Detailed information for compound 886565

Basic information

Technical information
  • TDR Targets ID: 886565
  • Name: 4-chloro-N-[3-[1-cyano-2-(2-methoxyethylamino )-2-oxoethylidene]isoindol-1-yl]benzamide
  • MW: 408.838 | Formula: C21H17ClN4O3
  • H donors: 2 H acceptors: 3 LogP: 2.25 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCNC(=O)/C(=C\1/N=C(c2c1cccc2)NC(=O)c1ccc(cc1)Cl)/C#N
  • InChi: 1S/C21H17ClN4O3/c1-29-11-10-24-21(28)17(12-23)18-15-4-2-3-5-16(15)19(25-18)26-20(27)13-6-8-14(22)9-7-13/h2-9H,10-11H2,1H3,(H,24,28)(H,25,26,27)/b18-17-
  • InChiKey: NHDRQWGCLXRHOT-ZCXUNETKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-N-[(3Z)-3-[1-cyano-2-(2-methoxyethylamino)-2-oxoethylidene]isoindol-1-yl]benzamide
  • 4-chloro-N-[3-[1-cyano-2-(2-methoxyethylamino)-2-oxo-ethylidene]isoindol-1-yl]benzamide
  • 4-chloro-N-[(3Z)-3-[1-cyano-2-(2-methoxyethylamino)-2-oxo-ethylidene]isoindol-1-yl]benzamide
  • 4-chloro-N-[(3Z)-3-[1-cyano-2-(2-methoxyethylamino)-2-oxoethylidene]-1-isoindolyl]benzamide
  • 4-chloro-N-[3-[1-cyano-2-(2-methoxyethylamino)-2-oxoethylidene]-1-isoindolyl]benzamide
  • 4-chloro-N-[(3Z)-3-[1-cyano-2-keto-2-(2-methoxyethylamino)ethylidene]isoindol-1-yl]benzamide
  • 4-chloro-N-[3-[1-cyano-2-keto-2-(2-methoxyethylamino)ethylidene]isoindol-1-yl]benzamide
  • ZINC05323985

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus allatostatin A receptor 0.0148 0.2501 0.4329
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0154 0.2683 0.529
Brugia malayi hypothetical protein 0.0148 0.2501 0.4932
Schistosoma mansoni biogenic amine receptor 0.0148 0.2501 0.4932
Schistosoma mansoni amine GPCR 0.0148 0.2501 0.4932
Echinococcus granulosus neuropeptide FF receptor 2 0.0148 0.2501 0.4329
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0081 0.0442 0.0871
Schistosoma mansoni amine GPCR 0.0148 0.2501 0.4932
Echinococcus multilocularis neuropeptide receptor 0.0148 0.2501 0.4329
Onchocerca volvulus 0.0148 0.2501 0.4932
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.2501 0.4932
Echinococcus multilocularis orexin receptor type 2 0.0148 0.2501 0.4329
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Schistosoma mansoni neuropeptide receptor 0.0148 0.2501 0.4932
Mycobacterium ulcerans hydrolase 0.0081 0.0442 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.2501 0.4932
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0118 0.1564 0.246
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0148 0.2501 0.4932
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0087 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0148 0.2501 0.4932
Brugia malayi Dopamine receptor 0.0148 0.2501 0.4932
Schistosoma mansoni alpha-1 adrenergic receptor 0.0148 0.2501 0.4932
Schistosoma mansoni neuropeptide f receptor 76f 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus granulosus 7TM GPCR rhodopsin 0.0148 0.2501 0.4329
Echinococcus multilocularis neuropeptides capa receptor 0.0148 0.2501 0.4329
Schistosoma mansoni amine GPCR 0.0148 0.2501 0.4932
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0188 0.3696 0.7289
Giardia lamblia Ceramide glucosyltransferase 0.0105 0.1191 0.5
Brugia malayi follicle stimulating hormone receptor 0.0148 0.2501 0.4932
Brugia malayi Tachykinin-like peptides receptor 99D 0.0148 0.2501 0.4932
Schistosoma mansoni adenoreceptor 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Brugia malayi G-protein coupled receptor 0.0148 0.2501 0.4932
Echinococcus granulosus g protein coupled receptor 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus multilocularis g protein coupled receptor 0.0148 0.2501 0.4329
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0148 0.2501 0.4329
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.2501 0.4932
Onchocerca volvulus 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Schistosoma mansoni amine GPCR 0.0148 0.2501 0.4932
Brugia malayi hypothetical protein 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus granulosus sex peptide receptor 0.0148 0.2501 0.4329
Brugia malayi AKH receptor 0.0148 0.2501 0.4932
Brugia malayi larval opioid receptor 0.0148 0.2501 0.4932
Echinococcus granulosus fmrfamide receptor 0.0148 0.2501 0.4329
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0148 0.2501 0.2501
Echinococcus multilocularis serotonin receptor 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0148 0.2501 0.4932
Onchocerca volvulus Neuropeptide F receptor homolog 0.0148 0.2501 0.4932
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Echinococcus granulosus neuropeptides capa receptor 0.0148 0.2501 0.4329
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0242 0.5343 1
Echinococcus granulosus G protein coupled receptor 139 0.0148 0.2501 0.4329
Echinococcus multilocularis g protein coupled receptor 0.0148 0.2501 0.4329
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0089 0.0676 0.0687
Schistosoma mansoni neuropeptide F-like receptor 0.0148 0.2501 0.4932
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Brugia malayi neuropeptide F receptor 0.0148 0.2501 0.4932
Brugia malayi G protein-coupled receptor F59B2.13 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Onchocerca volvulus 0.0148 0.2501 0.4932
Schistosoma mansoni ceramide glucosyltransferase 0.0233 0.5071 1
Echinococcus multilocularis fmrfamide receptor 0.0148 0.2501 0.4329
Echinococcus granulosus tachykinin peptides receptor 99D 0.0148 0.2501 0.4329
Schistosoma mansoni growth hormone secretagogue receptor 0.0148 0.2501 0.4932
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0077 0.0332 0.0654
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Schistosoma mansoni biogenic amine (5HT) receptor 0.0148 0.2501 0.4932
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.2501 0.4932
Echinococcus multilocularis G protein coupled receptor 139 0.0148 0.2501 0.4329
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0148 0.2501 0.4329
Echinococcus multilocularis somatostatin receptor 0.0148 0.2501 0.4329
Loa Loa (eye worm) neuropeptide F receptor 0.0148 0.2501 0.2501
Echinococcus multilocularis neuropeptide Y receptor 0.0148 0.2501 0.4329
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Onchocerca volvulus 0.0148 0.2501 0.4932
Echinococcus multilocularis neuropeptide FF receptor 2 0.0148 0.2501 0.4329
Loa Loa (eye worm) G-protein coupled receptor 0.0148 0.2501 0.2501
Brugia malayi hypothetical protein 0.0148 0.2501 0.4932
Echinococcus granulosus ankyrin repeat protein 0.0154 0.2683 0.4691
Echinococcus granulosus neuropeptide Y receptor 0.0148 0.2501 0.4329
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0148 0.2501 0.4932
Brugia malayi hypothetical protein 0.0148 0.2501 0.4932
Echinococcus granulosus tm gpcr rhodopsin 0.0148 0.2501 0.4329
Brugia malayi neuropeptide F receptor 0.0148 0.2501 0.4932
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0148 0.2501 0.2501
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus granulosus hypothetical protein 0.0148 0.2501 0.4329
Schistosoma mansoni neuropeptide receptor 0.0148 0.2501 0.4932
Echinococcus granulosus ceramide glucosyltransferase 0.0233 0.5071 0.9458
Echinococcus granulosus adam 17 protease 0.0206 0.4267 0.7853
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Brugia malayi Serotonin receptor 0.0148 0.2501 0.4932
Onchocerca volvulus 0.0148 0.2501 0.4932
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0148 0.2501 0.2501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.2501 0.4932
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0242 0.5343 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Onchocerca volvulus Matrilysin homolog 0.0147 0.2469 0.4868
Echinococcus granulosus g-protein coupled receptor 0.0148 0.2501 0.4329
Echinococcus granulosus serotonin receptor 0.0148 0.2501 0.4329
Schistosoma mansoni neuropeptide receptor 0.0148 0.2501 0.4932
Loa Loa (eye worm) TYRA-2 protein 0.0148 0.2501 0.2501
Schistosoma mansoni neuropeptide receptor 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Onchocerca volvulus 0.0148 0.2501 0.4932
Echinococcus granulosus somatostatin receptor 0.0148 0.2501 0.4329
Brugia malayi Matrixin family protein 0.0161 0.2874 0.5668
Echinococcus granulosus neuropeptide Y receptor 0.0148 0.2501 0.4329
Brugia malayi sulfakinin receptor protein 0.0148 0.2501 0.4932
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0148 0.2501 0.4932
Echinococcus granulosus neuropeptide receptor A26 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Brugia malayi Melatonin receptor type 1A 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Onchocerca volvulus 0.0148 0.2501 0.4932
Schistosoma mansoni hypothetical protein 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Schistosoma mansoni opsin-like receptor 0.0148 0.2501 0.4932
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0089 0.0676 0.0687
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0148 0.2501 0.4932
Echinococcus multilocularis g protein coupled receptor 0.0148 0.2501 0.4329
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Brugia malayi RE15519p 0.0148 0.2501 0.4932
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0148 0.2501 0.4932
Brugia malayi hypothetical protein 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus granulosus 7tm_1 domain containing protein 0.0148 0.2501 0.4329
Brugia malayi Hemopexin family protein 0.0094 0.0847 0.167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.2501 0.4932
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0148 0.2501 0.4932
Loa Loa (eye worm) ceramide glucosyltransferase 0.0233 0.5071 0.5071
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0148 0.2501 0.4329
Onchocerca volvulus 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Schistosoma mansoni biogenic amine receptor 0.0148 0.2501 0.4932
Echinococcus multilocularis neuropeptide Y receptor 0.0148 0.2501 0.4329
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0148 0.2501 0.4329
Brugia malayi Serotonin receptor 0.0148 0.2501 0.4932
Loa Loa (eye worm) G-protein coupled receptor 0.0148 0.2501 0.2501
Schistosoma mansoni neuropeptide F-like receptor 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus granulosus tm gpcr rhodopsin 0.0148 0.2501 0.4329
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0148 0.2501 0.4329
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0148 0.2501 0.4932
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0148 0.2501 0.4932
Onchocerca volvulus 0.0148 0.2501 0.4932
Schistosoma mansoni biogenic amine (5HT) receptor 0.0148 0.2501 0.4932
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0148 0.2501 0.4329
Schistosoma mansoni amine GPCR 0.0148 0.2501 0.4932
Echinococcus granulosus neuropeptide receptor 0.0148 0.2501 0.4329
Echinococcus granulosus biogenic amine 5HT receptor 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus granulosus dro:myosuppressin receptor 0.0148 0.2501 0.4329
Brugia malayi hypothetical protein 0.0148 0.2501 0.4932
Echinococcus multilocularis dro:myosuppressin receptor 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0081 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0148 0.2501 0.4932
Echinococcus granulosus transient receptor potential cation channel 0.0162 0.2927 0.518
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Schistosoma mansoni hypothetical protein 0.0094 0.0847 0.167
Schistosoma mansoni opsin-like receptor 0.0148 0.2501 0.4932
Onchocerca volvulus 0.0148 0.2501 0.4932
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Brugia malayi putative neuropeptide receptor NPR1 0.0148 0.2501 0.4932
Schistosoma mansoni myosin xvIII 0.0148 0.2501 0.4932
Schistosoma mansoni ceramide glucosyltransferase 0.0233 0.5071 1
Echinococcus multilocularis fmrfamide receptor 0.0148 0.2501 0.4329
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Echinococcus multilocularis G-protein coupled receptor, putative 0.0148 0.2501 0.4329
Onchocerca volvulus 0.0148 0.2501 0.4932
Echinococcus granulosus alpha 1A adrenergic receptor 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus multilocularis adam 17 protease 0.0188 0.3696 0.6714
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Echinococcus granulosus neuropeptide receptor 0.0148 0.2501 0.4329
Schistosoma mansoni biogenic amine receptor 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0233 0.5071 1
Schistosoma mansoni opsin-like receptor 0.0148 0.2501 0.4932
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0148 0.2501 0.4329
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus granulosus g protein coupled receptor 0.0148 0.2501 0.4329
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0148 0.2501 0.4329
Echinococcus granulosus tm gpcr rhodopsin 0.0148 0.2501 0.4329
Echinococcus granulosus g protein coupled receptor 0.0148 0.2501 0.4329
Echinococcus granulosus biogenic amine 5HT receptor 0.0148 0.2501 0.4329
Loa Loa (eye worm) neuropeptide F receptor 0.0148 0.2501 0.2501
Echinococcus multilocularis neuropeptide receptor 0.0148 0.2501 0.4329
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0089 0.0676 0.1332
Echinococcus multilocularis g-protein coupled receptor 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.0539 0.1064
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Onchocerca volvulus 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Brugia malayi G-protein coupled receptor 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Loa Loa (eye worm) matrixin family protein 0.0161 0.2874 0.2874
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0148 0.2501 0.4932
Onchocerca volvulus Matrix metalloproteinase homolog 0.0147 0.2469 0.4868
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0148 0.2501 0.4932
Echinococcus granulosus orexin receptor type 2 0.0148 0.2501 0.4329
Brugia malayi hypothetical protein 0.0148 0.2501 0.4932
Mycobacterium leprae PROBABLE HYDROLASE 0.0081 0.0442 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Onchocerca volvulus 0.0148 0.2501 0.4932
Echinococcus multilocularis ceramide glucosyltransferase 0.0233 0.5071 0.9458
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0148 0.2501 0.4329
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0148 0.2501 0.4932
Echinococcus granulosus peptide allatostatin:somatostatin 0.0148 0.2501 0.4329
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0148 0.2501 0.4329
Onchocerca volvulus 0.0148 0.2501 0.4932
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0148 0.2501 0.4329
Loa Loa (eye worm) melatonin receptor type 1A 0.0148 0.2501 0.2501
Echinococcus multilocularis serotonin receptor 0.0148 0.2501 0.4329
Echinococcus multilocularis neuropeptide s receptor 0.0148 0.2501 0.4329
Schistosoma mansoni hypothetical protein 0.0148 0.2501 0.4932
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0077 0.0332 0.0332
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0148 0.2501 0.4932
Brugia malayi GnHR receptor homolog 0.0148 0.2501 0.4932
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0148 0.2501 0.4932
Brugia malayi Dopamine receptor protein 2 0.0148 0.2501 0.4932
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0148 0.2501 0.4932
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0081 0.0442 0.5
Loa Loa (eye worm) matrixin family protein 0.0147 0.2469 0.2469
Echinococcus multilocularis ankyrin repeat protein 0.0154 0.2683 0.4691
Onchocerca volvulus 0.0148 0.2501 0.4932
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0148 0.2501 0.4932
Schistosoma mansoni hypothetical protein 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus multilocularis neuropeptides capa receptor 0.0148 0.2501 0.4329
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0148 0.2501 0.4329
Echinococcus granulosus neuropeptides capa receptor 0.0148 0.2501 0.4329
Echinococcus granulosus neuropeptide s receptor 0.0148 0.2501 0.4329
Brugia malayi hypothetical protein 0.0148 0.2501 0.4932
Echinococcus multilocularis neuropeptide receptor A26 0.0148 0.2501 0.4329
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Schistosoma mansoni histamine h1 receptor 0.0148 0.2501 0.4932
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0148 0.2501 0.2501
Echinococcus multilocularis rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0087 0.5
Brugia malayi Dopamine receptor protein 1 0.0148 0.2501 0.4932
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Onchocerca volvulus 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Schistosoma mansoni hypothetical protein 0.0148 0.2501 0.4932
Brugia malayi hypothetical protein 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Onchocerca volvulus 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0148 0.2501 0.4329
Echinococcus multilocularis allatostatin A receptor 0.0148 0.2501 0.4329
Echinococcus multilocularis transient receptor potential cation channel 0.0162 0.2927 0.518
Brugia malayi hypothetical protein 0.0148 0.2501 0.4932
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0148 0.2501 0.4329
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0089 0.0676 0.1332
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0148 0.2501 0.4329
Brugia malayi Ceramide glucosyltransferase 0.0233 0.5071 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Schistosoma mansoni voltage-gated potassium channel 0.0084 0.0539 0.1064
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Loa Loa (eye worm) hypothetical protein 0.0148 0.2501 0.2501
Echinococcus granulosus rhodopsin orphan GPCR 0.0148 0.2501 0.4329
Brugia malayi G protein-coupled receptor 0.0148 0.2501 0.4932
Onchocerca volvulus 0.0094 0.0847 0.167
Echinococcus multilocularis sex peptide receptor 0.0148 0.2501 0.4329
Brugia malayi putative neuropeptide receptor 0.0148 0.2501 0.4932
Loa Loa (eye worm) hypothetical protein 0.0068 0.0033 0.0033
Brugia malayi ORL1-like opioid receptor 0.0148 0.2501 0.4932
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0118 0.1564 0.246
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0148 0.2501 0.2501

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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