Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.2111 | 0.2059 | 1 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Leishmania major | cathepsin L-like protease | 0.4368 | 0.7342 | 1 |
Leishmania major | cathepsin L-like protease | 0.4368 | 0.7342 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1512 | 0.0655 | 0.0655 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1512 | 0.0655 | 0.0655 |
Onchocerca volvulus | Cathepsin L homolog | 0.2111 | 0.2059 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1512 | 0.0655 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2111 | 0.2059 | 0.2059 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.2889 | 0.3879 | 0.3879 |
Loa Loa (eye worm) | hypothetical protein | 0.2111 | 0.2059 | 0.1502 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.2111 | 0.2059 | 1 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1512 | 0.0655 | 0.0655 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3607 | 0.5562 | 0.5562 |
Brugia malayi | Cathepsin L-like precursor | 0.1512 | 0.0655 | 0.0655 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Echinococcus multilocularis | cathepsin b | 0.5503 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2111 | 0.2059 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Loa Loa (eye worm) | fibroinase | 0.2111 | 0.2059 | 0.1502 |
Brugia malayi | Cathepsin L-like precursor | 0.2111 | 0.2059 | 0.2059 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.2111 | 0.2059 | 0.2059 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Plasmodium vivax | vivapain-2 | 0.2111 | 0.2059 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2111 | 0.2059 | 0.2059 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.3607 | 0.5562 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.1512 | 0.0655 | 0.0655 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Brugia malayi | cathepsin L-like precursor | 0.1512 | 0.0655 | 0.0655 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.2111 | 0.2059 | 0.1502 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.2111 | 0.2059 | 0.1502 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2111 | 0.2059 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3607 | 0.5562 | 0.5562 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.5503 | 1 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.2111 | 0.2059 | 0.2059 |
Loa Loa (eye worm) | cathepsin B | 0.3607 | 0.5562 | 0.5251 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.3768 | 0.5938 | 0.5938 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.2111 | 0.2059 | 0.2059 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.5503 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1512 | 0.0655 | 0.1178 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Echinococcus multilocularis | cathepsin b | 0.5503 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.3607 | 0.5562 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.5503 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2111 | 0.2059 | 0.2059 |
Brugia malayi | Cathepsin L-like precursor | 0.2111 | 0.2059 | 0.2059 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.4368 | 0.7342 | 0.7342 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Echinococcus granulosus | cathepsin b | 0.5503 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1512 | 0.0655 | 0.1178 |
Loa Loa (eye worm) | ctsf protein | 0.2111 | 0.2059 | 0.1502 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2111 | 0.2059 | 0.2059 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.3607 | 0.5562 | 0.663 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.5503 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.2111 | 0.2059 | 1 |
Plasmodium vivax | vivapain-2 | 0.2111 | 0.2059 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.5503 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2111 | 0.2059 | 0.2059 |
Brugia malayi | Cathepsin L-like precursor | 0.2111 | 0.2059 | 0.2059 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2111 | 0.2059 | 0.2059 |
Giardia lamblia | Cathepsin B precursor | 0.3607 | 0.5562 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.2111 | 0.2059 | 0.2059 |
Onchocerca volvulus | Cathepsin F homolog | 0.2111 | 0.2059 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2111 | 0.2059 | 0.2059 |
Echinococcus multilocularis | cysteine protease | 0.2111 | 0.2059 | 0.2059 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Brugia malayi | Cathepsin L-like precursor | 0.2111 | 0.2059 | 0.2059 |
Onchocerca volvulus | Cathepsin L homolog | 0.2111 | 0.2059 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.4368 | 0.7342 | 0.7342 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.4368 | 0.7342 | 0.7342 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.3607 | 0.5562 | 0.7575 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.2111 | 0.2059 | 0.1502 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.3607 | 0.5562 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.4368 | 0.7342 | 0.7342 |
Entamoeba histolytica | cysteine protease, putative | 0.2111 | 0.2059 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Leishmania major | cathepsin L-like protease | 0.4368 | 0.7342 | 1 |
Toxoplasma gondii | cathepsin B | 0.3607 | 0.5562 | 1 |
Echinococcus multilocularis | cysteine protease | 0.2111 | 0.2059 | 0.2059 |
Brugia malayi | Cathepsin L-like precursor | 0.2111 | 0.2059 | 0.2059 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2111 | 0.2059 | 0.2059 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.5503 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.5503 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.