TDR Targets

Basic information

Technical information

TDR Targets ID: 865682
Name: N-[(2-ethoxyphenyl)methylideneamino]-2-(1-met hylbenzimidazol-2-yl)sulfanylacetamide
MW: 368.453 | Formula: C19H20N4O2S
H donors: 1 H acceptors: 2 LogP: 3.6 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccccc1C=NNC(=O)CSc1nc2c(n1C)cccc2
InChi: 1S/C19H20N4O2S/c1-3-25-17-11-7-4-8-14(17)12-20-22-18(24)13-26-19-21-15-9-5-6-10-16(15)23(19)2/h4-12H,3,13H2,1-2H3,(H,22,24)/b20-12+
InChiKey: BHYMENAXJGZVBI-UDWIEESQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(2-ethoxyphenyl)methyleneamino]-2-(1-methylbenzimidazol-2-yl)sulfanyl-acetamide
N-[(2-ethoxyphenyl)methyleneamino]-2-[(1-methyl-2-benzimidazolyl)thio]acetamide
N-[(2-ethoxybenzylidene)amino]-2-[(1-methylbenzimidazol-2-yl)thio]acetamide
N-[(2-ethoxyphenyl)methylideneamino]-2-(1-methylbenzimidazol-2-yl)sulfanyl-ethanamide
ST5061197

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0526	0.1849
Echinococcus multilocularis	cathepsin b	0.0438	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.0526	0.1849
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Loa Loa (eye worm)	calpain	0.0064	0.0719	0.0561
Trypanosoma brucei	kinesin, putative	0.0045	0.0239	0.0839
Echinococcus granulosus	calpain 5	0.0064	0.0719	0.0719
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.0526	0.1849
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0064	0.0719	0.0719
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0048	0.0321	0.1127
Echinococcus multilocularis	hypothetical protein	0.0064	0.0719	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0106	0.176	0.162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0171	0.3358	0.3358
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2878	0.2757
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.0526	0.1849
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0042	0.0167	0.0588
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0526	0.1849
Toxoplasma gondii	cathepsin B	0.015	0.2845	1
Leishmania major	cathepsin L-like protease	0.0057	0.0526	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3358	0.3245
Loa Loa (eye worm)	calpain family protein 1	0.0171	0.3358	0.3245
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0048	0.0321	0.0321
Trypanosoma brucei	calpain-like protein, putative	0.0064	0.0719	0.2528
Echinococcus granulosus	calpain A	0.0064	0.0719	0.0719
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0526	0.1849
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0438	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0042	0.0167	0.3182
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0438	1	1
Giardia lamblia	Cathepsin B precursor	0.015	0.2845	0.5
Onchocerca volvulus		0.0057	0.0526	0.2253
Plasmodium vivax	vivapain-2	0.0057	0.0526	0.7315
Trypanosoma cruzi	cysteine peptidase, putative	0.0057	0.0526	0.0526
Trypanosoma cruzi	cysteine peptidase, putative	0.0057	0.0526	0.0526
Schistosoma mansoni	cathepsin F (C01 family)	0.0057	0.0526	0.0526
Trypanosoma cruzi	kinesin, putative	0.0045	0.0239	0.0239
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0064	0.0719	0.2528
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0064	0.0719	0.0719
Echinococcus granulosus	cathepsin l1	0.0057	0.0526	0.0526
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0057	0.0526	0.0526
Echinococcus granulosus	cathepsin l1	0.0042	0.0167	0.0167
Echinococcus multilocularis	calpain	0.0064	0.0719	0.0719
Echinococcus multilocularis	calpain A	0.0178	0.355	0.355
Onchocerca volvulus		0.0057	0.0526	0.2253
Brugia malayi	calpain 7	0.0064	0.0719	0.0719
Leishmania major	cathepsin L-like protease	0.0057	0.0526	0.1103
Echinococcus multilocularis	calpain family protein 1, d	0.0126	0.224	0.224
Trypanosoma brucei	calpain-like protein, putative	0.0064	0.0719	0.2528
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0042	0.0167	0.0167
Entamoeba histolytica	cysteine proteinase, putative	0.0057	0.0526	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0057	0.0526	0.0526
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0438	1	1
Giardia lamblia	Cathepsin B precursor	0.015	0.2845	0.5
Echinococcus granulosus	cathepsin b	0.0438	1	1
Plasmodium falciparum	plasmepsin II	0.0048	0.0321	0.6095
Onchocerca volvulus	Cathepsin L homolog	0.0057	0.0526	0.2253
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0321	0.0156
Entamoeba histolytica	cysteine proteinase, putative	0.0057	0.0526	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0057	0.0526	0.0365
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0064	0.0719	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0126	0.224	0.2108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Trypanosoma brucei	cysteine peptidase C (CPC)	0.015	0.2845	1
Leishmania major	cathepsin L-like protease	0.0057	0.0526	0.1103
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0064	0.0719	0.0719
Trypanosoma cruzi	cysteine peptidase, putative	0.0057	0.0526	0.0526
Plasmodium vivax	aspartyl proteinase, putative	0.0048	0.0321	0.4458
Plasmodium falciparum	plasmepsin IV	0.0048	0.0321	0.6095
Brugia malayi	cathepsin L-like precursor	0.0042	0.0167	0.0167
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0526	0.0526
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0178	0.355	0.355
Brugia malayi	Cathepsin L-like precursor	0.0042	0.0167	0.0167
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0064	0.0719	0.0719
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.015	0.2845	1
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0526	0.0526
Leishmania major	cathepsin L-like protease	0.0057	0.0526	0.1103
Echinococcus granulosus	calpain A	0.0178	0.355	0.355
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0178	0.355	0.355
Loa Loa (eye worm)	ctsf protein	0.0057	0.0526	0.0365
Onchocerca volvulus		0.0106	0.176	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.015	0.2845	0.2845
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0048	0.0321	0.0156
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0057	0.0526	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.0526	0.1849
Echinococcus multilocularis	cysteine protease	0.0057	0.0526	0.0526
Onchocerca volvulus		0.0057	0.0526	0.2253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0064	0.0719	0.2528
Trypanosoma cruzi	kinesin, putative	0.0045	0.0239	0.0239
Schistosoma mansoni	cathepsin F (C01 family)	0.0042	0.0167	0.0167
Trypanosoma brucei	calpain-like protein, putative	0.0064	0.0719	0.2528
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0526	0.1849
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0526	0.0526
Leishmania major	cathepsin L-like protease	0.0057	0.0526	0.1103
Trypanosoma cruzi	cruzipain precursor, putative	0.0057	0.0526	0.0526
Echinococcus granulosus	calpain 7 C02 family	0.0064	0.0719	0.0719
Entamoeba histolytica	cysteine protease, putative	0.0057	0.0526	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0057	0.0526	0.0365
Leishmania major	cathepsin L-like protease	0.0057	0.0526	0.1103
Brugia malayi	calpain family protein 1	0.0171	0.3358	0.3358
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0526	0.1849
Plasmodium falciparum	plasmepsin I	0.0048	0.0321	0.6095
Brugia malayi	Cathepsin L-like precursor	0.0042	0.0167	0.0167
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0064	0.0719	0.0719
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Leishmania major	cathepsin L-like protease	0.0057	0.0526	0.1103
Echinococcus multilocularis	cysteine protease	0.0057	0.0526	0.0526
Loa Loa (eye worm)	calpain 5	0.0045	0.0239	0.0072
Echinococcus multilocularis	cathepsin L cysteine protease	0.0057	0.0526	0.0526
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0048	0.0321	0.0321
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0526	0.1849
Plasmodium vivax	calpain, putative	0.0064	0.0719	1
Brugia malayi	calpain 5	0.0045	0.0239	0.0239
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0526	0.1849
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.0526	0.1849
Echinococcus multilocularis	calpain 5	0.0064	0.0719	0.0719
Onchocerca volvulus	Cathepsin F homolog	0.0057	0.0526	0.2253
Echinococcus multilocularis	cathepsin L cysteine protease	0.0057	0.0526	0.0526
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0057	0.0526	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Schistosoma mansoni	calpain-7 (C02 family)	0.0064	0.0719	0.0719
Loa Loa (eye worm)	cathepsin B	0.015	0.2845	0.2723
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0526	0.1849
Schistosoma mansoni	calpain C (C02 family)	0.0064	0.0719	0.0719
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0064	0.0719	0.1844
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0057	0.0526	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0057	0.0526	0.0526
Onchocerca volvulus	Cathepsin L homolog	0.0057	0.0526	0.2253
Giardia lamblia	Cathepsin B precursor	0.015	0.2845	0.5
Toxoplasma gondii	cathepsin CPL	0.0057	0.0526	0.0814
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0438	1	1
Echinococcus granulosus	calpain	0.0064	0.0719	0.0719
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.0526	0.1849
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0057	0.0526	0.0526
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0064	0.0719	0.0719
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Loa Loa (eye worm)	calpain family protein 1	0.0126	0.224	0.2108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.0526	0.1849
Plasmodium falciparum	plasmepsin VI	0.0048	0.0321	0.6095
Onchocerca volvulus		0.0057	0.0526	0.2253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Plasmodium vivax	plasmepsin IV, putative	0.0048	0.0321	0.4458
Trypanosoma brucei	calpain-like protein, putative	0.0064	0.0719	0.2528
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0057	0.0526	0.1849
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.0526	0.1849
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0064	0.0719	0.0719
Loa Loa (eye worm)	cysteine protease	0.0057	0.0526	0.0365
Schistosoma mansoni	cathepsin D (A01 family)	0.0142	0.2659	0.2659
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0057	0.0526	0.1849
Onchocerca volvulus		0.0057	0.0526	0.2253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0057	0.0526	0.1849
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Brugia malayi	calpain family protein 1	0.0171	0.3358	0.3358
Plasmodium vivax	vivapain-2	0.0057	0.0526	0.7315
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0526	0.0526
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0057	0.0526	0.1849
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0438	1	1
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0048	0.0321	0.0321
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0042	0.0167	0.0167
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0064	0.0719	0.1844
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.0526	0.1849
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0064	0.0719	0.0719
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.0526	0.1849
Trypanosoma cruzi	cysteine peptidase, putative	0.0057	0.0526	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0438	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0057	0.0526	0.1849
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0178	0.355	0.355
Onchocerca volvulus		0.0057	0.0526	0.2253
Leishmania major	cysteine peptidase A (CPA)	0.0057	0.0526	0.1103
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0045	0.0239	0.4537
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0064	0.0719	0.0719
Onchocerca volvulus		0.0057	0.0526	0.2253
Echinococcus granulosus	cathepsin b	0.0438	1	1
Echinococcus multilocularis	cathepsin b	0.0438	1	1
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0526	0.0526
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0178	0.355	0.355
Trypanosoma brucei	antigen, putative	0.0064	0.0719	0.2528
Loa Loa (eye worm)	fibroinase	0.0057	0.0526	0.0365
Schistosoma mansoni	calpain-7 (C02 family)	0.0064	0.0719	0.0719
Leishmania major	cathepsin L-like protease	0.0057	0.0526	0.1103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0042	0.0167	0.0588
Schistosoma mansoni	calpain (C02 family)	0.0064	0.0719	0.0719
Brugia malayi	Cathepsin L-like precursor	0.0057	0.0526	0.0526
Schistosoma mansoni	cathepsin D (A01 family)	0.0142	0.2659	0.2659
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.015	0.2845	0.2845
Schistosoma mansoni	cathepsin F (C01 family)	0.0057	0.0526	0.0526
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0064	0.0719	0.1844
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0064	0.0719	0.0719
Echinococcus multilocularis	calpain 7 (C02 family)	0.0064	0.0719	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0526	0.0365
Brugia malayi	Papain family cysteine protease containing protein	0.0057	0.0526	0.0526
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.015	0.2845	1
Entamoeba histolytica	protein kinase, putative	0.0045	0.0239	0.4537

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 865682