TDR Targets

Basic information

Technical information

TDR Targets ID: 869849
Name: 6-chloro-2-ethyl-N-(3-methylphenyl)-2,3-dihyd ro-1,4-benzoxazine-4-carboxamide
MW: 330.809 | Formula: C18H19ClN2O2
H donors: 1 H acceptors: 1 LogP: 4.37 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCC1Oc2ccc(cc2N(C1)C(=O)Nc1cccc(c1)C)Cl
InChi: 1S/C18H19ClN2O2/c1-3-15-11-21(16-10-13(19)7-8-17(16)23-15)18(22)20-14-6-4-5-12(2)9-14/h4-10,15H,3,11H2,1-2H3,(H,20,22)
InChiKey: IINYLHAXXOIWSD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0398	0.0547	0.0666
Brugia malayi	cathepsin L-like precursor	0.1128	0.2538	0.309
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1608	0.3851	0.2405
Plasmodium vivax	unspecified product	0.0497	0.0816	0.0804
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Brugia malayi	Papain family cysteine protease containing protein	0.0398	0.0547	0.0666
Onchocerca volvulus	Cathepsin F homolog	0.1625	0.3896	1
Echinococcus granulosus	cathepsin L	0.0896	0.1904	0.1771
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Brugia malayi	Cathepsin L-like precursor	0.1625	0.3896	0.4743
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1608	0.3851	0.3495
Loa Loa (eye worm)	hypothetical protein	0.1128	0.2538	0.309
Brugia malayi	Cathepsin L-like precursor	0.1625	0.3896	0.4743
Entamoeba histolytica	cysteine proteinase, putative	0.0896	0.1904	0.4054
Entamoeba histolytica	cysteine proteinase 2	0.0896	0.1904	0.4054
Plasmodium vivax	vivapain-1	0.0896	0.1904	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1625	0.3896	1
Giardia lamblia	Cathepsin B precursor	0.1608	0.3851	1
Loa Loa (eye worm)	hypothetical protein	0.1128	0.2538	0.309
Echinococcus multilocularis	cathepsin b	0.3206	0.8214	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0497	0.0816	0.0994
Loa Loa (eye worm)	cathepsin B	0.1608	0.3851	0.4689
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0398	0.0547	0.1236
Onchocerca volvulus		0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0398	0.0547	0.1236
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1128	0.2538	0.6447
Entamoeba histolytica	cysteine proteinase, putative	0.1625	0.3896	1
Plasmodium vivax	unspecified product	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1608	0.3851	0.9884
Loa Loa (eye worm)	fibroinase	0.1625	0.3896	0.4743
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Loa Loa (eye worm)	cysteine protease	0.1625	0.3896	0.4743
Trypanosoma cruzi	cysteine protease, putative	0.0896	0.1904	0.1436
Brugia malayi	Cathepsin L-like precursor	0.1625	0.3896	0.4743
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1625	0.3896	1
Brugia malayi	Cathepsin L-like precursor	0.0497	0.0816	0.0994
Leishmania major	cathepsin L-like protease	0.1625	0.3896	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0497	0.0816	0.0994
Onchocerca volvulus		0.1625	0.3896	1
Toxoplasma gondii	cathepsin B	0.1608	0.3851	0.9867
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0398	0.0547	0.0666
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3206	0.8214	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0398	0.0547	0.1236
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1608	0.3851	0.431
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Loa Loa (eye worm)	hypothetical protein	0.1128	0.2538	0.309
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0398	0.0547	0.0666
Echinococcus multilocularis	cathepsin L cysteine protease	0.1625	0.3896	0.4368
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3206	0.8214	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0896	0.1904	0.1436
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Loa Loa (eye worm)	ctsf protein	0.1625	0.3896	0.4743
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0398	0.0547	0.1236
Trypanosoma cruzi	cysteine peptidase, putative	0.0497	0.0816	0.0285
Onchocerca volvulus		0.0398	0.0547	0.1236
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.1625	0.3896	1
Plasmodium vivax	vivapain-3	0.0896	0.1904	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0896	0.1904	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.386	1	1
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Onchocerca volvulus		0.1625	0.3896	1
Echinococcus granulosus	cathepsin l1	0.1128	0.2538	0.2597
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0398	0.0547	0.1236
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0896	0.1904	0.1771
Trypanosoma cruzi	cysteine peptidase, putative	0.1625	0.3896	0.3542
Brugia malayi	Cathepsin L-like precursor	0.1128	0.2538	0.309
Plasmodium vivax	vivapain-2	0.1625	0.3896	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1625	0.3896	0.4368
Echinococcus multilocularis	cysteine protease	0.1625	0.3896	0.4368
Onchocerca volvulus	Cathepsin L homolog	0.1625	0.3896	1
Onchocerca volvulus		0.1625	0.3896	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.3206	0.8214	1
Brugia malayi	Papain family cysteine protease containing protein	0.1625	0.3896	0.4743
Trypanosoma cruzi	cysteine peptidase, putative	0.0896	0.1904	0.1436
Trypanosoma cruzi	cysteine proteinase, putative	0.0896	0.1904	0.1436
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Entamoeba histolytica	cysteine proteinase, putative	0.0896	0.1904	0.4054
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.3206	0.8214	0.811
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1625	0.3896	0.4368
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1625	0.3896	1
Giardia lamblia	Cathepsin B precursor	0.1608	0.3851	1
Schistosoma mansoni	cathepsin s	0.0497	0.0816	0.0351
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.3206	0.8214	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0398	0.0547	0.0666
Brugia malayi	cathepsin L precursor	0.0398	0.0547	0.0666
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Leishmania major	cathepsin L-like protease	0.1625	0.3896	0.0072
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Loa Loa (eye worm)	hypothetical protein	0.0497	0.0816	0.0994
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0398	0.0547	0.0666
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1625	0.3896	1
Giardia lamblia	Cathepsin B precursor	0.1608	0.3851	1
Entamoeba histolytica	cysteine proteinase, putative	0.1128	0.2538	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0398	0.0547	0.0666
Echinococcus granulosus	cathepsin b	0.3206	0.8214	1
Echinococcus granulosus	cysteine protease	0.0896	0.1904	0.1771
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0398	0.0547	0.1236
Onchocerca volvulus		0.1625	0.3896	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0896	0.1904	0.1771
Echinococcus granulosus	cathepsin b	0.3206	0.8214	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.3363	0.8642	0.8564
Trypanosoma cruzi	cruzipain precursor, putative	0.386	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0398	0.0547	0.0666
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1625	0.3896	0.4368
Leishmania major	cathepsin L-like protease	0.386	1	1
Toxoplasma gondii	cathepsin CPL	0.1625	0.3896	1
Brugia malayi	Papain family cysteine protease containing protein	0.0896	0.1904	0.2319
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1625	0.3896	0.4743
Brugia malayi	cathepsin F-like cysteine proteinase	0.0398	0.0547	0.0666
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Plasmodium vivax	vivapain-2	0.1625	0.3896	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0497	0.0816	0.0285
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1625	0.3896	0.4743
Brugia malayi	Cathepsin L-like precursor	0.1625	0.3896	0.4743
Loa Loa (eye worm)	hypothetical protein	0.3206	0.8214	1
Brugia malayi	Papain family cysteine protease containing protein	0.0896	0.1904	0.2319
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0896	0.1904	0.4789
Brugia malayi	fibroinase precursor	0.0398	0.0547	0.0666
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Entamoeba histolytica	cysteine proteinase, putative	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0398	0.0547	0.1236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Leishmania major	cathepsin L-like protease	0.1625	0.3896	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1128	0.2538	0.309
Loa Loa (eye worm)	hypothetical protein	0.0398	0.0547	0.0666
Loa Loa (eye worm)	hypothetical protein	0.1625	0.3896	0.4743
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Echinococcus multilocularis	cysteine protease	0.1625	0.3896	0.4368
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Trypanosoma cruzi	cysteine peptidase, putative	0.386	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0398	0.0547	0.1236
Leishmania major	cathepsin L-like protease	0.386	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0398	0.0547	0.1236
Brugia malayi	Cathepsin L-like precursor	0.1625	0.3896	0.4743
Trypanosoma cruzi	major cysteine proteinase, putative	0.2634	0.6651	0.6458
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0398	0.0547	0.1236
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0398	0.0547	0.0666
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0896	0.1904	0.1436
Brugia malayi	Cathepsin L-like precursor	0.1128	0.2538	0.309
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1625	0.3896	1
Echinococcus granulosus	cathepsin l1	0.1625	0.3896	0.4368
Leishmania major	cathepsin L-like protease	0.1625	0.3896	0.0072
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1625	0.3896	0.4368
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0896	0.1904	0.4789
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1625	0.3896	1
Loa Loa (eye worm)	hypothetical protein	0.0497	0.0816	0.0994
Echinococcus multilocularis	cathepsin L	0.0896	0.1904	0.1771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0398	0.0547	0.1236
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.1128	0.2538	0.2597
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1625	0.3896	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0398	0.0547	0.0666
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.3206	0.8214	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0497	0.0816	0.0994
Leishmania major	cysteine peptidase A (CPA)	0.1625	0.3896	0.0072
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Onchocerca volvulus		0.1128	0.2538	0.6447
Echinococcus multilocularis	cathepsin L cysteine protease	0.1625	0.3896	0.4368
Schistosoma mansoni	cathepsin F (C01 family)	0.1625	0.3896	0.4368
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.386	1	1
Echinococcus multilocularis	cathepsin b	0.3206	0.8214	1
Onchocerca volvulus	Cathepsin L homolog	0.0398	0.0547	0.1236
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0896	0.1904	0.1771
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0896	0.1904	0.1771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1128	0.2538	0.6447
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0398	0.0547	0.1236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0398	0.0547	0.1236
Onchocerca volvulus		0.1625	0.3896	1
Leishmania major	cathepsin L-like protease	0.1625	0.3896	0.0072
Onchocerca volvulus		0.1625	0.3896	1
Brugia malayi	Papain family cysteine protease containing protein	0.0398	0.0547	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0398	0.0547	0.0666
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0398	0.0547	0.0666
Entamoeba histolytica	cysteine protease, putative	0.1625	0.3896	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0497	0.0816	0.0994
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0398	0.0547	0.1236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0398	0.0547	0.1236
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0398	0.0547	0.1236
Trichomonas vaginalis	conserved hypothetical protein	0.0398	0.0547	0.1236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0398	0.0547	0.1236
Entamoeba histolytica	cysteine protease, putative	0.0896	0.1904	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0398	0.0547	0.0666
Trypanosoma cruzi	cysteine peptidase, putative	0.386	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0398	0.0547	0.1236
Brugia malayi	Cathepsin L-like precursor	0.1625	0.3896	0.4743
Brugia malayi	Papain family cysteine protease containing protein	0.0398	0.0547	0.0666
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1625	0.3896	0.4368

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 869849