Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin F (C01 family) | 0.0026 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0048 | 0.2688 | 0.2688 |
Plasmodium vivax | vivapain-2 | 0.0026 | 0.086 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0138 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0138 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0026 | 0.086 | 0.086 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0026 | 0.086 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0026 | 0.086 | 1 | |
Loa Loa (eye worm) | cathepsin B | 0.0048 | 0.2688 | 0.2482 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin b | 0.0138 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0026 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0138 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0138 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0048 | 0.2688 | 0.2688 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.0274 | 0.3182 |
Onchocerca volvulus | Cathepsin L homolog | 0.0026 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0048 | 0.2688 | 1 |
Onchocerca volvulus | 0.0026 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0026 | 0.086 | 1 | |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0026 | 0.086 | 0.0603 |
Loa Loa (eye worm) | fibroinase | 0.0026 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0026 | 0.086 | 1 | |
Toxoplasma gondii | cathepsin B | 0.0048 | 0.2688 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0048 | 0.2688 | 1 |
Onchocerca volvulus | 0.0026 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Loa Loa (eye worm) | ctsf protein | 0.0026 | 0.086 | 0.0603 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0019 | 0.0274 | 0.0274 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0026 | 0.086 | 0.086 |
Onchocerca volvulus | 0.0026 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0274 | 0.1018 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0274 | 0.1018 |
Echinococcus granulosus | cathepsin b | 0.0138 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0026 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0.2688 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0026 | 0.086 | 0.086 |
Entamoeba histolytica | cysteine protease, putative | 0.0026 | 0.086 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.086 | 0.086 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0026 | 0.086 | 0.0603 |
Brugia malayi | cathepsin L-like precursor | 0.0019 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0274 | 0.0274 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0026 | 0.086 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0026 | 0.086 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0019 | 0.0274 | 0.0274 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0.2688 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0.2688 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0026 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin l1 | 0.0026 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0026 | 0.086 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0026 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0274 | 0.0274 |
Echinococcus multilocularis | cysteine protease | 0.0026 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0138 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0026 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0026 | 0.086 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0026 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin b | 0.0138 | 1 | 1 |
Onchocerca volvulus | 0.0026 | 0.086 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0138 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0026 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0026 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0026 | 0.086 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0026 | 0.086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.086 | 0.0603 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0274 | 0.0274 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cysteine protease | 0.0026 | 0.086 | 0.0603 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0048 | 0.2688 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.086 | 0.3201 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > 0.0001 uM | Cytotoxic activity against human lung cancer cell line | ChEMBL. | No reference |
GI50 (functional) | > 0.0001 uM | Cytotoxic activity against human colon cancer cell line | ChEMBL. | No reference |
GI50 (functional) | > 0.0001 uM | Cytotoxic activity against human ovarian cancer cell line | ChEMBL. | No reference |
GI50 (functional) | > 0.0001 uM | Cytotoxic activity against human renal cancer cell line | ChEMBL. | No reference |
GI50 (functional) | > 0.0001 uM | Cytotoxic activity against human prostate cancer cell line | ChEMBL. | No reference |
GI50 (functional) | > 0.0001 uM | Cytotoxic activity against human breast cancer cell line | ChEMBL. | No reference |
GI50 (functional) | > 0.0001 uM | Cytotoxic activity against human lung cancer cell line | ChEMBL. | No reference |
GI50 (functional) | > 0.0001 uM | Cytotoxic activity against human prostate cancer cell line | ChEMBL. | No reference |
GI50 (functional) | < 0.01 uM | Cytotoxic activity against human CNS SNB-75 cancer cell line | ChEMBL. | No reference |
GI50 (functional) | < 0.01 uM | Cytotoxic activity against human CNS SNB-75 cancer cell line | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.