Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1048 | 0.1383 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0782 | 0.044 | 0.044 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1521 | 0.3061 | 0.3991 |
Loa Loa (eye worm) | hypothetical protein | 0.1048 | 0.1383 | 0.0986 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1048 | 0.1383 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.1048 | 0.1383 | 0.0986 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1048 | 0.1383 | 0.1383 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Plasmodium vivax | vivapain-2 | 0.1048 | 0.1383 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1048 | 0.1383 | 0.1383 |
Onchocerca volvulus | 0.1048 | 0.1383 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.2821 | 0.767 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0782 | 0.044 | 0.044 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1048 | 0.1383 | 0.1383 |
Leishmania major | cathepsin L-like protease | 0.1521 | 0.3061 | 0.2669 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1048 | 0.1383 | 0.0986 |
Echinococcus multilocularis | cathepsin b | 0.3478 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0782 | 0.044 | 0.044 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1521 | 0.3061 | 0.3991 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Loa Loa (eye worm) | hypothetical protein | 0.3478 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.1048 | 0.1383 | 1 |
Echinococcus granulosus | cathepsin b | 0.3478 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1521 | 0.3061 | 0.3991 |
Echinococcus granulosus | cathepsin l1 | 0.1048 | 0.1383 | 0.1383 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1521 | 0.3061 | 0.3991 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1048 | 0.1383 | 0.1383 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1048 | 0.1383 | 0.1383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0782 | 0.044 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1521 | 0.3061 | 0.3061 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1048 | 0.1383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Onchocerca volvulus | Cathepsin L homolog | 0.1048 | 0.1383 | 1 |
Onchocerca volvulus | 0.1048 | 0.1383 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0782 | 0.044 | 0.044 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2821 | 0.767 | 0.767 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.2821 | 0.767 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0782 | 0.044 | 0.044 |
Leishmania major | cathepsin L-like protease | 0.1521 | 0.3061 | 0.2669 |
Entamoeba histolytica | cysteine protease, putative | 0.1048 | 0.1383 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3478 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0865 | 0.0735 | 0.0735 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Onchocerca volvulus | Cathepsin L homolog | 0.1048 | 0.1383 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Loa Loa (eye worm) | fibroinase | 0.1048 | 0.1383 | 0.0986 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1048 | 0.1383 | 1 |
Onchocerca volvulus | 0.1048 | 0.1383 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0782 | 0.044 | 0.0574 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.2821 | 0.767 | 0.767 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1521 | 0.3061 | 0.3991 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0782 | 0.044 | 0.0574 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1521 | 0.3061 | 0.3991 |
Giardia lamblia | Cathepsin B precursor | 0.2821 | 0.767 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.1255 | 0.2118 | 0.2118 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Giardia lamblia | Cathepsin B precursor | 0.2821 | 0.767 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Onchocerca volvulus | 0.1048 | 0.1383 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1521 | 0.3061 | 0.3991 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1521 | 0.3061 | 0.3061 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1521 | 0.3061 | 0.3061 |
Brugia malayi | Cathepsin L-like precursor | 0.1048 | 0.1383 | 0.1383 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1048 | 0.1383 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1048 | 0.1383 | 0.1383 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1048 | 0.1383 | 0.1383 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1048 | 0.1383 | 0.1383 |
Onchocerca volvulus | 0.1048 | 0.1383 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1521 | 0.3061 | 0.3061 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3478 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.3478 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1048 | 0.1383 | 0.1383 |
Echinococcus multilocularis | cysteine protease | 0.1048 | 0.1383 | 0.1383 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.2821 | 0.767 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.2821 | 0.767 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1521 | 0.3061 | 0.3991 |
Onchocerca volvulus | 0.1048 | 0.1383 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1048 | 0.1383 | 0.1383 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3478 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Leishmania major | cathepsin L-like protease | 0.1521 | 0.3061 | 0.2669 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1048 | 0.1383 | 0.0986 |
Loa Loa (eye worm) | ctsf protein | 0.1048 | 0.1383 | 0.0986 |
Brugia malayi | cathepsin L-like precursor | 0.0782 | 0.044 | 0.044 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1521 | 0.3061 | 0.3991 |
Echinococcus granulosus | cathepsin b | 0.3478 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1048 | 0.1383 | 0.1383 |
Brugia malayi | Cathepsin L-like precursor | 0.1048 | 0.1383 | 0.1383 |
Toxoplasma gondii | cathepsin B | 0.2821 | 0.767 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1521 | 0.3061 | 0.3991 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1048 | 0.1383 | 0.1383 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1048 | 0.1383 | 0.1383 |
Echinococcus multilocularis | cathepsin b | 0.3478 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.1048 | 0.1383 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1048 | 0.1383 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1048 | 0.1383 | 0.1383 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3478 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1048 | 0.1383 | 0.1803 |
Loa Loa (eye worm) | cathepsin B | 0.2821 | 0.767 | 0.7563 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1521 | 0.3061 | 0.3991 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1048 | 0.1383 | 0.1383 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.