Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0082 | 0.0514 | 0.0513 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0055 | 0.0139 | 0.0138 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0082 | 0.0514 | 0.0374 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0156 | 0.1555 | 0.2548 |
Toxoplasma gondii | subtilisin SUB1 | 0.0175 | 0.1825 | 0.3107 |
Echinococcus multilocularis | integrin beta 2 | 0.0603 | 0.7837 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.015 | 0.1466 | 0.1466 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0069 | 0.0328 | 0.0326 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit beta | 0.0133 | 0.1236 | 0.2227 |
Brugia malayi | FAD binding domain containing protein | 0.005 | 0.0075 | 0.0074 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0164 | 0.1672 | 0.2058 |
Mycobacterium ulcerans | hydrolase | 0.0055 | 0.0139 | 0.0286 |
Plasmodium falciparum | plasmepsin IV | 0.0064 | 0.0264 | 0.0499 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0082 | 0.0514 | 0.0374 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0082 | 0.0514 | 0.0972 |
Brugia malayi | Matrixin family protein | 0.0109 | 0.09 | 0.0899 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0082 | 0.0514 | 0.0374 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0124 | 0.1104 | 0.1103 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.0391 | 0.485 | 1 |
Plasmodium falciparum | subtilisin-like protease 1 | 0.0175 | 0.1825 | 0.3451 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0069 | 0.0328 | 0.0621 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0133 | 0.1236 | 0.2337 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0072 | 0.0384 | 0.0726 |
Plasmodium vivax | ribonucleoside-diphosphate reductase small chain, putative | 0.0133 | 0.1236 | 0.2337 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0069 | 0.0328 | 0.0326 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase small chain, putative | 0.0133 | 0.1236 | 0.2337 |
Echinococcus granulosus | integrin beta 2 | 0.0603 | 0.7837 | 1 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.0422 | 0.5287 | 0.6715 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.0422 | 0.5287 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0082 | 0.0514 | 0.0972 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.0391 | 0.485 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0082 | 0.0514 | 0.0566 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0164 | 0.1672 | 0.2058 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0069 | 0.0328 | 0.0326 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0082 | 0.0514 | 0.0545 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0072 | 0.0384 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0069 | 0.0328 | 0.0677 |
Plasmodium vivax | plasmepsin IV, putative | 0.0064 | 0.0264 | 0.0499 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0069 | 0.0328 | 0.0326 |
Leishmania major | ribonucleoside-diphosphate reductase small chain, putative | 0.0133 | 0.1236 | 0.183 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0156 | 0.1555 | 0.2548 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.0422 | 0.5287 | 0.5287 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0422 | 0.5287 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0064 | 0.0264 | 0.0263 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase small subunit | 0.0133 | 0.1236 | 0.1935 |
Loa Loa (eye worm) | ribonucleotide reductase M2 B | 0.0133 | 0.1236 | 0.1235 |
Onchocerca volvulus | Matrilysin homolog | 0.01 | 0.0773 | 0.5269 |
Trypanosoma cruzi | p450 reductase, putative | 0.0082 | 0.0514 | 0.0374 |
Echinococcus multilocularis | aminopeptidase N | 0.015 | 0.1466 | 0.1793 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0082 | 0.0514 | 0.0972 |
Echinococcus granulosus | aminopeptidase N | 0.015 | 0.1466 | 0.1793 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain, putative | 0.0133 | 0.1236 | 0.2337 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0069 | 0.0328 | 0.0326 |
Onchocerca volvulus | 0.0069 | 0.0328 | 0.2236 | |
Plasmodium falciparum | plasmepsin VI | 0.0064 | 0.0264 | 0.0499 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0082 | 0.0514 | 0.0513 |
Plasmodium vivax | subtilisin-like protease 1 | 0.0175 | 0.1825 | 0.3451 |
Brugia malayi | flavodoxin family protein | 0.0082 | 0.0514 | 0.0513 |
Brugia malayi | ribonucleoside-diphosphate reductase large chain, putative | 0.0422 | 0.5287 | 0.5287 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0082 | 0.0514 | 0.106 |
Giardia lamblia | Hypothetical protein | 0.0072 | 0.0384 | 0.5 |
Brugia malayi | Kelch motif family protein | 0.0124 | 0.1104 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0514 | 0.0513 |
Loa Loa (eye worm) | matrixin family protein | 0.0109 | 0.09 | 0.0899 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.01 | 0.0773 | 0.5269 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0064 | 0.0264 | 0.0243 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0428 | 0.5373 | 0.8809 |
Loa Loa (eye worm) | matrixin family protein | 0.01 | 0.0773 | 0.0772 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.0422 | 0.5287 | 1 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) | 0.0133 | 0.1236 | 0.2328 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.0422 | 0.5287 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0069 | 0.0328 | 0.0326 |
Brugia malayi | ribonucleotide reductase 2 | 0.0133 | 0.1236 | 0.1235 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0105 | 0.0843 | 0.0842 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1128 | 0.1128 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.0422 | 0.5287 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0069 | 0.0328 | 0.0621 |
Onchocerca volvulus | 0.015 | 0.1466 | 1 | |
Brugia malayi | hypothetical protein | 0.0124 | 0.1104 | 0.1103 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0072 | 0.0384 | 0.0261 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.0391 | 0.485 | 1 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.0422 | 0.5287 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0069 | 0.0328 | 0.0141 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase small chain, putative | 0.0133 | 0.1236 | 0.183 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0264 | 0.0263 |
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.0422 | 0.5287 | 0.6715 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.024 | 0.2729 | 0.3419 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0082 | 0.0514 | 0.0566 |
Plasmodium falciparum | plasmepsin II | 0.0064 | 0.0264 | 0.0499 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0064 | 0.0264 | 0.0243 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0069 | 0.0328 | 0.0326 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0082 | 0.0514 | 0.0566 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0069 | 0.0328 | 0.0621 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0069 | 0.0328 | 0.0326 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0082 | 0.0514 | 0.0972 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0082 | 0.0514 | 0.0972 |
Plasmodium falciparum | plasmepsin I | 0.0064 | 0.0264 | 0.0499 |
Onchocerca volvulus | 0.0064 | 0.0266 | 0.1808 | |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.0422 | 0.5287 | 0.8668 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0069 | 0.0328 | 0.0326 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0082 | 0.0514 | 0.0842 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0069 | 0.0328 | 0.0141 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.0422 | 0.5287 | 1 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase small chain, putative | 0.0133 | 0.1236 | 0.183 |
Schistosoma mansoni | integrin beta subunit | 0.048 | 0.61 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0072 | 0.0384 | 0.0111 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase small chain | 0.0133 | 0.1236 | 0.2025 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.005 | 0.0075 | 0.0122 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0133 | 0.1236 | 0.2337 |
Loa Loa (eye worm) | integrin beta-2 | 0.0757 | 1 | 1 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.0391 | 0.485 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0082 | 0.0514 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0139 | 0.0138 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0055 | 0.0139 | 0.0286 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.012 | 0.1049 | 0.1453 |
Entamoeba histolytica | aminopeptidase, putative | 0.0069 | 0.0328 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0266 | 0.0435 |
Loa Loa (eye worm) | aminopeptidase N | 0.0069 | 0.0328 | 0.0328 |
Brugia malayi | Hemopexin family protein | 0.0064 | 0.0266 | 0.0265 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.1104 | 0.1103 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0069 | 0.0328 | 0.0537 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0064 | 0.0264 | 0.0432 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase small chain | 0.0133 | 0.1236 | 0.2337 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase subunit | 0.0133 | 0.1236 | 0.1495 |
Brugia malayi | hypothetical protein | 0.0069 | 0.0328 | 0.0328 |
Brugia malayi | Peptidase family M1 containing protein | 0.0069 | 0.0328 | 0.0328 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0064 | 0.0264 | 0.0499 |
Echinococcus granulosus | ribonucleoside diphosphate reductase subunit | 0.0133 | 0.1236 | 0.1495 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0069 | 0.0328 | 0.0537 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.024 | 0.2729 | 0.3419 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.024 | 0.2729 | 0.4473 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0069 | 0.0328 | 0.0326 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0082 | 0.0514 | 0.0566 |
Leishmania major | p450 reductase, putative | 0.0082 | 0.0514 | 0.0374 |
Leishmania major | ribonucleoside-diphosphate reductase small chain, putative | 0.0133 | 0.1236 | 0.183 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.005 | 0.0075 | 0.0074 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.0422 | 0.5287 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0082 | 0.0514 | 0.0972 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.0391 | 0.485 | 1 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.014 | 0.1338 | 0.2545 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) | 0.0133 | 0.1236 | 0.2328 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0505 | 0.0504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.