Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.3939 | 0.3863 |
Echinococcus granulosus | caspase | 0.0114 | 0.0838 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.1405 | 0.1057 |
Leishmania major | fatty-acid desaturase, putative | 0.0843 | 1 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0843 | 1 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0801 | 0.948 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0083 | 0.0451 | 0.2873 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0147 | 0.125 | 0.0885 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0114 | 0.0838 | 0.1879 |
Onchocerca volvulus | 0.0402 | 0.4459 | 0.4205 | |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0114 | 0.0838 | 0.1879 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0801 | 0.948 | 1 |
Echinococcus granulosus | caspase 2 | 0.0083 | 0.0451 | 0.2873 |
Onchocerca volvulus | 0.0841 | 0.9984 | 1 | |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0083 | 0.0451 | 0.1012 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0843 | 1 | 1 |
Echinococcus multilocularis | caspase | 0.0114 | 0.0838 | 1 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0401 | 0.4443 | 0.4687 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0801 | 0.948 | 0.5 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0114 | 0.0838 | 1 |
Schistosoma mansoni | fatty acid desaturase | 0.0402 | 0.4459 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.0801 | 0.948 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0147 | 0.125 | 0.1319 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0114 | 0.0838 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0083 | 0.0451 | 0.0476 |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.4443 | 0.4422 |
Brugia malayi | hypothetical protein | 0.0159 | 0.1405 | 0.1482 |
Onchocerca volvulus | 0.0841 | 0.9984 | 1 | |
Loa Loa (eye worm) | FAT-3 protein | 0.0401 | 0.4443 | 0.4422 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.