TDR Targets

Basic information

Technical information

TDR Targets ID: 870523
Name: N-(tert-butyl-phenylphosphoryl)-1-phenylethan amine
MW: 301.363 | Formula: C18H24NOP
H donors: 1 H acceptors: 1 LogP: 3.58 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1ccccc1)NP(=O)(C(C)(C)C)c1ccccc1
InChi: 1S/C18H24NOP/c1-15(16-11-7-5-8-12-16)19-21(20,18(2,3)4)17-13-9-6-10-14-17/h5-15H,1-4H3,(H,19,20)
InChiKey: RLBMIUWPBJMKRP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(tert-butyl-phenyl-phosphoryl)-1-phenyl-ethanamine
(tert-butyl-phenyl-phosphoryl)-(1-phenylethyl)amine
Oprea1_599381
ST5442215

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Cathepsin L homolog	0.0624	0.286	1
Loa Loa (eye worm)	hypothetical protein	0.1705	1	1
Echinococcus granulosus	cysteine protease	0.0345	0.1017	0.0273
Echinococcus multilocularis	cysteine protease	0.0624	0.286	0.2269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Trypanosoma brucei	histone deacetylase, putative	0.0342	0.0998	0.0431
Entamoeba histolytica	cysteine proteinase, putative	0.0624	0.286	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0634	0.2928	0.3992
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0624	0.286	0.9689
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0634	0.2928	0.2342
Leishmania major	cysteine peptidase A (CPA)	0.0624	0.286	0.3868
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1127	0.6183	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1127	0.6183	1
Echinococcus granulosus	cathepsin L	0.0345	0.1017	0.0273
Echinococcus multilocularis	histone deacetylase 7	0.0342	0.0998	0.0253
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0624	0.286	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1127	0.6183	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0345	0.1017	0.1167
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1127	0.6183	1
Leishmania major	cathepsin L-like protease	0.1127	0.6183	1
Echinococcus multilocularis	histone deacetylase	0.0342	0.0998	0.0253
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0624	0.286	0.9689
Loa Loa (eye worm)	cysteine protease	0.0624	0.286	0.286
Loa Loa (eye worm)	ctsf protein	0.0624	0.286	0.286
Echinococcus granulosus	cathepsin b	0.1705	1	1
Loa Loa (eye worm)	histone deacetylase 7A	0.0342	0.0998	0.0998
Loa Loa (eye worm)	histone deacetylase 1	0.0306	0.0765	0.0765
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1705	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0658	0.3083	0.251
Onchocerca volvulus	Cathepsin L homolog	0.0624	0.286	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0345	0.1017	0.0273
Loa Loa (eye worm)	histone deacetylase 11	0.0347	0.1034	0.1034
Schistosoma mansoni	histone deacetylase hda2	0.0348	0.1043	0.0301
Trypanosoma cruzi	histone deacetylase, putative	0.0342	0.0998	0.0253
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Trypanosoma cruzi	cysteine peptidase, putative	0.0345	0.1017	0.0273
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Plasmodium vivax	histone deacetylase, putative	0.0342	0.0998	0.1113
Trypanosoma cruzi	cysteine peptidase, putative	0.1127	0.6183	0.5867
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Echinococcus multilocularis	cysteine protease	0.0624	0.286	0.2269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Loa Loa (eye worm)	hypothetical protein	0.0433	0.1604	0.1604
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0634	0.2928	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Schistosoma mansoni	histone deacetylase 4 5	0.0342	0.0998	0.0253
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0433	0.1604	0.1604
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0624	0.286	1
Echinococcus granulosus	cathepsin b	0.1705	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1127	0.6183	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1705	1	1
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Brugia malayi	Cathepsin L-like precursor	0.0624	0.286	0.2269
Trypanosoma cruzi	cysteine protease, putative	0.0345	0.1017	0.0273
Trypanosoma cruzi	histone deacetylase, putative	0.0342	0.0998	0.0253
Leishmania major	cathepsin L-like protease	0.0624	0.286	0.3868
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Giardia lamblia	Cathepsin B precursor	0.0634	0.2928	1
Leishmania major	cathepsin L-like protease	0.0624	0.286	0.3868
Loa Loa (eye worm)	cathepsin B	0.0634	0.2928	0.2928
Echinococcus granulosus	histone deacetylase 6	0.0348	0.1043	0.0301
Echinococcus granulosus	cathepsin l1	0.0624	0.286	0.2269
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Echinococcus multilocularis	histone deacetylase 6	0.0348	0.1043	0.0301
Entamoeba histolytica	cysteine proteinase, putative	0.0345	0.1017	0.1204
Plasmodium falciparum	histone deacetylase 2	0.0342	0.0998	0.1113
Toxoplasma gondii	histone deacetylase HDAC1	0.0342	0.0998	0.1079
Echinococcus multilocularis	histone deacetylase 6	0.0342	0.0998	0.0253
Brugia malayi	histone deacetylase 11	0.0347	0.1034	0.0291
Trypanosoma cruzi	cruzipain precursor, putative	0.1127	0.6183	0.5867
Loa Loa (eye worm)	hypothetical protein	0.0306	0.0765	0.0765
Echinococcus granulosus	histone deacetylase 6	0.0342	0.0998	0.0253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0634	0.2928	0.2342
Entamoeba histolytica	cysteine proteinase, putative	0.0345	0.1017	0.1204
Echinococcus granulosus	cathepsin l1	0.0433	0.1604	0.0908
Leishmania major	cathepsin L-like protease	0.1127	0.6183	1
Brugia malayi	Cathepsin L-like precursor	0.0624	0.286	0.2269
Toxoplasma gondii	cathepsin B	0.0634	0.2928	1
Leishmania major	cathepsin L-like protease	0.1127	0.6183	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1127	0.6183	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0345	0.1017	0.0273
Trypanosoma brucei	histone deacetylase 3	0.0342	0.0998	0.0431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0345	0.1017	0.1167
Brugia malayi	Cathepsin L-like precursor	0.0433	0.1604	0.0908
Loa Loa (eye worm)	histone deacetylase 3	0.0306	0.0765	0.0765
Plasmodium vivax	histone deacetylase 2, putative	0.0342	0.0998	0.1113
Onchocerca volvulus		0.0624	0.286	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0624	0.286	0.9689
Onchocerca volvulus		0.0624	0.286	1
Leishmania major	histone deacetylase, putative	0.0342	0.0998	0.0431
Echinococcus granulosus	histone deacetylase 6	0.0342	0.0998	0.0253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Plasmodium vivax	histone deacetylase, putative	0.0347	0.1034	0.1282
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0345	0.1017	0.0466
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0624	0.286	0.9689
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Plasmodium vivax	vivapain-2	0.0624	0.286	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.1604	0.3879
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1127	0.6183	1
Loa Loa (eye worm)	histone deacetylase	0.0342	0.0998	0.0998
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Echinococcus multilocularis	cathepsin L cysteine protease	0.0624	0.286	0.2269
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0624	0.286	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0624	0.286	0.9689
Echinococcus multilocularis	cathepsin L	0.0345	0.1017	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0433	0.1604	0.1604
Schistosoma mansoni	histone deacetylase 4 5	0.0342	0.0998	0.0253
Loa Loa (eye worm)	fibroinase	0.0624	0.286	0.286
Brugia malayi	Histone deacetylase family protein	0.0342	0.0998	0.0253
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0433	0.1604	0.0908
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0624	0.286	0.286
Trypanosoma brucei	histone deacetylase 4	0.0342	0.0998	0.0431
Leishmania major	cathepsin L-like protease	0.0624	0.286	0.3868
Echinococcus granulosus	cathepsin L cysteine protease	0.0345	0.1017	0.0273
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Onchocerca volvulus		0.0624	0.286	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0624	0.286	0.2269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0433	0.1604	0.3879
Brugia malayi	Papain family cysteine protease containing protein	0.0345	0.1017	0.0273
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Schistosoma mansoni	cathepsin F (C01 family)	0.0624	0.286	0.2269
Echinococcus multilocularis	histone deacetylase 6	0.0342	0.0998	0.0253
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1127	0.6183	1
Toxoplasma gondii	cathepsin CPL	0.0624	0.286	0.9689
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0624	0.286	0.9689
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0624	0.286	0.9689
Brugia malayi	Cathepsin L-like precursor	0.0433	0.1604	0.0908
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0345	0.1017	0.0273
Onchocerca volvulus	Cathepsin F homolog	0.0624	0.286	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0937	0.4926	0.4506
Brugia malayi	Papain family cysteine protease containing protein	0.0345	0.1017	0.0273
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1705	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0624	0.286	1
Plasmodium vivax	unspecified product	0.0345	0.1017	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0624	0.286	0.286
Plasmodium vivax	vivapain-2	0.0624	0.286	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0624	0.286	0.9689
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0345	0.1017	0.0273
Giardia lamblia	Cathepsin B precursor	0.0634	0.2928	1
Leishmania major	cathepsin L-like protease	0.0624	0.286	0.3868
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Onchocerca volvulus		0.0624	0.286	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0624	0.286	0.2269
Brugia malayi	Histone deacetylase family protein	0.0342	0.0998	0.0253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Brugia malayi	Papain family cysteine protease containing protein	0.0624	0.286	0.2269
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0624	0.286	0.9689
Plasmodium vivax	vivapain-3	0.0345	0.1017	0.1204
Brugia malayi	cathepsin L-like precursor	0.0433	0.1604	0.0908
Giardia lamblia	Cathepsin B precursor	0.0634	0.2928	1
Brugia malayi	Cathepsin L-like precursor	0.0624	0.286	0.2269
Onchocerca volvulus		0.0624	0.286	1
Onchocerca volvulus		0.0624	0.286	1
Onchocerca volvulus		0.0624	0.286	1
Leishmania major	cathepsin L-like protease	0.0624	0.286	0.3868
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1127	0.6183	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0345	0.1017	0.1204
Entamoeba histolytica	cysteine proteinase 2	0.0345	0.1017	0.1204
Brugia malayi	Cathepsin L-like precursor	0.0624	0.286	0.2269
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1705	1	1
Echinococcus granulosus	histone deacetylase 7	0.0342	0.0998	0.0253
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Entamoeba histolytica	cysteine proteinase, putative	0.0345	0.1017	0.1204
Plasmodium falciparum	histone deacetylase, putative	0.0342	0.0998	0.1113
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0624	0.286	0.9689
Plasmodium vivax	vivapain-1	0.0345	0.1017	0.1204
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0345	0.1017	0.0273
Toxoplasma gondii	histone deacetylase HDAC4	0.0347	0.1034	0.1242
Echinococcus multilocularis	cathepsin b	0.1705	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0345	0.1017	0.0273
Trypanosoma cruzi	cysteine peptidase, putative	0.1127	0.6183	0.5867
Trypanosoma cruzi	cysteine peptidase, putative	0.0624	0.286	0.2269
Schistosoma mansoni	cathepsin F (C01 family)	0.0433	0.1604	0.0908
Trypanosoma cruzi	histone deacetylase, putative	0.0342	0.0998	0.0253
Entamoeba histolytica	cysteine protease, putative	0.0624	0.286	1
Brugia malayi	Cathepsin L-like precursor	0.0624	0.286	0.2269
Echinococcus multilocularis	cathepsin b	0.1705	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1705	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0345	0.1017	0.1204
Trypanosoma cruzi	cysteine peptidase, putative	0.1127	0.6183	0.5867
Schistosoma mansoni	cathepsin F (C01 family)	0.0624	0.286	0.2269
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0624	0.286	0.286
Brugia malayi	Cathepsin L-like precursor	0.0624	0.286	0.2269
Entamoeba histolytica	cysteine proteinase, putative	0.0433	0.1604	0.4003
Echinococcus granulosus	histone deacetylase	0.0342	0.0998	0.0253
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0624	0.286	0.2269
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0345	0.1017	0.0466
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1127	0.6183	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0634	0.2928	0.3992
Entamoeba histolytica	cysteine proteinase, putative	0.0345	0.1017	0.1204
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0624	0.286	0.2269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0624	0.286	0.9689
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0624	0.286	0.9689
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0624	0.286	0.2269
Entamoeba histolytica	cysteine protease, putative	0.0345	0.1017	0.1204
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1127	0.6183	1
Leishmania major	histone deacetylase, putative	0.0342	0.0998	0.0431

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 870523