TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 374.404 | Formula: C19H16F2N2O2S
H donors: 1 H acceptors: 3 LogP: 3.42 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OCCN(C(=O)c1csc(n1)c1ccc(cc1F)F)Cc1ccccc1
InChi: 1S/C19H16F2N2O2S/c20-14-6-7-15(16(21)10-14)18-22-17(12-26-18)19(25)23(8-9-24)11-13-4-2-1-3-5-13/h1-7,10,12,24H,8-9,11H2
InChiKey: DQRFUMUWRCVPKI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0064	0.0992	0.1409
Brugia malayi	orphan nuclear receptor NR2E1	0.003	0.026	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0163	0.0162
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0064	0.0992	0.1409
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0075	0.1245	0.1768
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0992	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0023	0.0022
Entamoeba histolytica	hypothetical protein	0.0075	0.1245	1
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1004	0.1426
Brugia malayi	hypothetical protein	0.003	0.026	0.0259
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0163	0.1407
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0163	0.5
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.1156	1
Echinococcus multilocularis	Protein lozenge	0.006	0.0911	0.1294
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0064	0.0992	0.1409
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0064	0.0992	0.0991
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0338	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2778	0.2778
Brugia malayi	tailless protein	0.003	0.026	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0023	0.0022
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0603	0.0856
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Schistosoma mansoni	nuclear receptor	0.003	0.026	0.0369
Schistosoma mansoni	nuclear receptor	0.003	0.026	0.0369
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0064	0.0992	0.0991
Schistosoma mansoni	retinoic acid receptor RXR	0.0064	0.0992	0.1409
Echinococcus granulosus	Nuclear hormone receptor HR96	0.003	0.026	0.0369
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.003	0.026	0.0369
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0064	0.0988	0.1404
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.003	0.026	0.0369
Schistosoma mansoni	transcription factor LCR-F1	0.0075	0.1245	0.1768
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.1004	0.1003
Brugia malayi	ecdysone receptor	0.003	0.026	0.0259
Brugia malayi	Muscleblind-like protein	0.0146	0.2778	0.2778
Brugia malayi	hypothetical protein	0.0034	0.0338	0.0338
Schistosoma mansoni	hypothetical protein	0.0342	0.7034	1
Onchocerca volvulus	Bile acid receptor homolog	0.0064	0.0992	0.0842
Brugia malayi	photoreceptor-specific nuclear receptor	0.0064	0.0992	0.0991
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0226	0.4526	0.6434
Brugia malayi	Nuclear hormone receptor-like 1	0.0064	0.0992	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0988	0.0987
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0064	0.0992	0.1409
Brugia malayi	nuclear hormone receptor	0.0064	0.0992	0.0991
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.003	0.026	0.0259
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0064	0.0992	0.1409
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0071	0.1156	0.1642
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0023	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0064	0.0992	0.0991
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0064	0.0992	0.1409
Echinococcus granulosus	hormone sensitive lipase	0.0226	0.4526	0.6434
Brugia malayi	Nuclear hormone receptor-like 1	0.0034	0.0338	0.0338
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.1004	0.1003
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0163	0.5
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.003	0.026	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0992	0.0991
Onchocerca volvulus		0.0064	0.0992	0.0842
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0226	0.4526	0.6434
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0064	0.0992	0.1409
Schistosoma mansoni	thyroid hormone receptor	0.0064	0.0992	0.1409
Brugia malayi	Steroid receptor seven-up type 2	0.0064	0.0992	0.0991
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0064	0.0992	0.0991
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0163	1
Onchocerca volvulus		0.003	0.026	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0226	0.4526	0.4525
Schistosoma mansoni	hypothetical protein	0.0064	0.0988	0.1404
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0064	0.0988	0.0987
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0064	0.0992	0.0842
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0064	0.0992	0.0991
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0034	0.0338	0.048
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0025	0.0148	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0992	0.0991
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0064	0.0992	0.0991
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0064	0.0992	0.1409
Brugia malayi	nuclear receptor NHR-88	0.003	0.026	0.0259
Brugia malayi	latrophilin 2 splice variant baaae	0.0137	0.259	0.259
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.1004	0.1003
Brugia malayi	RNA binding protein	0.0064	0.1004	0.1003
Schistosoma mansoni	nuclear hormone receptor	0.0064	0.0992	0.1409
Onchocerca volvulus	Protein ultraspiracle homolog	0.0064	0.0992	0.0842
Brugia malayi	conserved hypotetical protein	0.003	0.026	0.0259
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0163	0.1407
Echinococcus granulosus	geminin	0.0342	0.7034	1
Echinococcus multilocularis	FTZ F1 alpha	0.0064	0.0992	0.1409
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0163	0.1306
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0064	0.0992	0.1409
Echinococcus multilocularis	GPCR, family 2	0.0064	0.0988	0.1404
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.003	0.026	0.0369
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0025	0.0148	0.1273
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0018	0.0002	0.0007
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0034	0.0338	0.0338
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0163	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0064	0.0992	0.0991
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Loa Loa (eye worm)	RNA binding protein	0.0064	0.1004	0.1003
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0201	0.3971	0.3971
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0064	0.0992	0.1409
Schistosoma mansoni	hypothetical protein	0.0137	0.259	0.3682
Loa Loa (eye worm)	hypothetical protein	0.0137	0.259	0.259
Brugia malayi	steroid hormone receptor	0.0064	0.0992	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0992	0.0991
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0163	1
Loa Loa (eye worm)	steroid hormone receptor	0.0064	0.0992	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2778	0.2778
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0163	0.0162
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0163	0.1407
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0064	0.0992	0.1409
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1004	0.1426
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0071	0.1156	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0603	0.0856
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0023	0.139
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1004	0.1426
Giardia lamblia	GTOR	0.0018	0.0001	0.5
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0071	0.1156	0.1642
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0603	0.0602
Onchocerca volvulus		0.0479	1	1
Onchocerca volvulus		0.003	0.026	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0992	0.0991
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0163	1
Brugia malayi	hypothetical protein	0.0034	0.0338	0.0338
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0064	0.0992	0.0991
Echinococcus multilocularis	hormone sensitive lipase	0.0226	0.4526	0.6434
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0064	0.0992	0.1409
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0603	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0338	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0479	1	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0603	0.0602
Loa Loa (eye worm)	DR-78	0.003	0.026	0.0259
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0163	0.0162
Brugia malayi	hypothetical protein	0.0075	0.1245	0.1244
Brugia malayi	hypothetical protein	0.003	0.026	0.0259
Schistosoma mansoni	hypothetical protein	0.0064	0.0988	0.1404
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0992	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0992	0.0991
Echinococcus granulosus	muscleblind protein	0.0146	0.2778	0.3949
Entamoeba histolytica	hypothetical protein	0.0075	0.1245	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.003	0.026	0.0369
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0064	0.0988	0.1404
Brugia malayi	TAR-binding protein	0.0064	0.1004	0.1003
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0064	0.0992	0.1409
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0603	0.0856
Echinococcus granulosus	Nuclear hormone receptor HR96	0.003	0.026	0.0369
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0064	0.0988	0.1404
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0071	0.1156	0.1155
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0201	0.3971	0.3971
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.003	0.026	0.0369
Schistosoma mansoni	coup transcription factor	0.0064	0.0992	0.1409
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0163	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0163	0.0162
Brugia malayi	nuclear receptor NHR-67	0.003	0.026	0.0259
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0163	1
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.1004	0.1426
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0603	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0023	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0338	0.0338
Echinococcus granulosus	GPCR family 2	0.0064	0.0988	0.1404
Brugia malayi	nuclear receptor RXR	0.0034	0.0338	0.0338
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0064	0.0992	0.1409
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0064	0.0992	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0338	0.0338
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0064	0.0992	0.0991
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.003	0.026	0.0369
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0075	0.1245	0.1768
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Brugia malayi	Latrophilin receptor protein 2	0.0064	0.0988	0.0987
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0992	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0338	0.0338
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0018	0.0002	0.0007
Schistosoma mansoni	hypothetical protein	0.0342	0.7034	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0064	0.0992	0.1409
Schistosoma mansoni	lozenge	0.006	0.0911	0.1294
Schistosoma mansoni	nuclear hormone receptor	0.003	0.026	0.0369
Echinococcus granulosus	tar DNA binding protein	0.0064	0.1004	0.1426
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0163	0.0162
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0603	0.0856
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0071	0.1156	0.9287
Brugia malayi	Nuclear hormone receptor E75	0.003	0.026	0.0259
Echinococcus multilocularis	nuclear receptor nhr 48	0.003	0.026	0.0369
Loa Loa (eye worm)	runx1	0.006	0.0911	0.091
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0034	0.0338	0.048
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0064	0.0992	0.0991
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0148	0.0147
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0064	0.0992	0.0991
Entamoeba histolytica	hypothetical protein	0.0075	0.1245	1
Toxoplasma gondii	FATC domain-containing protein	0.0025	0.0148	1
Entamoeba histolytica	hypothetical protein	0.0075	0.1245	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0064	0.0992	0.0991
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0064	0.0992	0.0991
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0064	0.0992	0.0991
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0163	0.1306
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0064	0.0992	0.1409
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0201	0.3971	0.3971
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0163	1
Brugia malayi	Nuclear hormone receptor E75	0.003	0.026	0.0259
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0023	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Schistosoma mansoni	nuclear receptor nhr-48	0.003	0.026	0.0369
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0148	1
Schistosoma mansoni	hypothetical protein	0.0075	0.1245	0.1768
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0226	0.4526	0.6434
Echinococcus multilocularis	muscleblind protein	0.0146	0.2778	0.3949
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0064	0.0992	0.0991
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0163	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0021	0.0072	0.0618
Schistosoma mansoni	nuclear hormone receptor	0.003	0.026	0.0369
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.003	0.026	0.0259
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0603	0.0856
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.1156	1
Loa Loa (eye worm)	nuclear hormone receptor	0.003	0.026	0.0259
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0163	0.0162
Echinococcus multilocularis	serine protein kinase ATM	0.0025	0.0148	0.0209
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0064	0.0992	0.0991
Entamoeba histolytica	hypothetical protein	0.0025	0.0148	0.1183
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0064	0.0988	0.0987
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0064	0.0992	0.1409
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0338	0.0338
Brugia malayi	ecdysteroid receptor	0.0064	0.0992	0.0991
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0023	0.0022
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.003	0.026	0.0098
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0034	0.0338	0.048
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0163	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0163	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0201	0.3971	0.3971
Echinococcus granulosus	nuclear receptor nhr 48	0.003	0.026	0.0369
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0064	0.0992	0.0991
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0034	0.0338	0.048
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0064	0.0992	0.1409
Echinococcus multilocularis	ecdysone induced protein 78C	0.0064	0.0992	0.1409
Schistosoma mansoni	thyroid hormone receptor	0.0064	0.0992	0.1409
Echinococcus granulosus	serine protein kinase ATM	0.0025	0.0148	0.0209
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0064	0.0992	0.0991
Brugia malayi	nuclear hormone receptor family member odr-7	0.003	0.026	0.0259
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.0504	0.0715
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.026	0.0369
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0064	0.0992	0.1409
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0071	0.1156	0.1155
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0064	0.0992	0.1409
Echinococcus multilocularis	geminin	0.0342	0.7034	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.026	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0479	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0064	0.0992	0.1409
Schistosoma mansoni	hypothetical protein	0.0064	0.0988	0.1404
Echinococcus granulosus	FTZ F1 alpha	0.0064	0.0992	0.1409
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.0504	0.0715
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.2778	0.3949
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0023	0.0022
Loa Loa (eye worm)	nuclear receptor NHR-67	0.003	0.026	0.0259
Echinococcus granulosus	ecdysone induced protein 78C	0.0064	0.0992	0.1409
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0025	0.0148	0.1273
Brugia malayi	nuclear receptor RXR	0.003	0.026	0.0259
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0064	0.0992	0.0991
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.1156	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0023	0.5
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0071	0.1156	0.1642
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.026	0.0369
Echinococcus granulosus	thyroid hormone receptor alpha	0.003	0.026	0.0369
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.003	0.026	0.0369
Brugia malayi	nuclear hormone receptor	0.003	0.026	0.0259
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1004	0.1426
Schistosoma mansoni	hypothetical protein	0.0064	0.0988	0.1404
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0064	0.0992	0.0991
Brugia malayi	nuclear receptor NHR-88	0.0064	0.0992	0.0991
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1004	0.1426
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0163	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0072	0.0071
Schistosoma mansoni	zinc finger protein	0.003	0.026	0.0369
Brugia malayi	nuclear hormone receptor family member nhr-6	0.003	0.026	0.0259
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0064	0.0988	0.1404

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 883818