Detailed information for compound 847279

Basic information

Technical information
  • TDR Targets ID: 847279
  • Name: 3-chloro-N-[(2-methoxyphenyl)methyl]benzamide
  • MW: 275.73 | Formula: C15H14ClNO2
  • H donors: 1 H acceptors: 1 LogP: 3.29 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CNC(=O)c1cccc(c1)Cl
  • InChi: 1S/C15H14ClNO2/c1-19-14-8-3-2-5-12(14)10-17-15(18)11-6-4-7-13(16)9-11/h2-9H,10H2,1H3,(H,17,18)
  • InChiKey: BXALAQJASDAQCX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-chloro-N-(2-methoxybenzyl)benzamide
  • Oprea1_685129
  • STK029965
  • 3-Chloro-N-(2-methoxy-benzyl)-benzamide
  • BAS 00409772
  • Oprea1_744936
  • CBMicro_018325
  • ZINC00299556
  • BIM-0018285.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad1 5 8 and 0.0025 0.0155 0.0039
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0122 0.0265
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.0671 0.0667
Schistosoma mansoni microtubule-associated protein tau 0.0722 1 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0213 0.0436
Loa Loa (eye worm) beta-lactamase 0.0038 0.034 0.0696
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0155 0.0151
Schistosoma mansoni hypothetical protein 0.0168 0.2174 0.2082
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0122 0.025
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0696
Brugia malayi hypothetical protein 0.0022 0.0117 0.0239
Leishmania major hypothetical protein, conserved 0.0038 0.034 0.3756
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0117 0.0113
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.034 0.0696
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0712 0.1541
Schistosoma mansoni hypothetical protein 0.0322 0.4355 0.4288
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0721 0.0612
Loa Loa (eye worm) MH2 domain-containing protein 0.036 0.4885 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.034 1
Plasmodium vivax hypothetical protein, conserved 0.0038 0.034 1
Schistosoma mansoni rab6-interacting 0.0022 0.0117 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0421
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0518 0.0515
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0235 0.529
Onchocerca volvulus 0.0038 0.034 0.0961
Schistosoma mansoni ran 0.0022 0.0122 0.0006
Schistosoma mansoni smad 0.0025 0.0155 0.0039
Plasmodium falciparum importin beta, putative 0.003 0.0235 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0235 0.529
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.034 0.0226
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0518 0.0515
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.034 0.0579
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0116 0.0238
Brugia malayi beta-lactamase family protein 0.0038 0.034 0.0696
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0116 0.5
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0122 0.025
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0213 0.0436
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.0671 0.0667
Mycobacterium ulcerans lipase LipD 0.0038 0.034 0.0579
Loa Loa (eye worm) hypothetical protein 0.003 0.0235 0.048
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.034 0.0579
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0712 0.0708
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.034 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.244 0.4995
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0154 0.169
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0721 0.0612
Brugia malayi hypothetical protein 0.0022 0.0117 0.0239
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0696
Schistosoma mansoni ran 0.0022 0.0122 0.0006
Trichomonas vaginalis ran, putative 0.0022 0.0122 0.0265
Schistosoma mansoni lipoxygenase 0.0061 0.0671 0.0561
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.1971 0.4035
Echinococcus granulosus geminin 0.0168 0.2174 0.2171
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0721 0.1476
Brugia malayi beta-lactamase 0.0038 0.034 0.0696
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.034 0.0579
Brugia malayi RNA binding protein 0.0065 0.0721 0.1476
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0493 0.0489
Leishmania major GTP-binding protein, putative 0.0022 0.0122 0.01
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0493 0.0489
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0204 0.2691 0.2605
Schistosoma mansoni polycystin 1-related 0.0022 0.0117 0.0001
Echinococcus multilocularis lamin 0.0029 0.0213 0.0209
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0721 0.0717
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0598 0.1224
Echinococcus multilocularis musashi 0.0029 0.0213 0.0209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0518 0.0515
Mycobacterium tuberculosis Probable oxidoreductase 0.0296 0.3982 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0116 0.0112
Leishmania major importin beta-1 subunit, putative 0.0024 0.0154 0.0635
Entamoeba histolytica hypothetical protein 0.0024 0.0154 1
Onchocerca volvulus 0.0038 0.034 0.0961
Loa Loa (eye worm) Smad1 0.0025 0.0155 0.0316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0518 0.0407
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0322 0.4355 0.8914
Schistosoma mansoni hypothetical protein 0.0168 0.2174 0.2082
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0025 0.0052
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0696
Brugia malayi MH1 domain containing protein 0.0025 0.0155 0.0316
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.034 0.0579
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.3203 0.7984
Mycobacterium tuberculosis Conserved protein 0.0038 0.034 0.0579
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0154 0.169
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0117 0.0113
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0721 0.0612
Schistosoma mansoni loxhd1 0.0022 0.0117 0.0001
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0204 0.2691 0.5508
Echinococcus multilocularis geminin 0.0168 0.2174 0.2171
Mycobacterium ulcerans beta-lactamase 0.0038 0.034 0.0579
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0155 0.0151
Brugia malayi MH2 domain containing protein 0.0025 0.0155 0.0316
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0493 0.1009
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0712 0.1541
Brugia malayi Importin beta-1 subunit 0.003 0.0235 0.048
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0696
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.034 0.0336
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.034 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0493 0.0489
Schistosoma mansoni smad1 5 8 and 0.0025 0.0155 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.034 1
Brugia malayi Smad1 0.0025 0.0155 0.0316
Mycobacterium ulcerans hypothetical protein 0.0038 0.034 0.0579
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0155 0.0039
Echinococcus granulosus snurportin 1 0.0322 0.4355 0.4353
Mycobacterium leprae conserved hypothetical protein 0.0038 0.034 0.5
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0235 0.529
Echinococcus multilocularis Smad4 0.0025 0.0155 0.0151
Onchocerca volvulus 0.0038 0.034 0.0961
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.034 0.0579
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0696
Echinococcus granulosus GPCR family 2 0.0048 0.0493 0.0489
Echinococcus granulosus Smad4 0.0025 0.0155 0.0151
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.034 0.0226
Echinococcus granulosus importin subunit beta 1 0.003 0.0235 0.0231
Echinococcus multilocularis snurportin 1 0.0322 0.4355 0.4353
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0155 0.0151
Brugia malayi MH1 domain containing protein 0.0025 0.0155 0.0316
Brugia malayi RNA, U transporter 1 0.0086 0.102 0.2087
Echinococcus granulosus smad 0.0025 0.0155 0.0151
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0712 0.1541
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0117 0.0022
Loa Loa (eye worm) hypothetical protein 0.0048 0.0493 0.1009
Brugia malayi N-terminal motif family protein 0.0186 0.244 0.4995
Echinococcus multilocularis smad 0.0025 0.0155 0.0151
Schistosoma mansoni hypothetical protein 0.0105 0.1287 0.1184
Loa Loa (eye worm) hypothetical protein 0.0022 0.0117 0.0239
Schistosoma mansoni hypothetical protein 0.0048 0.0493 0.0381
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.034 0.0579
Schistosoma mansoni intermediate filament proteins 0.0029 0.0213 0.0098
Schistosoma mansoni Smad4 0.0025 0.0155 0.0039
Entamoeba histolytica Ran family GTPase 0.0022 0.0122 0.1567
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0117 0.0113
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0122 0.0501
Loa Loa (eye worm) hypothetical protein 0.0038 0.034 0.0696
Schistosoma mansoni hypothetical protein 0.0048 0.0493 0.0381
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0122 0.0265
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0122 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0712 0.0603
Echinococcus multilocularis importin subunit beta 1 0.003 0.0235 0.0231
Brugia malayi TAR-binding protein 0.0065 0.0721 0.1476
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0117 0.0113
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0204 0.2691 0.2605
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0493 0.0489
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.034 1
Echinococcus granulosus hormone sensitive lipase 0.0204 0.2691 0.2688
Schistosoma mansoni rab6-interacting 0.0022 0.0117 0.0001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0518 0.1061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0518 0.0515
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0154 0.169
Schistosoma mansoni hypothetical protein 0.0048 0.0493 0.0381
Schistosoma mansoni hypothetical protein 0.0022 0.0117 0.0001
Loa Loa (eye worm) RNA binding protein 0.0065 0.0721 0.1476
Schistosoma mansoni hypothetical protein 0.0048 0.0493 0.0381
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0721 0.0612
Mycobacterium tuberculosis Conserved protein 0.0038 0.034 0.0579
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.034 0.0579
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0712 0.0708
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0493 0.1009
Trichomonas vaginalis esterase, putative 0.0038 0.034 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.1971 0.4035
Toxoplasma gondii ABC1 family protein 0.0038 0.034 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0155 0.0316
Echinococcus multilocularis hormone sensitive lipase 0.0204 0.2691 0.2688
Echinococcus multilocularis lamin dm0 0.0029 0.0213 0.0209
Echinococcus granulosus lamin 0.0029 0.0213 0.0209
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0721 0.1476
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0122 0.0265
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0117 0.0042
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0116 0.5
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0122 0.0265
Echinococcus multilocularis GPCR, family 2 0.0048 0.0493 0.0489
Schistosoma mansoni lipoxygenase 0.0022 0.0117 0.0001
Brugia malayi beta-lactamase family protein 0.0038 0.034 0.0696
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0518 0.1061
Brugia malayi MH2 domain containing protein 0.036 0.4885 1
Schistosoma mansoni lamin 0.0029 0.0213 0.0098
Loa Loa (eye worm) hypothetical protein 0.0029 0.0213 0.0436
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0025 0.0052
Echinococcus multilocularis microtubule associated protein 2 0.0722 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0155 0.0316
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0721 0.1476
Echinococcus granulosus RUN 0.0022 0.0117 0.0113
Plasmodium vivax importin-beta 2, putative 0.003 0.0235 0.529
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.034 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.1287 0.2634
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.034 0.0336
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0122 0.0265
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.1971 0.4035
Echinococcus granulosus lamin dm0 0.0029 0.0213 0.0209
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0117 0.0239
Echinococcus granulosus intermediate filament protein 0.0029 0.0213 0.0209
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.034 0.0579
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0721 0.0612
Loa Loa (eye worm) hypothetical protein 0.0022 0.0117 0.0239
Schistosoma mansoni importin beta-1 0.003 0.0235 0.012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.034 0.0696
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.034 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0213 0.0436
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0493 0.1009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0518 0.0407
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.034 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0154 0.169
Echinococcus multilocularis RUN 0.0022 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0153 0.1971 0.4035
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.244 1
Brugia malayi Doublecortin family protein 0.0022 0.0117 0.0239
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0518 0.0407
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0116 0.0238
Onchocerca volvulus 0.0029 0.0213 0.0415
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0116 0.0112
Onchocerca volvulus 0.0029 0.0213 0.0415
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.1287 0.2634
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0117 0.0113
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0122 0.0118
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0712 1
Brugia malayi intermediate filament protein 0.0029 0.0213 0.0436
Loa Loa (eye worm) transcription factor SMAD2 0.036 0.4885 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0155 0.0151
Mycobacterium ulcerans short chain dehydrogenase 0.0296 0.3982 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0204 0.2691 0.2605
Mycobacterium tuberculosis Conserved protein 0.0038 0.034 0.0579
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0712 0.1457
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0122 0.0118
Brugia malayi MH2 domain containing protein 0.0025 0.0155 0.0316
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.034 0.0579
Schistosoma mansoni smad1 5 8 and 0.0025 0.0155 0.0039
Echinococcus granulosus tar DNA binding protein 0.0065 0.0721 0.0717
Schistosoma mansoni lamin 0.0029 0.0213 0.0098
Mycobacterium leprae Probable lipase LipE 0.0038 0.034 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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