Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0081 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0081 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0072 | 0.7743 | 0.0127 |
Echinococcus multilocularis | deoxyhypusine synthase | 0.0072 | 0.7715 | 0.699 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0081 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.005 | 0.2407 | 0.2407 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0081 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0081 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0081 | 1 | 1 |
Entamoeba histolytica | deoxyhypusine synthase, putative | 0.0072 | 0.7715 | 0.5 |
Toxoplasma gondii | deoxyhypusine synthase | 0.0072 | 0.7715 | 1 |
Schistosoma mansoni | deoxyhypusine synthase | 0.0072 | 0.7715 | 0.7715 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0081 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0081 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0081 | 1 | 1 |
Echinococcus granulosus | deoxyhypusine synthase | 0.0072 | 0.7715 | 0.699 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0081 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | deoxyhypusine synthase | 0.0072 | 0.7715 | 0.699 |
Leishmania major | p450 reductase, putative | 0.0081 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0072 | 0.7743 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0081 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0072 | 0.7743 | 0.0127 |
Entamoeba histolytica | deoxyhypusine synthase, putative | 0.0072 | 0.7715 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.005 | 0.2407 | 0.5 |
Brugia malayi | deoxyhypusine synthase | 0.0072 | 0.7715 | 0.699 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0081 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0081 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0081 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0041 | 0.0151 | 0.0151 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0081 | 1 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0072 | 0.7743 | 0.0127 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0072 | 0.7743 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0081 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0081 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.