TDR Targets

Basic information

Technical information

TDR Targets ID: 869985
Name: 1-(2-ethyl-6-methyl2,3-dihydro-1,4-benzoxazin e-4-carbonyl)-N-[2-(4-methylsulfanylphenyl)et hyl]piperidine-4-carboxamide
MW: 481.65 | Formula: C27H35N3O3S
H donors: 1 H acceptors: 2 LogP: 4.6 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCC1Oc2ccc(cc2N(C1)C(=O)N1CCC(CC1)C(=O)NCCc1ccc(cc1)SC)C
InChi: 1S/C27H35N3O3S/c1-4-22-18-30(24-17-19(2)5-10-25(24)33-22)27(32)29-15-12-21(13-16-29)26(31)28-14-11-20-6-8-23(34-3)9-7-20/h5-10,17,21-22H,4,11-16,18H2,1-3H3,(H,28,31)
InChiKey: ODHDWUVSWCPWRY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2-ethyl-6-methyl-2,3-dihydro-1,4-benzoxazine-4-carbonyl)-N-[2-(4-methylsulfanylphenyl)ethyl]piperidine-4-carboxamide
1-[(2-ethyl-6-methyl-2,3-dihydro-1,4-benzoxazin-4-yl)-oxomethyl]-N-[2-[4-(methylthio)phenyl]ethyl]-4-piperidinecarboxamide
1-(2-ethyl-6-methyl-2,3-dihydro-1,4-benzoxazine-4-carbonyl)-N-[2-[4-(methylthio)phenyl]ethyl]isonipecotamide
1-[(2-ethyl-6-methyl-2,3-dihydro-1,4-benzoxazin-4-yl)carbonyl]-N-[2-(4-methylsulfanylphenyl)ethyl]piperidine-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0159	0.2414	0.2409
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Onchocerca volvulus		0.0085	0.1119	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0139	0.2067	0.2062
Trypanosoma cruzi	p450 reductase, putative	0.003	0.0169	0.0124
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0085	0.1119	0.1113
Onchocerca volvulus	Cathepsin L homolog	0.0085	0.1119	1
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0655	0.1516
Giardia lamblia	Cathepsin B precursor	0.0055	0.0601	1
Mycobacterium ulcerans	hypothetical protein	0.024	0.3813	1
Brugia malayi	Cathepsin L-like precursor	0.0085	0.1119	0.26
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0031	0.0199	0.0822
Trypanosoma cruzi	cysteine peptidase, putative	0.0085	0.1119	0.2404
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1119	0.26
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1998	0.4657
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0126	0.1842	0.4291
Mycobacterium tuberculosis	Possible transcriptional regulatory protein	0.024	0.3813	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0655	0.1516
Schistosoma mansoni	growth factor receptor-bound protein	0.0031	0.0199	0.0822
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0128	0.1869	0.1863
Mycobacterium ulcerans	putative regulatory protein	0.024	0.3813	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Entamoeba histolytica	cysteine proteinase 2	0.0045	0.0439	0.2319
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0036	0.0276	0.0269
Echinococcus granulosus	c src tyrosine kinase	0.0036	0.0276	0.0269
Brugia malayi	Sex muscle abnormal protein 5	0.0031	0.0199	0.0448
Schistosoma mansoni	tyrosine kinase	0.0159	0.2414	1
Onchocerca volvulus		0.0085	0.1119	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0159	0.2414	0.2409
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0159	0.2414	0.2409
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0045	0.0439	0.3257
Loa Loa (eye worm)	TK protein kinase	0.0144	0.2145	0.4999
Entamoeba histolytica	cysteine proteinase, putative	0.0085	0.1119	0.5972
Mycobacterium tuberculosis	Probable transcriptional regulatory protein	0.024	0.3813	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0085	0.1119	0.2404
Echinococcus multilocularis	NADPH dependent diflavin oxidoreductase 1	0.003	0.0169	0.0162
Schistosoma mansoni	cathepsin F (C01 family)	0.0058	0.0655	0.2713
Schistosoma mansoni	cathepsin s	0.0027	0.0117	0.0485
Echinococcus granulosus	NCK adaptor protein	0.0031	0.0199	0.0192
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0055	0.0601	0.1161
Onchocerca volvulus		0.0085	0.1119	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0267	0.4283	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0085	0.1119	1
Trichomonas vaginalis	sulfite reductase, putative	0.003	0.0169	0.0581
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0036	0.0276	0.0269
Brugia malayi	Cathepsin L-like precursor	0.0085	0.1119	0.26
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Loa Loa (eye worm)	TK protein kinase	0.0128	0.1869	0.4354
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0085	0.1119	1
Plasmodium vivax	vivapain-2	0.0085	0.1119	1
Giardia lamblia	Cathepsin B precursor	0.0055	0.0601	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0045	0.0439	0.0772
Entamoeba histolytica	cysteine proteinase, putative	0.0045	0.0439	0.2319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Entamoeba histolytica	cysteine proteinase, putative	0.0045	0.0439	0.2319
Leishmania major	NADPH-cytochrome p450 reductase-like protein	0.003	0.0169	0.014
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0117	0.0258
Mycobacterium tuberculosis	Possible two component transcriptional regulatory protein (probably LuxR-family)	0.024	0.3813	0.5
Loa Loa (eye worm)	cysteine protease	0.0085	0.1119	0.26
Echinococcus multilocularis	cathepsin L	0.0045	0.0439	0.0432
Entamoeba histolytica	cysteine proteinase, putative	0.0058	0.0655	0.3481
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0144	0.2145	0.2139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Echinococcus granulosus	growth factor receptor bound protein 2	0.0031	0.0199	0.0192
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0036	0.0276	0.1143
Entamoeba histolytica	cysteine proteinase 1, putative	0.0045	0.0439	0.2319
Onchocerca volvulus	Cathepsin L homolog	0.0085	0.1119	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0159	0.2414	0.2409
Entamoeba histolytica	cysteine proteinase, putative	0.0085	0.1119	0.5972
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0117	0.0258
Schistosoma mansoni	tyrosine kinase	0.0159	0.2414	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0085	0.1119	0.2404
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0045	0.0439	0.1817
Echinococcus multilocularis	NCK adaptor protein	0.0031	0.0199	0.0192
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0117	0.0258
Echinococcus granulosus	tyrosine protein kinase HCK	0.0128	0.1869	0.1863
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0159	0.2414	0.2409
Echinococcus multilocularis	cysteine protease	0.0085	0.1119	0.1113
Loa Loa (eye worm)	ctsf protein	0.0085	0.1119	0.26
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0139	0.2067	0.2062
Onchocerca volvulus	Cathepsin F homolog	0.0085	0.1119	1
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Mycobacterium leprae	PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN	0.024	0.3813	0.5
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0045	0.0439	0.2841
Brugia malayi	Cathepsin L-like precursor	0.0085	0.1119	0.26
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Mycobacterium ulcerans	two component transcriptional regulatory protein DevR	0.024	0.3813	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0655	0.1516
Loa Loa (eye worm)	SRC-1	0.0159	0.2414	0.5629
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0159	0.2414	0.2409
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0036	0.0276	0.0269
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0085	0.1119	0.1113
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0085	0.1119	0.1113
Brugia malayi	Papain family cysteine protease containing protein	0.0045	0.0439	0.101
Trypanosoma cruzi	cysteine protease, putative	0.0045	0.0439	0.0772
Echinococcus granulosus	cathepsin b	0.0135	0.1998	0.1993
Schistosoma mansoni	tyrosine kinase	0.002	0.0007	0.0028
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0031	0.0199	0.0448
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (probably LuxR/UhpA-family)	0.024	0.3813	0.5
Plasmodium vivax	vivapain-3	0.0045	0.0439	0.3257
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.0655	0.1291
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Brugia malayi	Variant SH3 domain containing protein	0.0031	0.0199	0.0448
Plasmodium vivax	unspecified product	0.0027	0.0117	0.007
Brugia malayi	Papain family cysteine protease containing protein	0.0085	0.1119	0.26
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0085	0.1119	0.26
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Onchocerca volvulus		0.0085	0.1119	1
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Echinococcus multilocularis	NADPH cytochrome P450 reductase	0.003	0.0169	0.0162
Plasmodium vivax	NADPH-cytochrome p450 reductase, putative	0.003	0.0169	0.0581
Schistosoma mansoni	tyrosine kinase	0.002	0.0007	0.0028
Echinococcus granulosus	cathepsin l1	0.0058	0.0655	0.0649
Brugia malayi	Tyrosine-protein kinase abl-1	0.0036	0.0276	0.0629
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0144	0.2145	0.2139
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0085	0.1119	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0045	0.0439	0.1817
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0055	0.0601	0.105
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0055	0.0601	0.1176
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0159	0.2414	0.2409
Schistosoma mansoni	tyrosine kinase	0.0036	0.0276	0.1143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0085	0.1119	1
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.003	0.0169	0.0124
Mycobacterium ulcerans	two component transcriptional regulator	0.024	0.3813	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0601	0.2488
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Echinococcus granulosus	NADPH dependent diflavin oxidoreductase 1	0.003	0.0169	0.0162
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0159	0.2414	0.2409
Trypanosoma cruzi	cysteine peptidase, putative	0.0045	0.0439	0.0772
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0135	0.1998	0.8279
Plasmodium vivax	vivapain-2	0.0085	0.1119	1
Brugia malayi	Cathepsin L-like precursor	0.0085	0.1119	0.26
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0135	0.1998	0.8279
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Echinococcus granulosus	NADPH cytochrome P450 reductase	0.003	0.0169	0.0162
Trypanosoma cruzi	cytochrome P450 reductase, putative	0.003	0.0169	0.0124
Giardia lamblia	Cathepsin B precursor	0.0055	0.0601	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0159	0.2414	0.2409
Trypanosoma cruzi	NADPH-dependent FMN/FAD containing oxidoreductase, putative	0.003	0.0169	0.0124
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Entamoeba histolytica	cysteine proteinase, putative	0.0045	0.0439	0.2319
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Echinococcus granulosus	cathepsin b	0.0135	0.1998	0.1993
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Echinococcus granulosus	tyrosine kinase	0.0144	0.2145	0.2139
Loa Loa (eye worm)	hypothetical protein	0.003	0.0169	0.0378
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0085	0.1119	0.1113
Entamoeba histolytica	cysteine proteinase, putative	0.0045	0.0439	0.2319
Brugia malayi	cathepsin F-like cysteine proteinase	0.0027	0.0117	0.0258
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0135	0.1998	0.8279
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0597	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0085	0.1119	0.2404
Onchocerca volvulus		0.0085	0.1119	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0085	0.1119	0.4635
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0159	0.2414	0.2409
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0045	0.0439	0.0656
Echinococcus granulosus	cathepsin L	0.0045	0.0439	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0137	0.202	0.4707
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0144	0.2145	0.2139
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Leishmania major	C-8 sterol isomerase-like protein	0.0267	0.4283	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0085	0.1119	0.26
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0045	0.0439	0.1817
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0135	0.1998	0.4516
Loa Loa (eye worm)	FAD binding domain-containing protein	0.003	0.0169	0.0378
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Trypanosoma cruzi	cysteine peptidase, putative	0.0085	0.1119	0.2404
Brugia malayi	Cathepsin L-like precursor	0.0085	0.1119	0.26
Loa Loa (eye worm)	fibroinase	0.0085	0.1119	0.26
Onchocerca volvulus		0.0085	0.1119	1
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Echinococcus multilocularis	cysteine protease	0.0085	0.1119	0.1113
Entamoeba histolytica	protein kinase, putative	0.0128	0.1869	1
Onchocerca volvulus		0.0085	0.1119	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0045	0.0439	0.0432
Brugia malayi	SRC-1	0.0159	0.2414	0.5629
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0159	0.2414	0.2409
Echinococcus multilocularis	cathepsin b	0.0135	0.1998	0.1993
Schistosoma mansoni	cathepsin F (C01 family)	0.0085	0.1119	0.4635
Trypanosoma cruzi	cysteine proteinase, putative	0.0045	0.0439	0.0772
Brugia malayi	Variant SH3 domain containing protein	0.0031	0.0199	0.0448
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0159	0.2414	0.2409
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Brugia malayi	cathepsin B-like cysteine proteinase	0.0135	0.1998	0.4657
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Loa Loa (eye worm)	hypothetical protein	0.0267	0.4283	1
Brugia malayi	Cathepsin L-like precursor	0.0058	0.0655	0.1516
Mycobacterium ulcerans	nitrate/nitrite response regulator protein NarL	0.024	0.3813	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0144	0.2145	0.2139
Schistosoma mansoni	tyrosine kinase	0.0036	0.0276	0.1143
Onchocerca volvulus		0.0058	0.0655	0.5829
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0267	0.4283	1
Loa Loa (eye worm)	cathepsin B	0.0055	0.0601	0.1389
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0159	0.2414	0.2409
Toxoplasma gondii	cathepsin CPL	0.0085	0.1119	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0117	0.0258
Schistosoma mansoni	cytochrome P450 reductase	0.003	0.0169	0.0699
Echinococcus granulosus	cysteine protease	0.0045	0.0439	0.0432
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0085	0.1119	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0159	0.2414	0.2409
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0045	0.0439	0.3257
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0085	0.1119	0.1113
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0031	0.0199	0.0192
Mycobacterium tuberculosis	Probable transcriptional regulatory protein (LuxR-family)	0.024	0.3813	0.5
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0199	0.0448
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0027	0.0117	0.0258
Echinococcus multilocularis	cathepsin b	0.0135	0.1998	0.1993
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0055	0.0601	0.4864
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0159	0.2414	0.2409
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Brugia malayi	flavodoxin family protein	0.003	0.0169	0.0378
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0159	0.2414	0.2409
Brugia malayi	FAD binding domain containing protein	0.003	0.0169	0.0378
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0655	0.5402
Echinococcus granulosus	cathepsin l1	0.0085	0.1119	0.1113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0144	0.2145	0.2139
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0045	0.0439	0.0656
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0045	0.0439	0.0772
Brugia malayi	Papain family cysteine protease containing protein	0.0045	0.0439	0.101
Schistosoma mansoni	hypothetical protein	0.0108	0.1519	0.6291
Schistosoma mansoni	nck2/grb4	0.0031	0.0199	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0117	0.0258
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Brugia malayi	follicle stimulating hormone receptor	0.0126	0.1842	0.4291
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0267	0.4283	1
Leishmania major	cathepsin L-like protease	0.0085	0.1119	0.2417
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0085	0.1119	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0085	0.1119	0.1113
Brugia malayi	cathepsin L-like precursor	0.0058	0.0655	0.1516
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Brugia malayi	Cathepsin L-like precursor	0.0085	0.1119	0.26
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0135	0.1998	0.8279
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0058	0.0655	0.1516
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0159	0.2414	0.2409
Plasmodium vivax	unspecified product	0.0045	0.0439	0.3257
Entamoeba histolytica	cysteine protease, putative	0.0085	0.1119	0.5972
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0058	0.0655	0.5402
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0031	0.0199	0.0448
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0085	0.1119	1
Leishmania major	p450 reductase, putative	0.003	0.0169	0.014
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0085	0.1119	0.2309
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0655	0.1516
Echinococcus multilocularis	c src tyrosine kinase	0.0036	0.0276	0.0269
Schistosoma mansoni	adapter molecule crk	0.0031	0.0199	0.0822
Trypanosoma brucei	RNA helicase, putative	0.0108	0.1519	0.3281
Schistosoma mansoni	growth factor receptor-bound protein	0.0031	0.0199	0.0822
Entamoeba histolytica	cysteine protease, putative	0.0045	0.0439	0.2319
Leishmania major	cysteine peptidase A (CPA)	0.0085	0.1119	0.2417
Brugia malayi	protein-tyrosine kinase	0.0144	0.2145	0.4999
Plasmodium vivax	vivapain-1	0.0045	0.0439	0.3257
Mycobacterium tuberculosis	Possible nitrate/nitrite response transcriptional regulatory protein NarL	0.024	0.3813	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 869985