Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.2575 | 0.266 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0294 | 0.0303 |
Leishmania major | delta-5 fatty acid desaturase | 0.062 | 0.2886 | 0.2818 |
Echinococcus granulosus | geminin | 0.0116 | 0.0362 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0102 | 0.0294 | 0.8108 |
Echinococcus multilocularis | transcription factor eb | 0.0074 | 0.0152 | 0.4203 |
Leishmania major | delta-6 fatty acid desaturase | 0.0064 | 0.0104 | 0.001 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0062 | 0.0094 | 0.2594 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.015 | 0.0155 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0081 | 0.0191 | 0.0198 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0062 | 0.0094 | 0.0097 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 0.0362 | 0.1251 |
Brugia malayi | Delta5 fatty acid desaturase | 0.062 | 0.2886 | 0.2981 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2042 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0116 | 0.0362 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1978 | 0.968 | 0.5 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0062 | 0.0094 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1978 | 0.968 | 0.5 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0064 | 0.0104 | 0.001 |
Brugia malayi | Fatty acid desaturase family protein | 0.0062 | 0.0094 | 0.0097 |
Echinococcus multilocularis | muscleblind protein | 0.0102 | 0.0294 | 0.8108 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0062 | 0.0094 | 0.2594 |
Brugia malayi | Muscleblind-like protein | 0.0102 | 0.0294 | 0.0303 |
Onchocerca volvulus | 0.204 | 0.999 | 1 | |
Loa Loa (eye worm) | FAT-3 protein | 0.062 | 0.2886 | 0.2981 |
Mycobacterium ulcerans | hypothetical protein | 0.0064 | 0.0104 | 1 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0062 | 0.0094 | 0.2594 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0062 | 0.0094 | 0.0097 |
Leishmania major | fatty-acid desaturase, putative | 0.2042 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0102 | 0.0294 | 0.8108 |
Echinococcus granulosus | transcription factor eb | 0.0074 | 0.0152 | 0.4203 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.198 | 0.969 | 0.9687 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.2042 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0064 | 0.0104 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0116 | 0.0362 | 0.1251 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1978 | 0.968 | 1 |
Onchocerca volvulus | 0.204 | 0.999 | 1 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0081 | 0.0191 | 0.0198 |
Brugia malayi | Fatty acid desaturase family protein | 0.0062 | 0.0094 | 0.0097 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.198 | 0.969 | 0.9687 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0062 | 0.0094 | 0.2594 |
Brugia malayi | MH2 domain containing protein | 0.0081 | 0.0191 | 0.0198 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0074 | 0.0152 | 0.0157 |
Brugia malayi | acyl-CoA desaturase | 0.1978 | 0.968 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0294 | 0.0303 |
Schistosoma mansoni | fatty acid desaturase | 0.0622 | 0.2895 | 1 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0073 | 0.015 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.062 | 0.2886 | 0.2981 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0062 | 0.0094 | 0.2594 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0064 | 0.0104 | 0.001 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.