Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0063 | 0.0968 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0063 | 0.0968 | 0.0968 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0944 | 0.1837 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0063 | 0.0968 | 0.0968 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0205 | 0.4435 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.1009 | 0.1009 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0968 | 0.0968 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0205 | 0.4435 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.003 | 0.0158 | 0.0158 |
Onchocerca volvulus | 0.0433 | 1 | 1 | |
Echinococcus granulosus | FTZ F1 alpha | 0.0063 | 0.0968 | 0.1895 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0037 | 0.0346 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0245 | 0.0245 |
Onchocerca volvulus | 0.0063 | 0.0968 | 0.0968 | |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.2463 | 0.5389 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0033 | 0.0245 | 0.0245 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0356 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0041 | 0.0439 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0944 | 0.1837 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0944 | 0.0944 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0944 | 0.0944 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0033 | 0.0245 | 0.0203 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0063 | 0.0968 | 0.1895 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0041 | 0.0439 | 0.0657 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0063 | 0.0968 | 0.1895 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0624 | 0.0624 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0033 | 0.0245 | 0.0203 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0063 | 0.0968 | 0.1895 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.0439 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0944 | 0.1837 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0063 | 0.0968 | 0.1895 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0063 | 0.0968 | 0.0968 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.007 | 0.115 | 0.2319 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.007 | 0.115 | 0.2319 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.1009 | 0.199 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0944 | 0.0944 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0063 | 0.0968 | 0.1895 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0968 | 0.0968 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0063 | 0.0968 | 0.1895 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0063 | 0.0968 | 0.1895 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.3471 | 0.7748 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0037 | 0.0346 | 0.0439 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0063 | 0.0968 | 0.0968 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0136 | 0.2755 | 0.6073 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0065 | 0.1009 | 0.199 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.003 | 0.0158 | 0.0158 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0063 | 0.0968 | 0.1895 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0063 | 0.0968 | 0.1895 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.3997 | 0.8976 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0944 | 0.0944 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0063 | 0.0968 | 0.1895 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0033 | 0.0245 | 0.0245 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0063 | 0.0968 | 0.1895 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0187 | 0.3997 | 0.8976 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0063 | 0.0968 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.1009 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0063 | 0.0968 | 0.1895 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.2463 | 0.5389 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0205 | 0.4435 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0063 | 0.0968 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0245 | 0.0245 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0944 | 0.1837 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0063 | 0.0968 | 0.1895 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0624 | 0.0624 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.014 | 0.2851 | 0.6297 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.2463 | 0.5389 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0 | 0.5 |
Brugia malayi | ecdysone receptor | 0.003 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | runx1 | 0.0054 | 0.076 | 0.076 |
Brugia malayi | Nuclear hormone receptor E75 | 0.003 | 0.0158 | 0.0158 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0063 | 0.0968 | 0.1895 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.0439 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0063 | 0.0968 | 0.0968 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0063 | 0.0968 | 0.1895 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0944 | 0.0944 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0063 | 0.0968 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0245 | 0.0245 |
Brugia malayi | Nuclear hormone receptor E75 | 0.003 | 0.0158 | 0.0158 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0063 | 0.0968 | 0.0968 |
Echinococcus multilocularis | Protein lozenge | 0.0054 | 0.076 | 0.1407 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0205 | 0.4435 | 1 |
Schistosoma mansoni | lozenge | 0.0054 | 0.076 | 0.1407 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0063 | 0.0968 | 0.0968 |
Loa Loa (eye worm) | acetyltransferase | 0.014 | 0.2851 | 0.2851 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.003 | 0.0158 | 0.0158 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.115 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0063 | 0.0968 | 0.0968 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0247 | 0.0209 |
Schistosoma mansoni | nuclear hormone receptor | 0.0063 | 0.0968 | 0.1895 |
Onchocerca volvulus | 0.003 | 0.0158 | 0.0158 | |
Brugia malayi | nuclear receptor NHR-88 | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | steroid hormone receptor | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | nuclear receptor RXR | 0.003 | 0.0158 | 0.0158 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0944 | 0.1837 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0041 | 0.0439 | 0.5 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.003 | 0.0158 | 0.0158 |
Onchocerca volvulus | 0.003 | 0.0158 | 0.0158 | |
Brugia malayi | hypothetical protein | 0.007 | 0.115 | 0.115 |
Echinococcus granulosus | hormone sensitive lipase | 0.0205 | 0.4435 | 1 |
Brugia malayi | conserved hypotetical protein | 0.003 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.003 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0968 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0624 | 0.0624 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.1009 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.3471 | 0.7748 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0063 | 0.0968 | 0.0968 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0063 | 0.0968 | 0.1895 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.003 | 0.0158 | 0.0158 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0065 | 0.1009 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0063 | 0.0968 | 0.0968 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0065 | 0.1009 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0063 | 0.0968 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0968 | 0.0968 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0063 | 0.0968 | 0.1895 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.115 | 0.2319 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0944 | 0.0944 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | nuclear hormone receptor | 0.0063 | 0.0968 | 0.0968 |
Echinococcus granulosus | geminin | 0.0165 | 0.3471 | 0.7748 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0063 | 0.0968 | 0.1895 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0063 | 0.0968 | 0.1895 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0063 | 0.0968 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Brugia malayi | nuclear hormone receptor | 0.003 | 0.0158 | 0.0158 |
Schistosoma mansoni | coup transcription factor | 0.0063 | 0.0968 | 0.1895 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0944 | 0.1837 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0968 | 0.0968 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.4435 | 0.4435 |
Brugia malayi | nuclear receptor RXR | 0.0033 | 0.0245 | 0.0245 |
Echinococcus multilocularis | geminin | 0.0165 | 0.3471 | 0.7748 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0245 | 0.0245 |
Brugia malayi | nuclear receptor NHR-88 | 0.003 | 0.0158 | 0.0158 |
Brugia malayi | hypothetical protein | 0.0033 | 0.0245 | 0.0245 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0063 | 0.0968 | 0.1895 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.0356 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0063 | 0.0968 | 0.0968 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.115 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0063 | 0.0968 | 0.1895 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0247 | 0.0247 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Brugia malayi | tailless protein | 0.003 | 0.0158 | 0.0158 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0065 | 0.1009 | 0.8776 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0065 | 0.1009 | 0.1009 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.0356 | 0.3092 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0033 | 0.0245 | 0.0245 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Entamoeba histolytica | hypothetical protein | 0.007 | 0.115 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0041 | 0.0439 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0624 | 0.0624 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0063 | 0.0968 | 0.0968 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0033 | 0.0245 | 0.0203 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0063 | 0.0968 | 0.1895 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0063 | 0.0968 | 0.1895 |
Brugia malayi | ecdysteroid receptor | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.003 | 0.0158 | 0.0158 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.014 | 0.2851 | 0.2851 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.007 | 0.115 | 0.2319 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0968 | 0.0968 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0063 | 0.0968 | 0.1895 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0063 | 0.0968 | 0.1895 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.003 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | DR-78 | 0.003 | 0.0158 | 0.0158 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0063 | 0.0968 | 0.0968 |
Brugia malayi | nuclear receptor NHR-67 | 0.003 | 0.0158 | 0.0158 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0065 | 0.1009 | 0.199 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0247 | 0.0247 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0944 | 0.1837 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0063 | 0.0968 | 0.0968 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0033 | 0.0245 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 1 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.003 | 0.0158 | 0.0158 |
Schistosoma mansoni | thyroid hormone receptor | 0.0187 | 0.3997 | 0.8976 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.014 | 0.2851 | 0.6297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.