TDR Targets

Basic information

Technical information

TDR Targets ID: 847463
Name: ethyl 2-[2-[2-(4-chlorophenoxy)ethylsulfanyl] benzimidazol-1-yl]acetate
MW: 390.884 | Formula: C19H19ClN2O3S
H donors: 0 H acceptors: 2 LogP: 4.97 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)Cn1c(SCCOc2ccc(cc2)Cl)nc2c1cccc2
InChi: 1S/C19H19ClN2O3S/c1-2-24-18(23)13-22-17-6-4-3-5-16(17)21-19(22)26-12-11-25-15-9-7-14(20)8-10-15/h3-10H,2,11-13H2,1H3
InChiKey: RZURCTMRADPBTP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[2-[2-(4-chlorophenoxy)ethylthio]-1-benzimidazolyl]acetic acid ethyl ester
2-[2-[2-(4-chlorophenoxy)ethylthio]benzimidazol-1-yl]acetic acid ethyl ester
ethyl 2-[2-[2-(4-chlorophenoxy)ethylsulfanyl]benzimidazol-1-yl]ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0185	0.5764	0.6364
Loa Loa (eye worm)	hypothetical protein	0.0275	0.9058	1
Brugia malayi	Cathepsin L-like precursor	0.0185	0.5764	0.6364
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0934	0.1031
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.052	0.0482
Brugia malayi	Papain family cysteine protease containing protein	0.0144	0.4227	0.4667
Loa Loa (eye worm)	hypothetical protein	0.0201	0.6329	0.6987
Entamoeba histolytica	cysteine proteinase, putative	0.0144	0.4227	0.3633
Onchocerca volvulus		0.0275	0.9058	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5764	0.6364
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0201	0.6329	0.6641
Brugia malayi	Muscleblind-like protein	0.0114	0.3146	0.3473
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0934	0.0548
Trypanosoma brucei	cysteine peptidase C (CPC)	0.01	0.2602	0.2873
Echinococcus multilocularis	cathepsin L	0.0144	0.4227	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0185	0.5764	0.6364
Echinococcus multilocularis	chromobox protein 1	0.0072	0.1568	0.078
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.03	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	0.9058	0.9018
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0934	0.1031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0934	0.0548
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2222	0.2453
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0275	0.9058	1
Echinococcus multilocularis	muscleblind protein	0.0114	0.3146	0.2723
Echinococcus multilocularis	cysteine protease	0.0275	0.9058	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	0.9058	1
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0934	0.0548
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0934	0.0548
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0144	0.4227	0.3982
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Onchocerca volvulus		0.0275	0.9058	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	0.9058	0.9018
Onchocerca volvulus	Cathepsin L homolog	0.0275	0.9058	1
Entamoeba histolytica	cysteine proteinase 2	0.0144	0.4227	0.3633
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0144	0.4227	0.3982
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Echinococcus granulosus	cathepsin b	0.0201	0.6329	0.6641
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0185	0.5764	0.6364
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0934	0.0548
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.052	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0934	0.1031
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0144	0.4227	0.4054
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Echinococcus multilocularis	chromobox protein 1	0.0072	0.1568	0.078
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0275	0.9058	1
Leishmania major	cathepsin L-like protease	0.0275	0.9058	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0089	0.2222	0.2453
Loa Loa (eye worm)	cathepsin B	0.01	0.2602	0.2873
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0144	0.4227	0.4667
Onchocerca volvulus		0.0275	0.9058	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0144	0.4227	0.4667
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0934	0.0548
Brugia malayi	Cytochrome P450 family protein	0.0061	0.1191	0.1315
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Echinococcus multilocularis	cathepsin b	0.0201	0.6329	0.6641
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	0.9058	0.9018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0185	0.5764	0.5584
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0934	0.1031
Brugia malayi	Cathepsin L-like precursor	0.0275	0.9058	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Leishmania major	cathepsin L-like protease	0.0275	0.9058	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0144	0.4227	0.4054
Echinococcus granulosus	cathepsin l1	0.0275	0.9058	1
Brugia malayi	cathepsin L precursor	0.0054	0.0934	0.1031
Trypanosoma cruzi	cysteine proteinase, putative	0.0144	0.4227	0.4667
Plasmodium vivax	unspecified product	0.0144	0.4227	0.4054
Onchocerca volvulus		0.0275	0.9058	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Onchocerca volvulus		0.0275	0.9058	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0934	0.0548
Entamoeba histolytica	cysteine protease, putative	0.0275	0.9058	0.8961
Brugia malayi	Papain family cysteine protease containing protein	0.0275	0.9058	1
Onchocerca volvulus		0.0275	0.9058	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0275	0.9058	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.03	1	1
Plasmodium vivax	vivapain-2	0.0275	0.9058	1
Brugia malayi	Papain family cysteine protease containing protein	0.0144	0.4227	0.4667
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Leishmania major	cathepsin L-like protease	0.0275	0.9058	1
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.0934	0.1031
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0275	0.9058	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Loa Loa (eye worm)	heterochromatin protein 1	0.0072	0.1568	0.1731
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0408	0.0356
Brugia malayi	chromobox protein homolog 3	0.004	0.0408	0.045
Onchocerca volvulus		0.0054	0.0934	0.0943
Brugia malayi	cathepsin F-like cysteine proteinase	0.0089	0.2222	0.2453
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Treponema pallidum	fructose-bisphosphate aldolase	0.03	1	0.5
Leishmania major	cathepsin L-like protease	0.0275	0.9058	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0054	0.0934	0.0548
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	0.9058	0.9018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	0.9058	1
Brugia malayi	cathepsin L-like precursor	0.0185	0.5764	0.6364
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0061	0.1191	0.1315
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	0.9058	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0088	0.0097
Brugia malayi	Cathepsin L-like precursor	0.0275	0.9058	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0054	0.0934	0.1031
Loa Loa (eye worm)	hypothetical protein	0.004	0.0408	0.045
Loa Loa (eye worm)	hypothetical protein	0.0114	0.3146	0.3473
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0054	0.0934	0.0548
Onchocerca volvulus		0.0185	0.5764	0.6328
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0054	0.0934	0.1031
Entamoeba histolytica	cysteine proteinase, putative	0.0144	0.4227	0.3633
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.0934	0.0943
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.01	0.2602	0.2873
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0934	0.1031
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0934	0.1031
Brugia malayi	Heterochromatin protein 1	0.0072	0.1568	0.1731
Schistosoma mansoni	cathepsin F (C01 family)	0.0275	0.9058	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.0934	0.1031
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0054	0.0934	0.0548
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	0.9058	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	0.9058	1
Echinococcus granulosus	chromobox protein 1	0.0072	0.1568	0.078
Giardia lamblia	Cathepsin B precursor	0.01	0.2602	0.184
Brugia malayi	Cathepsin L-like precursor	0.0089	0.2222	0.2453
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	0.9058	0.9018
Loa Loa (eye worm)	hypothetical protein	0.0114	0.3146	0.3473
Trypanosoma cruzi	cysteine peptidase, putative	0.0144	0.4227	0.4667
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0144	0.4227	0.4667
Entamoeba histolytica	cysteine proteinase, putative	0.0185	0.5764	0.5328
Loa Loa (eye worm)	cysteine protease	0.0275	0.9058	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0275	0.9058	1
Entamoeba histolytica	cysteine proteinase, putative	0.0144	0.4227	0.3633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2222	0.2453
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0201	0.6329	0.6641
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.0934	0.1031
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0144	0.4227	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0144	0.4227	0.3633
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	0.9058	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0054	0.0934	0.0548
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0147	0.4337	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0275	0.9058	1
Leishmania major	cathepsin L-like protease	0.0275	0.9058	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0054	0.0934	0.1031
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0201	0.6329	0.6987
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.052	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5764	0.6364
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.01	0.2602	0.2054
Loa Loa (eye worm)	ctsf protein	0.0275	0.9058	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Leishmania major	cathepsin L-like protease	0.0275	0.9058	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	0.9058	0.9018
Trypanosoma cruzi	cysteine peptidase, putative	0.0275	0.9058	1
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0201	0.6329	0.6641
Trypanosoma cruzi	cysteine peptidase, putative	0.0275	0.9058	1
Echinococcus granulosus	muscleblind protein	0.0114	0.3146	0.2723
Echinococcus granulosus	cathepsin b	0.0201	0.6329	0.6641
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0275	0.9058	0.9018
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0201	0.6329	0.6641
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0054	0.0934	0.0548
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0144	0.4227	0.4667
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	0.9058	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0275	0.9058	1
Onchocerca volvulus	Cathepsin L homolog	0.0275	0.9058	1
Onchocerca volvulus		0.0275	0.9058	1
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Onchocerca volvulus	Cathepsin F homolog	0.0275	0.9058	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0054	0.0934	0.0548
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0054	0.0934	0.0548
Trypanosoma cruzi	cruzipain precursor, putative	0.0275	0.9058	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0934	0.0548
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0147	0.4337	1
Echinococcus multilocularis	cysteine protease	0.0275	0.9058	1
Brugia malayi	fibroinase precursor	0.0054	0.0934	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5764	0.6364
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0054	0.0934	0.1031
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0934	0.1031
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0054	0.0934	0.1031
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.0934	0.0548
Plasmodium vivax	vivapain-2	0.0275	0.9058	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0089	0.2222	0.2453
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0934	0.0548
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.0934	0.1031
Giardia lamblia	Cathepsin B precursor	0.01	0.2602	0.184
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	0.9058	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0054	0.0934	0.1031
Echinococcus multilocularis	cathepsin b	0.0201	0.6329	0.6641
Giardia lamblia	Cathepsin B precursor	0.01	0.2602	0.184
Brugia malayi	Cathepsin L-like precursor	0.0275	0.9058	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0275	0.9058	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Echinococcus granulosus	cathepsin L	0.0144	0.4227	0.4054
Trypanosoma cruzi	cysteine protease, putative	0.0144	0.4227	0.4667
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0275	0.9058	1
Leishmania major	cathepsin L-like protease	0.0275	0.9058	1
Plasmodium vivax	vivapain-1	0.0144	0.4227	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0054	0.0934	0.0548
Toxoplasma gondii	cathepsin B	0.01	0.2602	0.2054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	0.9058	0.9018
Trypanosoma cruzi	cysteine peptidase, putative	0.0275	0.9058	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0089	0.2222	0.2453
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	0.9058	0.9018
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0934	0.1031
Brugia malayi	Cathepsin L-like precursor	0.0275	0.9058	1
Plasmodium vivax	vivapain-3	0.0144	0.4227	0.4054
Echinococcus multilocularis	muscleblind protein 1	0.0114	0.3146	0.2723
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	0.9058	1
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Brugia malayi	Cathepsin L-like precursor	0.0275	0.9058	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0275	0.9058	1
Schistosoma mansoni	chromobox protein	0.0072	0.1568	0.078
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0275	0.9058	1
Echinococcus granulosus	cathepsin l1	0.0185	0.5764	0.5946
Schistosoma mansoni	cathepsin F (C01 family)	0.0185	0.5764	0.5946
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0144	0.4227	0.4054
Leishmania major	cathepsin L-like protease	0.0275	0.9058	1
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.01	0.2602	0.2288
Echinococcus granulosus	cysteine protease	0.0144	0.4227	0.4054
Schistosoma mansoni	cathepsin s	0.0089	0.2222	0.1586
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.0934	0.1031
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.03	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2222	0.2453
Toxoplasma gondii	cathepsin CPL	0.0275	0.9058	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0275	0.9058	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0934	0.0548
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0275	0.9058	0.9018
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0147	0.4337	0.5
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Brugia malayi	cathepsin B-like cysteine proteinase	0.0201	0.6329	0.6987
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	0.9058	1
Entamoeba histolytica	cysteine proteinase, putative	0.0275	0.9058	0.8961
Plasmodium vivax	unspecified product	0.0089	0.2222	0.1586
Echinococcus granulosus	chromobox protein 1	0.0072	0.1568	0.078
Entamoeba histolytica	cysteine proteinase 1, putative	0.0144	0.4227	0.3633
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0275	0.9058	0.9018
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.1568	0.1209
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0275	0.9058	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.01	0.2602	0.2873
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0144	0.4227	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0089	0.2222	0.2453
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.1568	0.1209
Brugia malayi	Cathepsin L-like precursor	0.0275	0.9058	1
Leishmania major	cysteine peptidase A (CPA)	0.0275	0.9058	1
Entamoeba histolytica	cysteine protease, putative	0.0144	0.4227	0.3633
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0275	0.9058	0.9018
Echinococcus multilocularis	cathepsin L cysteine protease	0.0275	0.9058	1
Entamoeba histolytica	cysteine proteinase, putative	0.0275	0.9058	0.8961
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0185	0.5764	0.5584
Loa Loa (eye worm)	fibroinase	0.0275	0.9058	1
Schistosoma mansoni	chromobox protein	0.0072	0.1568	0.078

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 847463