TDR Targets

Basic information

Technical information

TDR Targets ID: 883592
Name: ethyl 4-[(2-methyl-6-propan-2-ylphenyl)carbam oyl]piperazine-1-carboxylate
MW: 333.425 | Formula: C18H27N3O3
H donors: 1 H acceptors: 2 LogP: 2.64 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)N1CCN(CC1)C(=O)Nc1c(C)cccc1C(C)C
InChi: 1S/C18H27N3O3/c1-5-24-18(23)21-11-9-20(10-12-21)17(22)19-16-14(4)7-6-8-15(16)13(2)3/h6-8,13H,5,9-12H2,1-4H3,(H,19,22)
InChiKey: LWVOMDWQLATMNF-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

ethyl 4-[(2-isopropyl-6-methyl-phenyl)carbamoyl]piperazine-1-carboxylate
4-[[(2-isopropyl-6-methylphenyl)amino]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester
4-[(2-isopropyl-6-methyl-phenyl)carbamoyl]piperazine-1-carboxylic acid ethyl ester
ethyl 4-[(2-methyl-6-propan-2-yl-phenyl)carbamoyl]piperazine-1-carboxylate
Oprea1_272663

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Schistosoma mansoni	cathepsin B (C01 family)	0.0769	0.0087	0.0087
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1489	0.1345	0.4054
Entamoeba histolytica	cysteine proteinase 1, putative	0.1489	0.1345	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0769	0.0087	0.0087
Echinococcus granulosus	cathepsin L	0.1489	0.1345	0.1269
Entamoeba histolytica	cysteine proteinase, putative	0.2544	0.319	1
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2544	0.319	0.4831
Trypanosoma cruzi	cysteine peptidase, putative	0.1489	0.1345	0.1345
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0769	0.0087	0.0087
Onchocerca volvulus	Cathepsin F homolog	0.2544	0.319	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.2544	0.319	0.3131
Leishmania major	cathepsin L-like protease	0.5124	0.77	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2544	0.319	0.4831
Trypanosoma brucei	cysteine peptidase C (CPC)	0.4444	0.6511	0.8129
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0769	0.0087	0.0271
Echinococcus multilocularis	cathepsin b	0.6439	1	1
Plasmodium vivax	vivapain-2	0.2544	0.319	1
Plasmodium vivax	vivapain-2	0.2544	0.319	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0769	0.0087	0.0271
Echinococcus granulosus	cathepsin b	0.6439	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1489	0.1345	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.2544	0.319	0.3131
Giardia lamblia	Cathepsin B precursor	0.4444	0.6511	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.5124	0.77	1
Echinococcus multilocularis	cysteine protease	0.2544	0.319	0.3131
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0769	0.0087	0.0271
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2544	0.319	0.4831
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0769	0.0087	0.0271
Leishmania major	cathepsin L-like protease	0.5124	0.77	1
Leishmania major	cathepsin L-like protease	0.5124	0.77	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.5124	0.77	1
Echinococcus multilocularis	cathepsin L	0.1489	0.1345	0.1269
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Brugia malayi	Cathepsin L-like precursor	0.2544	0.319	0.319
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.6439	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.2544	0.319	0.319
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2544	0.319	0.4831
Schistosoma mansoni	cathepsin S (C01 family)	0.0769	0.0087	0.0087
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2544	0.319	0.4831
Echinococcus granulosus	cathepsin l cysteine peptidase	0.2544	0.319	0.3131
Brugia malayi	fibroinase precursor	0.0769	0.0087	0.0087
Plasmodium vivax	unspecified product	0.1489	0.1345	0.4215
Trypanosoma cruzi	major cysteine proteinase, putative	0.3349	0.4597	0.4597
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.5124	0.77	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.2544	0.319	0.319
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.4444	0.6511	0.7363
Trypanosoma cruzi	cysteine peptidase, putative	0.5124	0.77	0.77
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2544	0.319	0.3131
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.4404	0.6442	0.6442
Trypanosoma cruzi	cruzipain precursor, putative	0.5124	0.77	0.77
Trypanosoma cruzi	cysteine proteinase, putative	0.1489	0.1345	0.1345
Loa Loa (eye worm)	hypothetical protein	0.0769	0.0087	0.0087
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0769	0.0087	0.0271
Echinococcus granulosus	cathepsin l1	0.1825	0.1932	0.1861
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1489	0.1345	0.1345
Entamoeba histolytica	cysteine proteinase, putative	0.1489	0.1345	0.4054
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0769	0.0087	0.0271
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.5124	0.77	1
Onchocerca volvulus	Cathepsin L homolog	0.2544	0.319	1
Brugia malayi	Cathepsin L-like precursor	0.2544	0.319	0.319
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0769	0.0087	0.0087
Echinococcus multilocularis	cysteine protease	0.2544	0.319	0.3131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Plasmodium vivax	unspecified product	0.0769	0.0087	0.0271
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0769	0.0087	0.0087
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0769	0.0087	0.0087
Plasmodium vivax	serine-repeat antigen (SERA)	0.0769	0.0087	0.0271
Trypanosoma cruzi	cysteine peptidase, putative	0.5124	0.77	0.77
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0769	0.0087	0.0271
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1489	0.1345	0.1345
Loa Loa (eye worm)	hypothetical protein	0.0769	0.0087	0.0087
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0769	0.0087	0.0087
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4444	0.6511	0.6511
Onchocerca volvulus		0.2544	0.319	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0769	0.0087	0.0087
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0769	0.0087	0.0087
Giardia lamblia	Cathepsin B precursor	0.4444	0.6511	1
Schistosoma mansoni	cathepsin F (C01 family)	0.2544	0.319	0.319
Entamoeba histolytica	cysteine proteinase, putative	0.1825	0.1932	0.5946
Trypanosoma cruzi	cysteine proteinase, putative	0.1489	0.1345	0.1345
Toxoplasma gondii	cathepsin B	0.4444	0.6511	1
Onchocerca volvulus		0.2544	0.319	1
Trypanosoma cruzi	cysteine protease, putative	0.1489	0.1345	0.1345
Brugia malayi	cathepsin F-like cysteine proteinase	0.0769	0.0087	0.0087
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2544	0.319	0.4831
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0769	0.0087	0.0087
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.6439	1	1
Onchocerca volvulus		0.2544	0.319	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1825	0.1932	0.1932
Brugia malayi	Papain family cysteine protease containing protein	0.0769	0.0087	0.0087
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.2544	0.319	1
Brugia malayi	Papain family cysteine protease containing protein	0.0769	0.0087	0.0087
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.6439	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.5124	0.77	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1825	0.1932	0.2872
Entamoeba histolytica	cysteine proteinase, putative	0.1489	0.1345	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Loa Loa (eye worm)	cathepsin B	0.4444	0.6511	0.6511
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Brugia malayi	Cathepsin L-like precursor	0.2544	0.319	0.319
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0769	0.0087	0.0271
Onchocerca volvulus		0.2544	0.319	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0769	0.0087	0.0087
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.2544	0.319	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1825	0.1932	0.2872
Brugia malayi	Cathepsin L-like precursor	0.2544	0.319	0.319
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Loa Loa (eye worm)	fibroinase	0.2544	0.319	0.319
Loa Loa (eye worm)	hypothetical protein	0.0769	0.0087	0.0087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.5124	0.77	1
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Brugia malayi	Cathepsin L-like precursor	0.1825	0.1932	0.1932
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2544	0.319	0.4831
Loa Loa (eye worm)	hypothetical protein	0.6439	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.1489	0.1345	0.1269
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.4444	0.6511	0.6511
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Onchocerca volvulus		0.2544	0.319	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2544	0.319	0.4831
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0769	0.0087	0.0087
Brugia malayi	Cathepsin L-like precursor	0.1825	0.1932	0.1932
Brugia malayi	cathepsin L-like cysteine proteinase	0.0769	0.0087	0.0087
Loa Loa (eye worm)	hypothetical protein	0.1825	0.1932	0.1932
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0769	0.0087	0.0087
Entamoeba histolytica	cysteine proteinase, putative	0.1489	0.1345	0.4054
Toxoplasma gondii	cathepsin CPL	0.2544	0.319	0.4831
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1825	0.1932	0.1932
Loa Loa (eye worm)	hypothetical protein	0.1825	0.1932	0.1932
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0769	0.0087	0.0087
Onchocerca volvulus		0.2544	0.319	1
Loa Loa (eye worm)	ctsf protein	0.2544	0.319	0.319
Schistosoma mansoni	cathepsin F (C01 family)	0.2544	0.319	0.319
Loa Loa (eye worm)	hypothetical protein	0.0769	0.0087	0.0087
Brugia malayi	Papain family cysteine protease containing protein	0.1489	0.1345	0.1345
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1489	0.1345	0.1958
Onchocerca volvulus	Cathepsin L homolog	0.2544	0.319	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0769	0.0087	0.0271
Loa Loa (eye worm)	hypothetical protein	0.1825	0.1932	0.1932
Brugia malayi	Papain family cysteine protease containing protein	0.0769	0.0087	0.0087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.5124	0.77	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1489	0.1345	0.1345
Onchocerca volvulus		0.1825	0.1932	0.5946
Plasmodium vivax	vivapain-1	0.1489	0.1345	0.4215
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2544	0.319	0.4831
Brugia malayi	cathepsin L precursor	0.0769	0.0087	0.0087
Entamoeba histolytica	cysteine proteinase, putative	0.2544	0.319	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.4444	0.6511	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.5124	0.77	1
Plasmodium vivax	vivapain-3	0.1489	0.1345	0.4215
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2544	0.319	0.4831
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.5124	0.77	1
Schistosoma mansoni	cathepsin C	0.0769	0.0087	0.0087
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0769	0.0087	0.0087
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0769	0.0087	0.0087
Echinococcus multilocularis	cathepsin b	0.6439	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.6439	1	1
Onchocerca volvulus		0.2544	0.319	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2544	0.319	0.4831
Brugia malayi	Papain family cysteine protease containing protein	0.2544	0.319	0.319
Echinococcus granulosus	cathepsin l1	0.2544	0.319	0.3131
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Trypanosoma cruzi	major cysteine proteinase, putative	0.0769	0.0087	0.0087
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.5124	0.77	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0769	0.0087	0.0271
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1489	0.1345	0.1345
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0769	0.0087	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0769	0.0087	0.0087
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2544	0.319	0.4831
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0769	0.0087	0.0087
Echinococcus granulosus	cathepsin b	0.6439	1	1
Loa Loa (eye worm)	hypothetical protein	0.2544	0.319	0.319
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Entamoeba histolytica	cysteine protease, putative	0.2544	0.319	1
Echinococcus granulosus	cysteine protease	0.1489	0.1345	0.1269
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.6439	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1489	0.1345	0.1958
Brugia malayi	Papain family cysteine protease containing protein	0.1489	0.1345	0.1345
Trypanosoma cruzi	cysteine peptidase, putative	0.2544	0.319	0.319
Trypanosoma cruzi	cysteine peptidase, putative	0.5124	0.77	0.77
Giardia lamblia	Cathepsin B precursor	0.4444	0.6511	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.2544	0.319	0.3131
Brugia malayi	cathepsin L-like precursor	0.1825	0.1932	0.1932
Entamoeba histolytica	cysteine proteinase 2	0.1489	0.1345	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 3	0.2544	0.319	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2544	0.319	0.3131
Brugia malayi	Cathepsin L-like precursor	0.2544	0.319	0.319
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Entamoeba histolytica	cysteine protease, putative	0.1489	0.1345	0.4054
Loa Loa (eye worm)	cysteine protease	0.2544	0.319	0.319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.5124	0.77	1
Brugia malayi	Cathepsin L-like precursor	0.2544	0.319	0.319

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 883592