TDR Targets

Basic information

Technical information

TDR Targets ID: 871459
Name: N-[2-[(2-chlorophenyl)carbamoyl]phenyl]furan- 2-carboxamide
MW: 340.76 | Formula: C18H13ClN2O3
H donors: 2 H acceptors: 2 LogP: 4.17 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccco1)Nc1ccccc1C(=O)Nc1ccccc1Cl
InChi: 1S/C18H13ClN2O3/c19-13-7-2-4-9-15(13)21-17(22)12-6-1-3-8-14(12)20-18(23)16-10-5-11-24-16/h1-11H,(H,20,23)(H,21,22)
InChiKey: VDIQPKLHPBSWIA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-[[(2-chlorophenyl)amino]-oxomethyl]phenyl]-2-furancarboxamide
N-[2-[(2-chlorophenyl)carbamoyl]phenyl]-2-furamide
CBMicro_047632
MixCom6_002576
STK096098
N-{2-[(2-chloroanilino)carbonyl]phenyl}-2-furamide
Oprea1_617890
ZINC00168824
BIM-0047618.P001
AP-064/11562347
EU-0039847

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Cathepsin L homolog	0.0187	0.0949	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0326	0.3281	0.2576
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0187	0.0949	0.0949
Brugia malayi	Cathepsin L-like precursor	0.0187	0.0949	0.0949
Brugia malayi	Cathepsin L-like precursor	0.0187	0.0949	0.0949
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Leishmania major	cathepsin L-like protease	0.0326	0.3281	0.8522
Onchocerca volvulus		0.0187	0.0949	1
Loa Loa (eye worm)	fibroinase	0.0187	0.0949	0.0949
Leishmania major	cathepsin L-like protease	0.0326	0.3281	0.8522
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0277	0.2451	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.035	0.3685	0.3023
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0187	0.0949	0.2574
Giardia lamblia	Cathepsin B precursor	0.035	0.3685	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0277	0.2451	1
Brugia malayi	Papain family cysteine protease containing protein	0.0187	0.0949	0.0949
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.035	0.3685	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.0949	0.2574
Giardia lamblia	Cathepsin B precursor	0.035	0.3685	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0725	1	1
Echinococcus granulosus	cathepsin b	0.0725	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0187	0.0949	0.0949
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.0949	0.2574
Giardia lamblia	Cathepsin B precursor	0.035	0.3685	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0277	0.2451	0.6465
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0725	1	1
Plasmodium vivax	vivapain-2	0.0187	0.0949	0.334
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Trypanosoma cruzi	major cysteine proteinase, putative	0.0199	0.1147	0.0219
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0725	1	1
Onchocerca volvulus		0.0187	0.0949	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.035	0.3685	0.3685
Entamoeba histolytica	cysteine proteinase, putative	0.0187	0.0949	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0725	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0326	0.3281	0.2576
Brugia malayi	Cathepsin L-like precursor	0.0187	0.0949	0.0949
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.0949	0.2574
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0725	1	1
Brugia malayi	Cathepsin L-like precursor	0.0187	0.0949	0.0949
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0187	0.0949	0.334
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.0949	0.2574
Plasmodium vivax	vivapain-2	0.0187	0.0949	0.334
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0277	0.2451	1
Toxoplasma gondii	cathepsin CPL	0.0187	0.0949	0.216
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.027	0.2332	0.1528
Loa Loa (eye worm)	ctsf protein	0.0187	0.0949	0.0949
Entamoeba histolytica	cysteine proteinase, putative	0.0187	0.0949	1
Onchocerca volvulus		0.0187	0.0949	1
Toxoplasma gondii	cathepsin B	0.035	0.3685	1
Onchocerca volvulus		0.0187	0.0949	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0187	0.0949	0.334
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0187	0.0949	0.0949
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0187	0.0949	0.2574
Onchocerca volvulus		0.0187	0.0949	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0277	0.2451	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Onchocerca volvulus		0.0187	0.0949	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0277	0.2451	0.6465
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0277	0.2451	0.2451
Brugia malayi	Cathepsin L-like precursor	0.0187	0.0949	0.0949
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Echinococcus multilocularis	cathepsin b	0.0725	1	1
Loa Loa (eye worm)	cysteine protease	0.0187	0.0949	0.0949
Echinococcus multilocularis	cathepsin b	0.0725	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.0949	0.2574
Entamoeba histolytica	cysteine protease, putative	0.0187	0.0949	1
Toxoplasma gondii	cathepsin CPC1	0.0277	0.2451	0.6465
Onchocerca volvulus		0.0187	0.0949	1
Echinococcus granulosus	cathepsin b	0.0725	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Trypanosoma brucei	cysteine peptidase C (CPC)	0.035	0.3685	1
Loa Loa (eye worm)	cathepsin B	0.035	0.3685	0.3685
Trypanosoma cruzi	cysteine peptidase, putative	0.0326	0.3281	0.2576
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0187	0.0949	0.0949
Schistosoma mansoni	cathepsin F (C01 family)	0.0187	0.0949	0.0949
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.0949	0.2574
Loa Loa (eye worm)	hypothetical protein	0.0187	0.0949	0.0949
Leishmania major	cathepsin L-like protease	0.0326	0.3281	0.8522
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.0949	0.2574
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.0949	0.2574
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0195	0.1072	0.2908
Trypanosoma cruzi	cysteine peptidase, putative	0.0326	0.3281	0.2576
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.035	0.3685	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0187	0.0949	0.2574
Onchocerca volvulus	Cathepsin L homolog	0.0187	0.0949	1
Echinococcus granulosus	cathepsin l1	0.0187	0.0949	0.0949
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Onchocerca volvulus	Cathepsin F homolog	0.0187	0.0949	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0187	0.0949	0.2574
Schistosoma mansoni	cathepsin F (C01 family)	0.0187	0.0949	0.0949
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0187	0.0949	0.334
Brugia malayi	Cathepsin L-like precursor	0.0187	0.0949	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0725	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 871459