Detailed information for compound 888815

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 388.431 | Formula: C20H18F2N2O2S
  • H donors: 1 H acceptors: 3 LogP: 3.85 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(N(C(=O)c1csc(n1)c1ccc(cc1F)F)Cc1ccccc1)C
  • InChi: 1S/C20H18F2N2O2S/c1-13(11-25)24(10-14-5-3-2-4-6-14)20(26)18-12-27-19(23-18)16-8-7-15(21)9-17(16)22/h2-9,12-13,25H,10-11H2,1H3
  • InChiKey: JZGVGXWLSCSFJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0064 0.0992 0.0991
Brugia malayi Steroid receptor seven-up type 2 0.0064 0.0992 0.0991
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0163 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.4526 0.4525
Schistosoma mansoni hypothetical protein 0.0064 0.0988 0.1404
Onchocerca volvulus 0.003 0.026 0.0098
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0034 0.0338 0.048
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0988 0.0987
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0064 0.0992 0.0842
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0064 0.0992 0.0991
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0148 0.0209
Loa Loa (eye worm) hypothetical protein 0.0064 0.0992 0.0991
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0064 0.0992 0.0991
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0064 0.0992 0.1409
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.259 0.259
Brugia malayi nuclear receptor NHR-88 0.003 0.026 0.0259
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0064 0.0992 0.1409
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0338 0.0338
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1004 0.1003
Echinococcus granulosus hormone sensitive lipase 0.0226 0.4526 0.6434
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.026 0.0098
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0163 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.0992 0.0991
Onchocerca volvulus 0.0064 0.0992 0.0842
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0226 0.4526 0.6434
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0064 0.0992 0.1409
Schistosoma mansoni thyroid hormone receptor 0.0064 0.0992 0.1409
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.3971 0.3971
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0064 0.0992 0.1409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0064 0.0992 0.0991
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Loa Loa (eye worm) RNA binding protein 0.0064 0.1004 0.1003
Brugia malayi steroid hormone receptor 0.0064 0.0992 0.0991
Schistosoma mansoni hypothetical protein 0.0137 0.259 0.3682
Loa Loa (eye worm) hypothetical protein 0.0137 0.259 0.259
Loa Loa (eye worm) hypothetical protein 0.0064 0.0992 0.0991
Loa Loa (eye worm) hypothetical protein 0.0146 0.2778 0.2778
Loa Loa (eye worm) steroid hormone receptor 0.0064 0.0992 0.0991
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0163 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0163 0.0162
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0163 0.1407
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1004 0.1426
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0064 0.0992 0.1409
Brugia malayi RNA binding protein 0.0064 0.1004 0.1003
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1004 0.1003
Onchocerca volvulus Protein ultraspiracle homolog 0.0064 0.0992 0.0842
Brugia malayi conserved hypotetical protein 0.003 0.026 0.0259
Schistosoma mansoni nuclear hormone receptor 0.0064 0.0992 0.1409
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0163 0.1407
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0163 0.1306
Echinococcus multilocularis FTZ F1 alpha 0.0064 0.0992 0.1409
Echinococcus granulosus geminin 0.0342 0.7034 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0064 0.0992 0.1409
Echinococcus multilocularis GPCR, family 2 0.0064 0.0988 0.1404
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.026 0.0369
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0034 0.0338 0.0338
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0002 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0163 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0148 0.1273
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0064 0.0992 0.1409
Echinococcus multilocularis Protein lozenge 0.006 0.0911 0.1294
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.1156 1
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0338 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0064 0.0992 0.0991
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Loa Loa (eye worm) hypothetical protein 0.0146 0.2778 0.2778
Brugia malayi tailless protein 0.003 0.026 0.0259
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0603 0.0856
Schistosoma mansoni nuclear receptor 0.003 0.026 0.0369
Schistosoma mansoni nuclear receptor 0.003 0.026 0.0369
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0064 0.0992 0.0991
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.0992 0.1409
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0162
Brugia malayi orphan nuclear receptor NR2E1 0.003 0.026 0.0259
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.0992 0.1409
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0022
Entamoeba histolytica hypothetical protein 0.0075 0.1245 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.1245 0.1768
Loa Loa (eye worm) hypothetical protein 0.0064 0.0992 0.0991
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1004 0.1426
Brugia malayi hypothetical protein 0.003 0.026 0.0259
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0163 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0163 0.1407
Brugia malayi photoreceptor-specific nuclear receptor 0.0064 0.0992 0.0991
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0226 0.4526 0.6434
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0064 0.0992 0.1409
Brugia malayi nuclear hormone receptor 0.0064 0.0992 0.0991
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0992 0.0991
Loa Loa (eye worm) hypothetical protein 0.0064 0.0988 0.0987
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.003 0.026 0.0259
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.1156 0.1642
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.0992 0.1409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0064 0.0992 0.0991
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0023 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0064 0.0992 0.1409
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.026 0.0369
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.003 0.026 0.0369
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0988 0.1404
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.003 0.026 0.0369
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.1245 0.1768
Brugia malayi ecdysone receptor 0.003 0.026 0.0259
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1004 0.1003
Brugia malayi Muscleblind-like protein 0.0146 0.2778 0.2778
Schistosoma mansoni hypothetical protein 0.0342 0.7034 1
Brugia malayi hypothetical protein 0.0034 0.0338 0.0338
Onchocerca volvulus Bile acid receptor homolog 0.0064 0.0992 0.0842
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0163 0.0162
Loa Loa (eye worm) nuclear hormone receptor 0.003 0.026 0.0259
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0148 0.0209
Entamoeba histolytica hypothetical protein 0.0025 0.0148 0.1183
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0064 0.0992 0.0991
Loa Loa (eye worm) hypothetical protein 0.0034 0.0338 0.0338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.0992 0.1409
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0988 0.0987
Brugia malayi ecdysteroid receptor 0.0064 0.0992 0.0991
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0022
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0163 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.026 0.0098
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0034 0.0338 0.048
Echinococcus granulosus nuclear receptor nhr 48 0.003 0.026 0.0369
Loa Loa (eye worm) hypothetical protein 0.0201 0.3971 0.3971
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0163 0.1306
Schistosoma mansoni nuclear receptor nhr-48 0.003 0.026 0.0369
Schistosoma mansoni hypothetical protein 0.0075 0.1245 0.1768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0148 1
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0226 0.4526 0.6434
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0072 0.0618
Echinococcus multilocularis muscleblind protein 0.0146 0.2778 0.3949
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0064 0.0992 0.0991
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0163 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.003 0.026 0.0259
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Schistosoma mansoni nuclear hormone receptor 0.003 0.026 0.0369
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0603 0.0856
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.1156 1
Brugia malayi nuclear receptor RXR 0.003 0.026 0.0259
Echinococcus granulosus ecdysone induced protein 78C 0.0064 0.0992 0.1409
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0148 0.1273
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.1156 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0064 0.0992 0.0991
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.003 0.026 0.0369
Brugia malayi nuclear hormone receptor 0.003 0.026 0.0259
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1004 0.1426
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0023 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.026 0.0369
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.1156 0.1642
Echinococcus granulosus thyroid hormone receptor alpha 0.003 0.026 0.0369
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0064 0.0992 0.0991
Schistosoma mansoni hypothetical protein 0.0064 0.0988 0.1404
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1004 0.1426
Brugia malayi nuclear receptor NHR-88 0.0064 0.0992 0.0991
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0163 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.003 0.026 0.0259
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0988 0.1404
Schistosoma mansoni zinc finger protein 0.003 0.026 0.0369
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0064 0.0992 0.0991
Echinococcus multilocularis ecdysone induced protein 78C 0.0064 0.0992 0.1409
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0338 0.048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.0992 0.1409
Schistosoma mansoni thyroid hormone receptor 0.0064 0.0992 0.1409
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0148 0.0209
Brugia malayi nuclear hormone receptor family member odr-7 0.003 0.026 0.0259
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0064 0.0992 0.0991
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0504 0.0715
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.1156 0.1155
Echinococcus multilocularis thyroid hormone receptor alpha 0.0064 0.0992 0.1409
Echinococcus multilocularis geminin 0.0342 0.7034 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.026 0.0369
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0064 0.0992 0.1409
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Echinococcus granulosus FTZ F1 alpha 0.0064 0.0992 0.1409
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0504 0.0715
Echinococcus multilocularis muscleblind protein 1 0.0146 0.2778 0.3949
Schistosoma mansoni RAR-like nuclear receptor 0.0064 0.0992 0.1409
Loa Loa (eye worm) hypothetical protein 0.0479 1 1
Schistosoma mansoni hypothetical protein 0.0064 0.0988 0.1404
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0022
Loa Loa (eye worm) nuclear receptor NHR-67 0.003 0.026 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0064 0.0992 0.0991
Loa Loa (eye worm) hypothetical protein 0.0064 0.0992 0.0991
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0163 1
Brugia malayi hypothetical protein 0.0034 0.0338 0.0338
Echinococcus multilocularis hormone sensitive lipase 0.0226 0.4526 0.6434
Loa Loa (eye worm) hypothetical protein 0.0479 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0338 0.0338
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0064 0.0992 0.1409
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0603 0.0856
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0163 0.0162
Brugia malayi hypothetical protein 0.003 0.026 0.0259
Brugia malayi hypothetical protein 0.0075 0.1245 0.1244
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0603 0.0602
Loa Loa (eye worm) DR-78 0.003 0.026 0.0259
Echinococcus granulosus muscleblind protein 0.0146 0.2778 0.3949
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.026 0.0369
Entamoeba histolytica hypothetical protein 0.0075 0.1245 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0988 0.1404
Schistosoma mansoni hypothetical protein 0.0064 0.0988 0.1404
Loa Loa (eye worm) hypothetical protein 0.0064 0.0992 0.0991
Loa Loa (eye worm) hypothetical protein 0.0064 0.0992 0.0991
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0064 0.0992 0.1409
Brugia malayi TAR-binding protein 0.0064 0.1004 0.1003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0603 0.0856
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.1156 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0603 0.0856
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0023 0.139
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1004 0.1426
Giardia lamblia GTOR 0.0018 0.0001 0.5
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.1156 0.1642
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0603 0.0602
Onchocerca volvulus 0.003 0.026 0.0098
Onchocerca volvulus 0.0479 1 1
Schistosoma mansoni hypothetical protein 0.0342 0.7034 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0064 0.0992 0.1409
Schistosoma mansoni lozenge 0.006 0.0911 0.1294
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0162
Schistosoma mansoni nuclear hormone receptor 0.003 0.026 0.0369
Echinococcus granulosus tar DNA binding protein 0.0064 0.1004 0.1426
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.1156 0.9287
Echinococcus multilocularis nuclear receptor nhr 48 0.003 0.026 0.0369
Brugia malayi Nuclear hormone receptor E75 0.003 0.026 0.0259
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0603 0.0856
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0034 0.0338 0.048
Loa Loa (eye worm) runx1 0.006 0.0911 0.091
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0064 0.0992 0.0991
Entamoeba histolytica hypothetical protein 0.0075 0.1245 1
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0148 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0064 0.0992 0.0991
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0148 0.0147
Entamoeba histolytica hypothetical protein 0.0075 0.1245 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0064 0.0992 0.0991
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0064 0.0992 0.0991
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0163 1
Brugia malayi Nuclear hormone receptor E75 0.003 0.026 0.0259
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0023 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0064 0.0992 0.1409
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0163 0.1306
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0064 0.0992 0.0991
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.3971 0.3971
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.1156 0.1155
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0988 0.1404
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.003 0.026 0.0369
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.3971 0.3971
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.026 0.0369
Schistosoma mansoni coup transcription factor 0.0064 0.0992 0.1409
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0163 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0163 0.0162
Brugia malayi nuclear receptor NHR-67 0.003 0.026 0.0259
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0603 0.0856
Echinococcus multilocularis tar DNA binding protein 0.0064 0.1004 0.1426
Loa Loa (eye worm) hypothetical protein 0.0034 0.0338 0.0338
Mycobacterium ulcerans hypothetical protein 0.0026 0.0163 1
Brugia malayi nuclear receptor RXR 0.0034 0.0338 0.0338
Echinococcus granulosus GPCR family 2 0.0064 0.0988 0.1404
Loa Loa (eye worm) hypothetical protein 0.0034 0.0338 0.0338
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.1245 0.1768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0064 0.0992 0.0991
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.003 0.026 0.0369
Loa Loa (eye worm) hypothetical protein 0.003 0.026 0.0259
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0064 0.0992 0.1409
Schistosoma mansoni steroid hormone receptor ad4bp 0.0064 0.0992 0.1409
Loa Loa (eye worm) hypothetical protein 0.0034 0.0338 0.0338
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0988 0.0987
Loa Loa (eye worm) hypothetical protein 0.0064 0.0992 0.0991

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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