Detailed information for compound 867577

Basic information

Technical information
  • TDR Targets ID: 867577
  • Name: 2-Amino-5-oxo-4-thiophen-2-yl-4H,5H-pyrano[3, 2-c]chromene-3-carbonitrile
  • MW: 322.338 | Formula: C17H10N2O3S
  • H donors: 1 H acceptors: 2 LogP: 2.73 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)Oc2c(C1c1cccs1)c(=O)oc1c2cccc1
  • InChi: 1S/C17H10N2O3S/c18-8-10-13(12-6-3-7-23-12)14-15(22-16(10)19)9-4-1-2-5-11(9)21-17(14)20/h1-7,13H,19H2
  • InChiKey: XQLJKVUBWFWJHH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • BAS 00667196
  • Oprea1_416112
  • A1982/0083351
  • Oprea1_468939
  • AE-848/10130049

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392
Schistosoma mansoni lozenge 0.0058 0.076 0.0845
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0798 0.2538
Brugia malayi orphan nuclear receptor NR2E1 0.0042 0.0392 0.0392
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0351 0.1408
Echinococcus multilocularis muscleblind protein 1 0.015 0.2841 0.3826
Loa Loa (eye worm) nuclear receptor NHR-67 0.0042 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.009 0.1465 0.1465
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.009 0.1465 0.1465
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0392 0.0392
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.009 0.1465 0.2617
Brugia malayi conserved hypotetical protein 0.0042 0.0392 0.0392
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0164 0.3143 1
Brugia malayi nuclear receptor RXR 0.0042 0.0392 0.0392
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0164 0.3143 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.009 0.1465 0.1855
Schistosoma mansoni nuclear receptor 0.0042 0.0392 0.0318
Schistosoma mansoni hypothetical protein 0.0068 0.0967 0.1141
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.009 0.1465 0.1465
Loa Loa (eye worm) hypothetical protein 0.0081 0.1268 0.1268
Loa Loa (eye worm) runx1 0.0058 0.076 0.076
Brugia malayi Muscleblind-like protein 0.015 0.2841 0.2841
Brugia malayi Nuclear hormone receptor family member nhr-25 0.009 0.1465 0.1465
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0798 0.1268
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0351 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.009 0.1465 0.1465
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0135 0.2491 0.3325
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0507 0.0483
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0392 0.0318
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.009 0.1465 0.1855
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0461 0.0588
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0221 0.4435 0.611
Mycobacterium ulcerans thymidylate synthase 0.0164 0.3143 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.176 0.176
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0798 0.2538
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0466 1 1
Loa Loa (eye worm) acetyltransferase 0.015 0.2834 0.2834
Loa Loa (eye worm) hypothetical protein 0.009 0.1465 0.1465
Schistosoma mansoni nuclear receptor 0.0042 0.0392 0.0318
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0164 0.3143 1
Schistosoma mansoni jun-related protein 0.0068 0.0967 0.1141
Brugia malayi Nuclear hormone receptor family member nhr-25 0.009 0.1465 0.1465
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.2834 0.3816
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392
Entamoeba histolytica hypothetical protein 0.0038 0.0293 0.1175
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0798 0.0899
Onchocerca volvulus 0.0466 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0461 0.0417
Loa Loa (eye worm) hypothetical protein 0.015 0.2841 0.2841
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0392 0.0449
Echinococcus multilocularis Protein lozenge 0.0058 0.076 0.0845
Brugia malayi Nuclear hormone receptor family member nhr-1 0.009 0.1465 0.1465
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392
Brugia malayi hypothetical protein 0.0038 0.0293 0.0293
Onchocerca volvulus 0.0065 0.0915 0.0915
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.009 0.1465 0.1855
Brugia malayi Nuclear hormone receptor family member nhr-19 0.009 0.1465 0.1465
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.2491 0.6648
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.009 0.1465 0.2617
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0164 0.3143 1
Onchocerca volvulus Bile acid receptor homolog 0.009 0.1465 0.1465
Echinococcus multilocularis jun protein 0.0083 0.132 0.1647
Loa Loa (eye worm) hypothetical protein 0.015 0.2841 0.2841
Echinococcus multilocularis nuclear receptor nhr 48 0.0042 0.0392 0.0318
Echinococcus granulosus muscleblind protein 0.015 0.2841 0.5396
Brugia malayi Nuclear hormone receptor family member nhr-41 0.009 0.1465 0.1465
Schistosoma mansoni coup transcription factor 0.009 0.1465 0.1855
Brugia malayi nuclear hormone receptor 0.009 0.1465 0.1465
Brugia malayi ecdysteroid receptor 0.009 0.1465 0.1465
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0042 0.0392 0.0318
Entamoeba histolytica hypothetical protein 0.0038 0.0293 0.1175
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.009 0.1465 0.2617
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.009 0.1465 0.1465
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0221 0.4435 0.611
Entamoeba histolytica hypothetical protein 0.0038 0.0293 0.1175
Echinococcus granulosus nuclear receptor nhr 48 0.0042 0.0392 0.0449
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.132 0.1647
Loa Loa (eye worm) steroid hormone receptor 0.009 0.1465 0.1465
Schistosoma mansoni thyroid hormone receptor 0.0341 0.715 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0798 0.2538
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392
Brugia malayi nuclear hormone receptor family member nhr-6 0.0042 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.009 0.1465 0.1465
Brugia malayi Latrophilin receptor protein 2 0.0032 0.017 0.017
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0047 0.0507 0.0507
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0135 0.2491 0.2491
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0392 0.0318
Brugia malayi tailless protein 0.0042 0.0392 0.0392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0461 0.0417
Loa Loa (eye worm) hypothetical protein 0.0221 0.4435 0.4435
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0798 0.0899
Echinococcus granulosus thymidylate synthase 0.0164 0.3143 0.6007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.009 0.1465 0.1855
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0798 0.2538
Loa Loa (eye worm) hypothetical protein 0.009 0.1465 0.1465
Brugia malayi hypothetical protein 0.0047 0.0507 0.0507
Echinococcus granulosus nuclear receptor 2DBD gamma 0.009 0.1465 0.2617
Brugia malayi thymidylate synthase 0.0164 0.3143 0.3143
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0047 0.0507 0.0483
Brugia malayi Nuclear hormone receptor family member nhr-19 0.009 0.1465 0.1465
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.1024 0.1024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.176 0.176
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0461 0.0417
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.2834 0.3816
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0461 0.0461
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0047 0.0507 0.0681
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0251 0.5119 0.709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392
Schistosoma mansoni retinoid-x-receptor (RXR) 0.009 0.1465 0.1855
Echinococcus multilocularis ecdysone induced protein 78C 0.009 0.1465 0.1855
Echinococcus granulosus retinoic acid receptor rxr beta a 0.009 0.1465 0.2617
Loa Loa (eye worm) hypothetical protein 0.0047 0.0507 0.0507
Schistosoma mansoni zinc finger protein 0.0042 0.0392 0.0318
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.176 0.176
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.2738 0.5189
Echinococcus multilocularis transcription factor Dp 1 0.0078 0.1204 0.1481
Echinococcus granulosus hormone sensitive lipase 0.0221 0.4435 0.8617
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0042 0.0392 0.0392
Brugia malayi nuclear hormone receptor 0.0042 0.0392 0.0392
Schistosoma mansoni nuclear receptor nhr-48 0.0042 0.0392 0.0318
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.009 0.1465 0.1465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.009 0.1465 0.1465
Schistosoma mansoni hypothetical protein 0.0038 0.0293 0.0175
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.017 0.017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0392 0.0449
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0042 0.0392 0.0449
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.1199 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.2491 0.6648
Echinococcus granulosus jun protein 0.0083 0.132 0.2323
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0461 0.0417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.009 0.1465 0.1465
Loa Loa (eye worm) hypothetical protein 0.0047 0.0507 0.0507
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0293 0.0175
Loa Loa (eye worm) DR-78 0.0042 0.0392 0.0392
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0293 0.0175
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0164 0.3143 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0164 0.3143 1
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.007 0.1024 0.1024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0461 0.0588
Brugia malayi steroid hormone receptor 0.009 0.1465 0.1465
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0392 0.0318
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0293 0.0247
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.132 0.2323
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0434 0.0533
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0251 0.5119 1
Brugia malayi bZIP transcription factor family protein 0.0083 0.132 0.132
Brugia malayi Nuclear hormone receptor-like 1 0.009 0.1465 0.1465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.009 0.1465 0.1465
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.009 0.1465 0.1465
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.009 0.1465 0.1855
Brugia malayi nuclear receptor RXR 0.0047 0.0507 0.0507
Echinococcus granulosus FTZ F1 alpha 0.009 0.1465 0.2617
Loa Loa (eye worm) hypothetical protein 0.0047 0.0507 0.0507
Schistosoma mansoni RAR-like nuclear receptor 0.009 0.1465 0.1855
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0042 0.0392 0.0318
Echinococcus multilocularis hormone sensitive lipase 0.0221 0.4435 0.611
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0392 0.0392
Brugia malayi hypothetical protein 0.0042 0.0392 0.0392
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0047 0.0507 0.0483
Schistosoma mansoni Tr4/Tr2 (homologue) 0.009 0.1465 0.1855
Brugia malayi nuclear receptor NHR-88 0.009 0.1465 0.1465
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0135 0.2491 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.009 0.1465 0.1465
Brugia malayi nuclear hormone receptor family member odr-7 0.0042 0.0392 0.0392
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0392 0.0318
Echinococcus multilocularis muscleblind protein 0.015 0.2841 0.3826
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0221 0.4435 0.611
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0164 0.3143 1
Schistosoma mansoni hypothetical protein 0.0251 0.5119 0.709
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.009 0.1465 0.1465
Loa Loa (eye worm) hypothetical protein 0.0047 0.0507 0.0507
Schistosoma mansoni steroid hormone receptor ad4bp 0.009 0.1465 0.1855
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0461 0.0417
Entamoeba histolytica hypothetical protein 0.0038 0.0293 0.1175
Loa Loa (eye worm) hypothetical protein 0.009 0.1465 0.1465
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392
Echinococcus multilocularis FTZ F1 alpha 0.009 0.1465 0.1855
Echinococcus granulosus transcription factor Dp 1 0.0078 0.1204 0.2088
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.176 0.176
Loa Loa (eye worm) hypothetical protein 0.009 0.1465 0.1465
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0392 0.0449
Mycobacterium tuberculosis Hypothetical protein 0.0078 0.1199 0.3814
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0392 0.0318
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0798 0.0899
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.009 0.1465 0.1465
Brugia malayi nuclear receptor NHR-67 0.0042 0.0392 0.0392
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0135 0.2491 0.7926
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.009 0.1465 0.2617
Onchocerca volvulus Protein ultraspiracle homolog 0.009 0.1465 0.1465
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0164 0.3143 0.4259
Brugia malayi ecdysone receptor 0.0042 0.0392 0.0392
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0798 0.2538
Onchocerca volvulus 0.0164 0.3143 0.3143
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0164 0.3143 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.009 0.1465 0.1855
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0135 0.2491 0.469
Brugia malayi Nuclear hormone receptor family member nhr-40 0.009 0.1465 0.1465
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0392 0.0392
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.2834 0.2834
Brugia malayi nuclear receptor NHR-88 0.0042 0.0392 0.0392
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0042 0.0392 0.0318
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.009 0.1465 0.1855
Brugia malayi hypothetical protein 0.0042 0.0392 0.0392
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.009 0.1465 0.1855
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.017 0.017
Echinococcus granulosus ecdysone induced protein 78C 0.009 0.1465 0.2617
Echinococcus multilocularis thymidylate synthase 0.0164 0.3143 0.4259
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0042 0.0392 0.0318
Echinococcus multilocularis thyroid hormone receptor alpha 0.0341 0.715 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0135 0.2491 0.3325
Loa Loa (eye worm) hypothetical protein 0.009 0.1465 0.1465
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0135 0.2491 0.2491
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.009 0.1465 0.1855
Schistosoma mansoni thyroid hormone receptor 0.0341 0.715 1
Onchocerca volvulus 0.0042 0.0392 0.0392
Onchocerca volvulus 0.009 0.1465 0.1465
Loa Loa (eye worm) hypothetical protein 0.009 0.1465 0.1465
Loa Loa (eye worm) hypothetical protein 0.0466 1 1
Brugia malayi photoreceptor-specific nuclear receptor 0.009 0.1465 0.1465
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0798 0.1342
Loa Loa (eye worm) hypothetical protein 0.0047 0.0507 0.0507
Echinococcus granulosus nuclear receptor 2DBD gamma 0.009 0.1465 0.2617
Loa Loa (eye worm) thymidylate synthase 0.0164 0.3143 0.3143
Onchocerca volvulus 0.0042 0.0392 0.0392
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0507 0.0507
Echinococcus granulosus thyroid hormone receptor alpha 0.0042 0.0392 0.0449
Loa Loa (eye worm) hypothetical protein 0.0032 0.017 0.017
Brugia malayi Nuclear hormone receptor family member nhr-31 0.009 0.1465 0.1465
Schistosoma mansoni retinoic acid receptor RXR 0.009 0.1465 0.1855
Schistosoma mansoni nuclear hormone receptor 0.009 0.1465 0.1855
Brugia malayi hypothetical protein 0.0047 0.0507 0.0507
Brugia malayi hypothetical protein 0.0065 0.0915 0.0915
Schistosoma mansoni hypothetical protein 0.007 0.1024 0.1224
Brugia malayi Nuclear hormone receptor family member nhr-3 0.009 0.1465 0.1465
Brugia malayi hypothetical protein 0.0078 0.1199 0.1199
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.009 0.1465 0.1855
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0042 0.0392 0.0392
Loa Loa (eye worm) nuclear hormone receptor 0.0042 0.0392 0.0392
Brugia malayi Steroid receptor seven-up type 2 0.009 0.1465 0.1465
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0042 0.0392 0.0392

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.