Detailed information for compound 885036

Basic information

Technical information
  • TDR Targets ID: 885036
  • Name: 1-[2-(1-phenylcyclopropanecarbonyl)pyrazolidi n-1-yl]pent-4-yn-1-one
  • MW: 296.364 | Formula: C18H20N2O2
  • H donors: 0 H acceptors: 2 LogP: 2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CCCC(=O)N1CCCN1C(=O)C1(CC1)c1ccccc1
  • InChi: 1S/C18H20N2O2/c1-2-3-10-16(21)19-13-7-14-20(19)17(22)18(11-12-18)15-8-5-4-6-9-15/h1,4-6,8-9H,3,7,10-14H2
  • InChiKey: SJBMCFSBMNBMKA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-[oxo-(1-phenylcyclopropyl)methyl]-1-pyrazolidinyl]pent-4-yn-1-one
  • 1-[2-(1-phenylcyclopropyl)carbonylpyrazolidin-1-yl]pent-4-yn-1-one
  • Oprea1_743884

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0129 0.1061 0.091
Schistosoma mansoni neuropeptide F-like receptor 0.0129 0.1061 0.091
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0129 0.1061 0.091
Loa Loa (eye worm) hypothetical protein 0.0071 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0129 0.1061 0.091
Echinococcus multilocularis neuropeptide Y receptor 0.0129 0.1061 0.1
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.1061 0.1
Echinococcus granulosus somatostatin receptor 0.0129 0.1061 0.1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0129 0.1061 0.0921
Schistosoma mansoni ceramide glucosyltransferase 0.0931 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.1061 0.1
Echinococcus granulosus g protein coupled receptor 0.0129 0.1061 0.1
Brugia malayi G protein-coupled receptor 0.0129 0.1061 0.0921
Loa Loa (eye worm) CYP4Cod1 0.0048 0.0154 0.0154
Schistosoma mansoni growth hormone secretagogue receptor 0.0129 0.1061 0.091
Echinococcus granulosus ceramide glucosyltransferase 0.0931 1 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0129 0.1061 0.091
Echinococcus multilocularis neuropeptide receptor A26 0.0129 0.1061 0.1
Echinococcus granulosus orexin receptor type 2 0.0129 0.1061 0.1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0058 0.0269 0.0204
Echinococcus multilocularis g protein coupled receptor 0.0129 0.1061 0.1
Echinococcus multilocularis nmda type glutamate receptor 0.0065 0.034 0.0275
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0129 0.1061 0.1
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Schistosoma mansoni hypothetical protein 0.0129 0.1061 0.091
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0058 0.0269 0.0204
Brugia malayi G-protein coupled receptor 0.0129 0.1061 0.0921
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.1061 0.1
Echinococcus granulosus tm gpcr rhodopsin 0.0129 0.1061 0.1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0129 0.1061 0.1
Echinococcus granulosus neuropeptide Y receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0082 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus multilocularis somatostatin receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) neuropeptide F receptor 0.0129 0.1061 0.1061
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0058 0.0269 0.0204
Brugia malayi Dopamine receptor protein 2 0.0129 0.1061 0.0921
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus granulosus tachykinin peptides receptor 99D 0.0129 0.1061 0.1
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0166 0.0099
Brugia malayi follicle stimulating hormone receptor 0.0129 0.1061 0.0921
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0471 0.5
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus granulosus 7tm_1 domain containing protein 0.0129 0.1061 0.1
Schistosoma mansoni integrin beta subunit 0.0205 0.191 0.1774
Schistosoma mansoni histamine h1 receptor 0.0129 0.1061 0.091
Echinococcus multilocularis sex peptide receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0058 0.0269 0.0204
Echinococcus granulosus g protein coupled receptor 0.0129 0.1061 0.1
Brugia malayi G-protein coupled receptor 0.0129 0.1061 0.0921
Brugia malayi ORL1-like opioid receptor 0.0129 0.1061 0.0921
Schistosoma mansoni neuropeptide receptor 0.0129 0.1061 0.091
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0129 0.1061 0.1
Brugia malayi hypothetical protein 0.0129 0.1061 0.0921
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.1061 0.091
Echinococcus granulosus glutamate NMDA receptor subunit 0.0049 0.0166 0.0099
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0047 0.0137 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0065 0.034 0.0275
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0082 0.0531 0.0467
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus multilocularis serotonin receptor 0.0129 0.1061 0.1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0129 0.1061 0.091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.1061 0.1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0047 0.0137 0.5
Schistosoma mansoni glutamate receptor NMDA 0.0058 0.0269 0.0105
Schistosoma mansoni biogenic amine receptor 0.0129 0.1061 0.091
Brugia malayi neuropeptide F receptor 0.0129 0.1061 0.0921
Schistosoma mansoni hypothetical protein 0.0129 0.1061 0.091
Schistosoma mansoni biogenic amine (5HT) receptor 0.0129 0.1061 0.091
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Brugia malayi hypothetical protein 0.0129 0.1061 0.0921
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0129 0.1061 0.091
Brugia malayi sulfakinin receptor protein 0.0129 0.1061 0.0921
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0129 0.1061 0.1
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0047 0.0137 0.5
Echinococcus granulosus hypothetical protein 0.0129 0.1061 0.1
Schistosoma mansoni opsin-like receptor 0.0129 0.1061 0.091
Echinococcus granulosus alpha 1A adrenergic receptor 0.0129 0.1061 0.1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0129 0.1061 0.091
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.1061 0.1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0082 0.0531 0.0467
Schistosoma mansoni hypothetical protein 0.0129 0.1061 0.091
Echinococcus multilocularis glutamate receptor 2 0.0058 0.0269 0.0204
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.1061 0.1
Brugia malayi putative neuropeptide receptor NPR1 0.0129 0.1061 0.0921
Echinococcus multilocularis G protein coupled receptor 139 0.0129 0.1061 0.1
Brugia malayi hypothetical protein 0.0129 0.1061 0.0921
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Loa Loa (eye worm) TYRA-2 protein 0.0129 0.1061 0.1061
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0129 0.1061 0.1
Brugia malayi hypothetical protein 0.0129 0.1061 0.0921
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.1061 0.091
Echinococcus granulosus neuropeptide receptor A26 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus multilocularis G-protein coupled receptor, putative 0.0129 0.1061 0.1
Loa Loa (eye worm) G-protein coupled receptor 0.0129 0.1061 0.1061
Brugia malayi Melatonin receptor type 1A 0.0129 0.1061 0.0921
Brugia malayi hypothetical protein 0.0056 0.0244 0.0092
Loa Loa (eye worm) glutamate receptor 2 0.0049 0.0166 0.0166
Schistosoma mansoni hypothetical protein 0.0129 0.1061 0.091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.1061 0.091
Echinococcus multilocularis ceramide glucosyltransferase 0.0931 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0129 0.1061 0.1
Echinococcus granulosus biogenic amine 5HT receptor 0.0129 0.1061 0.1
Echinococcus granulosus neuropeptides capa receptor 0.0129 0.1061 0.1
Schistosoma mansoni voltage-gated potassium channel 0.0089 0.0615 0.0457
Schistosoma mansoni neuropeptide receptor 0.0129 0.1061 0.091
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0129 0.1061 0.0921
Brugia malayi larval opioid receptor 0.0129 0.1061 0.0921
Echinococcus granulosus tm gpcr rhodopsin 0.0129 0.1061 0.1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0048 0.0154 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.1061 0.091
Brugia malayi hypothetical protein 0.0129 0.1061 0.0921
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0058 0.0269 0.0204
Echinococcus multilocularis neuropeptides capa receptor 0.0129 0.1061 0.1
Echinococcus granulosus nmda type glutamate receptor 0.0065 0.034 0.0275
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0129 0.1061 0.1
Loa Loa (eye worm) G-protein coupled receptor 0.0129 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Brugia malayi hypothetical protein 0.0129 0.1061 0.0921
Echinococcus multilocularis neuropeptide s receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus multilocularis g-protein coupled receptor 0.0129 0.1061 0.1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0129 0.1061 0.1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0129 0.1061 0.091
Echinococcus granulosus glutamate receptor 2 0.0058 0.0269 0.0204
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.1061 0.091
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.1061 0.1
Loa Loa (eye worm) melatonin receptor type 1A 0.0129 0.1061 0.1061
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0129 0.1061 0.1
Schistosoma mansoni biogenic amine receptor 0.0129 0.1061 0.091
Echinococcus granulosus tm gpcr rhodopsin 0.0129 0.1061 0.1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0058 0.0269 0.0204
Loa Loa (eye worm) glutamate receptor 1 0.0049 0.0166 0.0166
Schistosoma mansoni neuropeptide receptor 0.0129 0.1061 0.091
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Loa Loa (eye worm) ceramide glucosyltransferase 0.0931 1 1
Brugia malayi hypothetical protein 0.0129 0.1061 0.0921
Brugia malayi Serotonin receptor 0.0129 0.1061 0.0921
Schistosoma mansoni myosin xvIII 0.0129 0.1061 0.091
Schistosoma mansoni biogenic amine (5HT) receptor 0.0129 0.1061 0.091
Echinococcus granulosus neuropeptides capa receptor 0.0129 0.1061 0.1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.1061 0.1
Echinococcus multilocularis integrin beta 2 0.0262 0.2535 0.2485
Brugia malayi Serotonin receptor 0.0129 0.1061 0.0921
Echinococcus granulosus allatostatin A receptor 0.0129 0.1061 0.1
Schistosoma mansoni ceramide glucosyltransferase 0.0931 1 1
Brugia malayi AKH receptor 0.0129 0.1061 0.0921
Brugia malayi GnHR receptor homolog 0.0129 0.1061 0.0921
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0129 0.1061 0.091
Echinococcus granulosus g-protein coupled receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) neuropeptide F receptor 0.0129 0.1061 0.1061
Schistosoma mansoni amine GPCR 0.0129 0.1061 0.091
Echinococcus multilocularis g protein coupled receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.1061 0.1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0129 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Brugia malayi Tachykinin-like peptides receptor 99D 0.0129 0.1061 0.0921
Schistosoma mansoni amine GPCR 0.0129 0.1061 0.091
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0129 0.1061 0.1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0129 0.1061 0.1
Echinococcus multilocularis fmrfamide receptor 0.0129 0.1061 0.1
Echinococcus granulosus fmrfamide receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Schistosoma mansoni neuropeptide receptor 0.0129 0.1061 0.091
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0931 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0082 0.0531 0.0383
Echinococcus multilocularis neuropeptide receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0154 0.0154
Echinococcus multilocularis neuropeptides capa receptor 0.0129 0.1061 0.1
Brugia malayi G protein-coupled receptor F59B2.13 0.0129 0.1061 0.0921
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0076 0.0471 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0089 0.0615 0.0457
Schistosoma mansoni alpha-1 adrenergic receptor 0.0129 0.1061 0.091
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0056 0.0244 0.0244
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.1061 0.1
Brugia malayi hypothetical protein 0.0129 0.1061 0.0921
Echinococcus granulosus neuropeptide Y receptor 0.0129 0.1061 0.1
Schistosoma mansoni neuropeptide F-like receptor 0.0129 0.1061 0.091
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0154 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0129 0.1061 0.1
Schistosoma mansoni opsin-like receptor 0.0129 0.1061 0.091
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0129 0.1061 0.091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.1061 0.091
Echinococcus multilocularis allatostatin A receptor 0.0129 0.1061 0.1
Echinococcus granulosus biogenic amine 5HT receptor 0.0129 0.1061 0.1
Schistosoma mansoni opsin-like receptor 0.0129 0.1061 0.091
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0129 0.1061 0.1061
Brugia malayi Integrin beta pat-3 precursor 0.0357 0.3602 0.3502
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0129 0.1061 0.1061
Schistosoma mansoni biogenic amine receptor 0.0129 0.1061 0.091
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Schistosoma mansoni amine GPCR 0.0129 0.1061 0.091
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0129 0.1061 0.0921
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus granulosus integrin beta 2 0.0262 0.2535 0.2485
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0129 0.1061 0.091
Echinococcus multilocularis dro:myosuppressin receptor 0.0129 0.1061 0.1
Schistosoma mansoni adenoreceptor 0.0129 0.1061 0.091
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0129 0.1061 0.0921
Echinococcus multilocularis serotonin receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) integrin beta-2 0.0357 0.3602 0.3602
Echinococcus multilocularis g protein coupled receptor 0.0129 0.1061 0.1
Echinococcus multilocularis neuropeptide Y receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Schistosoma mansoni neuropeptide f receptor 76f 0.0129 0.1061 0.091
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0058 0.0269 0.0204
Echinococcus granulosus neuropeptide receptor 0.0129 0.1061 0.1
Leishmania major cytochrome p450-like protein 0.0048 0.0154 0.5
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus multilocularis fmrfamide receptor 0.0129 0.1061 0.1
Echinococcus granulosus serotonin receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus granulosus rhodopsin orphan GPCR 0.0129 0.1061 0.1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0049 0.0166 0.0099
Brugia malayi neuropeptide F receptor 0.0129 0.1061 0.0921
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.1061 0.1
Brugia malayi hypothetical protein 0.0129 0.1061 0.0921
Echinococcus granulosus neuropeptide receptor 0.0129 0.1061 0.1
Brugia malayi Glutamate receptor 2 precursor 0.0049 0.0166 0.0012
Echinococcus granulosus g protein coupled receptor 0.0129 0.1061 0.1
Echinococcus multilocularis neuropeptide receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0129 0.1061 0.1061
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0154 0.5
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Brugia malayi RE15519p 0.0129 0.1061 0.0921
Giardia lamblia Ceramide glucosyltransferase 0.0422 0.4325 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0129 0.1061 0.1
Trypanosoma brucei cytochrome P450, putative 0.0048 0.0154 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0129 0.1061 0.1
Brugia malayi Dopamine receptor protein 1 0.0129 0.1061 0.0921
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus granulosus neuropeptide FF receptor 2 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0129 0.1061 0.1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0129 0.1061 0.1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus granulosus dro:myosuppressin receptor 0.0129 0.1061 0.1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0129 0.1061 0.1061
Brugia malayi Kelch motif family protein 0.0056 0.0244 0.0092
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0129 0.1061 0.1
Echinococcus granulosus neuropeptide s receptor 0.0129 0.1061 0.1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.1061 0.091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.1061 0.091
Echinococcus multilocularis orexin receptor type 2 0.0129 0.1061 0.1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0056 0.0244 0.0244
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0129 0.1061 0.1
Echinococcus granulosus sex peptide receptor 0.0129 0.1061 0.1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0129 0.1061 0.091
Schistosoma mansoni amine GPCR 0.0129 0.1061 0.091
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0129 0.1061 0.1
Schistosoma mansoni amine GPCR 0.0129 0.1061 0.091
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Brugia malayi Dopamine receptor 0.0129 0.1061 0.0921
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Brugia malayi putative neuropeptide receptor 0.0129 0.1061 0.0921
Loa Loa (eye worm) hypothetical protein 0.0129 0.1061 0.1061
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0058 0.0269 0.0204
Chlamydia trachomatis glutamine binding protein 0.0047 0.0137 0.5
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0129 0.1061 0.1
Brugia malayi Glutamate receptor 1 precursor 0.0049 0.0166 0.0012
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0129 0.1061 0.091
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0129 0.1061 0.0921
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0047 0.0137 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0129 0.1061 0.1
Brugia malayi hypothetical protein 0.0129 0.1061 0.0921
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0129 0.1061 0.091

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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