TDR Targets

Basic information

Technical information

TDR Targets ID: 846807
Name: 3-(3,4-dichlorophenyl)-2-(4-methylphenyl)-1,3 -thiazolidin-4-one
MW: 338.252 | Formula: C16H13Cl2NOS
H donors: 0 H acceptors: 1 LogP: 4.98 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)C1SCC(=O)N1c1ccc(c(c1)Cl)Cl
InChi: 1S/C16H13Cl2NOS/c1-10-2-4-11(5-3-10)16-19(15(20)9-21-16)12-6-7-13(17)14(18)8-12/h2-8,16H,9H2,1H3
InChiKey: OXDKGYVRIJMVGI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(3,4-dichlorophenyl)-2-(4-methylphenyl)thiazolidin-4-one
3-(3,4-dichlorophenyl)-2-(4-methylphenyl)-4-thiazolidinone
5377-27-5
CBMicro_019736
BIM-0019647.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Cathepsin F homolog	0.0278	1	1
Schistosoma mansoni	cathepsin s	0.009	0.2519	0.1586
Brugia malayi	Cathepsin L-like precursor	0.0278	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0055	0.1109	0.1109
Entamoeba histolytica	cysteine protease, putative	0.0278	1	1
Onchocerca volvulus		0.0278	1	1
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0278	1	1
Brugia malayi	Cytochrome P450 family protein	0.0062	0.1389	0.1389
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Plasmodium vivax	vivapain-2	0.0278	1	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1109	0.1109
Toxoplasma gondii	cathepsin CPL	0.0278	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0055	0.1109	0.1109
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0203	0.7009	0.7009
Onchocerca volvulus		0.0278	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0278	1	1
Giardia lamblia	Cathepsin B precursor	0.0101	0.2934	1
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Onchocerca volvulus		0.0278	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0278	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1529	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0087	0.0087
Onchocerca volvulus		0.0278	1	1
Plasmodium vivax	vivapain-1	0.0145	0.4714	0.4714
Schistosoma mansoni	cathepsin F (C01 family)	0.0187	0.6396	0.5946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0278	1	1
Echinococcus multilocularis	cathepsin b	0.0203	0.7009	0.6636
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0278	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0278	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0055	0.1109	0.1109
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0278	1	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1109	0.1109
Entamoeba histolytica	cysteine proteinase, putative	0.0145	0.4714	0.4054
Leishmania major	cathepsin L-like protease	0.0278	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0278	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0055	0.1109	0.1109
Trypanosoma cruzi	cysteine protease, putative	0.0145	0.4714	0.4714
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Brugia malayi	MH2 domain containing protein	0.0129	0.4054	0.4054
Loa Loa (eye worm)	cysteine protease	0.0278	1	1
Echinococcus granulosus	cysteine protease	0.0145	0.4714	0.4054
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.1529	0.1529
Trypanosoma cruzi	cysteine proteinase, putative	0.0145	0.4714	0.4714
Entamoeba histolytica	cysteine proteinase 1, putative	0.0145	0.4714	0.4054
Echinococcus granulosus	cathepsin L	0.0145	0.4714	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0278	1	1
Leishmania major	cathepsin L-like protease	0.0278	1	1
Plasmodium falciparum	serine repeat antigen 5	0.0055	0.1109	0.1109
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0055	0.1109	0.1109
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0203	0.7009	0.6636
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0278	1	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0055	0.1109	0.1109
Trypanosoma cruzi	cysteine peptidase, putative	0.009	0.2519	0.2519
Entamoeba histolytica	cysteine proteinase, putative	0.0145	0.4714	0.4054
Loa Loa (eye worm)	fibroinase	0.0278	1	1
Brugia malayi	cathepsin L precursor	0.0055	0.1109	0.1109
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0055	0.1109	0.1109
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0087	0.0087
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0278	1	1
Brugia malayi	Cathepsin L-like precursor	0.0278	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0278	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0278	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0187	0.6396	0.6396
Plasmodium vivax	serine-repeat antigen (SERA)	0.0055	0.1109	0.1109
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.009	0.2519	0.2519
Loa Loa (eye worm)	hypothetical protein	0.009	0.2519	0.2519
Trypanosoma cruzi	cysteine peptidase, putative	0.0278	1	1
Plasmodium falciparum	serine repeat antigen 8	0.0055	0.1109	0.1109
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0278	1	1
Echinococcus granulosus	cathepsin l1	0.0278	1	1
Toxoplasma gondii	cathepsin CPC2	0.0055	0.1109	0.1109
Brugia malayi	Cathepsin L-like precursor	0.0278	1	1
Leishmania major	cathepsin L-like protease	0.0278	1	1
Trypanosoma cruzi	cytochrome P450, putative	0.0029	0.0087	0.0087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0145	0.4714	0.4714
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0101	0.2934	0.2934
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.1529	0.1529
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0278	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1529	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1109	0.1109
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1529	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0278	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0278	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0278	1	1
Plasmodium falciparum	serine repeat antigen 2	0.0055	0.1109	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1109	0.1109
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Plasmodium vivax	vivapain-3	0.0145	0.4714	0.4714
Loa Loa (eye worm)	hypothetical protein	0.009	0.2519	0.2519
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0145	0.4714	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0278	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0203	0.7009	0.6636
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Onchocerca volvulus		0.0278	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0101	0.2934	0.2934
Loa Loa (eye worm)	CYP4Cod1	0.0029	0.0087	0.0087
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Leishmania major	cathepsin L-like protease	0.0278	1	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.1529	0.5
Plasmodium falciparum	serine repeat antigen 4	0.0055	0.1109	0.1109
Entamoeba histolytica	cysteine proteinase, putative	0.0278	1	1
Plasmodium falciparum	serine repeat antigen 6	0.0055	0.1109	0.1109
Trypanosoma cruzi	cysteine proteinase, putative	0.0145	0.4714	0.4714
Plasmodium falciparum	serine repeat antigen 3	0.0055	0.1109	0.1109
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0055	0.1109	0.1109
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0055	0.1109	0.1109
Plasmodium falciparum	serine repeat antigen 1	0.0055	0.1109	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1109	0.1109
Brugia malayi	Papain family cysteine protease containing protein	0.0055	0.1109	0.1109
Loa Loa (eye worm)	hypothetical protein	0.009	0.2519	0.2519
Brugia malayi	Cathepsin L-like precursor	0.0187	0.6396	0.6396
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.6396	0.5946
Brugia malayi	cathepsin B-like cysteine proteinase	0.0203	0.7009	0.7009
Loa Loa (eye worm)	hypothetical protein	0.0278	1	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0055	0.1109	0.1109
Entamoeba histolytica	cysteine proteinase 2	0.0145	0.4714	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0278	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0278	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.009	0.2519	0.2519
Entamoeba histolytica	cysteine proteinase, putative	0.0145	0.4714	0.4054
Brugia malayi	Cathepsin L-like precursor	0.009	0.2519	0.2519
Loa Loa (eye worm)	hypothetical protein	0.0187	0.6396	0.6396
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0055	0.1109	0.1109
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1529	0.0472
Brugia malayi	cathepsin L-like precursor	0.0187	0.6396	0.6396
Brugia malayi	Papain family cysteine protease containing protein	0.0145	0.4714	0.4714
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0055	0.1109	0.1109
Leishmania major	cathepsin L-like protease	0.0278	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0278	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.6396	0.5946
Giardia lamblia	Cathepsin B precursor	0.0101	0.2934	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0062	0.1389	0.1389
Brugia malayi	Papain family cysteine protease containing protein	0.0278	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0145	0.4714	0.4714
Loa Loa (eye worm)	hypothetical protein	0.0187	0.6396	0.6396
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0278	1	1
Giardia lamblia	Cathepsin B precursor	0.0101	0.2934	1
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0145	0.4714	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0055	0.1109	0.1109
Plasmodium vivax	unspecified product	0.0055	0.1109	0.1109
Loa Loa (eye worm)	cathepsin B	0.0101	0.2934	0.2934
Leishmania major	cathepsin L-like protease	0.0278	1	1
Onchocerca volvulus		0.0187	0.6396	0.5946
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0055	0.1109	0.1109
Trypanosoma brucei	cytochrome P450, putative	0.0029	0.0087	0.0087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0278	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.009	0.2519	0.2519
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.009	0.2519	0.2519
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0278	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0278	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0145	0.4714	0.4714
Echinococcus multilocularis	cysteine protease	0.0278	1	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.7009	0.7009
Leishmania major	cathepsin L-like protease	0.0278	1	1
Echinococcus granulosus	cathepsin b	0.0203	0.7009	0.6636
Loa Loa (eye worm)	hypothetical protein	0.0187	0.6396	0.6396
Trypanosoma cruzi	cytochrome P450, putative	0.0029	0.0087	0.0087
Brugia malayi	Papain family cysteine protease containing protein	0.0145	0.4714	0.4714
Onchocerca volvulus		0.0278	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0145	0.4714	0.4714
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0278	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0203	0.7009	0.6636
Brugia malayi	fibroinase precursor	0.0055	0.1109	0.1109
Echinococcus granulosus	cathepsin L cysteine protease	0.0145	0.4714	0.4054
Plasmodium vivax	unspecified product	0.0145	0.4714	0.4714
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0278	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Brugia malayi	Cathepsin L-like precursor	0.0187	0.6396	0.6396
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0278	1	1
Plasmodium falciparum	serine repeat antigen 9	0.0055	0.1109	0.1109
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0055	0.1109	0.1109
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0278	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0145	0.4714	0.4054
Plasmodium falciparum	serine repeat antigen 7	0.0055	0.1109	0.1109
Entamoeba histolytica	cysteine proteinase, putative	0.0145	0.4714	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0055	0.1109	0.1109
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0278	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0055	0.1109	0.1109
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0087	0.0087
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0055	0.1109	0.1109
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0145	0.4714	0.4054
Leishmania major	cathepsin L-like protease	0.0278	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0145	0.4714	0.4054
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0055	0.1109	0.1109
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0055	0.1109	0.1109
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1529	0.0472
Trypanosoma cruzi	cruzipain precursor, putative	0.0278	1	1
Toxoplasma gondii	cathepsin B	0.0101	0.2934	0.2934
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0055	0.1109	0.1109
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0278	1	1
Echinococcus granulosus	cathepsin b	0.0203	0.7009	0.6636
Echinococcus multilocularis	cathepsin L	0.0145	0.4714	0.4054
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.4054	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0203	0.7009	0.6636
Brugia malayi	Cathepsin L-like precursor	0.0278	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0278	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0278	1	1
Leishmania major	cytochrome p450-like protein	0.0029	0.0087	0.0087
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0087	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1109	0.1109
Echinococcus multilocularis	cathepsin b	0.0203	0.7009	0.6636
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0187	0.6396	0.6396
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0278	1	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0055	0.1109	0.1109
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Leishmania major	cysteine peptidase A (CPA)	0.0278	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0278	1	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.1529	0.0472
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0101	0.2934	0.2052
Echinococcus granulosus	cathepsin l1	0.0187	0.6396	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0278	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0101	0.2934	0.2934
Onchocerca volvulus	Cathepsin L homolog	0.0278	1	1
Echinococcus multilocularis	cysteine protease	0.0278	1	1
Plasmodium vivax	vivapain-2	0.0278	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0145	0.4714	0.4714
Echinococcus multilocularis	cathepsin L cysteine protease	0.0278	1	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0055	0.1109	0.1109
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.1529	0.0472
Entamoeba histolytica	cysteine protease, putative	0.0145	0.4714	0.4054
Loa Loa (eye worm)	ctsf protein	0.0278	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0187	0.6396	0.5946
Onchocerca volvulus		0.0278	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0278	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0101	0.2934	0.2052
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0055	0.1109	0.1109
Brugia malayi	Papain family cysteine protease containing protein	0.0055	0.1109	0.1109
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0278	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0278	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0278	1	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0055	0.1109	0.1109
Plasmodium vivax	unspecified product	0.009	0.2519	0.2519
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0055	0.1109	0.1109
Toxoplasma gondii	cathepsin CPC1	0.0055	0.1109	0.1109

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 846807