmania major	cathepsin L-like protease	0.0092	0.5193	1
Loa Loa (eye worm)	cathepsin B	0.006	0.2589	0.2589
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.015	1	1
Plasmodium vivax	vivapain-3	0.0049	0.1672	0.322
Leishmania major	cathepsin L-like protease	0.0092	0.5193	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.5193	1
Loa Loa (eye worm)	hypothetical protein	0.015	1	1
Leishmania major	cathepsin L-like protease	0.0092	0.5193	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.2589	0.2589
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Onchocerca volvulus		0.0092	0.5193	1
Brugia malayi	Cathepsin L-like precursor	0.0063	0.2792	0.2792
Onchocerca volvulus		0.0092	0.5193	1
Brugia malayi	Cathepsin L-like precursor	0.0092	0.5193	0.5193
Plasmodium vivax	vivapain-2	0.0092	0.5193	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.015	1	1
Echinococcus granulosus	cathepsin b	0.015	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0092	0.5193	0.4228
Onchocerca volvulus		0.0092	0.5193	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2792	0.2792
Trypanosoma cruzi	cysteine protease, putative	0.0049	0.1672	0.1672
Echinococcus granulosus	cathepsin l1	0.0092	0.5193	0.4228
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Onchocerca volvulus		0.0092	0.5193	1
Onchocerca volvulus	Cathepsin L homolog	0.0092	0.5193	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0049	0.1672	0.1672
Schistosoma mansoni	cathepsin F (C01 family)	0.0063	0.2792	0.2792
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0049	0.1672	0.1672
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Brugia malayi	cathepsin L-like precursor	0.0063	0.2792	0.2792
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.5193	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0092	0.5193	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0049	0.1672	0.1672
Trypanosoma cruzi	cysteine proteinase, putative	0.0049	0.1672	0.1672
Brugia malayi	Cathepsin L-like precursor	0.0092	0.5193	0.5193
Entamoeba histolytica	cysteine proteinase, putative	0.0063	0.2792	0.3182
Leishmania major	cathepsin L-like protease	0.0092	0.5193	1
Brugia malayi	Cathepsin L-like precursor	0.0063	0.2792	0.2792
Giardia lamblia	Cathepsin B precursor	0.006	0.2589	0.5
Loa Loa (eye worm)	fibroinase	0.0092	0.5193	0.5193
Plasmodium vivax	vivapain-2	0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.2792	0.3182
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.2589	0.2606
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0092	0.5193	0.4228
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.5193	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0092	0.5193	0.5193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Echinococcus multilocularis	cathepsin b	0.015	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0092	0.5193	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.2589	0.2589
Entamoeba histolytica	cysteine proteinase, putative	0.0092	0.5193	1
Echinococcus granulosus	cathepsin l1	0.0063	0.2792	0.1345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0092	0.5193	1
Leishmania major	cathepsin L-like protease	0.0092	0.5193	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0063	0.2792	0.2792
Leishmania major	cathepsin L-like protease	0.0092	0.5193	1
Leishmania major	cathepsin L-like protease	0.0092	0.5193	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.5193	1
Leishmania major	cysteine peptidase A (CPA)	0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0092	0.5193	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.5193	1
Onchocerca volvulus		0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0063	0.2792	0.3182
Entamoeba histolytica	cysteine protease, putative	0.0092	0.5193	1
Echinococcus granulosus	cathepsin b	0.015	1	1
Brugia malayi	Cathepsin L-like precursor	0.0092	0.5193	0.5193
Giardia lamblia	Cathepsin B precursor	0.006	0.2589	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0092	0.5193	0.5193
Echinococcus multilocularis	cathepsin b	0.015	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0092	0.5193	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0049	0.1672	0.1672
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Plasmodium vivax	vivapain-1	0.0049	0.1672	0.322
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.2792	0.2792
Leishmania major	cathepsin L-like protease	0.0092	0.5193	1
Echinococcus multilocularis	cysteine protease	0.0092	0.5193	0.4228
Brugia malayi	Cathepsin L-like precursor	0.0092	0.5193	0.5193
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Brugia malayi	Papain family cysteine protease containing protein	0.0049	0.1672	0.1672
Loa Loa (eye worm)	hypothetical protein	0.0092	0.5193	0.5193
Trypanosoma cruzi	cruzipain precursor, putative	0.0092	0.5193	0.5193
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.5193	1
Brugia malayi	Cathepsin L-like precursor	0.0092	0.5193	0.5193
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0092	0.5193	0.4228
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0049	0.1672	0.1672
Giardia lamblia	Cathepsin B precursor	0.006	0.2589	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0054	0.2098	0.2098
Echinococcus multilocularis	cathepsin L cysteine protease	0.0092	0.5193	0.4228
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.5193	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0092	0.5193	0.4228
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0092	0.5193	1
Onchocerca volvulus		0.0092	0.5193	1
Loa Loa (eye worm)	cysteine protease	0.0092	0.5193	0.5193
Onchocerca volvulus		0.0092	0.5193	1
Onchocerca volvulus	Cathepsin L homolog	0.0092	0.5193	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.5193	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.015	1	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.2792	0.2792
Trypanosoma cruzi	cysteine proteinase, putative	0.0049	0.1672	0.1672
Entamoeba histolytica	cysteine proteinase, putative	0.0092	0.5193	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0092	0.5193	0.5193
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0092	0.5193	1
Loa Loa (eye worm)	ctsf protein	0.0092	0.5193	0.5193
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0092	0.5193	0.5193
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.015	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0092	0.5193	0.4228
Toxoplasma gondii	cathepsin CPL	0.0092	0.5193	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.015	1	1
Echinococcus multilocularis	cysteine protease	0.0092	0.5193	0.4228
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0092	0.5193	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0092	0.5193	0.5193
Brugia malayi	Papain family cysteine protease containing protein	0.0092	0.5193	0.5193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Brugia malayi	Cytochrome P450 family protein	0.0054	0.2098	0.2098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.5193	1
Brugia malayi	Papain family cysteine protease containing protein	0.0049	0.1672	0.1672
Plasmodium vivax	unspecified product	0.0049	0.1672	0.322
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0092	0.5193	0.5193

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 846697