Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.5503 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.2111 | 0.2059 | 1 |
Plasmodium vivax | vivapain-2 | 0.2111 | 0.2059 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2111 | 0.2059 | 0.2059 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.5503 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2111 | 0.2059 | 0.2059 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.3607 | 0.5562 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2111 | 0.2059 | 0.2059 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.2111 | 0.2059 | 0.2059 |
Giardia lamblia | Cathepsin B precursor | 0.3607 | 0.5562 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.2111 | 0.2059 | 0.2059 |
Echinococcus granulosus | cathepsin b | 0.5503 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2111 | 0.2059 | 0.2059 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.4368 | 0.7342 | 0.7342 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Echinococcus granulosus | cathepsin b | 0.5503 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.3607 | 0.5562 | 0.663 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2111 | 0.2059 | 0.2059 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1512 | 0.0655 | 0.1178 |
Loa Loa (eye worm) | ctsf protein | 0.2111 | 0.2059 | 0.1502 |
Entamoeba histolytica | cysteine protease, putative | 0.2111 | 0.2059 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Leishmania major | cathepsin L-like protease | 0.4368 | 0.7342 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.4368 | 0.7342 | 0.7342 |
Toxoplasma gondii | cathepsin B | 0.3607 | 0.5562 | 1 |
Echinococcus multilocularis | cysteine protease | 0.2111 | 0.2059 | 0.2059 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.5503 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.5503 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2111 | 0.2059 | 0.2059 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2111 | 0.2059 | 0.2059 |
Echinococcus multilocularis | cysteine protease | 0.2111 | 0.2059 | 0.2059 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Brugia malayi | Cathepsin L-like precursor | 0.2111 | 0.2059 | 0.2059 |
Onchocerca volvulus | Cathepsin F homolog | 0.2111 | 0.2059 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2111 | 0.2059 | 0.2059 |
Onchocerca volvulus | Cathepsin L homolog | 0.2111 | 0.2059 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.4368 | 0.7342 | 0.7342 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.4368 | 0.7342 | 0.7342 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.3607 | 0.5562 | 0.7575 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Loa Loa (eye worm) | cysteine protease | 0.2111 | 0.2059 | 0.1502 |
Giardia lamblia | Cathepsin B precursor | 0.3607 | 0.5562 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.2111 | 0.2059 | 1 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.2111 | 0.2059 | 0.1502 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1512 | 0.0655 | 0.0655 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.2889 | 0.3879 | 0.3879 |
Brugia malayi | Cathepsin L-like precursor | 0.1512 | 0.0655 | 0.0655 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3607 | 0.5562 | 0.5562 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Echinococcus multilocularis | cathepsin b | 0.5503 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.2111 | 0.2059 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Loa Loa (eye worm) | fibroinase | 0.2111 | 0.2059 | 0.1502 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.2111 | 0.2059 | 1 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Onchocerca volvulus | Cathepsin L homolog | 0.2111 | 0.2059 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.1512 | 0.0655 | 0.0655 |
Brugia malayi | Cathepsin L-like precursor | 0.1512 | 0.0655 | 0.0655 |
Leishmania major | cathepsin L-like protease | 0.4368 | 0.7342 | 1 |
Leishmania major | cathepsin L-like protease | 0.4368 | 0.7342 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2111 | 0.2059 | 0.2059 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1512 | 0.0655 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5503 | 1 | 1 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.5503 | 1 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.3607 | 0.5562 | 0.5251 |
Echinococcus granulosus | cathepsin l1 | 0.2111 | 0.2059 | 0.2059 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.3768 | 0.5938 | 0.5938 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.2111 | 0.2059 | 0.2059 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Echinococcus multilocularis | cathepsin b | 0.5503 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1512 | 0.0655 | 0.1178 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Plasmodium vivax | vivapain-2 | 0.2111 | 0.2059 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.2111 | 0.2059 | 0.2059 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Brugia malayi | Cathepsin L-like precursor | 0.2111 | 0.2059 | 0.2059 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.4368 | 0.7342 | 1 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.1512 | 0.0655 | 0.0655 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2111 | 0.2059 | 0.2059 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.3607 | 0.5562 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.1512 | 0.0655 | 0.0655 |
Onchocerca volvulus | 0.2111 | 0.2059 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3607 | 0.5562 | 0.5562 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2111 | 0.2059 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.2111 | 0.2059 | 0.1502 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.2111 | 0.2059 | 0.1502 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2111 | 0.2059 | 0.3702 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.