Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lipoxygenase | 0.0063 | 0.0221 | 0.0341 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0445 | 0.3517 | 0.5469 |
Leishmania major | calcium-transporting ATPase, putative | 0.0104 | 0.0573 | 1 |
Echinococcus granulosus | calcium transporting atpase | 0.0104 | 0.0573 | 0.0585 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.0968 | 0.1539 |
Echinococcus multilocularis | sarco:endoplasmic reticulum calcium ATPase | 0.0095 | 0.049 | 0.0447 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8425 |
Toxoplasma gondii | plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 | 0.0104 | 0.0573 | 1 |
Brugia malayi | Na,K-ATPase alpha subunit | 0.0274 | 0.2044 | 1 |
Echinococcus multilocularis | Na+:K+ ATPase alpha subunit | 0.0274 | 0.2044 | 0.3024 |
Toxoplasma gondii | P-type ATPase4, putative | 0.0104 | 0.0573 | 1 |
Entamoeba histolytica | calcium-transporting P-type ATPase, putative | 0.0104 | 0.0573 | 1 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase | 0.0104 | 0.0573 | 0.0585 |
Echinococcus granulosus | nervana 2 | 0.0538 | 0.432 | 0.6803 |
Leishmania major | calcium-translocating P-type ATPase | 0.0095 | 0.049 | 0.8167 |
Plasmodium falciparum | calcium-transporting ATPase | 0.0104 | 0.0573 | 0.5 |
Trypanosoma cruzi | plasma-membrane proton-efflux P-type ATPase, putative | 0.0052 | 0.0118 | 0.1409 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0104 | 0.0573 | 1 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1195 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0246 | 0.0569 |
Echinococcus multilocularis | calcium transporting ATPase type 2C member | 0.0104 | 0.0573 | 0.0585 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha chain, putative | 0.0236 | 0.1716 | 0.839 |
Schistosoma mansoni | transmemberane protein | 0.0538 | 0.432 | 0.6912 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0008 | 0.0018 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0104 | 0.0573 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0445 | 0.3517 | 0.5469 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0538 | 0.432 | 0.6803 |
Schistosoma mansoni | calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) | 0.0104 | 0.0573 | 0.0907 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.0872 | 0.1385 |
Echinococcus multilocularis | nervana 2 | 0.0445 | 0.3517 | 0.5469 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0761 | 0.6247 | 1 |
Brugia malayi | calcium ATPase | 0.0053 | 0.0127 | 0.0587 |
Schistosoma mansoni | ATPase | 0.0095 | 0.049 | 0.0773 |
Trypanosoma cruzi | Calcium ATPase SERCA-like | 0.0095 | 0.049 | 0.8425 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8425 |
Leishmania major | calcium motive p-type ATPase, putative | 0.0104 | 0.0573 | 1 |
Echinococcus granulosus | nervana 2 | 0.0538 | 0.432 | 0.6803 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0163 | 0.0378 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.0968 | 0.1539 |
Echinococcus granulosus | Na:K ATPase alpha subunit | 0.0274 | 0.2044 | 0.3024 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase 2 | 0.0104 | 0.0573 | 0.0585 |
Mycobacterium ulcerans | metal cation-transporting p-type ATPase F, CtpF | 0.0104 | 0.0573 | 0.0418 |
Onchocerca volvulus | 0.0445 | 0.3517 | 0.6596 | |
Leishmania major | P-type ATPase, putative | 0.0104 | 0.0573 | 1 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0445 | 0.3517 | 0.5624 |
Echinococcus multilocularis | nervana 2 | 0.0538 | 0.432 | 0.6803 |
Schistosoma mansoni | plasma membrane calcium-transporting atpase | 0.0104 | 0.0573 | 0.0907 |
Echinococcus multilocularis | Tetracycline resistance leader peptide, TetL | 0.0104 | 0.0573 | 0.0585 |
Plasmodium vivax | P-type ATPase4, putative | 0.0104 | 0.0573 | 0.5 |
Brugia malayi | Membrane calcium atpase protein 3 | 0.0104 | 0.0573 | 0.2778 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0163 | 0.0763 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0052 | 0.0118 | 0.1409 |
Trypanosoma cruzi | calcium-transporting ATPase, putative | 0.0066 | 0.0246 | 0.3812 |
Schistosoma mansoni | Na+/K+ transporting ATPase subunit alpha | 0.0274 | 0.2044 | 0.3263 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 1 | 0.0095 | 0.049 | 0.8167 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.1261 | 0.2918 |
Onchocerca volvulus | 0.0538 | 0.432 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.432 | 1 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1195 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0139 | 0.0872 | 0.108 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0445 | 0.3517 | 0.5624 |
Schistosoma mansoni | calcium-transporting atpase 2 (atpase 2) | 0.0104 | 0.0573 | 0.0907 |
Echinococcus granulosus | nervana 2 | 0.0445 | 0.3517 | 0.5469 |
Schistosoma mansoni | calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) | 0.0104 | 0.0573 | 0.0907 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0118 | 0.0274 |
Loa Loa (eye worm) | Na,K-ATPase alpha subunit | 0.0274 | 0.2044 | 0.473 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1195 | 1 | 1 |
Giardia lamblia | Potassium-transporting ATPase alpha chain 1 | 0.0274 | 0.2044 | 1 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Loa Loa (eye worm) | E1-E2 ATPase | 0.0052 | 0.0118 | 0.0274 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8425 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0139 | 0.0872 | 0.108 |
Loa Loa (eye worm) | calcium ATPase | 0.0053 | 0.0127 | 0.0295 |
Brugia malayi | Probable calcium-transporting ATPase KIAA0703 | 0.0066 | 0.0246 | 0.1168 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.0804 | 0.186 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0052 | 0.0118 | 0.1409 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0163 | 0.0763 |
Loa Loa (eye worm) | sodium potassium adenosine triphosphatase | 0.0052 | 0.0118 | 0.0274 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0538 | 0.432 | 0.6803 |
Toxoplasma gondii | sarco/endoplasmic reticulum Ca2+-ATPase | 0.0104 | 0.0573 | 1 |
Plasmodium vivax | calcium-transporting ATPase, putative | 0.0104 | 0.0573 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.1514 | 0.3504 |
Schistosoma mansoni | ATPase | 0.0095 | 0.049 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.2044 | 0.473 |
Echinococcus granulosus | sarco:endoplasmic reticulum calcium ATPase | 0.0095 | 0.049 | 0.0447 |
Echinococcus granulosus | nervana 2 | 0.0445 | 0.3517 | 0.5469 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0538 | 0.432 | 0.6803 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.0804 | 0.186 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.0095 | 0.049 | 0.8425 |
Schistosoma mansoni | na+/k+ atpase alpha subunit | 0.0274 | 0.2044 | 0.3263 |
Schistosoma mansoni | plasma membrane calcium-transporting atpase | 0.0104 | 0.0573 | 0.0907 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0538 | 0.432 | 0.6912 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1195 | 1 | 1 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 2 | 0.0095 | 0.049 | 0.8167 |
Mycobacterium ulcerans | metal cation transporter p-type ATPase a | 0.0265 | 0.196 | 0.1827 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0761 | 0.6247 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.015 | 0.0968 | 0.124 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Echinococcus granulosus | calcium transporting ATPase type 2C member | 0.0104 | 0.0573 | 0.0585 |
Echinococcus multilocularis | nervana 2 | 0.0538 | 0.432 | 0.6803 |
Echinococcus multilocularis | plasma membrane calcium transporting ATPase | 0.0104 | 0.0573 | 0.0585 |
Trypanosoma cruzi | calcium-translocating P-type ATPase, putative | 0.0052 | 0.0118 | 0.1409 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1195 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.0804 | 0.3909 |
Trypanosoma brucei | calcium-transporting ATPase, putative | 0.0066 | 0.0246 | 0.2797 |
Brugia malayi | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0104 | 0.0573 | 0.2778 |
Toxoplasma gondii | calcium-translocating P-type ATPase, PMCA-type protein | 0.0095 | 0.049 | 0.8167 |
Brugia malayi | calcium ATPase | 0.0052 | 0.0118 | 0.0543 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha-3 chain, putative | 0.0052 | 0.0118 | 0.0543 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Brugia malayi | haloacid dehalogenase-like hydrolase family protein | 0.0053 | 0.0127 | 0.0587 |
Echinococcus multilocularis | Ca2+ transporting ATPase plasma membrane | 0.0104 | 0.0573 | 0.0585 |
Loa Loa (eye worm) | calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0066 | 0.0246 | 0.0569 |
Entamoeba histolytica | plasma membrane calcium ion-transporting ATPase, putative | 0.0053 | 0.0127 | 0.1575 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.1142 | 0.2644 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0104 | 0.0573 | 1 |
Brugia malayi | E1-E2 ATPase family protein | 0.0061 | 0.0202 | 0.0953 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0538 | 0.432 | 0.6803 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.432 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.049 | 0.1134 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0052 | 0.0118 | 0.1409 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0163 | 0.0378 |
Mycobacterium leprae | Isocitrate lyase | 0.056 | 0.4513 | 0.3443 |
Entamoeba histolytica | plasma membrane calcium ion-transporting ATPase, putative | 0.0061 | 0.0202 | 0.2984 |
Trypanosoma brucei | calcium motive p-type ATPase, putative | 0.0104 | 0.0573 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Plasmodium falciparum | non-SERCA-type Ca2+ -transporting P-ATPase | 0.0104 | 0.0573 | 0.5 |
Trypanosoma brucei | calcium-translocating P-type ATPase | 0.0104 | 0.0573 | 1 |
Trichomonas vaginalis | cation-transporting ATPase fungi, putative | 0.0095 | 0.049 | 0.8167 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0538 | 0.432 | 0.6803 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0104 | 0.0573 | 1 |
Echinococcus multilocularis | calcium transporting atpase | 0.0104 | 0.0573 | 0.0585 |
Loa Loa (eye worm) | sodium/potassium-transporting ATPase subunit alpha | 0.0236 | 0.1716 | 0.3971 |
Echinococcus multilocularis | nervana 2 | 0.0445 | 0.3517 | 0.5469 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0538 | 0.432 | 0.6803 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.0095 | 0.049 | 0.8425 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0538 | 0.432 | 0.6912 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0761 | 0.6247 | 1 |
Echinococcus granulosus | Ca2 transporting ATPase plasma membrane | 0.0104 | 0.0573 | 0.0585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.